Department of Biological Sciences
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Suppression of polyglutamine-induced protein aggregation in Caenorhabditis elegans by torsin proteins.
Human molecular genetics Feb, 2003 | Pubmed ID: 12554684
Role for NudC, a dynein-associated nuclear movement protein, in mitosis and cytokinesis.
Journal of cell science May, 2003 | Pubmed ID: 12679384
An animal model to discern torsin function: suppression of protein aggregation in C. elegans.
Advances in neurology , 2004 | Pubmed ID: 14509658
Using Caenorhabditis elegans to probe toxicity of 1-alkyl-3-methylimidazolium chloride based ionic liquids.
Chemical communications (Cambridge, England) Mar, 2004 | Pubmed ID: 15010772
Epileptic-like convulsions associated with LIS-1 in the cytoskeletal control of neurotransmitter signaling in Caenorhabditis elegans.
Human molecular genetics Sep, 2004 | Pubmed ID: 15254012
Torsin-mediated protection from cellular stress in the dopaminergic neurons of Caenorhabditis elegans.
The Journal of neuroscience : the official journal of the Society for Neuroscience Apr, 2005 | Pubmed ID: 15829632
Alpha-synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson's models.
Science (New York, N.Y.) Jul, 2006 | Pubmed ID: 16794039
Deletion of the ubiquitin ligase CHIP leads to the accumulation, but not the aggregation, of both endogenous phospho- and caspase-3-cleaved tau species.
The Journal of neuroscience : the official journal of the Society for Neuroscience Jun, 2006 | Pubmed ID: 16807328
Genetic interactions among cortical malformation genes that influence susceptibility to convulsions in C. elegans.
Brain research Nov, 2006 | Pubmed ID: 16996038
Ubiquitin conjugating enzymes participate in polyglutamine protein aggregation.
BMC cell biology , 2007 | Pubmed ID: 17663792
The Parkinson's disease protein alpha-synuclein disrupts cellular Rab homeostasis.
Proceedings of the National Academy of Sciences of the United States of America Jan, 2008 | Pubmed ID: 18162536
Hypothesis-based RNAi screening identifies neuroprotective genes in a Parkinson's disease model.
Proceedings of the National Academy of Sciences of the United States of America Jan, 2008 | Pubmed ID: 18182484
Acetaminophen attenuates dopamine neuron degeneration in animal models of Parkinson's disease.
Neuroscience letters Jul, 2008 | Pubmed ID: 18514411
The microtubule-associated protein, NUD-1, exhibits chaperone activity in vitro.
Cell stress & chaperones Jan, 2009 | Pubmed ID: 18626791
Lysosomal enzyme cathepsin D protects against alpha-synuclein aggregation and toxicity.
Molecular brain , 2008 | Pubmed ID: 19021916
Traversing a wormhole to combat Parkinson's disease.
Disease models & mechanisms Jul-Aug, 2008 | Pubmed ID: 19048050
Alpha-synuclein is part of a diverse and highly conserved interaction network that includes PARK9 and manganese toxicity.
Nature genetics Mar, 2009 | Pubmed ID: 19182805
Rapid selection of cyclic peptides that reduce alpha-synuclein toxicity in yeast and animal models.
Nature chemical biology Sep, 2009 | Pubmed ID: 19597508
Pharmacogenetic analysis reveals a post-developmental role for Rac GTPases in Caenorhabditis elegans GABAergic neurotransmission.
Genetics Dec, 2009 | Pubmed ID: 19797046
Investigating bacterial sources of toxicity as an environmental contributor to dopaminergic neurodegeneration.
PloS one , 2009 | Pubmed ID: 19806188
VPS41, a protein involved in lysosomal trafficking, is protective in Caenorhabditis elegans and mammalian cellular models of Parkinson's disease.
Neurobiology of disease Feb, 2010 | Pubmed ID: 19850127
Compounds from an unbiased chemical screen reverse both ER-to-Golgi trafficking defects and mitochondrial dysfunction in Parkinson's disease models.
Disease models & mechanisms Mar-Apr, 2010 | Pubmed ID: 20038714
C. elegans as a model organism to investigate molecular pathways involved with Parkinson's disease.
Developmental dynamics : an official publication of the American Association of Anatomists May, 2010 | Pubmed ID: 20108318
The early-onset torsion dystonia-associated protein, torsinA, displays molecular chaperone activity in vitro.
Cell stress & chaperones Sep, 2010 | Pubmed ID: 20169475
Chemical enhancement of torsinA function in cell and animal models of torsion dystonia.
Disease models & mechanisms May-Jun, 2010 | Pubmed ID: 20223934
Low-dose bafilomycin attenuates neuronal cell death associated with autophagy-lysosome pathway dysfunction.
Journal of neurochemistry Aug, 2010 | Pubmed ID: 20534000
The early-onset torsion dystonia-associated protein, torsinA, is a homeostatic regulator of endoplasmic reticulum stress response.
Human molecular genetics Sep, 2010 | Pubmed ID: 20584926
Caenorhabditis elegans as a model system for identifying effectors of α-synuclein misfolding and dopaminergic cell death associated with Parkinson's disease.
Methods (San Diego, Calif.) Mar, 2011 | Pubmed ID: 21195766
Structural features and chaperone activity of the NudC protein family.
Journal of molecular biology Jun, 2011 | Pubmed ID: 21530541
TorsinA participates in endoplasmic reticulum-associated degradation.
Nature communications , 2011 | Pubmed ID: 21750546
Inhibitors of LRRK2 kinase attenuate neurodegeneration and Parkinson-like phenotypes in Caenorhabditis elegans and Drosophila Parkinson's disease models.
Human molecular genetics Oct, 2011 | Pubmed ID: 21768216
Modeling dopamine neuron degeneration in Caenorhabditis elegans.
Methods in molecular biology (Clifton, N.J.) , 2011 | Pubmed ID: 21913098
Functional links between Aβ toxicity, endocytic trafficking, and Alzheimer's disease risk factors in yeast.
Science (New York, N.Y.) Dec, 2011 | Pubmed ID: 22033521
Different 8-Hydroxyquinolines Protect Models of TDP-43 Protein, α-Synuclein, and Polyglutamine Proteotoxicity through Distinct Mechanisms.
The Journal of biological chemistry Feb, 2012 | Pubmed ID: 22147697
Functional Analysis of VPS41-Mediated Neuroprotection in Caenorhabditis elegans and Mammalian Models of Parkinson's Disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience Feb, 2012 | Pubmed ID: 22323726
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