Department of Biochemistry,
Cardiovascular Research Institute Maastricht (CARIM),
Department of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM)
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Differential lipoprotein transport pathways of K-vitamins in healthy subjects.
Biochimica et biophysica acta Feb, 2002 | Pubmed ID: 11960685
Novel effects of diets enriched with corn oil or with an olive oil/sunflower oil mixture on vitamin K metabolism and vitamin K-dependent proteins in young men.
Journal of lipid research Jun, 2002 | Pubmed ID: 12032162
Characteristics and performance of an immunosorbent assay for human matrix Gla-protein.
Clinica chimica acta; international journal of clinical chemistry Jan, 2005 | Pubmed ID: 15563881
Novel conformation-specific antibodies against matrix gamma-carboxyglutamic acid (Gla) protein: undercarboxylated matrix Gla protein as marker for vascular calcification.
Arteriosclerosis, thrombosis, and vascular biology Aug, 2005 | Pubmed ID: 15961706
Regression of warfarin-induced medial elastocalcinosis by high intake of vitamin K in rats.
Blood Apr, 2007 | Pubmed ID: 17138823
The circulating inactive form of matrix Gla Protein (ucMGP) as a biomarker for cardiovascular calcification.
Journal of vascular research , 2008 | Pubmed ID: 18401181
Anticoagulant effect of dietary fish oil in hyperlipidemia: a study of hepatic gene expression in APOE2 knock-in mice.
Arteriosclerosis, thrombosis, and vascular biology Nov, 2008 | Pubmed ID: 18757293
Matrix Gla-protein: the calcification inhibitor in need of vitamin K.
Thrombosis and haemostasis Oct, 2008 | Pubmed ID: 18841280
Uncarboxylated matrix Gla protein (ucMGP) is associated with coronary artery calcification in haemodialysis patients.
Thrombosis and haemostasis Feb, 2009 | Pubmed ID: 19190822
Association of kidney function and uncarboxylated matrix Gla protein: data from the Heart and Soul Study.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association Jul, 2009 | Pubmed ID: 19204017
The association of uncarboxylated matrix Gla protein with mitral annular calcification differs by diabetes status: The Heart and Soul study.
Atherosclerosis May, 2010 | Pubmed ID: 20015492
Chronic coumarin treatment is associated with increased extracoronary arterial calcification in humans.
Blood Jun, 2010 | Pubmed ID: 20354170
The associations of fibroblast growth factor 23 and uncarboxylated matrix Gla protein with mortality in coronary artery disease: the Heart and Soul Study.
Annals of internal medicine May, 2010 | Pubmed ID: 20479029
Calcium scores and matrix Gla protein levels: association with vitamin K status.
European journal of clinical investigation Apr, 2010 | Pubmed ID: 20486996
Characterisation and potential diagnostic value of circulating matrix Gla protein (MGP) species.
Thrombosis and haemostasis Oct, 2010 | Pubmed ID: 20694284
Arterial calcifications.
Journal of cellular and molecular medicine Sep, 2010 | Pubmed ID: 20716128
Circulating nonphosphorylated carboxylated matrix gla protein predicts survival in ESRD.
Journal of the American Society of Nephrology : JASN Feb, 2011 | Pubmed ID: 21289218
Microcalcifications in early intimal lesions of atherosclerotic human coronary arteries.
The American journal of pathology Jun, 2011 | Pubmed ID: 21531376
Vitamin K supplementation increases vitamin K tissue levels but fails to counteract ectopic calcification in a mouse model for pseudoxanthoma elasticum.
Journal of molecular medicine (Berlin, Germany) Nov, 2011 | Pubmed ID: 21725681
Patients using vitamin K antagonists show increased levels of coronary calcification: an observational study in low-risk atrial fibrillation patients.
European heart journal Oct, 2011 | Pubmed ID: 21775389
Association of vitamin K status with adiponectin and body composition in healthy subjects: uncarboxylated osteocalcin is not associated with fat mass and body weight.
The British journal of nutrition Sep, 2012 | Pubmed ID: 22136751
Low-dose menaquinone-7 supplementation improved extra-hepatic vitamin K status, but had no effect on thrombin generation in healthy subjects.
The British journal of nutrition Nov, 2012 | Pubmed ID: 22289649
Vitamin K intake and status are low in hemodialysis patients.
Kidney international Sep, 2012 | Pubmed ID: 22648294
Vitamin K-antagonists accelerate atherosclerotic calcification and induce a vulnerable plaque phenotype.
PloS one , 2012 | Pubmed ID: 22952653
Molecular imaging to identify the vulnerable plaque--from basic research to clinical practice.
Molecular imaging and biology Oct, 2012 | Pubmed ID: 22983911
Incorporation of disulfide containing protein modules into multivalent antigenic conjugates: generation of antibodies against the thrombin-sensitive region of murine protein S.
Journal of the American Chemical Society Nov, 2012 | Pubmed ID: 23066897
Vitamin k intake and plasma desphospho-uncarboxylated matrix Gla-protein levels in kidney transplant recipients.
PloS one , 2012 | Pubmed ID: 23118917
Mechanisms of arterial remodeling: lessons from genetic diseases.
Frontiers in genetics , 2012 | Pubmed ID: 23248645
Vitamin K-dependent carboxylation of matrix Gla-protein: a crucial switch to control ectopic mineralization.
Trends in molecular medicine Apr, 2013 | Pubmed ID: 23375872
Vitamin K: key vitamin in controlling vascular calcification in chronic kidney disease.
Kidney international May, 2013 | Pubmed ID: 23633049
The realm of vitamin K dependent proteins: shifting from coagulation toward calcification.
Molecular nutrition & food research Aug, 2014 | Pubmed ID: 24668744
AnxA5 reduces plaque inflammation of advanced atherosclerotic lesions in apoE(-/-) mice.
Journal of cellular and molecular medicine Oct, 2014 | Pubmed ID: 25214012
Differential cellular effects of old and new oral anticoagulants: consequences to the genesis and progression of atherosclerosis.
Thrombosis and haemostasis Nov, 2014 | Pubmed ID: 25298033
Vascular smooth muscle cell calcification is mediated by regulated exosome secretion.
Circulation research Apr, 2015 | Pubmed ID: 25711438
Prevention of vasculopathy by vitamin K supplementation: can we turn fiction into fact?
Atherosclerosis May, 2015 | Pubmed ID: 25744701
Pharmacological Treatment with Annexin A1 Reduces Atherosclerotic Plaque Burden in LDLR-/- Mice on Western Type Diet.
PloS one , 2015 | Pubmed ID: 26090792
High-Dose Menaquinone-7 Supplementation Reduces Cardiovascular Calcification in a Murine Model of Extraosseous Calcification.
Nutrients Aug, 2015 | Pubmed ID: 26295257
What's in a name? The pharmacy of vitamin K.
British journal of haematology 09, 2016 | Pubmed ID: 26492096
Menaquinone-7 Supplementation to Reduce Vascular Calcification in Patients with Coronary Artery Disease: Rationale and Study Protocol (VitaK-CAC Trial).
Nutrients Oct, 2015 | Pubmed ID: 26516910
Intra-Section Analysis of Human Coronary Arteries Reveals a Potential Role for Micro-Calcifications in Macrophage Recruitment in the Early Stage of Atherosclerosis.
PloS one , 2015 | Pubmed ID: 26555788
New Insights into the Pros and Cons of the Clinical Use of Vitamin K Antagonists (VKAs) Versus Direct Oral Anticoagulants (DOACs).
Nutrients Nov, 2015 | Pubmed ID: 26593943
Cathepsin K Deficiency Prevents the Aggravated Vascular Remodeling Response to Flow Cessation in ApoE-/- Mice.
PloS one , 2016 | Pubmed ID: 27636705
Does statins promote vascular calcification in chronic kidney disease?
European journal of clinical investigation Feb, 2017 | Pubmed ID: 28036114
Slower Progress of Aortic Valve Calcification With Vitamin K Supplementation: Results From a Prospective Interventional Proof-of-Concept Study.
Circulation 05, 2017 | Pubmed ID: 28533322
Platelet extracellular vesicles induce a pro-inflammatory smooth muscle cell phenotype.
Journal of extracellular vesicles , 2017 | Pubmed ID: 28717419
Calcific aortic valve stenosis: hard disease in the heart: A biomolecular approach towards diagnosis and treatment.
European heart journal 07, 2018 | Pubmed ID: 29136138
Use of Cyclic Backbone NGR-Based SPECT to Increase Efficacy of Postmyocardial Infarction Angiogenesis Imaging.
Contrast media & molecular imaging , 2017 | Pubmed ID: 29204107
Desphospho-Uncarboxylated Matrix-Gla Protein Is Increased Postoperatively in Cardiovascular Risk Patients.
Nutrients Jan, 2018 | Pubmed ID: 29303985
Influence of pH and phosphate concentration on the phosphate binding capacity of five contemporary binders. An in vitro study.
Nephrology (Carlton, Vic.) Feb, 2019 | Pubmed ID: 29479762
Bicuspid Aortic Valve Stenosis and the Effect of Vitamin K2 on Calcification Using F-Sodium Fluoride Positron Emission Tomography/Magnetic Resonance: The BASIK2 Rationale and Trial Design.
Nutrients Mar, 2018 | Pubmed ID: 29561783
Ucma/GRP inhibits phosphate-induced vascular smooth muscle cell calcification via SMAD-dependent BMP signalling.
Scientific reports 03, 2018 | Pubmed ID: 29563538
Decreased Levels of Circulating Carboxylated Osteocalcin in Children with Low Energy Fractures: A Pilot Study.
Nutrients Jun, 2018 | Pubmed ID: 29882816
A Novel Biomimetic Tool for Assessing Vitamin K Status Based on Molecularly Imprinted Polymers.
Nutrients Jun, 2018 | Pubmed ID: 29891757
Renal matrix Gla protein expression increases progressively with CKD and predicts renal outcome.
Experimental and molecular pathology 08, 2018 | Pubmed ID: 29981754
Missense mutation of VKORC1 leads to medial arterial calcification in rats.
Scientific reports 09, 2018 | Pubmed ID: 30214074
Target identification for the diagnosis and intervention of vulnerable atherosclerotic plaques beyond F-fluorodeoxyglucose positron emission tomography imaging: promising tracers on the horizon.
European journal of nuclear medicine and molecular imaging 01, 2019 | Pubmed ID: 30302506
Vitamin K deficiency in critical ill patients; a prospective observational study.
Journal of critical care 02, 2019 | Pubmed ID: 30415179
Effect of 6-Month Vitamin D Supplementation on Plasma Matrix Gla Protein in Older Adults.
Nutrients Jan, 2019 | Pubmed ID: 30678199
Annexin A1 as Neuroprotective Determinant for Blood-Brain Barrier Integrity in Neonatal Hypoxic-Ischemic Encephalopathy.
Journal of clinical medicine Jan, 2019 | Pubmed ID: 30682787
Vitamin K: Double Bonds beyond Coagulation Insights into Differences between Vitamin K1 and K2 in Health and Disease.
International journal of molecular sciences Feb, 2019 | Pubmed ID: 30791399
The Bone-Vasculature Axis: Calcium Supplementation and the Role of Vitamin K.
Frontiers in cardiovascular medicine , 2019 | Pubmed ID: 30805347
Targeting Coagulation Factor Xa Promotes Regression of Advanced Atherosclerosis in Apolipoprotein-E Deficient Mice.
Scientific reports 03, 2019 | Pubmed ID: 30846818
Vitamin K Antagonists, Non-Vitamin K Antagonist Oral Anticoagulants, and Vascular Calcification in Patients with Atrial Fibrillation.
TH open : companion journal to thrombosis and haemostasis Oct, 2018 | Pubmed ID: 31249966
A Combination of seeds and Rhizome Extracts Improves Knee Joint Function and Alleviates Pain in Non-Arthritic Adults Following Physical Activity.
International journal of medical sciences , 2019 | Pubmed ID: 31337958
Pharmacological and Nutritional Modulation of Vascular Calcification.
Nutrients Dec, 2019 | Pubmed ID: 31905884
Vitamin K Antagonist Use and Risk for Intracranial Carotid Artery Calcification in Patients With Intracerebral Hemorrhage.
Frontiers in neurology , 2019 | Pubmed ID: 31920910
Cheese and Healthy Diet: Associations With Incident Cardio-Metabolic Diseases and All-Cause Mortality in the General Population.
Frontiers in nutrition , 2019 | Pubmed ID: 31921878
Aortic Valve Calcium Associates with All-Cause Mortality Independent of Coronary Artery Calcium and Inflammation in Patients with End-Stage Renal Disease.
Journal of clinical medicine Feb, 2020 | Pubmed ID: 32102408
Early vascular ageing in chronic kidney disease: impact of inflammation, vitamin K, senescence and genomic damage.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 03, 2020 | Pubmed ID: 32162665
Matrix Gla protein is an independent predictor of both intimal and medial vascular calcification in chronic kidney disease.
Scientific reports 04, 2020 | Pubmed ID: 32313061
Sevelamer Use in End-Stage Kidney Disease (ESKD) Patients Associates with Poor Vitamin K Status and High Levels of Gut-Derived Uremic Toxins: A Drug-Bug Interaction?
Toxins 05, 2020 | Pubmed ID: 32471179
Intimal and medial calcification in relation to cardiovascular risk factors.
PloS one , 2020 | Pubmed ID: 32658909
Biomarkers Associated With Aortic Valve Calcification: Should We Focus on Sex Specific Processes?
Frontiers in cell and developmental biology , 2020 | Pubmed ID: 32754594
Combined low vitamin D and K status amplifies mortality risk: a prospective study.
European journal of nutrition Apr, 2021 | Pubmed ID: 32808059
Reduced Vitamin K Status as a Potentially Modifiable Risk Factor of Severe Coronavirus Disease 2019.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 12, 2021 | Pubmed ID: 32852539
Endoplasmic Reticulum Stress Mediates Vascular Smooth Muscle Cell Calcification via Increased Release of Grp78 (Glucose-Regulated Protein, 78 kDa)-Loaded Extracellular Vesicles.
Arteriosclerosis, thrombosis, and vascular biology 02, 2021 | Pubmed ID: 33297752
Functional vitamin K status and risk of incident chronic kidney disease and microalbuminuria: a prospective general population-based cohort study.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 12, 2021 | Pubmed ID: 33313895
γ-Glutamyl carboxylase mutations differentially affect the biological function of vitamin K-dependent proteins.
Blood 01, 2021 | Pubmed ID: 33507293
Sodium [F]Fluoride PET Can Efficiently Monitor In Vivo Atherosclerotic Plaque Calcification Progression and Treatment.
Cells 01, 2021 | Pubmed ID: 33573188
Menaquinone-7 Supplementation Improves Osteogenesis in Pluripotent Stem Cell Derived Mesenchymal Stem Cells.
Frontiers in cell and developmental biology , 2020 | Pubmed ID: 33585456
Locking and loading the bullet against micro-calcification.
European journal of preventive cardiology Apr, 2020 | Pubmed ID: 33611501
Functional vitamin K insufficiency, vascular calcification and mortality in advanced chronic kidney disease: A cohort study.
PloS one , 2021 | Pubmed ID: 33626087
Off-target effects of oral anticoagulants - vascular effects of vitamin K antagonist and non-vitamin K antagonist oral anticoagulant dabigatran etexilate.
Journal of thrombosis and haemostasis : JTH 05, 2021 | Pubmed ID: 33687782
Effects of Combined Vitamin K2 and Vitamin D3 Supplementation on Na[F]F PET/MRI in Patients with Carotid Artery Disease: The INTRICATE Rationale and Trial Design.
Nutrients Mar, 2021 | Pubmed ID: 33808652
Deficiency of myeloid PHD proteins aggravates atherogenesis via macrophage apoptosis and paracrine fibrotic signalling.
Cardiovascular research 03, 2022 | Pubmed ID: 33913468
Proteoglycan 4 Modulates Osteogenic Smooth Muscle Cell Differentiation during Vascular Remodeling and Intimal Calcification.
Cells 05, 2021 | Pubmed ID: 34063989
Vitamin K and cardiovascular complications in chronic kidney disease patients.
Kidney international 11, 2021 | Pubmed ID: 34310988
Development of the BioHybrid Assay: Combining Primary Human Vascular Smooth Muscle Cells and Blood to Measure Vascular Calcification Propensity.
Cells 08, 2021 | Pubmed ID: 34440866
Hepatic and Vascular Vitamin K Status in Patients with High Cardiovascular Risk.
Nutrients Oct, 2021 | Pubmed ID: 34684491
Combining phosphate binder therapy with vitamin K2 inhibits vascular calcification in an experimental animal model of kidney failure.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 03, 2022 | Pubmed ID: 34718756
Vitamin K-a neglected player in cardiovascular health: a narrative review.
Open heart 11, 2021 | Pubmed ID: 34785587
Vascular Remodeling in Pulmonary Arterial Hypertension: The Potential Involvement of Innate and Adaptive Immunity.
Frontiers in medicine , 2021 | Pubmed ID: 35004784
Differential Effects of Platelet Factor 4 (CXCL4) and Its Non-Allelic Variant (CXCL4L1) on Cultured Human Vascular Smooth Muscle Cells.
International journal of molecular sciences Jan, 2022 | Pubmed ID: 35054772
Improved Quantification of Cell Density in the Arterial Wall-A Novel Nucleus Splitting Approach Applied to 3D Two-Photon Laser-Scanning Microscopy.
Frontiers in physiology , 2021 | Pubmed ID: 35095571
Dietary magnesium supplementation inhibits abdominal vascular calcification in an experimental animal model of chronic kidney disease.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association May, 2022 | Pubmed ID: 35134986
Vitamin K Supplementation in Chronic Kidney Disease Patients: Where is the Evidence?
Current vascular pharmacology , 2022 | Pubmed ID: 35139790
Osteomodulin attenuates smooth muscle cell osteogenic transition in vascular calcification.
Clinical and translational medicine 02, 2022 | Pubmed ID: 35184400
Prenatal administration of multipotent adult progenitor cells modulates the systemic and cerebral immune response in an ovine model of chorioamnionitis.
Brain, behavior, & immunity - health Aug, 2022 | Pubmed ID: 35647567
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