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JoVE Journal

Chemistry

This content is Open Access.

Technical Aspect of the Automated Synthesis and Real-Time Kinetic Evaluation of [11C]SNAP-7941

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09:50 min

April 28th, 2019

April 28th, 2019

7,377 Views

0:04

Title

1:20

Automated Synthesis of [11C]SNAP-7941 for Preclinical Use

4:40

Quality Control (QC) of [11C]SNAP-7941

5:55

Real-Time Kinetic Assay

8:02

Results: Evaluation of [11C]SNAP-7941 Interactions Towards the Permeability Glycoprotein 1 (P-gp) Transporter

8:44

Conclusion

Transkript

Here, we represent a protocol for the fully automated radiolabelling of [11C]SNAP-7941 and the analysis of the real-time kinetics of this PET-tracer on P-gp expressing and non-expressing cells.

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