Laboratory for Genetic Code,
Graduate School of Life and Medical Sciences,
Laboratory for Genetic Code, Graduate School of Life and Medical Sciences
Hiroaki Taniguchi is an assistant professor and a team leader of laboratory for Genome Editing and Transcriptional Regulation at Institute of Genetics and Animal Breeding of the Polish Academy of Sciences. He received a Ph.D. from Université Laval (Faculty of Medicine, CANADA). His current research focuses on CRISPR-mediated gene editing and transcriptional gene regulation in the field of regenerative medicine, reproductive biology, and cancer biology.
High plasma levels of matrix metalloproteinase-8 in patients with unstable angina.
Atherosclerosis Mar, 2010 | Pubmed ID: 19674746
The lipoxygenase pathways are involved in LH-stimulated progesterone production in bovine corpus luteum.
Prostaglandins & other lipid mediators Jan, 2002 | Pubmed ID: 11789897
Fas-Fas ligand system mediates luteal cell death in bovine corpus luteum.
Biology of reproduction Mar, 2002 | Pubmed ID: 11870083
Comparison of green tea intake in Japanese patients with and without angiographic coronary artery disease.
The American journal of cardiology Nov, 2002 | Pubmed ID: 12423723
Association of trypsin expression with tumour progression and matrilysin expression in human colorectal cancer.
The Journal of pathology Feb, 2003 | Pubmed ID: 12533830
[Expression of trypsin and cancer proliferation in colorectal neoplasms].
Nihon rinsho. Japanese journal of clinical medicine Sep, 2003 | Pubmed ID: 14574885
Expression of ets-related transcriptional factor E1AF is associated with tumor progression and over-expression of matrilysin in human gastric cancer.
Carcinogenesis Mar, 2004 | Pubmed ID: 14604892
Plasma osteopontin levels are associated with the presence and extent of coronary artery disease.
Atherosclerosis Oct, 2003 | Pubmed ID: 14612215
[Beneficial effect of glucocorticosteroids for esophageal varices due to idiopathic portal hypertension following systemic lupus erythematosus].
Nihon Rinshō Men'eki Gakkai kaishi = Japanese journal of clinical immunology Feb, 2004 | Pubmed ID: 15045815
In vivo magnetic resonance evaluation of associations between aortic atherosclerosis and both risk factors and coronary artery disease in patients referred for coronary angiography.
American heart journal Jul, 2004 | Pubmed ID: 15215803
Role of the GATA family of transcription factors in andrology.
Journal of andrology Jul-Aug, 2004 | Pubmed ID: 15223831
Association of Mycoplasma pneumoniae infection with coronary artery disease and its interaction with chlamydial infection.
Atherosclerosis Sep, 2004 | Pubmed ID: 15306186
Association of matrilysin-2 (MMP-26) expression with tumor progression and activation of MMP-9 in esophageal squamous cell carcinoma.
Carcinogenesis Dec, 2004 | Pubmed ID: 15333466
[Abnormal fluorine-18 fluorodeoxy-glucose uptakes in the aorta and subclavian artery of a 66-year-old woman].
Journal of cardiology Sep, 2004 | Pubmed ID: 15500163
[Three successful case reports of advanced gastric cancer with chemotherapy].
Gan to kagaku ryoho. Cancer & chemotherapy Oct, 2004 | Pubmed ID: 15553684
An oxidized low-density lipoprotein receptor gene variant is inversely associated with the severity of coronary artery disease.
Clinical cardiology Nov, 2004 | Pubmed ID: 15562935
Associations of plasma C-reactive protein levels with the presence and extent of coronary stenosis in patients with stable coronary artery disease.
Atherosclerosis Jan, 2005 | Pubmed ID: 15585215
Interplay of insulin-like growth factor-II, insulin-like growth factor-I, insulin-like growth factor-I receptor, COX-2, and matrix metalloproteinase-7, play key roles in the early stage of colorectal carcinogenesis.
Clinical cancer research : an official journal of the American Association for Cancer Research Dec, 2004 | Pubmed ID: 15585629
Levels of matrix metalloproteinase-1 in patients with and without coronary artery disease and relation to complex and noncomplex coronary plaques.
The American journal of cardiology Jan, 2005 | Pubmed ID: 15619398
Association of Ets-related transcriptional factor E1AF expression with overexpression of matrix metalloproteinases, COX-2 and iNOS in the early stage of colorectal carcinogenesis.
Carcinogenesis May, 2005 | Pubmed ID: 15695237
Effect of lipid-lowering therapy with atorvastatin on atherosclerotic aortic plaques detected by noninvasive magnetic resonance imaging.
Journal of the American College of Cardiology Mar, 2005 | Pubmed ID: 15734619
GATA factors and the nuclear receptors, steroidogenic factor 1/liver receptor homolog 1, are key mutual partners in the regulation of the human 3beta-hydroxysteroid dehydrogenase type 2 promoter.
Molecular endocrinology (Baltimore, Md.) Sep, 2005 | Pubmed ID: 15928316
Lack of any association between persistent hepatitis B or C virus infection and coronary artery disease.
Atherosclerosis Jul, 2005 | Pubmed ID: 15939074
Polymorphism of the 3'-untranslated region of interleukin-12 p40 gene is not associated with the presence or severity of coronary artery disease.
Circulation journal : official journal of the Japanese Circulation Society Jul, 2005 | Pubmed ID: 15988104
Frequent epigenetic inactivation of Wnt inhibitory factor-1 in human gastrointestinal cancers.
Oncogene Nov, 2005 | Pubmed ID: 16007117
Associations between serum resistin levels and insulin resistance, inflammation, and coronary artery disease.
Journal of the American College of Cardiology Jul, 2005 | Pubmed ID: 16022972
Protein kinase A-dependent synergism between GATA factors and the nuclear receptor, liver receptor homolog-1, regulates human aromatase (CYP19) PII promoter activity in breast cancer cells.
Endocrinology Nov, 2005 | Pubmed ID: 16109788
Plasma matrix metalloproteinase-8 concentrations are associated with the presence and severity of coronary artery disease.
Circulation journal : official journal of the Japanese Circulation Society Sep, 2005 | Pubmed ID: 16127182
Green tea consumption and serum malondialdehyde-modified LDL concentrations in healthy subjects.
Journal of the American College of Nutrition Oct, 2005 | Pubmed ID: 16192258
High plasma levels of osteopontin in patients with restenosis after percutaneous coronary intervention.
Arteriosclerosis, thrombosis, and vascular biology Jan, 2006 | Pubmed ID: 16373617
A possible association between coronary plaque instability and complex plaques in abdominal aorta.
Arteriosclerosis, thrombosis, and vascular biology Apr, 2006 | Pubmed ID: 16424346
LDL fractions assessed by anion-exchange high-performance liquid chromatography in patients with coronary artery disease.
Atherosclerosis Jul, 2006 | Pubmed ID: 16620833
Association between osteoprotegerin gene polymorphism and coronary artery disease in Japanese men.
Atherosclerosis Jul, 2006 | Pubmed ID: 16678184
Overexpression of poly(ADP-ribose) polymerase-1 (PARP-1) in the early stage of colorectal carcinogenesis.
European journal of cancer (Oxford, England : 1990) Sep, 2006 | Pubmed ID: 16809031
LRH-1/NR5A2 cooperates with GATA factors to regulate inhibin alpha-subunit promoter activity.
Molecular and cellular endocrinology Sep, 2006 | Pubmed ID: 16893604
Mutational analysis of beta-catenin and the RAS-RAF signalling pathway in early flat-type colorectal tumours.
European journal of cancer (Oxford, England : 1990) Nov, 2006 | Pubmed ID: 17011185
Flat-type colorectal advanced adenomas (laterally spreading tumors) have different genetic and epigenetic alterations from protruded-type advanced adenomas.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc Jan, 2007 | Pubmed ID: 17143260
Genetic and epigenetic profiling in early colorectal tumors and prediction of invasive potential in pT1 (early invasive) colorectal cancers.
Carcinogenesis Jun, 2007 | Pubmed ID: 17183069
Effect of bezafibrate therapy on atherosclerotic aortic plaques detected by MRI in dyslipidemic patients with hypertriglyceridemia.
Atherosclerosis Jan, 2008 | Pubmed ID: 17196967
Differential expression of angiogenesis-related genes in human gastric cancers with and those without high-frequency microsatellite instability.
Cancer letters Aug, 2007 | Pubmed ID: 17374440
Magnetic resonance evaluation of the associations of thoracic and abdominal aortic plaques with the presence and extent of coronary artery stenosis.
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance , 2007 | Pubmed ID: 18066744
Correlation of laterally spreading type and JC virus with methylator phenotype status in colorectal adenoma.
Human pathology May, 2008 | Pubmed ID: 18284934
A GATA4/WT1 cooperation regulates transcription of genes required for mammalian sex determination and differentiation.
BMC molecular biology , 2008 | Pubmed ID: 18445271
Transcriptional silencing of Dickkopf gene family by CpG island hypermethylation in human gastrointestinal cancer.
World journal of gastroenterology May, 2008 | Pubmed ID: 18461655
LDL-3 fraction levels in patients with unstable angina: Assessment by anion-exchange high-performance liquid chromatography.
Atherosclerosis Mar, 2009 | Pubmed ID: 18687436
Overexpression of the receptor tyrosine kinase EphA4 in human gastric cancers.
World journal of gastroenterology Oct, 2008 | Pubmed ID: 18837080
The effect of human GATA4 gene mutations on the activity of target gonadal promoters.
Journal of molecular endocrinology Feb, 2009 | Pubmed ID: 19008335
Prognostic significance of plasma osteopontin levels in patients undergoing percutaneous coronary intervention.
Circulation journal : official journal of the Japanese Circulation Society Jan, 2009 | Pubmed ID: 19023151
Cross-sectional, prospective study of MRI reproducibility in the assessment of plaque burden of the carotid arteries and aorta.
Nature clinical practice. Cardiovascular medicine Mar, 2009 | Pubmed ID: 19174763
Effect of lipid-lowering therapy with atorvastatin on atherosclerotic aortic plaques: a 2-year follow-up by noninvasive MRI.
European journal of cardiovascular prevention and rehabilitation : official journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology Apr, 2009 | Pubmed ID: 19242355
The RNA-binding protein HuR regulates DNA methylation through stabilization of DNMT3b mRNA.
Nucleic acids research May, 2009 | Pubmed ID: 19270063
Cardiovascular magnetic resonance parameters of atherosclerotic plaque burden improve discrimination of prior major adverse cardiovascular events.
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance , 2009 | Pubmed ID: 19393089
The expression of the nuclear receptors NR5A1 and NR5A2 and transcription factor GATA6 correlates with steroidogenic gene expression in the bovine corpus luteum.
Molecular reproduction and development Sep, 2009 | Pubmed ID: 19455657
Overexpression of beta3/gamma2 chains of laminin-5 and MMP7 in biliary cancer.
World journal of gastroenterology Aug, 2009 | Pubmed ID: 19701966
Epigenetic inactivation of the circadian clock gene BMAL1 in hematologic malignancies.
Cancer research Nov, 2009 | Pubmed ID: 19861541
Genetic and epigenetic characteristics of gastric cancers with JC virus T-antigen.
World journal of gastroenterology Nov, 2009 | Pubmed ID: 19938198
Associations between plasma osteopontin levels and the severities of coronary and aortic atherosclerosis.
Atherosclerosis Jun, 2010 | Pubmed ID: 20074733
Epidermal growth factor receptor is an obligatory intermediate for oxytocin-induced cyclooxygenase 2 expression and prostaglandin F2 alpha production in bovine endometrial epithelial cells.
Endocrinology Mar, 2010 | Pubmed ID: 20080869
Associations between plasma C-reactive protein levels and the severities of coronary and aortic atherosclerosis.
Journal of atherosclerosis and thrombosis May, 2010 | Pubmed ID: 20134100
Association of glypican-3 expression with growth signaling molecules in hepatocellular carcinoma.
World journal of gastroenterology Jul, 2010 | Pubmed ID: 20653060
Antitumor effect of inhalatory lipopolysaccharide and synergetic effect in combination with cyclophosphamide.
Anticancer research Aug, 2010 | Pubmed ID: 20871031
Cytotoxic effects of activated alveolar macrophages on lung carcinoma cells via cell-to-cell contact and nitric oxide.
Anticancer research Aug, 2010 | Pubmed ID: 20871032
Lipopolysaccharide-activated alveolar macrophages having cytotoxicity toward lung tumor cells through cell-to-cell binding-dependent mechanism.
Anticancer research Aug, 2010 | Pubmed ID: 20871035
Serum resistin levels and cardiovascular events in patients undergoing percutaneous coronary intervention.
Journal of atherosclerosis and thrombosis , 2011 | Pubmed ID: 21071880
Epigenetic inactivation of calcium-sensing receptor in colorectal carcinogenesis.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc Jun, 2011 | Pubmed ID: 21317879
A DNA methylation fingerprint of 1628 human samples.
Genome research Feb, 2012 | Pubmed ID: 21613409
Co-expression of laminin β3 and γ2 chains and epigenetic inactivation of laminin α3 chain in gastric cancer.
International journal of oncology Sep, 2011 | Pubmed ID: 21617852
The efficacy of IGF-I receptor monoclonal antibody against human gastrointestinal carcinomas is independent of k-ras mutation status.
Clinical cancer research : an official journal of the American Association for Cancer Research Aug, 2011 | Pubmed ID: 21642381
A case of anti-GA1 antibody-positive Fisher syndrome with elevated tau protein in cerebrospinal fluid.
Brain & development Apr, 2012 | Pubmed ID: 21742448
Insulin-like growth factor receptor expression is associated with aggressive phenotypes and has therapeutic activity in biliary tract cancers.
Cancer science Feb, 2012 | Pubmed ID: 22044563
Chromatin modification of Notch targets in olfactory receptor neuron diversification.
Nature neuroscience , 2011 | Pubmed ID: 22197833
Associations between serum lipoprotein(a) levels and the severity of coronary and aortic atherosclerosis.
Atherosclerosis May, 2012 | Pubmed ID: 22387060
Heterogeneity in clonal nature in the smoldering subtype of adult T-cell leukemia: continuity from carrier status to smoldering ATL.
International journal of hematology Apr, 2012 | Pubmed ID: 22453915
The LDL-cholesterol to HDL-cholesterol ratio and the severity of coronary and aortic atherosclerosis.
Atherosclerosis Jun, 2012 | Pubmed ID: 22516791
Interrelationship between microsatellite instability and microRNA in gastrointestinal cancer.
World journal of gastroenterology Jun, 2012 | Pubmed ID: 22719182
Association between kidney dysfuction and the severity of coronary and aortic atherosclerosis.
Atherosclerosis Aug, 2012 | Pubmed ID: 22770127
Treatment of relapsed adult T-cell leukemia/lymphoma after allogeneic hematopoietic stem cell transplantation: the Nagasaki Transplant Group experience.
Blood Jan, 2013 | Pubmed ID: 23100309
[An overview of antibody therapy against cancer].
Nihon rinsho. Japanese journal of clinical medicine Dec, 2012 | Pubmed ID: 23259378
[Prevention of tumour invasion].
Nihon rinsho. Japanese journal of clinical medicine Nov, 2012 | Pubmed ID: 23513830
Cancer detection by ubiquitin carboxyl-terminal esterase L1 methylation in pancreatobiliary fluids.
World journal of gastroenterology Mar, 2013 | Pubmed ID: 23555160
The casein kinase 2-nrf1 axis controls the clearance of ubiquitinated proteins by regulating proteasome gene expression.
Molecular and cellular biology Sep, 2013 | Pubmed ID: 23816881
The effect of IGF-I receptor blockade for human esophageal squamous cell carcinoma and adenocarcinoma.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine Feb, 2014 | Pubmed ID: 24026884
Molecular analysis of the BCR-ABL1 kinase domain in chronic-phase chronic myelogenous leukemia treated with tyrosine kinase inhibitors in practice: study by the Nagasaki CML Study Group.
Leukemia research Jan, 2014 | Pubmed ID: 24262285
[Outcome of patients with relapsed/refractory adult T-cell leukemia-lymphoma after salvage therapy].
[Rinshō ketsueki] The Japanese journal of clinical hematology Dec, 2013 | Pubmed ID: 24452146
An updated review of gastric cancer in the next-generation sequencing era: insights from bench to bedside and vice versa.
World journal of gastroenterology Apr, 2014 | Pubmed ID: 24744582
Chromatin regulators in neurodevelopment and disease: Analysis of fly neural circuits provides insights: Networks of chromatin regulators and transcription factors underlie Drosophila neurogenesis and cognitive defects in intellectual disability and neuropsychiatric disorder models.
BioEssays : news and reviews in molecular, cellular and developmental biology Sep, 2014 | Pubmed ID: 25067789
[Successful treatment with a combination of lenalidomide and dexamethasone for cryoglobulinemia associated with multiple myeloma].
[Rinshō ketsueki] The Japanese journal of clinical hematology Aug, 2014 | Pubmed ID: 25186485
Treatment outcome of elderly patients with aggressive adult T cell leukemia-lymphoma: Nagasaki University Hospital experience.
International journal of hematology Nov, 2014 | Pubmed ID: 25209605
Heat shock protein 90 inhibitor NVP-AUY922 exerts potent activity against adult T-cell leukemia-lymphoma cells.
Cancer science Dec, 2014 | Pubmed ID: 25263741
Inhibitory mechanism of FAT4 gene expression in response to actin dynamics during Src-induced carcinogenesis.
PloS one , 2015 | Pubmed ID: 25679223
Constitutive activation of Drosophila CncC transcription factor reduces lipid formation in the fat body.
Biochemical and biophysical research communications Aug, 2015 | Pubmed ID: 26049108
Proteolysis of EphA2 Converts It from a Tumor Suppressor to an Oncoprotein.
Cancer research Aug, 2015 | Pubmed ID: 26130649
Selective autophagic receptor p62 regulates the abundance of transcriptional coregulator ARIP4 during nutrient starvation.
Scientific reports , 2015 | Pubmed ID: 26412716
CCR4 frameshift mutation identifies a distinct group of adult T cell leukaemia/lymphoma with poor prognosis.
The Journal of pathology Apr, 2016 | Pubmed ID: 26847489
Whole-genome mutational landscape and characterization of noncoding and structural mutations in liver cancer.
Nature genetics May, 2016 | Pubmed ID: 27064257
Induction of apoptosis by HBI-8000 in adult T-cell leukemia/lymphoma is associated with activation of Bim and NLRP3.
Cancer science May, 2016 | Pubmed ID: 27193821
Adult T-cell leukemia/lymphoma in donor cells responding to second allogeneic hematopoietic stem cell transplantation using unrelated cord blood: the Nagasaki Transplant Group experience.
Leukemia & lymphoma May, 2016 | Pubmed ID: 27210445
Systematic analysis of mutation distribution in three dimensional protein structures identifies cancer driver genes.
Scientific reports , 2016 | Pubmed ID: 27225414
Erratum: Whole-genome mutational landscape and characterization of noncoding and structural mutations in liver cancer.
Nature genetics May, 2016 | Pubmed ID: 27230686
USP15 stabilizes the transcription factor Nrf1 in the nucleus, promoting the proteasome gene expression.
Biochemical and biophysical research communications Sep, 2016 | Pubmed ID: 27416755
PD-L1 expression on neoplastic or stromal cells is respectively a poor or good prognostic factor for adult T-cell leukemia/lymphoma.
Blood Sep, 2016 | Pubmed ID: 27418641
Fluorescence multispectral imaging-based diagnostic system for atherosclerosis.
Biomedical engineering online Aug, 2016 | Pubmed ID: 27542354
Cancer stem cells in human gastrointestinal cancer.
Cancer science Nov, 2016 | Pubmed ID: 27575869
Possible roles of the transcription factor Nrf1 (NFE2L1) in neural homeostasis by regulating the gene expression of deubiquitinating enzymes.
Biochemical and biophysical research communications Jan, 2017 | Pubmed ID: 28088524
Influence of Single-Nucleotide Polymorphisms in PPAR-δ, PPAR-γ, and PRKAA2 on the Changes in Anthropometric Indices and Blood Measurements through Exercise-Centered Lifestyle Intervention in Japanese Middle-Aged Men.
International journal of molecular sciences 03, 2018 | Pubmed ID: 29494521
Manipulating Living Cells to Construct a 3D Single-Cell Assembly without an Artificial Scaffold.
Polymers Jul, 2017 | Pubmed ID: 30970994
1Biotechnology and Genetic Engineering Department, Jahangirnagar University,
2, JT Biohistory Research Hall,
3Division of Cell Regeneration and Transplantation, School of Medicine, Nihon University,
4Graduate School of Life and Medical Sciences, Doshisha University,
5, Institute of Genetics and Animal Breeding of the Polish Academy of Sciences
1Graduate School of Frontier Biosciences, Osaka University,
2Department of Biotechnology and Genetic Engineering, Jahangirnagar University,
3Division of Cell Regeneration and Transplantation, School of Medicine, Nihon University,
4, Institute of Genetics and Animal Breeding of the Polish Academy of Sciences,
5Graduate School of Life and Medical Sciences, Doshisha University
Paweł Leszczyński1,
Magdalena Śmiech1,
Aamir S. Teeli1,
Aleksandra Zołocińska2,
Anna Słysz2,
Zygmunt Pojda2,
Mariusz Pierzchała3,
Hiroaki Taniguchi1
1Department of Experimental Embryology, Institute of Genetics and Animal Breeding, Polish Academy of Sciences,
2Department of Regenerative Medicine, Maria Skłodowska-Curie Institute - Oncology Center,
3Department of Genomics and Biodiversities, Institute of Genetics and Animal Breeding, Polish Academy of Sciences
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