Aron M. Geurts

Structure-function analysis of the inverted terminal repeats of the sleeping beauty transposon.

Gene transfer into genomes of human cells by the sleeping beauty transposon system.

Transposon vectors for gene-trap insertional mutagenesis in vertebrates.

Target-site preferences of Sleeping Beauty transposons.

Structure-based prediction of insertion-site preferences of transposons into chromosomes.

Conditional gene expression in the mouse using a Sleeping Beauty gene-trap transposon.

Gene mutations and genomic rearrangements in the mouse as a result of transposon mobilization from chromosomal concatemers.

Efficient transgenic rat production by a lentiviral vector.

Generation of rat mutants using a coat color-tagged Sleeping Beauty transposon system.

Predicting preferential DNA vector insertion sites: implications for functional genomics and gene therapy.

Progress and prospects in rat genetics: a community view.

Knockout rats via embryo microinjection of zinc-finger nucleases.

Generation of gene-specific mutated rats using zinc-finger nucleases.

Efficient mammalian germline transgenesis by cis-enhanced Sleeping Beauty transposition.

Zinc-finger nucleases: new strategies to target the rat genome.

Gene targeting in the rat: advances and opportunities.

Creation and characterization of a renin knockout rat.

Exacerbated pulmonary arterial hypertension and right ventricular hypertrophy in animals with loss of function of extracellular superoxide dismutase.

The emerging role for rat models in gene discovery.

Efficient non-viral integration and stable gene expression in multipotent adult progenitor cells.

Increased expression of NAD(P)H oxidase subunit p67(phox) in the renal medulla contributes to excess oxidative stress and salt-sensitive hypertension.

Transposon-mediated transgenesis, transgenic rescue, and tissue-specific gene expression in rodents and rabbits.

Heterozygous knockout of transforming growth factor-β1 protects Dahl S rats against high salt-induced renal injury.

Genetic mutation of recombination activating gene 1 in Dahl salt-sensitive rats attenuates hypertension and renal damage.

Derivation and genetic modification of embryonic stem cells from disease-model inbred rat strains.

Rats are the smart choice: Rationale for a renewed focus on rats in behavioral genetics.

Gene targeting in NOD mouse embryos using zinc-finger nucleases.

Identifying multiple causative genes at a single GWAS locus.

Amelioration of salt-induced vascular dysfunction in mesenteric arteries of Dahl salt-sensitive rats by missense mutation of extracellular superoxide dismutase.

CD247 modulates blood pressure by altering T-lymphocyte infiltration in the kidney.

HV1 acts as a sodium sensor and promotes superoxide production in medullary thick ascending limb of Dahl salt-sensitive rats.

Mutation of Plekha7 attenuates salt-sensitive hypertension in the rat.

CXM: a new tool for mapping breast cancer risk in the tumor microenvironment.

Zinc-finger nuclease knockout of dual-specificity protein phosphatase-5 enhances the myogenic response and autoregulation of cerebral blood flow in FHH.1BN rats.

Maternal diet during gestation and lactation modifies the severity of salt-induced hypertension and renal injury in dahl salt-sensitive rats.

Impaired myogenic response and autoregulation of cerebral blood flow is rescued in CYP4A1 transgenic Dahl salt-sensitive rat.

SH2B3 Is a Genetic Determinant of Cardiac Inflammation and Fibrosis.

Mutation of SH2B3 (LNK), a genome-wide association study candidate for hypertension, attenuates Dahl salt-sensitive hypertension via inflammatory modulation.

Efficient CRISPR/Cas9-Mediated Genome Editing in Mice by Zygote Electroporation of Nuclease.