Fabrication of the Sensor and Acquisition of the Data
3:31
Sensor Bulk Sensitivity Test and Sensor Surface Modification
5:34
Cardiac Troponin I (cTnI) Assay
6:48
Results: cTnI Assay
7:56
Conclusion
Transkript
The overall goal of this technique is to measure biomarkers present in a complex biological fluid background at clinically relevant concentrations in a point of care setting without the need for elaborate optical or electrical setups. This method
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This work describes a nanoimprinting lithography method to fabricate high-quality sensing arrays that work on the principle of extraordinary optical transmission. The biosensor is low-cost, robust, easy to use, and can detect cardiac troponin I in serum at clinically relevant concentrations (99th percentile cutoff ∼10-400 pg/mL, depending on the assay).