Development and Stem Cells Program,
Monash Biomedicine Discovery Institute,
and Department of Anatomy and Developmental Biology,
Biomedicine Discovery Institute,
Department of Anatomy and Developmental Biology,
Biomedicine Discovery Institute, Department of Anatomy and Developmental Biology
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Cisplatin-induced primordial follicle oocyte killing and loss of fertility are not prevented by imatinib.
Nature medicine Aug, 2012 | Pubmed ID: 22869179
DNA damage-induced primordial follicle oocyte apoptosis and loss of fertility require TAp63-mediated induction of Puma and Noxa.
Molecular cell Nov, 2012 | Pubmed ID: 23000175
Molecular correlates of platinum response in human high-grade serous ovarian cancer patient-derived xenografts.
Molecular oncology May, 2014 | Pubmed ID: 24560445
Loss of the proapoptotic BH3-only protein BCL-2 modifying factor prolongs the fertile life span in female mice.
Biology of reproduction Apr, 2014 | Pubmed ID: 24571986
Dual roles for Id4 in the regulation of estrogen signaling in the mammary gland and ovary.
Development (Cambridge, England) Aug, 2014 | Pubmed ID: 25038044
What is the "ovarian reserve"?
Fertility and sterility Mar, 2015 | Pubmed ID: 25500021
Ovarian reserve screening: a scientific and ethical analysis.
Human reproduction (Oxford, England) Apr, 2015 | Pubmed ID: 25637623
How Is the Number of Primordial Follicles in the Ovarian Reserve Established?
Biology of reproduction Nov, 2015 | Pubmed ID: 26423124
BCL2-modifying factor promotes germ cell loss during murine oogenesis.
Reproduction (Cambridge, England) May, 2016 | Pubmed ID: 26917450
The ovarian reserve is depleted during puberty in a hormonally driven process dependent on the pro-apoptotic protein BMF.
Cell death & disease 08, 2017 | Pubmed ID: 28771225
The importance of DNA repair for maintaining oocyte quality in response to anti-cancer treatments, environmental toxins and maternal ageing.
Human reproduction update Mar, 2018 | Pubmed ID: 29377997
Examination of the ovotoxicity of 5-fluorouracil in mice.
Journal of assisted reproduction and genetics Jun, 2018 | Pubmed ID: 29589294
Dacarbazine depletes the ovarian reserve in mice and depletion is enhanced with age.
Scientific reports 04, 2018 | Pubmed ID: 29695822
The capacity of oocytes for DNA repair.
Cellular and molecular life sciences : CMLS 08, 2018 | Pubmed ID: 29748894
Loss of PUMA protects the ovarian reserve during DNA-damaging chemotherapy and preserves fertility.
Cell death & disease 05, 2018 | Pubmed ID: 29795269
Maternal low-protein diet programmes low ovarian reserve in offspring
Reproduction (Cambridge, England) 10, 2018 | Pubmed ID: 29991566
Multidose 5-Fluorouracil is Highly Toxic to Growing Ovarian Follicles in Mice.
Toxicological sciences : an official journal of the Society of Toxicology 11, 2018 | Pubmed ID: 30085306
Oocytes from stem cells.
Best practice & research. Clinical obstetrics & gynaecology Feb, 2019 | Pubmed ID: 30120061
Methylation of all BRCA1 copies predicts response to the PARP inhibitor rucaparib in ovarian carcinoma.
Nature communications 09, 2018 | Pubmed ID: 30266954
Maternal low-protein diet programmes low ovarian reserve in offspring
Reproduction (Cambridge, England) 10, 2018 | Pubmed ID: 30306601
Vincristine Chemotherapy Induces Atresia of Growing Ovarian Follicles in Mice.
Toxicological sciences : an official journal of the Society of Toxicology 05, 2019 | Pubmed ID: 30657998
Do BRCA1 and BRCA2 gene mutation carriers have a reduced ovarian reserve? Protocol for a prospective observational study.
BMJ open 11, 2019 | Pubmed ID: 31772111
Do cancer therapies damage the uterus and compromise fertility?
Human reproduction update Feb, 2020 | Pubmed ID: 31863097
Evaluation of mitochondria in oocytes following γ-irradiation.
Scientific reports 12, 2019 | Pubmed ID: 31882895
Moderate episodic prenatal alcohol does not impact female offspring fertility in rats.
Reproduction (Cambridge, England) 05, 2020 | Pubmed ID: 32168471
Oocytes can efficiently repair DNA double-strand breaks to restore genetic integrity and protect offspring health.
Proceedings of the National Academy of Sciences of the United States of America 05, 2020 | Pubmed ID: 32381741
The PARP inhibitor, olaparib, depletes the ovarian reserve in mice: implications for fertility preservation.
Human reproduction (Oxford, England) Aug, 2020 | Pubmed ID: 32604417
Comparison of methods for quantifying primordial follicles in the mouse ovary.
Journal of ovarian research Oct, 2020 | Pubmed ID: 33054849
Evaluation of inflammation and follicle depletion during ovarian ageing in mice.
Scientific reports Jan, 2021 | Pubmed ID: 33432051
The Inflammasome Contributes to Depletion of the Ovarian Reserve During Aging in Mice.
Frontiers in cell and developmental biology , 2020 | Pubmed ID: 33644037
Prolonged atrazine exposure beginning and adult uterine morphology in mice.
Journal of developmental origins of health and disease Feb, 2022 | Pubmed ID: 33781367
DNA repair in primordial follicle oocytes following cisplatin treatment.
Journal of assisted reproduction and genetics Jun, 2021 | Pubmed ID: 33864208
Evaluation of mitochondria in mouse oocytes following cisplatin exposure.
Journal of ovarian research May, 2021 | Pubmed ID: 33971923
Assessment of Ovarian Function in Phase III (Neo)Adjuvant Breast Cancer Clinical Trials: A Systematic Evaluation.
Journal of the National Cancer Institute Nov, 2021 | Pubmed ID: 34048575
HENMT1 is involved in the maintenance of normal female fertility in the mouse.
Molecular human reproduction Nov, 2021 | Pubmed ID: 34590701
Development of an embryo transfer model to study uterine contributions to pregnancy in mice.
Reproduction & fertility Jan, 2022 | Pubmed ID: 35198982
Checkpoint inhibitor immunotherapy diminishes oocyte number and quality in mice.
Nature cancer Aug, 2022 | Pubmed ID: 36008687
Melatonin as an oncostatic agent: Review of the modulation of tumor microenvironment and overcoming multidrug resistance.
Biochimie Nov, 2022 | Pubmed ID: 36116742
Does single-strand DNA break repair capacity influence oocyte maintenance and quality?
Reproduction (Cambridge, England) Dec, 2022 | Pubmed ID: 36215096
Impact of Chronic Multi-Generational Exposure to an Environmentally Relevant Atrazine Concentration on Testicular Development and Function in Mice.
Cells Feb, 2023 | Pubmed ID: 36831314
Beyond apoptosis: evidence of other regulated cell death pathways in the ovary throughout development and life.
Human reproduction update Feb, 2023 | Pubmed ID: 36857094
Radiotherapy exposure directly damages the uterus and causes pregnancy loss.
JCI insight Mar, 2023 | Pubmed ID: 36946464
Meaghan J. Griffiths*,1,2,
Jordan N. Higgins*,1,
Fiona L. Cousins3,
Lauren R. Alesi1,
Amy L. Winship*,1,
Karla J. Hutt*,1
1Biomedicine Discovery Institute, Department of Anatomy and Developmental Biology, Monash University,
2Gynaecology Research Centre, Royal Women’s Hospital and Department of Obstetrics and Gynaecology, University of Melbourne,
3The Ritchie Centre, Hudson Institute for Medical Research and Department of Obstetrics and Gynaecology, Monash University
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