Mark C. Leake

The elasticity of single kettin molecules using a two-bead laser-tweezers assay.

Damped elastic recoil of the titin spring in myofibrils of human myocardium.

Association of the chaperone alphaB-crystallin with titin in heart muscle.

Developmentally regulated switching of titin size alters myofibrillar stiffness in the perinatal heart.

The elasticity of single titin molecules using a two-bead optical tweezers assay.

Multiple sources of passive stress relaxation in muscle fibres.

Direct observation of steps in rotation of the bacterial flagellar motor.

Fluorescence measurement of intracellular sodium concentration in single Escherichia coli cells.

The molecular elasticity of the insect flight muscle proteins projectin and kettin.

Mechanical properties of cardiac titin's N2B-region by single-molecule atomic force spectroscopy.

The maximum number of torque-generating units in the flagellar motor of Escherichia coli is at least 11.

Stoichiometry and turnover in single, functioning membrane protein complexes.

Nonequivalence of membrane voltage and ion-gradient as driving forces for the bacterial flagellar motor at low load.

Are Escherichia coli OXPHOS complexes concentrated in specialized zones within the plasma membrane?

Variable stoichiometry of the TatA component of the twin-arginine protein transport system observed by in vivo single-molecule imaging.

Clustering and dynamics of cytochrome bd-I complexes in the Escherichia coli plasma membrane in vivo.

A molecular brake, not a clutch, stops the Rhodobacter sphaeroides flagellar motor.

Stoichiometry and architecture of active DNA replication machinery in Escherichia coli.

Signal-dependent turnover of the bacterial flagellar switch protein FliM.

Shining the spotlight on functional molecular complexes: The new science of single-molecule cell biology.

Functioning nanomachines seen in real-time in living bacteria using single-molecule and super-resolution fluorescence imaging.