Institute of Biophysics,
Faculty of Medicine,
Coimbra Institute for Clinical and Biomedical Research (iCBR),
area of Environment Genetics and Oncobiology (CIMAGO),
CNC.IBILI/Center for Innovative Biomedicine and Biotechnology (CIBB),
Institute of Biophysics, Faculty of Medicine,
Coimbra Institute for Clinical and Biomedical Research (iCBR), area of Environment Genetics and Oncobiology (CIMAGO), Faculty of Medicine
Mafalda Laranjo obtained a degree in Biology in 2006, a master's degree in Cellular and Molecular Biology in 2010, and a Ph.D. degree in 2014 at the University of Coimbra. She is currently an Investigator at the Faculty of Medicine, University of Coimbra.
Dr. Laranjo's main scientific interest is Photodynamic therapy (PDT) applied to cancer treatment. In this field, she has developed and patented new compounds and has demonstrated its selective cytotoxicity in several cancer types, both in vitro and in vivo. Also, Dr. Laranjo has been working in multidisciplinary teams focusing on oncology, dentistry, gynecology, and ophthalmology research, contributing with her know-how on primary cell cultures, cellular and molecular technique's and animal models, like mouse and rat. At the same time, she contributes to science dissemination and network formation, being actively involved in international projects in South Europe regarding cancer research.
Dr. Laranjo develops her work at Coimbra Institute for Clinical and Biomedical Research (iCBR)/Centre for Innovative Biomedicine and Biotechnology (CIBB), where besides her research activities, she is enrolled in teaching activities of under and postgraduate studies and supervision of BSc, MSc, and Ph.D. students.
Hypoxia-induced redox alterations and their correlation with 99mTc-MIBI and 99mTc-HL-91 uptake in colon cancer cells.
Nuclear medicine and biology Feb, 2010 | Pubmed ID: 20152711
Chiral 6-hydroxymethyl-1H,3H-pyrrolo[1,2-c]thiazoles: novel antitumor DNA monoalkylating agents.
European journal of medicinal chemistry Oct, 2010 | Pubmed ID: 20705366
Chiral 6,7-bis(hydroxymethyl)-1H,3H-pyrrolo[1,2-c]thiazoles with anti-breast cancer properties.
European journal of medicinal chemistry Feb, 2013 | Pubmed ID: 23313634
2-Bromo-5-hydroxyphenylporphyrins for photodynamic therapy: photosensitization efficiency, subcellular localization and in vivo studies.
Photodiagnosis and photodynamic therapy Feb, 2013 | Pubmed ID: 23465373
Study of hepatocellular function in the murine model following hepatic artery selective clamping.
Acta cirurgica brasileira Sep, 2013 | Pubmed ID: 24000059
Evaluation of a (99m) Tc-labelled meso-bisphenylporphyrin as a tumour image agent.
Journal of labelled compounds & radiopharmaceuticals Mar, 2014 | Pubmed ID: 24634158
Targeting triple-negative breast cancer cells with 6,7-bis(hydroxymethyl)-1H,3H-pyrrolo[1,2-c]thiazoles.
European journal of medicinal chemistry May, 2014 | Pubmed ID: 24747064
Retinoblastoma: might photodynamic therapy be an option?
Cancer metastasis reviews Dec, 2015 | Pubmed ID: 25579236
Clinical translation for endometrial cancer stem cells hypothesis.
Cancer metastasis reviews Sep, 2015 | Pubmed ID: 26224131
Novel 4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine fused chlorins as very active photodynamic agents for melanoma cells.
European journal of medicinal chemistry Oct, 2015 | Pubmed ID: 26383124
Influence of P53 on the radiotherapy response of hepatocellular carcinoma.
Clinical and molecular hepatology Sep, 2015 | Pubmed ID: 26527121
Effects of X-radiation on lung cancer cells: the interplay between oxidative stress and P53 levels.
Medical oncology (Northwood, London, England) Dec, 2015 | Pubmed ID: 26582337
The role of immune system exhaustion on cancer cell escape and anti-tumor immune induction after irradiation.
Biochimica et biophysica acta Apr, 2016 | Pubmed ID: 26868867
New Approach for Treatment of Primary Liver Tumors: The Role of Quercetin.
Nutrition and cancer , 2016 | Pubmed ID: 26943884
Ascorbic acid and colon cancer: an oxidative stimulus to cell death depending on cell profile.
European journal of cell biology Jun-Jul, 2016 | Pubmed ID: 27083410
Proceedings of the 3rd IPLeiria's International Health Congress : Leiria, Portugal. 6-7 May 2016.
BMC health services research 07, 2016 | Pubmed ID: 27409075
Liver diseases: what is known so far about the therapy with human amniotic membrane?
Cell and tissue banking Dec, 2016 | Pubmed ID: 27550013
Platinum(II) Ring-Fused Chlorins as Near-Infrared Emitting Oxygen Sensors and Photodynamic Agents.
ACS medicinal chemistry letters Mar, 2017 | Pubmed ID: 28337322
Mammospheres of hormonal receptor positive breast cancer diverge to triple-negative phenotype.
Breast (Edinburgh, Scotland) Apr, 2018 | Pubmed ID: 29182983
Advances on photodynamic therapy of melanoma through novel ring-fused 5,15-diphenylchlorins.
European journal of medicinal chemistry Feb, 2018 | Pubmed ID: 29407966
Amniotic membrane extract differentially regulates human peripheral blood T cell subsets, monocyte subpopulations and myeloid dendritic cells.
Cell and tissue research 08, 2018 | Pubmed ID: 29582167
Butyrate, a dietary fiber derivative that improves irinotecan effect in colon cancer cells.
The Journal of nutritional biochemistry 06, 2018 | Pubmed ID: 29587241
Revisiting colorectal cancer animal model - An improved metastatic model for distal rectosigmoid colon carcinoma.
Pathophysiology : the official journal of the International Society for Pathophysiology Jun, 2018 | Pubmed ID: 29628185
Ascorbic Acid Chemosensitizes Colorectal Cancer Cells and Synergistically Inhibits Tumor Growth.
Frontiers in physiology , 2018 | Pubmed ID: 30083105
Endometrial Cancer Spheres Show Cancer Stem Cells Phenotype and Preference for Oxidative Metabolism.
Pathology oncology research : POR Jul, 2019 | Pubmed ID: 30499076
Direct Pulp Capping: What is the Most Effective Therapy?-Systematic Review and Meta-Analysis.
The journal of evidence-based dental practice 12, 2018 | Pubmed ID: 30514444
Biodentine Boosts, WhiteProRootMTA Increases and Life Suppresses Odontoblast Activity.
Materials (Basel, Switzerland) Apr, 2019 | Pubmed ID: 30978943
Synthetic Calcium Phosphate Ceramics as a Potential Treatment for Bisphosphonate-Related Osteonecrosis of the Jaw.
Materials (Basel, Switzerland) Jun, 2019 | Pubmed ID: 31174333
Evaluation of the efficacy of dentin hypersensitivity treatments-A systematic review and follow-up analysis.
Journal of oral rehabilitation Oct, 2019 | Pubmed ID: 31216069
Direct Pulp Capping: Which is the Most Effective Biomaterial? A Retrospective Clinical Study.
Materials (Basel, Switzerland) Oct, 2019 | Pubmed ID: 31623190
Cytotoxic effects of a chlorhexidine mouthwash and of an enzymatic mouthwash on human gingival fibroblasts.
Odontology Oct, 2019 | Pubmed ID: 31624978
Ring-Fused Diphenylchlorins as Potent Photosensitizers for Photodynamic Therapy Applications: In Vitro Tumor Cell Biology and in Vivo Chick Embryo Chorioallantoic Membrane Studies.
ACS omega Oct, 2019 | Pubmed ID: 31656898
Iodine‑131 metabolic radiotherapy leads to cell death and genomic alterations through NIS overexpression on cholangiocarcinoma.
International journal of oncology Mar, 2020 | Pubmed ID: 31922240
Plasma activated media and direct exposition can selectively ablate retinoblastoma cells.
Free radical biology & medicine 08, 2021 | Pubmed ID: 34022401
Mafalda Laranjo*,1,2,3,4,
Maria João Carvalho*,1,2,3,4,5,6,
Beatriz Serambeque1,2,3,
André Alves2,7,
Carlos Miguel Marto1,2,3,4,8,
Isabel Silva9,
Artur Paiva3,9,10,
Maria Filomena Botelho1,2,3,4,8
1Institute of Biophysics, Faculty of Medicine, University of Coimbra,
2Coimbra Institute for Clinical and Biomedical Research (iCBR), area of Environment Genetics and Oncobiology (CIMAGO), Faculty of Medicine, University of Coimbra,
3CNC.IBILI/Center for Innovative Biomedicine and Biotechnology (CIBB), University of Coimbra,
4, Clinical Academic Center of Coimbra (CACC),
5Universitary Clinic of Gynecology, Faculty of Medicine, University of Coimbra,
6Gynecology A Service, Coimbra Hospital and Universitary Center,
7Institute of Pharmacology & Experimental Therapeutics, Faculty of Medicine, University of Coimbra,
8Institute of Experimental Pathology, Faculty of Medicine, University of Coimbra,
9Cytometry Operational Management Unit, Clinical Pathology Service, Coimbra Hospital and Universitary Center,
10Polytechnic Institute of Coimbra, ESTESC-Coimbra Health School, Laboratory Biomedical Sciences
Anabela Baptista Paula*,1,2,3,4,
Mafalda Laranjo*,2,3,4,5,
Ana Sofia Coelho1,2,3,4,
Ana Margarida Abrantes2,3,4,5,
Ana Cristina Gonçalves2,3,4,6,
Ana Bela Sarmento-Ribeiro2,3,4,6,
Manuel Marques Ferreira2,3,4,7,
Maria Filomena Botelho2,3,4,5,
Carlos Miguel Marto1,2,3,4,8,
Eunice Carrilho1,2,3,4
1Institute of Integrated Clinical Practice, Faculty of Medicine, University of Coimbra, Coimbra, Portugal,
2Coimbra Institute for Clinical and Biomedical Research (iCBR) area of Environment Genetics and Oncobiology (CIMAGO), University of Coimbra, Coimbra, Portugal,
3Center for Innovative Biomedicine and Biotechnology (CIBB), University of Coimbra, Coimbra, Portugal,
4, Clinical Academic Center of Coimbra, CACC, Portugal,
5Institute of Biophysics, Faculty of Medicine, University of Coimbra, Coimbra, Portugal,
6Laboratory of Oncobiology and Hematology, Faculty of Medicine, University of Coimbra, Coimbra, Portugal,
7Institute of Endodontics, Faculty of Medicine, University of Coimbra, Coimbra, Portugal,
8Institute of Experimental Pathology, Faculty of Medicine, University of Coimbra, Coimbra, Portugal
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