Hua Ling

Cyclin D1-dependent induction of luminal inflammatory breast tumors by activated notch3.

The chitinase 3-like protein human cartilage glycoprotein 39 (HC-gp39) stimulates proliferation of human connective-tissue cells and activates both extracellular signal-regulated kinase- and protein kinase B-mediated signalling pathways.

[Clinical study of yishen jianpi yangxue tongli therapy in treating polycystic ovary syndrome].

The chitinase 3-like protein human cartilage glycoprotein 39 inhibits cellular responses to the inflammatory cytokines interleukin-1 and tumour necrosis factor-alpha.

Radiation therapy for orbital lymphoma.

Inflammatory cytokines induce production of CHI3L1 by articular chondrocytes.

Long-term outcome and mortality trends in early-stage, Grade 1-2 follicular lymphoma treated with radiation therapy.

Lanosterol biosynthesis in plants.

Stereoselective enzymatic synthesis of chiral alcohols with the use of a carbonyl reductase from Candida magnoliae with anti-Prelog enantioselectivity.

Isolation and expression analysis of a GDSL-like lipase gene from Brassica napus L.

Overexpression of GbERF confers alteration of ethylene-responsive gene expression and enhanced resistance to Pseudomonas syringae in transgenic tobacco.

Stereoselective ketone reduction by a carbonyl reductase from Sporobolomyces salmonicolor. Substrate specificity, enantioselectivity and enzyme-substrate docking studies.

Emergence of a new disease as a result of interspecific virulence gene transfer.

Comparison of cerebral blood volume and permeability in preoperative grading of intracranial glioma using CT perfusion imaging.

Unexpected stereorecognition in nitrilase-catalyzed hydrolysis of beta-hydroxy nitriles.

Oral cancer exams among cigarette smokers in Maryland.

Enantioselective enzymatic reductions of sterically bulky aryl alkyl ketones catalyzed by a NADPH-dependent carbonyl reductase.

Scale-up of enzymatic production of lactobionic acid using the rotary jet head system.

The Tsn1-ToxA interaction in the wheat-Stagonospora nodorum pathosystem parallels that of the wheat-tan spot system.

Molecular cloning, expression profiling and functional analysis of a DXR gene encoding 1-deoxy-D-xylulose 5-phosphate reductoisomerase from Camptotheca acuminata.

A molecular modeling study on the enantioselectivity of aryl alkyl ketone reductions by a NADPH-dependent carbonyl reductase.

Molecular epidemiology of measles viruses in China, 1995-2003.

Over-expression GbERF2 transcription factor in tobacco enhances brown spots disease resistance by activating expression of downstream genes.

Isolation and characterization of a class III homeodomain-leucine zipper-like gene from Gossypium barbadense.

Discovery of a mandelonitrile hydrolase from Bradyrhizobium japonicum USDA110 by rational genome mining.

Asymmetric reduction of beta-ketonitriles with a recombinant carbonyl reductase and enzymatic transformation to optically pure beta-hydroxy carboxylic acids.

Genetic and phenotypic architecture of metabolic syndrome-associated components in dyslipidemic and normolipidemic subjects: the GEMS Study.

A new nitrilase from Bradyrhizobium japonicum USDA 110. Gene cloning, biochemical characterization and substrate specificity.

Inverting the enantioselectivity of a carbonyl reductase via substrate-enzyme docking-guided point mutation.

Isolation of a novel lipase gene from Serratia liquefaciens S33 DB-1, functional expression in Pichia pastoris and its properties.

[Genetic characterization of Chinese rubella virus isolates from 2003 to 2007].

Gambogic acid induced tumor cell apoptosis by T lymphocyte activation in H22 transplanted mice.

Cloning, protein sequence clarification, and substrate specificity of a leucine dehydrogenase from Bacillus sphaericus ATCC4525.

Synthesis of optically pure 2-azido-1-arylethanols with isolated enzymes and conversion to triazole-containing beta-blocker analogues employing click chemistry.

Involvement of matrix metalloproteinase 2 and 9 in gambogic acid induced suppression of MDA-MB-435 human breast carcinoma cell lung metastasis.

Sequence analysis of GDSL lipase gene family in Arabidopsis thaliana.

Gambogic acid mediates apoptosis as a p53 inducer through down-regulation of mdm2 in wild-type p53-expressing cancer cells.

Genetic characterization of measles viruses in China, 2004.

Asymmetric synthesis of both antipodes of beta-hydroxy nitriles and beta-hydroxy carboxylic acids via enzymatic reduction or sequential reduction/hydrolysis.

Genome-wide linkage and association analyses to identify genes influencing adiponectin levels: the GEMS Study.

Human leukocyte antigen profile in HIV-1 infected individuals and AIDS patients from Chongqing, China.

Biocatalytic asymmetric amination of carbonyl functional groups - a synthetic biology approach to organic chemistry.

A time-course transcriptome analysis of Escherichia coli with direct electrochemistry behavior in microbial fuel cells.

Association of HLA-A, B, DRB1 alleles and haplotypes with HIV-1 infection in Chongqing, China.

Development of a reverse transcription-loop-mediated isothermal amplification (RT-LAMP) system for a highly sensitive detection of enterovirus in the stool samples of acute flaccid paralysis cases.

Application of sex-specific single-nucleotide polymorphism filters in genome-wide association data.

The Gene, Environment Association Studies consortium (GENEVA): maximizing the knowledge obtained from GWAS by collaboration across studies of multiple conditions.

[Surveillance on HIV-1 incidence among men who have sex with men in Chongqing, China, 2006 - 2008].

Rubella virus genotypes in the People's Republic of China between 1979 and 2007: a shift in endemic viruses during the 2001 Rubella Epidemic.

A genome-wide association study of cleft lip with and without cleft palate identifies risk variants near MAFB and ABCA4.

A predicted S-type pyocin shows a bactericidal activity against clinical Pseudomonas aeruginosa isolates through membrane damage.

Novel short antibacterial and antifungal peptides with low cytotoxicity: Efficacy and action mechanisms.

Hepatitis B virus-induced liver fibrosis and cirrhosis: the value of liver and spleen volumetry with multi-detector spiral computed tomography.

The absence of the luxS gene increases swimming motility and flagella synthesis in Escherichia coli K12.

Highly Enantioselective Mutant Carbonyl Reductases Created via Structure-Based Site-Saturation Mutagenesis.

Vaccinia-related kinase 1 is required for the maintenance of undifferentiated spermatogonia in mouse male germ cells.

Quality control procedures for genome-wide association studies.

Genome partitioning of genetic variation for complex traits using common SNPs.

Evidence for gene-environment interaction in a genome wide study of nonsyndromic cleft palate.

Accelerating haplotype-based genome-wide association study using perfect phylogeny and phase-known reference data.

Engineering microbes to sense and eradicate Pseudomonas aeruginosa, a human pathogen.

Flavivirus RNA cap methyltransferase: structure, function, and inhibition.

Pitfalls of merging GWAS data: lessons learned in the eMERGE network and quality control procedures to maintain high data quality.

[An outbreak of human orf disease caused by introduced black goats].

Genome-wide association analysis of ischemic stroke in young adults.

Detectable clonal mosaicism from birth to old age and its relationship to cancer.

Prevalence and trend of HIV infection among voluntary blood donors in China since implementation of the Blood Donation Law: a systematic review and meta-analysis.

Short communication: emerging transmitted HIV type 1 drug resistance mutations among patients prior to start of first-line antiretroviral therapy in middle and low prevalence sites in China.

A novel meso-Diaminopimelate dehydrogenase from Symbiobacterium thermophilum: overexpression, characterization, and potential for D-amino acid synthesis.

Systems-level characterization and engineering of oxidative stress tolerance in Escherichia coli under anaerobic conditions.

Exome array analysis identifies new loci and low-frequency variants influencing insulin processing and secretion.

Novel strategies for managing dyslipidemia: treatment beyond statins.

Expansion of the red cell distribution width and evolving iron deficiency as predictors of poor outcome in chronic heart failure.

Transporter engineering for improved tolerance against alkane biofuels in Saccharomyces cerevisiae.

Microbial engineering strategies to improve cell viability for biochemical production.

Complete genome analysis of the C4 subgenotype strains of enterovirus 71: predominant recombination C4 viruses persistently circulating in China for 14 years.

Ablative hypofractionated radiotherapy normalizes tumor vasculature in lewis lung carcinoma mice model.

Th17-relevant cytokines vary with sera of different ANA staining patterns.

Genomic analysis of a newly isolated of Japanese encephalitis virus strain, CQ11-66, from a pediatric patient in China.

Reducing the risk of obesity: defining the role of weight loss drugs.

Polymorphisms in the SOCS7 gene and glucose homeostasis traits.

Transcriptome response to alkane biofuels in Saccharomyces cerevisiae: identification of efflux pumps involved in alkane tolerance.

Impact of ranolazine on clinical outcomes and healthcare resource utilization in patients with refractory angina pectoris.

Imputation-based genomic coverage assessments of current human genotyping arrays.

Genetic characterization of the hemagglutinin genes of wild-type measles virus circulating in china, 1993-2009.

A predicted immunity protein confers resistance to pyocin S5 in a sensitive strain of Pseudomonas aeruginosa.

Study of drug resistance and molecular typing of 59 cholerae01 clinical isolates from 1984 to 2002 in Chongqing, China.

An update on the clinical development of proprotein convertase subtilisin kexin 9 inhibitors, novel therapeutic agents for lowering low-density lipoprotein cholesterol.

Pfit is a structurally novel Crohn's disease-associated superantigen.

Mutations in PCYT1A, encoding a key regulator of phosphatidylcholine metabolism, cause spondylometaphyseal dysplasia with cone-rod dystrophy.

[Construction and identification of a full-length human secretory antibody library in Pichia pastoris].

Virological outcomes and drug resistance in Chinese patients after 12 months of 3TC-based first-line antiretroviral treatment, 2011-2012.

Highly efficient production of peptides: N-glycosidase F for N-glycomics analysis.

Microbial tolerance engineering toward biochemical production: from lignocellulose to products.

[The bio-effects of high single-dose radiation on xenografts of Lewis lung carcinoma].

Whole exome sequencing of distant relatives in multiplex families implicates rare variants in candidate genes for oral clefts.

Characterization of the genomic architecture and mutational spectrum of a small cell prostate carcinoma.

Therapeutic microbes for infectious disease.

In vitro and in vivo growth suppression of human papillomavirus 16-positive cervical cancer cells by CRISPR/Cas9.

Influence of Cofactor Regeneration Strategies on Preparative-Scale, Asymmetric Carbonyl Reductions by Engineered Escherichia coli.

Serum albumin changes and multivariate dynamic risk modelling in chronic heart failure.

Expression and biochemical characterization of recombinant human epididymis protein 4.

Genetic Associations with Plasma B12, B6, and Folate Levels in an Ischemic Stroke Population from the Vitamin Intervention for Stroke Prevention (VISP) Trial.

Calculated plasma volume status and prognosis in chronic heart failure.

Novel Deletion of SERPINF1 Causes Autosomal Recessive Osteogenesis Imperfecta Type VI in Two Brazilian Families.

Assessment of incidental findings in 232 whole-exome sequences from the Baylor-Hopkins Center for Mendelian Genomics.

Lessons learned from whole exome sequencing in multiplex families affected by a complex genetic disorder, intracranial aneurysm.

Mechanism of Arctigenin-Induced Specific Cytotoxicity against Human Hepatocellular Carcinoma Cell Lines: Hep G2 and SMMC7721.

The Genetic Basis of Mendelian Phenotypes: Discoveries, Challenges, and Opportunities.

Metabolic engineering of Saccharomyces cerevisiae for production of fatty acid short- and branched-chain alkyl esters biodiesel.

Whole-Exome Sequencing in Familial Parkinson Disease.

Engineering transcription factors to improve tolerance against alkane biofuels in Saccharomyces cerevisiae.

Clinical efficacy and safety of evolocumab for low-density lipoprotein cholesterol reduction.

A practical community-based response strategy to interrupt Ebola transmission in sierra Leone, 2014-2015.

Enhanced tumor delivery and antitumor response of doxorubicin-loaded albumin nanoparticles formulated based on a Schiff base.

Maternal cardiac function at 35-37 weeks' gestation: prediction for preeclampsia and gestational hypertension.