Modeling Intracerebral Hemorrhage in Mice: Injection of Autologous Blood or Bacterial CollagenasePaul R. Krafft 1, William B. Rolland 1, Kamil Duris 1, Tim Lekic 1, Aaron Campbell 2, Jiping Tang 1, John H. Zhang 1,3,4
1Department of Physiology and Pharmacology, Loma Linda University School of Medicine, 2College of Natural and Agricultural Sciences, University of California, Riverside , 3Department of Anesthesiology, Loma Linda University School of Medicine, 4Department of Neurosurgery, Loma Linda University School of Medicine
Clinically relevant animal models of intracerebral hemorrhage (ICH) are needed to extend our knowledge of hemorrhagic stroke and to examine novel therapeutic strategies. In this study, we describe and evaluate two ICH models that implement unilateral injections of either autologous whole blood or bacterial collagenase into the basal ganglia (corpus striatum) of mice.
