Department of Neurosurgery
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Gene therapy for brain cancer: combination therapies provide enhanced efficacy and safety.
Current gene therapy Oct, 2009 | Pubmed ID: 19860655
Immunology of viral-vector-mediated gene transfer into the brain: an evolutionary and developmental perspective.
Trends in immunology Jan, 2002 | Pubmed ID: 11801451
Prolonged blockade of CD40-CD40 ligand interactions by gene transfer of CD40Ig results in long-term heart allograft survival and donor-specific hyporesponsiveness, but does not prevent chronic rejection.
Journal of immunology (Baltimore, Md. : 1950) Feb, 2002 | Pubmed ID: 11823487
Adenovirus binding to the coxsackievirus and adenovirus receptor or integrins is not required to elicit brain inflammation but is necessary to transduce specific neural cell types.
Journal of virology Apr, 2002 | Pubmed ID: 11884569
Dendritic cells and immune responses in the central nervous system.
Trends in immunology Feb, 2002 | Pubmed ID: 11956012
Progress and challenges in viral vector-mediated gene transfer to the brain.
Current opinion in molecular therapeutics Aug, 2002 | Pubmed ID: 12222874
Adenovirus vector-mediated delivery of the prodrug-converting enzyme carboxypeptidase G2 in a secreted or GPI-anchored form: High-level expression of this active conditional cytotoxic enzyme at the plasma membrane.
Cancer gene therapy Nov, 2002 | Pubmed ID: 12386828
Use of recombinant adenovirus for gene transfer into the rat brain. Evaluation of gene transfer efficiency, toxicity, and inflammatory and immune reactions.
Methods in molecular medicine , 2003 | Pubmed ID: 12526161
Adenovirus expression of IL-1 and NF-kappaB inhibitors does not inhibit acute adenoviral-induced brain inflammation, but delays immune system-mediated elimination of transgene expression.
Molecular therapy : the journal of the American Society of Gene Therapy Sep, 2003 | Pubmed ID: 12946313
Nonneurotropic adenovirus: a vector for gene transfer to the brain and gene therapy of neurological disorders.
International review of neurobiology , 2003 | Pubmed ID: 12968530
Adenovirus-mediated gene transfer of transforming growth factor-beta3, but not transforming growth factor-beta1, inhibits constrictive remodeling and reduces luminal loss after coronary angioplasty.
Circulation Dec, 2003 | Pubmed ID: 14638551
Gene therapy for liver transplantation using adenoviral vectors: CD40-CD154 blockade by gene transfer of CD40Ig protects rat livers from cold ischemia and reperfusion injury.
Molecular therapy : the journal of the American Society of Gene Therapy Jan, 2004 | Pubmed ID: 14741776
Development of a novel helper-dependent adenovirus-Epstein-Barr virus hybrid system for the stable transformation of mammalian cells.
Journal of virology Jun, 2004 | Pubmed ID: 15163748
Input virion proteins: cryptic targets of antivector immune responses in preimmunized subjects.
Molecular therapy : the journal of the American Society of Gene Therapy Jun, 2004 | Pubmed ID: 15222326
Effects of ectopic decorin in modulating intracranial glioma progression in vivo, in a rat syngeneic model.
Cancer gene therapy Nov, 2004 | Pubmed ID: 15475879
The Collaborative Cross, a community resource for the genetic analysis of complex traits.
Nature genetics Nov, 2004 | Pubmed ID: 15514660
Inflammatory and anti-glioma effects of an adenovirus expressing human soluble Fms-like tyrosine kinase 3 ligand (hsFlt3L): treatment with hsFlt3L inhibits intracranial glioma progression.
Molecular therapy : the journal of the American Society of Gene Therapy Dec, 2004 | Pubmed ID: 15564139
Stability of lentiviral vector-mediated transgene expression in the brain in the presence of systemic antivector immune responses.
Human gene therapy Jun, 2005 | Pubmed ID: 15960605
The case for immunosuppression in clinical gene transfer.
Molecular therapy : the journal of the American Society of Gene Therapy Aug, 2005 | Pubmed ID: 16002339
Mutagenesis-induced, large fitness variations with an invariant arenavirus consensus genomic nucleotide sequence.
Journal of virology Aug, 2005 | Pubmed ID: 16051837
Combined immunostimulation and conditional cytotoxic gene therapy provide long-term survival in a large glioma model.
Cancer research Aug, 2005 | Pubmed ID: 16103070
Combining cytotoxic and immune-mediated gene therapy to treat brain tumors.
Current topics in medicinal chemistry , 2005 | Pubmed ID: 16248789
Platelets mediate cytotoxic T lymphocyte-induced liver damage.
Nature medicine Nov, 2005 | Pubmed ID: 16258538
Regulatable gutless adenovirus vectors sustain inducible transgene expression in the brain in the presence of an immune response against adenoviruses.
Journal of virology Jan, 2006 | Pubmed ID: 16352528
Gene therapy and targeted toxins for glioma.
Current gene therapy Dec, 2005 | Pubmed ID: 16457645
Fms-like tyrosine kinase 3 ligand recruits plasmacytoid dendritic cells to the brain.
Journal of immunology (Baltimore, Md. : 1950) Mar, 2006 | Pubmed ID: 16517725
Rapid upregulation of interferon-regulated and chemokine mRNAs upon injection of 108 international units, but not lower doses, of adenoviral vectors into the brain.
Journal of virology Jun, 2006 | Pubmed ID: 16699048
Effective high-capacity gutless adenoviral vectors mediate transgene expression in human glioma cells.
Molecular therapy : the journal of the American Society of Gene Therapy Sep, 2006 | Pubmed ID: 16798098
In vivo mature immunological synapses forming SMACs mediate clearance of virally infected astrocytes from the brain.
The Journal of experimental medicine Sep, 2006 | Pubmed ID: 16923851
Immune regulation of transgene expression in the brain: B cells regulate an early phase of elimination of transgene expression from adenoviral vectors.
Viral immunology , 2006 | Pubmed ID: 16987068
Adenoviral-mediated gene transfer into the canine brain in vivo.
Neurosurgery Jan, 2007 | Pubmed ID: 17228266
Optimization of adenoviral vector-mediated transgene expression in the canine brain in vivo, and in canine glioma cells in vitro.
Neuro-oncology Jul, 2007 | Pubmed ID: 17522335
Efficacy of nonviral gene transfer in the canine brain.
Journal of neurosurgery Jul, 2007 | Pubmed ID: 17639883
Intracranial glioblastoma models in preclinical neuro-oncology: neuropathological characterization and tumor progression.
Journal of neuro-oncology Nov, 2007 | Pubmed ID: 17874037
Improved distribution of small molecules and viral vectors in the murine brain using a hollow fiber catheter.
Journal of neurosurgery Sep, 2007 | Pubmed ID: 17886557
One-year expression from high-capacity adenoviral vectors in the brains of animals with pre-existing anti-adenoviral immunity: clinical implications.
Molecular therapy : the journal of the American Society of Gene Therapy Dec, 2007 | Pubmed ID: 17895861
Immunology of neurological gene therapy: how T cells modulate viral vector-mediated therapeutic transgene expression through immunological synapses.
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics Oct, 2007 | Pubmed ID: 17920552
Immune responses to adenovirus and adeno-associated vectors used for gene therapy of brain diseases: the role of immunological synapses in understanding the cell biology of neuroimmune interactions.
Current gene therapy Oct, 2007 | Pubmed ID: 17979681
Flt3L and TK gene therapy eradicate multifocal glioma in a syngeneic glioblastoma model.
Neuro-oncology Feb, 2008 | Pubmed ID: 18079358
Immunological thresholds in neurological gene therapy: highly efficient elimination of transduced cells might be related to the specific formation of immunological synapses between T cells and virus-infected brain cells.
Neuron glia biology Nov, 2006 | Pubmed ID: 18084640
Immunization against the transgene but not the TetON switch reduces expression from gutless adenoviral vectors in the brain.
Molecular therapy : the journal of the American Society of Gene Therapy Feb, 2008 | Pubmed ID: 18180781
In vivo polarization of IFN-gamma at Kupfer and non-Kupfer immunological synapses during the clearance of virally infected brain cells.
Journal of immunology (Baltimore, Md. : 1950) Feb, 2008 | Pubmed ID: 18209028
Flt3L in combination with HSV1-TK-mediated gene therapy reverses brain tumor-induced behavioral deficits.
Molecular therapy : the journal of the American Society of Gene Therapy Apr, 2008 | Pubmed ID: 18283279
High-capacity adenovirus vector-mediated anti-glioma gene therapy in the presence of systemic antiadenovirus immunity.
Journal of virology May, 2008 | Pubmed ID: 18287240
Turning the gene tap off; implications of regulating gene expression for cancer therapeutics.
Molecular cancer therapeutics Mar, 2008 | Pubmed ID: 18347132
Gene delivery to the nervous system.
Molecular therapy : the journal of the American Society of Gene Therapy Apr, 2008 | Pubmed ID: 18362921
Treg depletion inhibits efficacy of cancer immunotherapy: implications for clinical trials.
PloS one , 2008 | Pubmed ID: 18431473
Regulated expression of adenoviral vectors-based gene therapies: therapeutic expression of toxins and immune-modulators.
Methods in molecular biology (Clifton, N.J.) , 2008 | Pubmed ID: 18470649
With a little help from my f(X)riends!: the basis of Ad5-mediated transduction of the liver revealed.
Molecular therapy : the journal of the American Society of Gene Therapy Jun, 2008 | Pubmed ID: 18500239
CD20, CD3, and CD40 ligand microclusters segregate three-dimensionally in vivo at B-cell-T-cell immunological synapses after viral immunity in primate brain.
Journal of virology Oct, 2008 | Pubmed ID: 18684835
T cells' immunological synapses induce polarization of brain astrocytes in vivo and in vitro: a novel astrocyte response mechanism to cellular injury.
PloS one , 2008 | Pubmed ID: 18714338
Clinical trials in gene therapy: ethics of informed consent and the future of experimental medicine.
Current opinion in molecular therapeutics Oct, 2008 | Pubmed ID: 18830917
A call for physiopathological ethics.
Molecular therapy : the journal of the American Society of Gene Therapy Nov, 2008 | Pubmed ID: 18956015
Gene transfer into neural cells in vitro using adenoviral vectors.
Current protocols in neuroscience / editorial board, Jacqueline N. Crawley ... [et al.] Oct, 2008 | Pubmed ID: 18972378
Crossing the rubicon.
Nature biotechnology Jan, 2009 | Pubmed ID: 19131996
HMGB1 mediates endogenous TLR2 activation and brain tumor regression.
PLoS medicine Jan, 2009 | Pubmed ID: 19143470
Release of HMGB1 in response to proapoptotic glioma killing strategies: efficacy and neurotoxicity.
Clinical cancer research : an official journal of the American Association for Cancer Research Jul, 2009 | Pubmed ID: 19570774
Infiltrating CTLs in human glioblastoma establish immunological synapses with tumorigenic cells.
The American journal of pathology Aug, 2009 | Pubmed ID: 19628762
Antiglioma immunological memory in response to conditional cytotoxic/immune-stimulatory gene therapy: humoral and cellular immunity lead to tumor regression.
Clinical cancer research : an official journal of the American Association for Cancer Research Oct, 2009 | Pubmed ID: 19789315
Challenges in the evaluation, consent, ethics and history of early clinical trials - Implications of the Tuskegee 'trial' for safer and more ethical clinical trials.
Current opinion in molecular therapeutics Oct, 2009 | Pubmed ID: 19806495
Gene therapy continues to make progress: clinical and regulatory perspectives.
Current gene therapy Oct, 2009 | Pubmed ID: 19860647
Uncertainty in the translation of preclinical experiments to clinical trials. Why do most phase III clinical trials fail?
Current gene therapy Oct, 2009 | Pubmed ID: 19860651
Risk in clinical research: size matters!
Molecular therapy : the journal of the American Society of Gene Therapy Nov, 2009 | Pubmed ID: 19876046
Gene transfer into rat brain using adenoviral vectors.
Current protocols in neuroscience / editorial board, Jacqueline N. Crawley ... [et al.] Jan, 2010 | Pubmed ID: 20066657
Anti-tumor immune response correlates with neurological symptoms in a dog with spontaneous astrocytoma treated by gene and vaccine therapy.
Vaccine Apr, 2010 | Pubmed ID: 20197146
A novel bicistronic high-capacity gutless adenovirus vector that drives constitutive expression of herpes simplex virus type 1 thymidine kinase and tet-inducible expression of Flt3L for glioma therapeutics.
Journal of virology Jun, 2010 | Pubmed ID: 20375153
Human Flt3L generates dendritic cells from canine peripheral blood precursors: implications for a dog glioma clinical trial.
PloS one , 2010 | Pubmed ID: 20552015
Exogenous fms-like tyrosine kinase 3 ligand overrides brain immune privilege and facilitates recognition of a neo-antigen without causing autoimmune neuropathology.
Proceedings of the National Academy of Sciences of the United States of America Aug, 2010 | Pubmed ID: 20660723
Cancer vaccines in glioma: how to balance the challenges of small trials, efficiency, and potential adverse events.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology Nov, 2010 | Pubmed ID: 20921460
Gene therapy-mediated delivery of targeted cytotoxins for glioma therapeutics.
Proceedings of the National Academy of Sciences of the United States of America Nov, 2010 | Pubmed ID: 21030678
Gene therapy and virotherapy: novel therapeutic approaches for brain tumors.
Discovery medicine Oct, 2010 | Pubmed ID: 21034670
AAV6-mediated gene silencing fALS short.
Molecular therapy : the journal of the American Society of Gene Therapy Feb, 2011 | Pubmed ID: 21289637
Gene therapy and targeted toxins for glioma.
Current gene therapy Jun, 2011 | Pubmed ID: 21453286
Combined Flt3L/TK gene therapy induces immunological surveillance which mediates an immune response against a surrogate brain tumor neoantigen.
Molecular therapy : the journal of the American Society of Gene Therapy Oct, 2011 | Pubmed ID: 21505426
Moving forward toward a cure for Parkinson's: neuropathology of the nigrostriatal pathway determines the location of growth factor delivery.
Molecular therapy : the journal of the American Society of Gene Therapy May, 2011 | Pubmed ID: 21532611
Engineering the brain tumor microenvironment enhances the efficacy of dendritic cell vaccination: implications for clinical trial design.
Clinical cancer research : an official journal of the American Association for Cancer Research Jul, 2011 | Pubmed ID: 21632862
Targeted toxins for glioblastoma multiforme: pre-clinical studies and clinical implementation.
Anti-cancer agents in medicinal chemistry Oct, 2011 | Pubmed ID: 21707497
Identification and visualization of CD8+ T cell mediated IFN-γ signaling in target cells during an antiviral immune response in the brain.
PloS one , 2011 | Pubmed ID: 21897844
B cells are critical to T-cell-mediated antitumor immunity induced by a combined immune-stimulatory/conditionally cytotoxic therapy for glioblastoma.
Neoplasia (New York, N.Y.) Oct, 2011 | Pubmed ID: 22028620
Immune-mediated loss of transgene expression from virally transduced brain cells is irreversible, mediated by IFNγ, perforin, and TNFα, and due to the elimination of transduced cells.
Molecular therapy : the journal of the American Society of Gene Therapy Apr, 2012 | Pubmed ID: 22233583
Pushing the limits of glioma resection using electrophysiologic brain mapping.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology Jul, 2012 | Pubmed ID: 22529267
Cytotoxic immunological synapses do not restrict the action of interferon-γ to antigenic target cells.
Proceedings of the National Academy of Sciences of the United States of America May, 2012 | Pubmed ID: 22547816
Gene therapy for brain tumors: basic developments and clinical implementation.
Neuroscience letters Oct, 2012 | Pubmed ID: 22906921
Safety profile of gutless adenovirus vectors delivered into the normal brain parenchyma: implications for a glioma phase 1 clinical trial.
Human gene therapy methods Aug, 2012 | Pubmed ID: 22950971
Plasmacytoid dendritic cells in the tumor microenvironment: immune targets for glioma therapeutics.
Neoplasia (New York, N.Y.) Aug, 2012 | Pubmed ID: 22952428
Gene therapy-mediated reprogramming tumor infiltrating T cells using IL-2 and inhibiting NF-κB signaling improves the efficacy of immunotherapy in a brain cancer model.
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics Oct, 2012 | Pubmed ID: 22996231
Safety profile, efficacy, and biodistribution of a bicistronic high-capacity adenovirus vector encoding a combined immunostimulation and cytotoxic gene therapy as a prelude to a phase I clinical trial for glioblastoma.
Toxicology and applied pharmacology May, 2013 | Pubmed ID: 23403069
Progress in gene therapy for neurological disorders.
Nature reviews. Neurology May, 2013 | Pubmed ID: 23609618
Effectiveness and preclinical safety profile of doxycycline to be used "off-label" to induce therapeutic transgene expression in a phase I clinical trial for glioma.
Human gene therapy. Clinical development Sep, 2013 | Pubmed ID: 24007469
Neuro-oncology: The long and winding road--gene therapy for glioma.
Nature reviews. Neurology Nov, 2013 | Pubmed ID: 24061435
Dendritic cell-based immunotherapy for glioma: multiple regimens and implications in clinical trials.
Neurologia medico-chirurgica , 2013 | Pubmed ID: 24140772
Temozolomide does not impair gene therapy-mediated antitumor immunity in syngeneic brain tumor models.
Clinical cancer research : an official journal of the American Association for Cancer Research Mar, 2014 | Pubmed ID: 24501391
Preclinical characterization of signal transducer and activator of transcription 3 small molecule inhibitors for primary and metastatic brain cancer therapy.
The Journal of pharmacology and experimental therapeutics Jun, 2014 | Pubmed ID: 24696041
Lentiviral-induced high-grade gliomas in rats: the effects of PDGFB, HRAS-G12V, AKT, and IDH1-R132H.
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics Jul, 2014 | Pubmed ID: 24752661
Adenoviral vector-mediated gene therapy for gliomas: coming of age.
Expert opinion on biological therapy Sep, 2014 | Pubmed ID: 24773178
Assessing the role of STAT3 in DC differentiation and autologous DC immunotherapy in mouse models of GBM.
PloS one , 2014 | Pubmed ID: 24806510
The value of EGFRvIII as the target for glioma vaccines.
American Society of Clinical Oncology educational book / ASCO. American Society of Clinical Oncology. Meeting , 2014 | Pubmed ID: 24857059
Blocking immunosuppressive checkpoints for glioma therapy: the more the Merrier!
Clinical cancer research : an official journal of the American Association for Cancer Research Oct, 2014 | Pubmed ID: 24879798
Natural killer cells eradicate galectin-1-deficient glioma in the absence of adaptive immunity.
Cancer research Sep, 2014 | Pubmed ID: 25038230
Marmosets as a preclinical model for testing "off-label" use of doxycycline to turn on Flt3L expression from high-capacity adenovirus vectors.
Molecular therapy. Methods & clinical development Feb, 2014 | Pubmed ID: 25068145
Mechanisms of glioma formation: iterative perivascular glioma growth and invasion leads to tumor progression, VEGF-independent vascularization, and resistance to antiangiogenic therapy.
Neoplasia (New York, N.Y.) Jul, 2014 | Pubmed ID: 25117977
Blockade of mTOR signaling via rapamycin combined with immunotherapy augments antiglioma cytotoxic and memory T-cell functions.
Molecular cancer therapeutics Dec, 2014 | Pubmed ID: 25256739
Glioma trials and viral tribulations: can anything be concluded from non-controlled trials?
Journal of neurology, neurosurgery, and psychiatry Feb, 2015 | Pubmed ID: 25280917
Flor M. Mendez1,
Felipe J. Núñez1,2,
Rocío I. Zorrilla-Veloz3,4,
Pedro R. Lowenstein1,2,
Maria G. Castro1,2
1Department of Cell and Developmental Biology, University of Michigan Medical School,
2Department of Neurosurgery, University of Michigan Medical School,
3Cancer Research Summer Internship Program (CARSIP), Cancer Biology Program, University of Michigan Medical School,
4Department of Biology, University of Puerto Rico-Río Piedras Campus
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