Departments of Physiology,
Human and Molecular Genetics Center,
Cardiovascular Center,
Department of Physiology
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Structure-function analysis of the inverted terminal repeats of the sleeping beauty transposon.
Journal of molecular biology May, 2002 | Pubmed ID: 12083513
Gene transfer into genomes of human cells by the sleeping beauty transposon system.
Molecular therapy : the journal of the American Society of Gene Therapy Jul, 2003 | Pubmed ID: 12842434
Transposon vectors for gene-trap insertional mutagenesis in vertebrates.
Genesis (New York, N.Y. : 2000) Aug, 2004 | Pubmed ID: 15286994
Target-site preferences of Sleeping Beauty transposons.
Journal of molecular biology Feb, 2005 | Pubmed ID: 15663935
Structure-based prediction of insertion-site preferences of transposons into chromosomes.
Nucleic acids research , 2006 | Pubmed ID: 16717285
Conditional gene expression in the mouse using a Sleeping Beauty gene-trap transposon.
BMC biotechnology , 2006 | Pubmed ID: 16800892
Gene mutations and genomic rearrangements in the mouse as a result of transposon mobilization from chromosomal concatemers.
PLoS genetics Sep, 2006 | Pubmed ID: 17009875
Efficient transgenic rat production by a lentiviral vector.
American journal of physiology. Heart and circulatory physiology Jul, 2007 | Pubmed ID: 17322424
Generation of rat mutants using a coat color-tagged Sleeping Beauty transposon system.
Mammalian genome : official journal of the International Mammalian Genome Society May, 2007 | Pubmed ID: 17557177
Predicting preferential DNA vector insertion sites: implications for functional genomics and gene therapy.
Genome biology , 2007 | Pubmed ID: 18047689
Progress and prospects in rat genetics: a community view.
Nature genetics May, 2008 | Pubmed ID: 18443588
Knockout rats via embryo microinjection of zinc-finger nucleases.
Science (New York, N.Y.) Jul, 2009 | Pubmed ID: 19628861
Generation of gene-specific mutated rats using zinc-finger nucleases.
Methods in molecular biology (Clifton, N.J.) , 2010 | Pubmed ID: 20013236
Efficient mammalian germline transgenesis by cis-enhanced Sleeping Beauty transposition.
Transgenic research Feb, 2011 | Pubmed ID: 20352328
Zinc-finger nucleases: new strategies to target the rat genome.
Clinical science (London, England : 1979) Oct, 2010 | Pubmed ID: 20615201
Gene targeting in the rat: advances and opportunities.
Trends in genetics : TIG Dec, 2010 | Pubmed ID: 20869786
Creation and characterization of a renin knockout rat.
Hypertension Mar, 2011 | Pubmed ID: 21242461
Exacerbated pulmonary arterial hypertension and right ventricular hypertrophy in animals with loss of function of extracellular superoxide dismutase.
Hypertension Aug, 2011 | Pubmed ID: 21730301
The emerging role for rat models in gene discovery.
Mammalian genome : official journal of the International Mammalian Genome Society Aug, 2011 | Pubmed ID: 21732192
Efficient non-viral integration and stable gene expression in multipotent adult progenitor cells.
Stem cells international , 2011 | Pubmed ID: 21977042
Increased expression of NAD(P)H oxidase subunit p67(phox) in the renal medulla contributes to excess oxidative stress and salt-sensitive hypertension.
Cell metabolism Feb, 2012 | Pubmed ID: 22326221
Transposon-mediated transgenesis, transgenic rescue, and tissue-specific gene expression in rodents and rabbits.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology Mar, 2013 | Pubmed ID: 23195032
Heterozygous knockout of transforming growth factor-β1 protects Dahl S rats against high salt-induced renal injury.
Physiological genomics Feb, 2013 | Pubmed ID: 23249995
Genetic mutation of recombination activating gene 1 in Dahl salt-sensitive rats attenuates hypertension and renal damage.
American journal of physiology. Regulatory, integrative and comparative physiology Mar, 2013 | Pubmed ID: 23364523
Derivation and genetic modification of embryonic stem cells from disease-model inbred rat strains.
Stem cells and development May, 2013 | Pubmed ID: 23635087
Rats are the smart choice: Rationale for a renewed focus on rats in behavioral genetics.
Neuropharmacology Jan, 2014 | Pubmed ID: 23791960
Gene targeting in NOD mouse embryos using zinc-finger nucleases.
Diabetes Jan, 2014 | Pubmed ID: 23974926
Identifying multiple causative genes at a single GWAS locus.
Genome research Dec, 2013 | Pubmed ID: 24006081
Amelioration of salt-induced vascular dysfunction in mesenteric arteries of Dahl salt-sensitive rats by missense mutation of extracellular superoxide dismutase.
American journal of physiology. Heart and circulatory physiology Feb, 2014 | Pubmed ID: 24322611
CD247 modulates blood pressure by altering T-lymphocyte infiltration in the kidney.
Hypertension Mar, 2014 | Pubmed ID: 24343121
HV1 acts as a sodium sensor and promotes superoxide production in medullary thick ascending limb of Dahl salt-sensitive rats.
Hypertension Sep, 2014 | Pubmed ID: 24935944
Mutation of Plekha7 attenuates salt-sensitive hypertension in the rat.
Proceedings of the National Academy of Sciences of the United States of America Sep, 2014 | Pubmed ID: 25136115
CXM: a new tool for mapping breast cancer risk in the tumor microenvironment.
Cancer research Nov, 2014 | Pubmed ID: 25172839
Zinc-finger nuclease knockout of dual-specificity protein phosphatase-5 enhances the myogenic response and autoregulation of cerebral blood flow in FHH.1BN rats.
PloS one , 2014 | Pubmed ID: 25397684
Maternal diet during gestation and lactation modifies the severity of salt-induced hypertension and renal injury in dahl salt-sensitive rats.
Hypertension Feb, 2015 | Pubmed ID: 25452472
Impaired myogenic response and autoregulation of cerebral blood flow is rescued in CYP4A1 transgenic Dahl salt-sensitive rat.
American journal of physiology. Regulatory, integrative and comparative physiology Mar, 2015 | Pubmed ID: 25540098
SH2B3 Is a Genetic Determinant of Cardiac Inflammation and Fibrosis.
Circulation. Cardiovascular genetics Apr, 2015 | Pubmed ID: 25628389
Mutation of SH2B3 (LNK), a genome-wide association study candidate for hypertension, attenuates Dahl salt-sensitive hypertension via inflammatory modulation.
Hypertension May, 2015 | Pubmed ID: 25776069
Efficient CRISPR/Cas9-Mediated Genome Editing in Mice by Zygote Electroporation of Nuclease.
Genetics Mar, 2015 | Pubmed ID: 25819794
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