Hideyuki Takeshima

Fabrication of wool keratin sponge scaffolds for long-term cell cultivation.

Distinct enzymatic properties of recombinant mouse DNA methyltransferases Dnmt3a and Dnmt3b.

DNMT3L stimulates the DNA methylation activity of Dnmt3a and Dnmt3b through a direct interaction.

Distinct DNA methylation activity of Dnmt3a and Dnmt3b towards naked and nucleosomal DNA.

Mouse Dnmt3a preferentially methylates linker DNA and is inhibited by histone H1.

The presence of RNA polymerase II, active or stalled, predicts epigenetic fate of promoter CpG islands.

Development of a novel output value for quantitative assessment in methylated DNA immunoprecipitation-CpG island microarray analysis.

Methylation destiny: Moira takes account of histones and RNA polymerase II.

Hippocampal epigenetic modification at the brain-derived neurotrophic factor gene induced by an enriched environment.

Enhanced IL-1beta production in response to the activation of hippocampal glial cells impairs neurogenesis in aged mice.

Hippocampal epigenetic modification at the doublecortin gene is involved in the impairment of neurogenesis with aging.

Epigenetic modulation at the CCR2 gene correlates with the maintenance of behavioral sensitization to methamphetamine.

Characterization of DNA-binding activity in the N-terminal domain of the DNA methyltransferase Dnmt3a.

Effects of genome architecture and epigenetic factors on susceptibility of promoter CpG islands to aberrant DNA methylation induction.

Development of a novel approach, the epigenome-based outlier approach, to identify tumor-suppressor genes silenced by aberrant DNA methylation.

[Application of epigenetics to cancer diagnosis and therapy].

Induction of aberrant trimethylation of histone H3 lysine 27 by inflammation in mouse colonic epithelial cells.

Comprehensive DNA methylation and extensive mutation analyses reveal an association between the CpG island methylator phenotype and oncogenic mutations in gastric cancers.

Epigenetic transcriptional activation of monocyte chemotactic protein 3 contributes to long-lasting neuropathic pain.

[Epigenetics as a novel therapeutic target of cancer].

Usefulness of low-dose methotrexate monotherapy for treating sarcoidosis.

Integrated analysis of cancer-related pathways affected by genetic and epigenetic alterations in gastric cancer.

Frequent involvement of chromatin remodeler alterations in gastric field cancerization.

Identification of coexistence of DNA methylation and H3K27me3 specifically in cancer cells as a promising target for epigenetic therapy.

Establishment of a DNA methylation marker to evaluate cancer cell fraction in gastric cancer.

Interleukin-17A and Toll-Like Receptor 3 Ligand Poly(I:C) Synergistically Induced Neutrophil Chemoattractant Production by Bronchial Epithelial Cells.

[Case Report; Influenza vaccination-associated acute lung injury: two cases report].

Early-Stage Induction of SWI/SNF Mutations during Esophageal Squamous Cell Carcinogenesis.