Department of Physics,
Center for the Physics of Living Cells,
Center for Biophysics and Computational Biology
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Single molecule FRET reveals pore size and opening mechanism of a mechano-sensitive ion channel.
eLife , 2014 | Pubmed ID: 24550255
Motor domain phosphorylation modulates kinesin-1 transport.
The Journal of biological chemistry Nov, 2013 | Pubmed ID: 24072715
Holding two heads together: stability of the myosin II rod measured by resonance energy transfer between the heads.
Proceedings of the National Academy of Sciences of the United States of America Apr, 2002 | Pubmed ID: 11972024
Principles and biophysical applications of lanthanide-based probes.
Annual review of biophysics and biomolecular structure , 2002 | Pubmed ID: 11988471
Thiol-reactive lanthanide chelates for phasing protein X-ray diffraction data.
Acta crystallographica. Section D, Biological crystallography Jul, 2002 | Pubmed ID: 12077430
Lighting up single ion channels.
Biophysical journal Jan, 2003 | Pubmed ID: 12524260
An actin-dependent conformational change in myosin.
Nature structural biology May, 2003 | Pubmed ID: 12679807
Myosin V walks hand-over-hand: single fluorophore imaging with 1.5-nm localization.
Science (New York, N.Y.) Jun, 2003 | Pubmed ID: 12791999
Thiol-reactive luminescent lanthanide chelates: part 2.
Bioconjugate chemistry Sep-Oct, 2003 | Pubmed ID: 13129389
Does the S2 rod of myosin II uncoil upon two-headed binding to actin? A leucine-zippered HMM study.
Biochemistry Nov, 2003 | Pubmed ID: 14596602
Kinesin walks hand-over-hand.
Science (New York, N.Y.) Jan, 2004 | Pubmed ID: 14684828
3D Super-Resolution Imaging with Blinking Quantum Dots.
Nano letters Nov, 2013 | Pubmed ID: 24093439
Single-molecule high-resolution imaging with photobleaching.
Proceedings of the National Academy of Sciences of the United States of America Apr, 2004 | Pubmed ID: 15096603
Myosin VI steps via a hand-over-hand mechanism with its lever arm undergoing fluctuations when attached to actin.
The Journal of biological chemistry Sep, 2004 | Pubmed ID: 15254036
Nanometer localization of single green fluorescent proteins: evidence that myosin V walks hand-over-hand via telemark configuration.
Biophysical journal Sep, 2004 | Pubmed ID: 15345556
Carbostyril derivatives as antenna molecules for luminescent lanthanide chelates.
Bioconjugate chemistry Sep-Oct, 2004 | Pubmed ID: 15366964
Kinesin: walking, crawling or sliding along?
Trends in cell biology Feb, 2005 | Pubmed ID: 15695098
Kinesin and dynein move a peroxisome in vivo: a tug-of-war or coordinated movement?
Science (New York, N.Y.) Jun, 2005 | Pubmed ID: 15817813
Interhead distance measurements in myosin VI via SHRImP support a simplified hand-over-hand model.
Biophysical journal Jul, 2005 | Pubmed ID: 15863481
Fluorescence imaging with one nanometer accuracy: application to molecular motors.
Accounts of chemical research Jul, 2005 | Pubmed ID: 16028892
Small vertical movement of a K+ channel voltage sensor measured with luminescence energy transfer.
Nature Aug, 2005 | Pubmed ID: 16094368
Step-size is determined by neck length in myosin V.
Biochemistry Dec, 2005 | Pubmed ID: 16331980
Full-length myosin VI dimerizes and moves processively along actin filaments upon monomer clustering.
Molecular cell Feb, 2006 | Pubmed ID: 16455488
Adaptability of myosin V studied by simultaneous detection of position and orientation.
The EMBO journal May, 2006 | Pubmed ID: 16601691
Defocused orientation and position imaging (DOPI) of myosin V.
Proceedings of the National Academy of Sciences of the United States of America Apr, 2006 | Pubmed ID: 16614073
Maximum likelihood estimation of molecular motor kinetics from staircase dwell-time sequences.
Biophysical journal Aug, 2006 | Pubmed ID: 16679362
Extracting dwell time sequences from processive molecular motor data.
Biophysical journal Nov, 2006 | Pubmed ID: 16905607
Distance measurements reveal a common topology of prokaryotic voltage-gated ion channels in the lipid bilayer.
Proceedings of the National Academy of Sciences of the United States of America Oct, 2006 | Pubmed ID: 17043236
Rapid DNA mapping by fluorescent single molecule detection.
Nucleic acids research , 2007 | Pubmed ID: 17175538
The unique insert at the end of the myosin VI motor is the sole determinant of directionality.
Proceedings of the National Academy of Sciences of the United States of America Jan, 2007 | Pubmed ID: 17213313
New fluorescent tools for watching nanometer-scale conformational changes of single molecules.
Annual review of biophysics and biomolecular structure , 2007 | Pubmed ID: 17298239
Microtubule binding by dynactin is required for microtubule organization but not cargo transport.
The Journal of cell biology Feb, 2007 | Pubmed ID: 17325206
Tracking melanosomes inside a cell to study molecular motors and their interaction.
Proceedings of the National Academy of Sciences of the United States of America Mar, 2007 | Pubmed ID: 17369356
Determination of haplotypes from single DNA molecules: a method for single-molecule barcoding.
Human mutation Sep, 2007 | Pubmed ID: 17443670
How myosin VI coordinates its heads during processive movement.
The EMBO journal Jun, 2007 | Pubmed ID: 17510632
Three-dimensional particle tracking via bifocal imaging.
Nano letters Jul, 2007 | Pubmed ID: 17583964
Single-molecule fluorescence to study molecular motors.
Quarterly reviews of biophysics Feb, 2007 | Pubmed ID: 17666122
The mitotic kinesin CENP-E is a processive transport motor.
Proceedings of the National Academy of Sciences of the United States of America Apr, 2008 | Pubmed ID: 18427114
New 9- or 10-dentate luminescent lanthanide chelates.
Bioconjugate chemistry May, 2008 | Pubmed ID: 18442281
Extent of voltage sensor movement during gating of shaker K+ channels.
Neuron Jul, 2008 | Pubmed ID: 18614032
The role of microtubule movement in bidirectional organelle transport.
Proceedings of the National Academy of Sciences of the United States of America Jul, 2008 | Pubmed ID: 18626022
FIONA on Caenorhabditis elegans.
Biochemistry Jun, 2009 | Pubmed ID: 19397310
Polarization effect on position accuracy of fluorophore localization.
Optics express Sep, 2006 | Pubmed ID: 19529183
Why kinesin is so processive.
Proceedings of the National Academy of Sciences of the United States of America Aug, 2009 | Pubmed ID: 19617538
Myosin VI dimerization triggers an unfolding of a three-helix bundle in order to extend its reach.
Molecular cell Aug, 2009 | Pubmed ID: 19664948
Myosin VI undergoes a 180 degrees power stroke implying an uncoupling of the front lever arm.
Proceedings of the National Academy of Sciences of the United States of America Oct, 2009 | Pubmed ID: 19828438
Super-accuracy and super-resolution getting around the diffraction limit.
Methods in enzymology , 2010 | Pubmed ID: 20627151
Formation of salt bridges mediates internal dimerization of myosin VI medial tail domain.
Structure (London, England : 1993) Nov, 2010 | Pubmed ID: 21070943
Counting bungarotoxin binding sites of nicotinic acetylcholine receptors in mammalian cells with high signal/noise ratios.
Biophysical journal Nov, 2010 | Pubmed ID: 21081055
Improved hidden Markov models for molecular motors, part 1: basic theory.
Biophysical journal Dec, 2010 | Pubmed ID: 21112293
Improved hidden Markov models for molecular motors, part 2: extensions and application to experimental data.
Biophysical journal Dec, 2010 | Pubmed ID: 21112294
Equipment Setup for Fluorescence Imaging with One-Nanometer Accuracy (FIONA).
CSH protocols , 2007 | Pubmed ID: 21356942
Data Analysis Methods for Fluorescence Imaging with One-Nanometer Accuracy (FIONA).
CSH protocols , 2007 | Pubmed ID: 21356943
Constructing Sample Chambers for Fluorescence Imaging with One-Nanometer Accuracy (FIONA).
CSH protocols , 2007 | Pubmed ID: 21356955
Fluorescence Imaging with One-Nanometer Accuracy (FIONA) of Cy3-DNA under Deoxygenation Conditions.
CSH protocols , 2007 | Pubmed ID: 21356956
Fluorescence Imaging with One-Nanometer Accuracy (FIONA).
CSH protocols , 2007 | Pubmed ID: 21356960
Single-virus tracking reveals a spatial receptor-dependent search mechanism.
Biophysical journal Jun, 2011 | Pubmed ID: 21689520
Extension of a three-helix bundle domain of myosin VI and key role of calmodulins.
Biophysical journal Jun, 2011 | Pubmed ID: 21689530
Molecular motors one at a time: FIONA to the rescue.
Journal of physics. Condensed matter : an Institute of Physics journal Nov, 2005 | Pubmed ID: 21690736
Fluorescence imaging with one nanometer accuracy: in vitro and in vivo studies of molecular motors.
Methods in molecular biology (Clifton, N.J.) , 2011 | Pubmed ID: 21809199
Two-photon 3D FIONA of individual quantum dots in an aqueous environment.
Nano letters Oct, 2011 | Pubmed ID: 21882883
Single-molecule-based super-resolution images in the presence of multiple fluorophores.
Nano letters Nov, 2011 | Pubmed ID: 22003850
Biomimetic surface engineering of lanthanide-doped upconversion nanoparticles as versatile bioprobes.
Angewandte Chemie (International ed. in English) Jun, 2012 | Pubmed ID: 22566291
Multicolor super-resolution DNA imaging for genetic analysis.
Nano letters Jul, 2012 | Pubmed ID: 22698062
Using fixed fiduciary markers for stage drift correction.
Optics express May, 2012 | Pubmed ID: 22714205
Direct detection of adenosine in undiluted serum using a luminescent aptamer sensor attached to a terbium complex.
Analytical chemistry Sep, 2012 | Pubmed ID: 22894546
In vivo optical trapping indicates kinesin's stall force is reduced by dynein during intracellular transport.
Proceedings of the National Academy of Sciences of the United States of America Feb, 2013 | Pubmed ID: 23404705
Single-molecule fluorescence and in vivo optical traps: how multiple dyneins and kinesins interact.
Chemical reviews Mar, 2014 | Pubmed ID: 24666199
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