Pedro R. Lowenstein

Department of Neurosurgery, University of Michigan School of Medicine

Affiliated withUniversity of Michigan School of Medicine University of Michigan University of Michigan Medical School

Research Area

MedicineImmunology and InfectionCancer ResearchNeuroscience

Biography

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JoVE Journal Publications

ArticleTotal : 5	Year
Publication title	2015
Publication title	2015
Publication title	2018
Publication title	2019
Publication title	2020

Other Publications

Article	Year
Gene therapy for brain cancer: combination therapies provide enhanced efficacy and safety. Current gene therapy\| PubMed ID: 19860655	2009
Immunology of viral-vector-mediated gene transfer into the brain: an evolutionary and developmental perspective. Trends in immunology\| PubMed ID: 11801451	2002
Prolonged blockade of CD40-CD40 ligand interactions by gene transfer of CD40Ig results in long-term heart allograft survival and donor-specific hyporesponsiveness, but does not prevent chron... Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 11823487	2002
Adenovirus binding to the coxsackievirus and adenovirus receptor or integrins is not required to elicit brain inflammation but is necessary to transduce specific neural cell types. Journal of virology\| PubMed ID: 11884569	2002
Dendritic cells and immune responses in the central nervous system. Trends in immunology\| PubMed ID: 11956012	2002
Progress and challenges in viral vector-mediated gene transfer to the brain. Current opinion in molecular therapeutics\| PubMed ID: 12222874	2002
Adenovirus vector-mediated delivery of the prodrug-converting enzyme carboxypeptidase G2 in a secreted or GPI-anchored form: High-level expression of this active conditional cytotoxic enzyme... Cancer gene therapy\| PubMed ID: 12386828	2002
Use of recombinant adenovirus for gene transfer into the rat brain. Evaluation of gene transfer efficiency, toxicity, and inflammatory and immune reactions. Methods in molecular medicine\| PubMed ID: 12526161	2003
Adenovirus expression of IL-1 and NF-kappaB inhibitors does not inhibit acute adenoviral-induced brain inflammation, but delays immune system-mediated elimination of transgene expression. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 12946313	2003
Nonneurotropic adenovirus: a vector for gene transfer to the brain and gene therapy of neurological disorders. International review of neurobiology\| PubMed ID: 12968530	2003
Adenovirus-mediated gene transfer of transforming growth factor-beta3, but not transforming growth factor-beta1, inhibits constrictive remodeling and reduces luminal loss after coronary angi... Circulation\| PubMed ID: 14638551	2003
Gene therapy for liver transplantation using adenoviral vectors: CD40-CD154 blockade by gene transfer of CD40Ig protects rat livers from cold ischemia and reperfusion injury. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 14741776	2004
Development of a novel helper-dependent adenovirus-Epstein-Barr virus hybrid system for the stable transformation of mammalian cells. Journal of virology\| PubMed ID: 15163748	2004
Input virion proteins: cryptic targets of antivector immune responses in preimmunized subjects. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 15222326	2004
Effects of ectopic decorin in modulating intracranial glioma progression in vivo, in a rat syngeneic model. Cancer gene therapy\| PubMed ID: 15475879	2004
The Collaborative Cross, a community resource for the genetic analysis of complex traits. Nature genetics\| PubMed ID: 15514660	2004
Inflammatory and anti-glioma effects of an adenovirus expressing human soluble Fms-like tyrosine kinase 3 ligand (hsFlt3L): treatment with hsFlt3L inhibits intracranial glioma progression. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 15564139	2004
Stability of lentiviral vector-mediated transgene expression in the brain in the presence of systemic antivector immune responses. Human gene therapy\| PubMed ID: 15960605	2005
The case for immunosuppression in clinical gene transfer. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 16002339	2005
Mutagenesis-induced, large fitness variations with an invariant arenavirus consensus genomic nucleotide sequence. Journal of virology\| PubMed ID: 16051837	2005
Combined immunostimulation and conditional cytotoxic gene therapy provide long-term survival in a large glioma model. Cancer research\| PubMed ID: 16103070	2005
Combining cytotoxic and immune-mediated gene therapy to treat brain tumors. Current topics in medicinal chemistry\| PubMed ID: 16248789	2005
Platelets mediate cytotoxic T lymphocyte-induced liver damage. Nature medicine\| PubMed ID: 16258538	2005
Regulatable gutless adenovirus vectors sustain inducible transgene expression in the brain in the presence of an immune response against adenoviruses. Journal of virology\| PubMed ID: 16352528	2006
Gene therapy and targeted toxins for glioma. Current gene therapy\| PubMed ID: 16457645	2005
Fms-like tyrosine kinase 3 ligand recruits plasmacytoid dendritic cells to the brain. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 16517725	2006
Rapid upregulation of interferon-regulated and chemokine mRNAs upon injection of 108 international units, but not lower doses, of adenoviral vectors into the brain. Journal of virology\| PubMed ID: 16699048	2006
Effective high-capacity gutless adenoviral vectors mediate transgene expression in human glioma cells. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 16798098	2006
In vivo mature immunological synapses forming SMACs mediate clearance of virally infected astrocytes from the brain. The Journal of experimental medicine\| PubMed ID: 16923851	2006
Immune regulation of transgene expression in the brain: B cells regulate an early phase of elimination of transgene expression from adenoviral vectors. Viral immunology\| PubMed ID: 16987068	2006
Adenoviral-mediated gene transfer into the canine brain in vivo. Neurosurgery\| PubMed ID: 17228266	2007
Optimization of adenoviral vector-mediated transgene expression in the canine brain in vivo, and in canine glioma cells in vitro. Neuro-oncology\| PubMed ID: 17522335	2007
Efficacy of nonviral gene transfer in the canine brain. Journal of neurosurgery\| PubMed ID: 17639883	2007
Intracranial glioblastoma models in preclinical neuro-oncology: neuropathological characterization and tumor progression. Journal of neuro-oncology\| PubMed ID: 17874037	2007
Improved distribution of small molecules and viral vectors in the murine brain using a hollow fiber catheter. Journal of neurosurgery\| PubMed ID: 17886557	2007
One-year expression from high-capacity adenoviral vectors in the brains of animals with pre-existing anti-adenoviral immunity: clinical implications. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 17895861	2007
Immunology of neurological gene therapy: how T cells modulate viral vector-mediated therapeutic transgene expression through immunological synapses. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics\| PubMed ID: 17920552	2007
Immune responses to adenovirus and adeno-associated vectors used for gene therapy of brain diseases: the role of immunological synapses in understanding the cell biology of neuroimmune inter... Current gene therapy\| PubMed ID: 17979681	2007
Flt3L and TK gene therapy eradicate multifocal glioma in a syngeneic glioblastoma model. Neuro-oncology\| PubMed ID: 18079358	2008
Immunological thresholds in neurological gene therapy: highly efficient elimination of transduced cells might be related to the specific formation of immunological synapses between T cells a... Neuron glia biology\| PubMed ID: 18084640	2006
Immunization against the transgene but not the TetON switch reduces expression from gutless adenoviral vectors in the brain. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 18180781	2008
In vivo polarization of IFN-gamma at Kupfer and non-Kupfer immunological synapses during the clearance of virally infected brain cells. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 18209028	2008
Flt3L in combination with HSV1-TK-mediated gene therapy reverses brain tumor-induced behavioral deficits. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 18283279	2008
High-capacity adenovirus vector-mediated anti-glioma gene therapy in the presence of systemic antiadenovirus immunity. Journal of virology\| PubMed ID: 18287240	2008
Turning the gene tap off; implications of regulating gene expression for cancer therapeutics. Molecular cancer therapeutics\| PubMed ID: 18347132	2008
Gene delivery to the nervous system. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 18362921	2008
Treg depletion inhibits efficacy of cancer immunotherapy: implications for clinical trials. PloS one\| PubMed ID: 18431473	2008
Regulated expression of adenoviral vectors-based gene therapies: therapeutic expression of toxins and immune-modulators. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 18470649	2008
With a little help from my f(X)riends!: the basis of Ad5-mediated transduction of the liver revealed. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 18500239	2008
CD20, CD3, and CD40 ligand microclusters segregate three-dimensionally in vivo at B-cell-T-cell immunological synapses after viral immunity in primate brain. Journal of virology\| PubMed ID: 18684835	2008
T cells' immunological synapses induce polarization of brain astrocytes in vivo and in vitro: a novel astrocyte response mechanism to cellular injury. PloS one\| PubMed ID: 18714338	2008
Clinical trials in gene therapy: ethics of informed consent and the future of experimental medicine. Current opinion in molecular therapeutics\| PubMed ID: 18830917	2008
A call for physiopathological ethics. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 18956015	2008
Gene transfer into neural cells in vitro using adenoviral vectors. Current protocols in neuroscience / editorial board, Jacqueline N. Crawley ... [et al.]\| PubMed ID: 18972378	2008
Crossing the rubicon. Nature biotechnology\| PubMed ID: 19131996	2009
HMGB1 mediates endogenous TLR2 activation and brain tumor regression. PLoS medicine\| PubMed ID: 19143470	2009
Release of HMGB1 in response to proapoptotic glioma killing strategies: efficacy and neurotoxicity. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 19570774	2009
Infiltrating CTLs in human glioblastoma establish immunological synapses with tumorigenic cells. The American journal of pathology\| PubMed ID: 19628762	2009
Antiglioma immunological memory in response to conditional cytotoxic/immune-stimulatory gene therapy: humoral and cellular immunity lead to tumor regression. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 19789315	2009
Challenges in the evaluation, consent, ethics and history of early clinical trials - Implications of the Tuskegee 'trial' for safer and more ethical clinical trials. Current opinion in molecular therapeutics\| PubMed ID: 19806495	2009
Gene therapy continues to make progress: clinical and regulatory perspectives. Current gene therapy\| PubMed ID: 19860647	2009
Uncertainty in the translation of preclinical experiments to clinical trials. Why do most phase III clinical trials fail? Current gene therapy\| PubMed ID: 19860651	2009
Risk in clinical research: size matters! Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 19876046	2009
Gene transfer into rat brain using adenoviral vectors. Current protocols in neuroscience / editorial board, Jacqueline N. Crawley ... [et al.]\| PubMed ID: 20066657	2010
Anti-tumor immune response correlates with neurological symptoms in a dog with spontaneous astrocytoma treated by gene and vaccine therapy. Vaccine\| PubMed ID: 20197146	2010
A novel bicistronic high-capacity gutless adenovirus vector that drives constitutive expression of herpes simplex virus type 1 thymidine kinase and tet-inducible expression of Flt3L for glio... Journal of virology\| PubMed ID: 20375153	2010
Human Flt3L generates dendritic cells from canine peripheral blood precursors: implications for a dog glioma clinical trial. PloS one\| PubMed ID: 20552015	2010
Exogenous fms-like tyrosine kinase 3 ligand overrides brain immune privilege and facilitates recognition of a neo-antigen without causing autoimmune neuropathology. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 20660723	2010
Cancer vaccines in glioma: how to balance the challenges of small trials, efficiency, and potential adverse events. Journal of clinical oncology : official journal of the American Society of Clinical Oncology\| PubMed ID: 20921460	2010
Gene therapy-mediated delivery of targeted cytotoxins for glioma therapeutics. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 21030678	2010
Gene therapy and virotherapy: novel therapeutic approaches for brain tumors. Discovery medicine\| PubMed ID: 21034670	2010
AAV6-mediated gene silencing fALS short. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 21289637	2011
Gene therapy and targeted toxins for glioma. Current gene therapy\| PubMed ID: 21453286	2011
Combined Flt3L/TK gene therapy induces immunological surveillance which mediates an immune response against a surrogate brain tumor neoantigen. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 21505426	2011
Moving forward toward a cure for Parkinson's: neuropathology of the nigrostriatal pathway determines the location of growth factor delivery. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 21532611	2011
Engineering the brain tumor microenvironment enhances the efficacy of dendritic cell vaccination: implications for clinical trial design. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 21632862	2011
Targeted toxins for glioblastoma multiforme: pre-clinical studies and clinical implementation. Anti-cancer agents in medicinal chemistry\| PubMed ID: 21707497	2011
Identification and visualization of CD8+ T cell mediated IFN-γ signaling in target cells during an antiviral immune response in the brain. PloS one\| PubMed ID: 21897844	2011
B cells are critical to T-cell-mediated antitumor immunity induced by a combined immune-stimulatory/conditionally cytotoxic therapy for glioblastoma. Neoplasia (New York, N.Y.)\| PubMed ID: 22028620	2011
Immune-mediated loss of transgene expression from virally transduced brain cells is irreversible, mediated by IFNγ, perforin, and TNFα, and due to the elimination of transduced cells. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 22233583	2012
Pushing the limits of glioma resection using electrophysiologic brain mapping. Journal of clinical oncology : official journal of the American Society of Clinical Oncology\| PubMed ID: 22529267	2012
Cytotoxic immunological synapses do not restrict the action of interferon-γ to antigenic target cells. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 22547816	2012
Gene therapy for brain tumors: basic developments and clinical implementation. Neuroscience letters\| PubMed ID: 22906921	2012
Safety profile of gutless adenovirus vectors delivered into the normal brain parenchyma: implications for a glioma phase 1 clinical trial. Human gene therapy methods\| PubMed ID: 22950971	2012
Plasmacytoid dendritic cells in the tumor microenvironment: immune targets for glioma therapeutics. Neoplasia (New York, N.Y.)\| PubMed ID: 22952428	2012
Gene therapy-mediated reprogramming tumor infiltrating T cells using IL-2 and inhibiting NF-κB signaling improves the efficacy of immunotherapy in a brain cancer model. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics\| PubMed ID: 22996231	2012
Safety profile, efficacy, and biodistribution of a bicistronic high-capacity adenovirus vector encoding a combined immunostimulation and cytotoxic gene therapy as a prelude to a phase I clin... Toxicology and applied pharmacology\| PubMed ID: 23403069	2013
Progress in gene therapy for neurological disorders. Nature reviews. Neurology\| PubMed ID: 23609618	2013
Effectiveness and preclinical safety profile of doxycycline to be used "off-label" to induce therapeutic transgene expression in a phase I clinical trial for glioma. Human gene therapy. Clinical development\| PubMed ID: 24007469	2013
Neuro-oncology: The long and winding road--gene therapy for glioma. Nature reviews. Neurology\| PubMed ID: 24061435	2013
Dendritic cell-based immunotherapy for glioma: multiple regimens and implications in clinical trials. Neurologia medico-chirurgica\| PubMed ID: 24140772	2013
Temozolomide does not impair gene therapy-mediated antitumor immunity in syngeneic brain tumor models. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 24501391	2014
Preclinical characterization of signal transducer and activator of transcription 3 small molecule inhibitors for primary and metastatic brain cancer therapy. The Journal of pharmacology and experimental therapeutics\| PubMed ID: 24696041	2014
Lentiviral-induced high-grade gliomas in rats: the effects of PDGFB, HRAS-G12V, AKT, and IDH1-R132H. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics\| PubMed ID: 24752661	2014
Adenoviral vector-mediated gene therapy for gliomas: coming of age. Expert opinion on biological therapy\| PubMed ID: 24773178	2014
Assessing the role of STAT3 in DC differentiation and autologous DC immunotherapy in mouse models of GBM. PloS one\| PubMed ID: 24806510	2014
The value of EGFRvIII as the target for glioma vaccines. American Society of Clinical Oncology educational book / ASCO. American Society of Clinical Oncology. Meeting\| PubMed ID: 24857059	2014
Blocking immunosuppressive checkpoints for glioma therapy: the more the Merrier! Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 24879798	2014
Natural killer cells eradicate galectin-1-deficient glioma in the absence of adaptive immunity. Cancer research\| PubMed ID: 25038230	2014
Marmosets as a preclinical model for testing "off-label" use of doxycycline to turn on Flt3L expression from high-capacity adenovirus vectors. Molecular therapy. Methods & clinical development\| PubMed ID: 25068145	2014
Mechanisms of glioma formation: iterative perivascular glioma growth and invasion leads to tumor progression, VEGF-independent vascularization, and resistance to antiangiogenic therapy. Neoplasia (New York, N.Y.)\| PubMed ID: 25117977	2014
Blockade of mTOR signaling via rapamycin combined with immunotherapy augments antiglioma cytotoxic and memory T-cell functions. Molecular cancer therapeutics\| PubMed ID: 25256739	2014
Glioma trials and viral tribulations: can anything be concluded from non-controlled trials? Journal of neurology, neurosurgery, and psychiatry\| PubMed ID: 25280917	2015