Barbara Gatto

2,6-Di(omega-aminoalkyl)-2,5,6,7-tetrahydropyrazolo[3,4,5-mn]pyrimido[5,6,1-de]acridine-5,7-diones: novel, potent, cytotoxic, and DNA-binding agents.

Sequence-specific interactions of drugs interfering with the topoisomerase-DNA cleavage complex.

New anti-human immunodeficiency virus type 1 6-aminoquinolones: mechanism of action.

Design, synthesis, and biological properties of new bis(acridine-4-carboxamides) as anticancer agents.

Involvement of p53 in specific anti-neuroectodermal tumor activity of aloe-emodin.

Clerocidin alkylates DNA through its epoxide function: evidence for a fine tuned mechanism of action.

Effects of common buffer systems on drug activity: the case of clerocidin.

Inhibition of human immunodeficiency virus type 1 tat-trans-activation-responsive region interaction by an antiviral quinolone derivative.

Monoclonal antibodies in cancer therapy.

Antiviral 6-amino-quinolones: molecular basis for potency and selectivity.

Clerocidin interacts with the cleavage complex of Streptococcus pneumoniae topoisomerase IV to induce selective irreversible DNA damage.

From proteins to nucleic acid-based drugs: the role of biotech in anti-VEGF therapy.

Perylene side chains modulate G-quadruplex conformation in biologically relevant DNA sequences.

Atacicept, a homodimeric fusion protein for the potential treatment of diseases triggered by plasma cells.

Synthesis and biological evaluation of 2-phenylquinolones targeted at Tat/TAR recognition.

2-Phenylquinolones as inhibitors of the HIV-1 Tat-TAR interaction.

Effective DNA inhibitors of cathepsin g by in vitro selection.

Inhibition of subgenomic hepatitis C virus RNA replication by acridone derivatives: identification of an NS3 helicase inhibitor.

The 6-aminoquinolone WC5 inhibits human cytomegalovirus replication at an early stage by interfering with the transactivating activity of viral immediate-early 2 protein.

Rational design, synthesis, and DNA binding properties of novel sequence-selective peptidyl congeners of ametantrone.

Studies of anti-HIV transcription inhibitor quinolones: identification of potent N1-vinyl derivatives.

The evolving world of protein-G-quadruplex recognition: a medicinal chemist's perspective.

Human thrombin detection through a sandwich aptamer microarray: interaction analysis in solution and in solid phase.

Ellagic acid and polyhydroxylated urolithins are potent catalytic inhibitors of human topoisomerase II: an in vitro study.

Development of a multiplex sandwich aptamer microarray for the detection of VEGF165 and thrombin.

Enzymatic formation of PEGylated oligonucleotides.

Synthesis and DNA cleavage activity of Bis-3-chloropiperidines as alkylating agents.

The topoisomerase II poison clerocidin alkylates non-paired guanines of DNA: implications for irreversible stimulation of DNA cleavage.

Drugs acting on the beta isoform of human topoisomerase II (p180).

Biologics targeted at TNF: design, production and challenges.

Bis-3-chloropiperidines containing bridging lysine linkers: Influence of side chain structure on DNA alkylating activity.

Synthesis and evaluation of a bis-3-chloropiperidine derivative incorporating an anthraquinone pharmacophore.

Development and Optimization of a Thrombin Sandwich Aptamer Microarray.

Virtual Cross-Linking of the Active Nemorubicin Metabolite PNU-159682 to Double-Stranded DNA.

Direct and Topoisomerase II Mediated DNA Damage by Bis-3-chloropiperidines: The Importance of Being an Earnest G.

Identification of novel 2-benzoxazolinone derivatives with specific inhibitory activity against the HIV-1 nucleocapsid protein.

Behind the Mirror: Chirality Tunes the Reactivity and Cytotoxicity of Chloropiperidines as Potential Anticancer Agents.

Multiple Inhibition of HIV-1 Proteins by 2,6-Dipeptidyl-anthraquinone Conjugates Targeting the PBS RNA.

Aromatic Linkers Unleash the Antiproliferative Potential of 3-Chloropiperidines Against Pancreatic Cancer Cells.

Appended Aromatic Moieties in Flexible Bis-3-chloropiperidines Confer Tropism against Pancreatic Cancer Cells.

Bis-3-Chloropiperidines Targeting TAR RNA as A Novel Strategy to Impair the HIV-1 Nucleocapsid Protein.

B-CePs as cross-linking probes for the investigation of RNA higher-order structure.

In Vitro Evaluation of Bis-3-Chloropiperidines as RNA Modulators Targeting TAR and TAR-Protein Interaction.

Computationally driven discovery of SARS-CoV-2 M inhibitors: from design to experimental validation.

Decoding mechanism of action and sensitivity to drug candidates from integrated transcriptome and chromatin state.

Multifaceted Aspects of HIV-1 Nucleocapsid Inhibition by TAR-Targeting Peptidyl-Anthraquinones Bearing Terminal Aromatic Moieties.