Matthias Gunzer

DC-T-cell synapses.

Localization of mu-opioid receptor 1A on sensory nerve fibers in human skin.

Loss of S100A9 (MRP14) results in reduced interleukin-8-induced CD11b surface expression, a polarized microfilament system, and diminished responsiveness to chemoattractants in vitro.

Molecular and functional analysis of Shiga toxin-induced response patterns in human vascular endothelial cells.

A spectrum of biophysical interaction modes between T cells and different antigen-presenting cells during priming in 3-D collagen and in vivo.

The Mycoplasma-derived macrophage-activating 2-kilodalton lipopeptide triggers global immune activation on nasal mucosa-associated lymphoid tissues.

Systemic administration of a TLR7 ligand leads to transient immune incompetence due to peripheral-blood leukocyte depletion.

Tuning immune responses: diversity and adaptation of the immunological synapse.

Microglia provide neuroprotection after ischemia.

Immune response modifiers--mode of action.

The biophysics of T lymphocyte activation in vitro and in vivo.

Imaging the immunological synapse.

Environmental dimensionality controls the interaction of phagocytes with the pathogenic fungi Aspergillus fumigatus and Candida albicans.

Naive B cells generate regulatory T cells in the presence of a mature immunologic synapse.

Stem cells, aging, niche, adhesion and Cdc42: a model for changes in cell-cell interactions and hematopoietic stem cell aging.

Vitamin D receptor signaling contributes to susceptibility to infection with Leishmania major.

The power of single and multibeam two-photon microscopy for high-resolution and high-speed deep tissue and intravital imaging.

The molecular makeup and function of regulatory and effector synapses.

Analyzing the physicodynamics of immune cells in a three-dimensional collagen matrix.

Basal expression of the Aspergillus fumigatus transcriptional activator CpcA is sufficient to support pulmonary aspergillosis.

Intravital two-photon microscopy: focus on speed and time resolved imaging modalities.

Signaling signatures and functional properties of anti-human CD28 superagonistic antibodies.

Microglia cells protect neurons by direct engulfment of invading neutrophil granulocytes: a new mechanism of CNS immune privilege.

3D and 4D imaging of immune cells in vitro and in vivo.

Deriving a germinal center lymphocyte migration model from two-photon data.

Increased susceptibility for superinfection with Streptococcus pneumoniae during influenza virus infection is not caused by TLR7-mediated lymphopenia.

Altered cellular dynamics and endosteal location of aged early hematopoietic progenitor cells revealed by time-lapse intravital imaging in long bones.

Human chorionic gonadotropin attracts regulatory T cells into the fetal-maternal interface during early human pregnancy.

Guanine nucleotide-binding proteins of the G12 family shape immune functions by controlling CD4+ T cell adhesiveness and motility.

Retrospective: Birth of the cool - imaging and microbiology from Ibn al-Haytham to Jean Comandon.

Identification of a putative Crf splice variant and generation of recombinant antibodies for the specific detection of Aspergillus fumigatus.

Src homology 2-domain containing leukocyte-specific phosphoprotein of 76 kDa is mandatory for TCR-mediated inside-out signaling, but dispensable for CXCR4-mediated LFA-1 activation, adhesion, and migration of T cells.

Immune synapse formation determines interaction forces between T cells and antigen-presenting cells measured by atomic force microscopy.

Imaging immunity.

APC, T cells, and the immune synapse.

Production of extracellular traps against Aspergillus fumigatus in vitro and in infected lung tissue is dependent on invading neutrophils and influenced by hydrophobin RodA.

Toll-like receptor 4 signaling by follicular dendritic cells is pivotal for germinal center onset and affinity maturation.

Pharmacological inhibition of EGFR signaling enhances G-CSF-induced hematopoietic stem cell mobilization.

G-CSF-mediated thrombopoietin release triggers neutrophil motility and mobilization from bone marrow via induction of Cxcr2 ligands.

Rapid immunomagnetic negative enrichment of neutrophil granulocytes from murine bone marrow for functional studies in vitro and in vivo.

Sphingosine 1-phosphate-induced motility and endocytosis of dendritic cells is regulated by SWAP-70 through RhoA.

On the way toward systems biology of Aspergillus fumigatus infection.

Shaping the fungal adaptome--stress responses of Aspergillus fumigatus.

Phagocyte responses towards Aspergillus fumigatus.

Imaging hematopoietic stem cells in the marrow of long bones in vivo.

Mast cells are key promoters of contact allergy that mediate the adjuvant effects of haptens.

Surface display of Gaussia princeps luciferase allows sensitive fungal pathogen detection during cutaneous aspergillosis.

Vaccine adjuvants: Tailor-made mast-cell granules.

Human regulatory T cells rapidly suppress T cell receptor-induced Ca(2+), NF-κB, and NFAT signaling in conventional T cells.

Connexin-43 in the osteogenic BM niche regulates its cellular composition and the bidirectional traffic of hematopoietic stem cells and progenitors.

Cdc42 activity regulates hematopoietic stem cell aging and rejuvenation.

White-opaque switching of Candida albicans allows immune evasion in an environment-dependent fashion.

TLR7 Contributes to the Rapid Progression but Not to the Overall Fatal Outcome of Secondary Pneumococcal Disease following Influenza A Virus Infection.

Pilus adhesin RrgA interacts with complement receptor 3, thereby affecting macrophage function and systemic pneumococcal disease.

Cellular immune reactions in the lung.

T cell activation results in conformational changes in the Src family kinase Lck to induce its activation.

A role for LFA-1 in delaying T-lymphocyte egress from lymph nodes.

Mast cell and macrophage chemokines CXCL1/CXCL2 control the early stage of neutrophil recruitment during tissue inflammation.

Multimolecular analysis of stable immunological synapses reveals sustained recruitment and sequential assembly of signaling clusters.

Transiently reduced PI3K/Akt activity drives the development of regulatory function in antigen-stimulated Naïve T-cells.

Traps and hyper inflammation - new ways that neutrophils promote or hinder survival.

Automated characterization and parameter-free classification of cell tracks based on local migration behavior.

Human dendritic cell subsets display distinct interactions with the pathogenic mould Aspergillus fumigatus.

Very-late-antigen-4 (VLA-4)-mediated brain invasion by neutrophils leads to interactions with microglia, increased ischemic injury and impaired behavior in experimental stroke.

Catchup: a mouse model for imaging-based tracking and modulation of neutrophil granulocytes.

Role of Neutrophils in Exacerbation of Brain Injury After Focal Cerebral Ischemia in Hyperlipidemic Mice.

Metastatic status of sentinel lymph nodes in melanoma determined noninvasively with multispectral optoacoustic imaging.

ImmunoPET/MR imaging allows specific detection of Aspergillus fumigatus lung infection in vivo.

Survival of residual neutrophils and accelerated myelopoiesis limit the efficacy of antibody-mediated depletion of Ly-6G+ cells in tumor-bearing mice.

Neutrophil Migration into the Infected Uroepithelium Is Regulated by the Crosstalk between Resident and Helper Macrophages.

Alveolar Type II Epithelial Cells Contribute to the Anti-Influenza A Virus Response in the Lung by Integrating Pathogen- and Microenvironment-Derived Signals.

CD11c.DTR mice develop a fatal fulminant myocarditis after local or systemic treatment with diphtheria toxin.

Fully Automated Evaluation of Total Glomerular Number and Capillary Tuft Size in Nephritic Kidneys Using Lightsheet Microscopy.

3D visualization and quantification of microvessels in the whole ischemic mouse brain using solvent-based clearing and light sheet microscopy.