Laurence G. Rahme

Identification of virulence genes in a pathogenic strain of Pseudomonas aeruginosa by representational difference analysis.

Use of plant and insect hosts to model bacterial pathogenesis.

The Drosophila melanogaster toll pathway participates in resistance to infection by the gram-negative human pathogen Pseudomonas aeruginosa.

Pseudomonas aeruginosa-plant root interactions. Pathogenicity, biofilm formation, and root exudation.

Analysis of Pseudomonas aeruginosa 4-hydroxy-2-alkylquinolines (HAQs) reveals a role for 4-hydroxy-2-heptylquinoline in cell-to-cell communication.

The broad host range pathogen Pseudomonas aeruginosa strain PA14 carries two pathogenicity islands harboring plant and animal virulence genes.

Challenge of Drosophila melanogaster with Cryptococcus neoformans and role of the innate immune response.

Electrospray/mass spectrometric identification and analysis of 4-hydroxy-2-alkylquinolines (HAQs) produced by Pseudomonas aeruginosa.

The contribution of MvfR to Pseudomonas aeruginosa pathogenesis and quorum sensing circuitry regulation: multiple quorum sensing-regulated genes are modulated without affecting lasRI, rhlRI or the production of N-acyl-L-homoserine lactones.

Profiling early infection responses: Pseudomonas aeruginosa eludes host defenses by suppressing antimicrobial peptide gene expression.

Burn injury causes mitochondrial dysfunction in skeletal muscle.

Proton NMR spectroscopy shows lipids accumulate in skeletal muscle in response to burn trauma-induced apoptosis.

Mutation analysis of the Pseudomonas aeruginosa mvfR and pqsABCDE gene promoters demonstrates complex quorum-sensing circuitry.

Local and distant burn injury alter immuno-inflammatory gene expression in skeletal muscle.

Genomic analysis reveals that Pseudomonas aeruginosa virulence is combinatorial.

MvfR, a key Pseudomonas aeruginosa pathogenicity LTTR-class regulatory protein, has dual ligands.

Uncoupling protein 3 expression and intramyocellular lipid accumulation by NMR following local burn trauma.

Dynorphin activates quorum sensing quinolone signaling in Pseudomonas aeruginosa.

Combination of high-resolution magic angle spinning proton magnetic resonance spectroscopy and microscale genomics to type brain tumor biopsies.

PqsA is required for the biosynthesis of 2,4-dihydroxyquinoline (DHQ), a newly identified metabolite produced by Pseudomonas aeruginosa and Burkholderia thailandensis.

Inhibitors of pathogen intercellular signals as selective anti-infective compounds.

Involvement of skeletal muscle gene regulatory network in susceptibility to wound infection following trauma.

Reduced rate of adenosine triphosphate synthesis by in vivo 31P nuclear magnetic resonance spectroscopy and downregulation of PGC-1beta in distal skeletal muscle following burn.

Use of the lambda Red recombinase system to rapidly generate mutants in Pseudomonas aeruginosa.

Murine intramyocellular lipids quantified by NMR act as metabolic biomarkers in burn trauma.

Modeling Pseudomonas aeruginosa pathogenesis in plant hosts.

Microarray analysis suggests that burn injury results in mitochondrial dysfunction in human skeletal muscle.

Drosophila melanogaster as a model host for studying Pseudomonas aeruginosa infection.

Dysfunctional expansion of hematopoietic stem cells and block of myeloid differentiation in lethal sepsis.

The pathogenic properties of a novel and conserved gene product, KerV, in proteobacteria.

Homeostatic interplay between bacterial cell-cell signaling and iron in virulence.

In vivo high-resolution magic angle spinning magnetic resonance spectroscopy of Drosophila melanogaster at 14.1 T shows trauma in aging and in innate immune-deficiency is linked to reduced insulin signaling.

Combined off-resonance imaging and T2 relaxation in the rotating frame for positive contrast MR imaging of infection in a murine burn model.

Nuclear magnetic resonance in conjunction with functional genomics suggests mitochondrial dysfunction in a murine model of cancer cachexia.

Burn trauma in skeletal muscle results in oxidative stress as assessed by in vivo electron paramagnetic resonance.

Drosophila melanogaster as a model for human intestinal infection and pathology.

Combining magnetic resonance spectroscopy and molecular genomics offers better accuracy in brain tumor typing and prediction of survival than either methodology alone.

A quorum sensing regulated small volatile molecule reduces acute virulence and promotes chronic infection phenotypes.

Down-regulation of glutatione S-transferase α 4 (hGSTA4) in the muscle of thermally injured patients is indicative of susceptibility to bacterial infection.