Brant E. Isakson

Culturing alveolar type I, alveolar type II, and mixed cell populations by altering the extracellular matrix promotes changes in intercellular signaling mechanisms.

Heterocellular cultures of pulmonary alveolar epithelial cells grown on laminin-5 supplemented matrix.

Cell-cell communication in heterocellular cultures of alveolar epithelial cells.

Connexins: gaps in our knowledge of vascular function.

Heterocellular contact at the myoendothelial junction influences gap junction organization.

Extracellular matrix-driven alveolar epithelial cell differentiation in vitro.

Connexin40 and connexin43 in mouse aortic endothelium: evidence for coordinated regulation.

Oxidized phospholipids alter vascular connexin expression, phosphorylation, and heterocellular communication.

Laminin-332 alters connexin profile, dye coupling and intercellular Ca2+ waves in ciliated tracheal epithelial cells.

Vascular gap junctions in hypertension.

Ca2+ and inositol 1,4,5-trisphosphate-mediated signaling across the myoendothelial junction.

Incidence of protein on actin bridges between endothelium and smooth muscle in arterioles demonstrates heterogeneous connexin expression and phosphorylation.

Connexins in vascular physiology and pathology.

Localized expression of an Ins(1,4,5)P3 receptor at the myoendothelial junction selectively regulates heterocellular Ca2+ communication.

The myoendothelial junction: breaking through the matrix?

Oxidized phospholipid species promote in vivo differential cx43 phosphorylation and vascular smooth muscle cell proliferation.

The importance of serine 161 in the sodium channel beta3 subunit for modulation of Na(V)1.2 gating.

Site-specific connexin phosphorylation is associated with reduced heterocellular communication between smooth muscle and endothelium.

Plasminogen activator inhibitor-1 regulates myoendothelial junction formation.

Enhanced connexin 43 expression delays intra-mitotic duration and cell cycle traverse independently of gap junction channel function.

Identification of a novel macrophage phenotype that develops in response to atherogenic phospholipids via Nrf2.

Pannexin 1 channels mediate 'find-me' signal release and membrane permeability during apoptosis.

Compartmentalized connexin 43 s-nitrosylation/denitrosylation regulates heterocellular communication in the vessel wall.

A new method for in vivo visualization of vessel remodeling using a near-infrared dye.

Pannexin1 regulates α1-adrenergic receptor- mediated vasoconstriction.

Spontaneous lung dysfunction and fibrosis in mice lacking connexin 40 and endothelial cell connexin 43.

Characterization of the thoracodorsal artery: morphology and reactivity.

A novel mRNA binding protein complex promotes localized plasminogen activator inhibitor-1 accumulation at the myoendothelial junction.

Loss of compliance in small arteries, but not in conduit arteries, after 6 weeks exposure to high fat diet.

Smooth muscle specific deletion of Ndst1 leads to decreased vessel luminal area and no change in blood pressure in conscious mice.

MAPK phosphorylation of connexin 43 promotes binding of cyclin E and smooth muscle cell proliferation.

Mechanisms of ATP release and signalling in the blood vessel wall.

Expression of pannexin isoforms in the systemic murine arterial network.

Posttranslational modifications in connexins and pannexins.

Pannexin 1 in the regulation of vascular tone.

S-nitrosylation inhibits pannexin 1 channel function.

Hypoxic pulmonary vasoconstriction requires connexin 40-mediated endothelial signal conduction.

Endothelial cell expression of haemoglobin α regulates nitric oxide signalling.

Loss of collectrin, an angiotensin-converting enzyme 2 homolog, uncouples endothelial nitric oxide synthase and causes hypertension and vascular dysfunction.

Vascular biomechanical properties in mice with smooth muscle specific deletion of Ndst1.

Diverse post-translational modifications of the pannexin family of channel-forming proteins.

Secreting von Willebrand factor in a Gα-SNAP.

Differentiating connexin hemichannels and pannexin channels in cellular ATP release.

Pannexin-1 as a potentiator of ligand-gated receptor signaling.

Connexins, pannexins and innexins: protein cousins with overlapping functions.

Regulation of cellular communication by signaling microdomains in the blood vessel wall.

Hemoglobin α in the blood vessel wall.

The myoendothelial junction: connections that deliver the message.

Hemoglobin α/eNOS coupling at myoendothelial junctions is required for nitric oxide scavenging during vasoconstriction.

A molecular signature in the pannexin1 intracellular loop confers channel activation by the α1 adrenoreceptor in smooth muscle cells.

Emerging concepts regarding pannexin 1 in the vasculature.

Pannexin 1 channels regulate leukocyte emigration through the venous endothelium during acute inflammation.

The connexin 43/ZO-1 complex regulates cerebral endothelial F-actin architecture and migration.

Endothelial nitric oxide synthase in the microcirculation.

Pannexin 1 is required for full activation of insulin-stimulated glucose uptake in adipocytes.

CCR7 and IRF4-dependent dendritic cells regulate lymphatic collecting vessel permeability.

Two functionally distinct pools of eNOS in endothelium are facilitated by myoendothelial junction lipid composition.

Small Interfering RNA-Mediated Connexin Gene Knockdown in Vascular Endothelial and Smooth Muscle Cells.

Central Role of P2Y6 UDP Receptor in Arteriolar Myogenic Tone.

Cardiovascular magnetic resonance detects the progression of impaired myocardial perfusion reserve and increased left-ventricular mass in mice fed a high-fat diet.

AXL-Mediated Productive Infection of Human Endothelial Cells by Zika Virus.

Modulating Vascular Hemodynamics With an Alpha Globin Mimetic Peptide (HbαX).

Red Blood Cell Function and Dysfunction: Redox Regulation, Nitric Oxide Metabolism, Anemia.

Pannexin channel and connexin hemichannel expression in vascular function and inflammation.

Signaling Pathways Linked to Serotonin-Induced Superoxide Anion Production: A Physiological Role for Mitochondria in Pulmonary Arteries.

Smooth muscle cell-specific deletion of Col15a1 unexpectedly leads to impaired development of advanced atherosclerotic lesions.

The Evolving Role of Diverse Gaseous Transmitters Mediating Heterocellular Communication Within the Vasculature.

ZP1609/danegaptide and mitochondrial connexin hemichannels: a harbinger for peptide drug design.