Department of Biochemistry,
Yong Loo Lin School of Medicine,
NUS Synthetic Biology for Clinical and Technological Innovation (SynCTI),
Life Sciences Institute,
Department of Biochemistry, Yong Loo Lin School of Medicine,
NUS Synthetic Biology for Clinical and Technological Innovation (SynCTI), Life Sciences Institute
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Cyclin D1-dependent induction of luminal inflammatory breast tumors by activated notch3.
Cancer research Oct, 2013 | Pubmed ID: 23928992
The chitinase 3-like protein human cartilage glycoprotein 39 (HC-gp39) stimulates proliferation of human connective-tissue cells and activates both extracellular signal-regulated kinase- and protein kinase B-mediated signalling pathways.
The Biochemical journal Jul, 2002 | Pubmed ID: 12071845
[Clinical study of yishen jianpi yangxue tongli therapy in treating polycystic ovary syndrome].
Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine / Zhongguo Zhong xi yi jie he xue hui, Zhongguo Zhong yi yan jiu yuan zhu ban Nov, 2003 | Pubmed ID: 14666761
The chitinase 3-like protein human cartilage glycoprotein 39 inhibits cellular responses to the inflammatory cytokines interleukin-1 and tumour necrosis factor-alpha.
The Biochemical journal Jun, 2004 | Pubmed ID: 15015934
Radiation therapy for orbital lymphoma.
International journal of radiation oncology, biology, physics Nov, 2005 | Pubmed ID: 15925453
Inflammatory cytokines induce production of CHI3L1 by articular chondrocytes.
The Journal of biological chemistry Dec, 2005 | Pubmed ID: 16234240
Long-term outcome and mortality trends in early-stage, Grade 1-2 follicular lymphoma treated with radiation therapy.
International journal of radiation oncology, biology, physics Mar, 2006 | Pubmed ID: 16243446
Lanosterol biosynthesis in plants.
Archives of biochemistry and biophysics Mar, 2006 | Pubmed ID: 16445886
Stereoselective enzymatic synthesis of chiral alcohols with the use of a carbonyl reductase from Candida magnoliae with anti-Prelog enantioselectivity.
The Journal of organic chemistry May, 2006 | Pubmed ID: 16709061
Isolation and expression analysis of a GDSL-like lipase gene from Brassica napus L.
Journal of biochemistry and molecular biology May, 2006 | Pubmed ID: 16756759
Overexpression of GbERF confers alteration of ethylene-responsive gene expression and enhanced resistance to Pseudomonas syringae in transgenic tobacco.
Journal of biosciences Jun, 2006 | Pubmed ID: 16809858
Stereoselective ketone reduction by a carbonyl reductase from Sporobolomyces salmonicolor. Substrate specificity, enantioselectivity and enzyme-substrate docking studies.
Organic & biomolecular chemistry Jul, 2006 | Pubmed ID: 16826293
Emergence of a new disease as a result of interspecific virulence gene transfer.
Nature genetics Aug, 2006 | Pubmed ID: 16832356
Comparison of cerebral blood volume and permeability in preoperative grading of intracranial glioma using CT perfusion imaging.
Neuroradiology Oct, 2006 | Pubmed ID: 16937146
Unexpected stereorecognition in nitrilase-catalyzed hydrolysis of beta-hydroxy nitriles.
Organic letters Sep, 2006 | Pubmed ID: 16986917
Oral cancer exams among cigarette smokers in Maryland.
Cancer detection and prevention , 2006 | Pubmed ID: 17113720
Enantioselective enzymatic reductions of sterically bulky aryl alkyl ketones catalyzed by a NADPH-dependent carbonyl reductase.
The Journal of organic chemistry Dec, 2006 | Pubmed ID: 17137377
Scale-up of enzymatic production of lactobionic acid using the rotary jet head system.
Biotechnology and bioengineering Jul, 2007 | Pubmed ID: 17154315
The Tsn1-ToxA interaction in the wheat-Stagonospora nodorum pathosystem parallels that of the wheat-tan spot system.
Genome / National Research Council Canada = Génome / Conseil national de recherches Canada Oct, 2006 | Pubmed ID: 17213908
Molecular cloning, expression profiling and functional analysis of a DXR gene encoding 1-deoxy-D-xylulose 5-phosphate reductoisomerase from Camptotheca acuminata.
Journal of plant physiology Feb, 2008 | Pubmed ID: 17257708
A molecular modeling study on the enantioselectivity of aryl alkyl ketone reductions by a NADPH-dependent carbonyl reductase.
Journal of molecular modeling Jul, 2007 | Pubmed ID: 17279371
Molecular epidemiology of measles viruses in China, 1995-2003.
Virology journal , 2007 | Pubmed ID: 17280609
Over-expression GbERF2 transcription factor in tobacco enhances brown spots disease resistance by activating expression of downstream genes.
Gene Apr, 2007 | Pubmed ID: 17321073
Isolation and characterization of a class III homeodomain-leucine zipper-like gene from Gossypium barbadense.
DNA sequence : the journal of DNA sequencing and mapping Oct, 2006 | Pubmed ID: 17343206
Discovery of a mandelonitrile hydrolase from Bradyrhizobium japonicum USDA110 by rational genome mining.
Journal of biotechnology May, 2007 | Pubmed ID: 17350705
Asymmetric reduction of beta-ketonitriles with a recombinant carbonyl reductase and enzymatic transformation to optically pure beta-hydroxy carboxylic acids.
Organic letters Jun, 2007 | Pubmed ID: 17521195
Genetic and phenotypic architecture of metabolic syndrome-associated components in dyslipidemic and normolipidemic subjects: the GEMS Study.
Atherosclerosis Apr, 2008 | Pubmed ID: 17888929
A new nitrilase from Bradyrhizobium japonicum USDA 110. Gene cloning, biochemical characterization and substrate specificity.
Journal of biotechnology Feb, 2008 | Pubmed ID: 18061298
Inverting the enantioselectivity of a carbonyl reductase via substrate-enzyme docking-guided point mutation.
Organic letters Feb, 2008 | Pubmed ID: 18205368
Isolation of a novel lipase gene from Serratia liquefaciens S33 DB-1, functional expression in Pichia pastoris and its properties.
Molecular biotechnology Feb, 2008 | Pubmed ID: 18219590
[Genetic characterization of Chinese rubella virus isolates from 2003 to 2007].
Bing du xue bao = Chinese journal of virology / [bian ji, Bing du xue bao bian ji wei yuan hui] Jan, 2008 | Pubmed ID: 18320816
Gambogic acid induced tumor cell apoptosis by T lymphocyte activation in H22 transplanted mice.
International immunopharmacology Nov, 2008 | Pubmed ID: 18573352
Cloning, protein sequence clarification, and substrate specificity of a leucine dehydrogenase from Bacillus sphaericus ATCC4525.
Applied biochemistry and biotechnology Aug, 2009 | Pubmed ID: 18626578
Synthesis of optically pure 2-azido-1-arylethanols with isolated enzymes and conversion to triazole-containing beta-blocker analogues employing click chemistry.
The Journal of organic chemistry Aug, 2008 | Pubmed ID: 18630881
Involvement of matrix metalloproteinase 2 and 9 in gambogic acid induced suppression of MDA-MB-435 human breast carcinoma cell lung metastasis.
Journal of molecular medicine (Berlin, Germany) Dec, 2008 | Pubmed ID: 18777017
Sequence analysis of GDSL lipase gene family in Arabidopsis thaliana.
Pakistan journal of biological sciences : PJBS Mar, 2008 | Pubmed ID: 18819574
Gambogic acid mediates apoptosis as a p53 inducer through down-regulation of mdm2 in wild-type p53-expressing cancer cells.
Molecular cancer therapeutics Oct, 2008 | Pubmed ID: 18852133
Genetic characterization of measles viruses in China, 2004.
Virology journal , 2008 | Pubmed ID: 18928575
Asymmetric synthesis of both antipodes of beta-hydroxy nitriles and beta-hydroxy carboxylic acids via enzymatic reduction or sequential reduction/hydrolysis.
The Journal of organic chemistry Feb, 2009 | Pubmed ID: 19161324
Genome-wide linkage and association analyses to identify genes influencing adiponectin levels: the GEMS Study.
Obesity (Silver Spring, Md.) Apr, 2009 | Pubmed ID: 19165155
Human leukocyte antigen profile in HIV-1 infected individuals and AIDS patients from Chongqing, China.
Microbiology and immunology Sep, 2009 | Pubmed ID: 19703245
Biocatalytic asymmetric amination of carbonyl functional groups - a synthetic biology approach to organic chemistry.
Biotechnology journal Oct, 2009 | Pubmed ID: 19757497
A time-course transcriptome analysis of Escherichia coli with direct electrochemistry behavior in microbial fuel cells.
Chemical communications (Cambridge, England) Nov, 2009 | Pubmed ID: 19826662
Association of HLA-A, B, DRB1 alleles and haplotypes with HIV-1 infection in Chongqing, China.
BMC infectious diseases , 2009 | Pubmed ID: 20003377
Development of a reverse transcription-loop-mediated isothermal amplification (RT-LAMP) system for a highly sensitive detection of enterovirus in the stool samples of acute flaccid paralysis cases.
BMC infectious diseases , 2009 | Pubmed ID: 20015403
Application of sex-specific single-nucleotide polymorphism filters in genome-wide association data.
BMC proceedings , 2009 | Pubmed ID: 20018050
The Gene, Environment Association Studies consortium (GENEVA): maximizing the knowledge obtained from GWAS by collaboration across studies of multiple conditions.
Genetic epidemiology May, 2010 | Pubmed ID: 20091798
[Surveillance on HIV-1 incidence among men who have sex with men in Chongqing, China, 2006 - 2008].
Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi Sep, 2009 | Pubmed ID: 20193218
Rubella virus genotypes in the People's Republic of China between 1979 and 2007: a shift in endemic viruses during the 2001 Rubella Epidemic.
Journal of clinical microbiology May, 2010 | Pubmed ID: 20351211
A genome-wide association study of cleft lip with and without cleft palate identifies risk variants near MAFB and ABCA4.
Nature genetics Jun, 2010 | Pubmed ID: 20436469
A predicted S-type pyocin shows a bactericidal activity against clinical Pseudomonas aeruginosa isolates through membrane damage.
FEBS letters Aug, 2010 | Pubmed ID: 20580355
Novel short antibacterial and antifungal peptides with low cytotoxicity: Efficacy and action mechanisms.
Biochemical and biophysical research communications Jul, 2010 | Pubmed ID: 20603106
Hepatitis B virus-induced liver fibrosis and cirrhosis: the value of liver and spleen volumetry with multi-detector spiral computed tomography.
Journal of digestive diseases Aug, 2010 | Pubmed ID: 20649734
The absence of the luxS gene increases swimming motility and flagella synthesis in Escherichia coli K12.
Biochemical and biophysical research communications Oct, 2010 | Pubmed ID: 20875395
Highly Enantioselective Mutant Carbonyl Reductases Created via Structure-Based Site-Saturation Mutagenesis.
The Journal of organic chemistry Oct, 2010 | Pubmed ID: 20964397
Vaccinia-related kinase 1 is required for the maintenance of undifferentiated spermatogonia in mouse male germ cells.
PloS one , 2010 | Pubmed ID: 21179456
Quality control procedures for genome-wide association studies.
Current protocols in human genetics / editorial board, Jonathan L. Haines ... [et al.] Jan, 2011 | Pubmed ID: 21234875
Genome partitioning of genetic variation for complex traits using common SNPs.
Nature genetics Jun, 2011 | Pubmed ID: 21552263
Evidence for gene-environment interaction in a genome wide study of nonsyndromic cleft palate.
Genetic epidemiology Sep, 2011 | Pubmed ID: 21618603
Accelerating haplotype-based genome-wide association study using perfect phylogeny and phase-known reference data.
PloS one , 2011 | Pubmed ID: 21789217
Engineering microbes to sense and eradicate Pseudomonas aeruginosa, a human pathogen.
Molecular systems biology , 2011 | Pubmed ID: 21847113
Flavivirus RNA cap methyltransferase: structure, function, and inhibition.
Frontiers in biology Aug, 2010 | Pubmed ID: 21927615
Pitfalls of merging GWAS data: lessons learned in the eMERGE network and quality control procedures to maintain high data quality.
Genetic epidemiology Dec, 2011 | Pubmed ID: 22125226
[An outbreak of human orf disease caused by introduced black goats].
Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi Sep, 2011 | Pubmed ID: 22340880
Genome-wide association analysis of ischemic stroke in young adults.
G3 (Bethesda, Md.) Nov, 2011 | Pubmed ID: 22384361
Detectable clonal mosaicism from birth to old age and its relationship to cancer.
Nature genetics Jun, 2012 | Pubmed ID: 22561516
Prevalence and trend of HIV infection among voluntary blood donors in China since implementation of the Blood Donation Law: a systematic review and meta-analysis.
Tropical medicine & international health : TM & IH Aug, 2012 | Pubmed ID: 22686403
Short communication: emerging transmitted HIV type 1 drug resistance mutations among patients prior to start of first-line antiretroviral therapy in middle and low prevalence sites in China.
AIDS research and human retroviruses Jul, 2012 | Pubmed ID: 22822770
A novel meso-Diaminopimelate dehydrogenase from Symbiobacterium thermophilum: overexpression, characterization, and potential for D-amino acid synthesis.
Applied and environmental microbiology Dec, 2012 | Pubmed ID: 23023754
Systems-level characterization and engineering of oxidative stress tolerance in Escherichia coli under anaerobic conditions.
Molecular bioSystems Feb, 2013 | Pubmed ID: 23224080
Exome array analysis identifies new loci and low-frequency variants influencing insulin processing and secretion.
Nature genetics Feb, 2013 | Pubmed ID: 23263489
Novel strategies for managing dyslipidemia: treatment beyond statins.
Postgraduate medicine Nov, 2012 | Pubmed ID: 23322138
Expansion of the red cell distribution width and evolving iron deficiency as predictors of poor outcome in chronic heart failure.
International journal of cardiology Oct, 2013 | Pubmed ID: 23351789
Transporter engineering for improved tolerance against alkane biofuels in Saccharomyces cerevisiae.
Biotechnology for biofuels , 2013 | Pubmed ID: 23402697
Microbial engineering strategies to improve cell viability for biochemical production.
Biotechnology advances Nov, 2013 | Pubmed ID: 23403071
Complete genome analysis of the C4 subgenotype strains of enterovirus 71: predominant recombination C4 viruses persistently circulating in China for 14 years.
PloS one , 2013 | Pubmed ID: 23441179
Ablative hypofractionated radiotherapy normalizes tumor vasculature in lewis lung carcinoma mice model.
Radiation research Apr, 2013 | Pubmed ID: 23480563
Th17-relevant cytokines vary with sera of different ANA staining patterns.
International immunopharmacology Apr, 2013 | Pubmed ID: 23507192
Genomic analysis of a newly isolated of Japanese encephalitis virus strain, CQ11-66, from a pediatric patient in China.
Virology journal , 2013 | Pubmed ID: 23548058
Reducing the risk of obesity: defining the role of weight loss drugs.
Pharmacotherapy Dec, 2013 | Pubmed ID: 23712541
Polymorphisms in the SOCS7 gene and glucose homeostasis traits.
BMC research notes , 2013 | Pubmed ID: 23767996
Transcriptome response to alkane biofuels in Saccharomyces cerevisiae: identification of efflux pumps involved in alkane tolerance.
Biotechnology for biofuels , 2013 | Pubmed ID: 23826995
Impact of ranolazine on clinical outcomes and healthcare resource utilization in patients with refractory angina pectoris.
American journal of cardiovascular drugs : drugs, devices, and other interventions Dec, 2013 | Pubmed ID: 23873327
Imputation-based genomic coverage assessments of current human genotyping arrays.
G3 (Bethesda, Md.) Oct, 2013 | Pubmed ID: 23979933
Genetic characterization of the hemagglutinin genes of wild-type measles virus circulating in china, 1993-2009.
PloS one , 2013 | Pubmed ID: 24073194
A predicted immunity protein confers resistance to pyocin S5 in a sensitive strain of Pseudomonas aeruginosa.
Chembiochem : a European journal of chemical biology Dec, 2013 | Pubmed ID: 24222552
Study of drug resistance and molecular typing of 59 cholerae01 clinical isolates from 1984 to 2002 in Chongqing, China.
International journal of clinical and experimental medicine , 2013 | Pubmed ID: 24260599
An update on the clinical development of proprotein convertase subtilisin kexin 9 inhibitors, novel therapeutic agents for lowering low-density lipoprotein cholesterol.
Cardiovascular therapeutics Apr, 2014 | Pubmed ID: 24354905
Pfit is a structurally novel Crohn's disease-associated superantigen.
PLoS pathogens , 2013 | Pubmed ID: 24385909
Mutations in PCYT1A, encoding a key regulator of phosphatidylcholine metabolism, cause spondylometaphyseal dysplasia with cone-rod dystrophy.
American journal of human genetics Jan, 2014 | Pubmed ID: 24387990
[Construction and identification of a full-length human secretory antibody library in Pichia pastoris].
Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology Jan, 2014 | Pubmed ID: 24405598
Virological outcomes and drug resistance in Chinese patients after 12 months of 3TC-based first-line antiretroviral treatment, 2011-2012.
PloS one , 2014 | Pubmed ID: 24516631
Highly efficient production of peptides: N-glycosidase F for N-glycomics analysis.
Protein expression and purification May, 2014 | Pubmed ID: 24582822
Microbial tolerance engineering toward biochemical production: from lignocellulose to products.
Current opinion in biotechnology Oct, 2014 | Pubmed ID: 24743028
[The bio-effects of high single-dose radiation on xenografts of Lewis lung carcinoma].
Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition Mar, 2014 | Pubmed ID: 24749336
Whole exome sequencing of distant relatives in multiplex families implicates rare variants in candidate genes for oral clefts.
Genetics Jul, 2014 | Pubmed ID: 24793288
Characterization of the genomic architecture and mutational spectrum of a small cell prostate carcinoma.
Genes , 2014 | Pubmed ID: 24823478
Therapeutic microbes for infectious disease.
Methods in molecular biology (Clifton, N.J.) , 2014 | Pubmed ID: 24838883
In vitro and in vivo growth suppression of human papillomavirus 16-positive cervical cancer cells by CRISPR/Cas9.
Biochemical and biophysical research communications Aug, 2014 | Pubmed ID: 25044113
Influence of Cofactor Regeneration Strategies on Preparative-Scale, Asymmetric Carbonyl Reductions by Engineered Escherichia coli.
Organic process research & development Jun, 2014 | Pubmed ID: 25067899
Serum albumin changes and multivariate dynamic risk modelling in chronic heart failure.
International journal of cardiology Sep, 2014 | Pubmed ID: 25129278
Expression and biochemical characterization of recombinant human epididymis protein 4.
Protein expression and purification Oct, 2014 | Pubmed ID: 25131860
Genetic Associations with Plasma B12, B6, and Folate Levels in an Ischemic Stroke Population from the Vitamin Intervention for Stroke Prevention (VISP) Trial.
Frontiers in public health , 2014 | Pubmed ID: 25147783
Calculated plasma volume status and prognosis in chronic heart failure.
European journal of heart failure Jan, 2015 | Pubmed ID: 25469484
Novel Deletion of SERPINF1 Causes Autosomal Recessive Osteogenesis Imperfecta Type VI in Two Brazilian Families.
Molecular syndromology Dec, 2014 | Pubmed ID: 25565926
Assessment of incidental findings in 232 whole-exome sequences from the Baylor-Hopkins Center for Mendelian Genomics.
Genetics in medicine : official journal of the American College of Medical Genetics Oct, 2015 | Pubmed ID: 25569433
Lessons learned from whole exome sequencing in multiplex families affected by a complex genetic disorder, intracranial aneurysm.
PloS one , 2015 | Pubmed ID: 25803036
Mechanism of Arctigenin-Induced Specific Cytotoxicity against Human Hepatocellular Carcinoma Cell Lines: Hep G2 and SMMC7721.
PloS one , 2015 | Pubmed ID: 25933104
The Genetic Basis of Mendelian Phenotypes: Discoveries, Challenges, and Opportunities.
American journal of human genetics Aug, 2015 | Pubmed ID: 26166479
Metabolic engineering of Saccharomyces cerevisiae for production of fatty acid short- and branched-chain alkyl esters biodiesel.
Biotechnology for biofuels , 2015 | Pubmed ID: 26543501
Whole-Exome Sequencing in Familial Parkinson Disease.
JAMA neurology Jan, 2016 | Pubmed ID: 26595808
Engineering transcription factors to improve tolerance against alkane biofuels in Saccharomyces cerevisiae.
Biotechnology for biofuels , 2015 | Pubmed ID: 26719765
Clinical efficacy and safety of evolocumab for low-density lipoprotein cholesterol reduction.
Vascular health and risk management , 2016 | Pubmed ID: 27143910
A practical community-based response strategy to interrupt Ebola transmission in sierra Leone, 2014-2015.
Infectious diseases of poverty , 2016 | Pubmed ID: 27491387
Enhanced tumor delivery and antitumor response of doxorubicin-loaded albumin nanoparticles formulated based on a Schiff base.
International journal of nanomedicine , 2016 | Pubmed ID: 27574421
Maternal cardiac function at 35-37 weeks' gestation: prediction for preeclampsia and gestational hypertension.
Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology Sep, 2016 | Pubmed ID: 27619066
Ai-Qun Yu1,2,
Nina Pratomo1,2,
Tee-Kheang Ng1,2,
Hua Ling1,2,
Han-Saem Cho1,2,
Susanna Su Jan Leong1,2,3,
Matthew Wook Chang1,2
1Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore,
2NUS Synthetic Biology for Clinical and Technological Innovation (SynCTI), Life Sciences Institute, National University of Singapore,
3Food Science and Chemical Engineering, Singapore Institute of Technology
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