Hua Ling

Department of Biochemistry, National University of Singapore

Affiliated withNational University of Singapore Capital Medical University China Rehabilitation Science Institute

Research Area

GeneticsMedicine

Biography

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JoVE Journal Publications

ArticleTotal : 2	Year
Publication title	2016
Publication title	2024

Other Publications

Article	Year
Cyclin D1-dependent induction of luminal inflammatory breast tumors by activated notch3. Cancer research\| PubMed ID: 23928992	2013
The chitinase 3-like protein human cartilage glycoprotein 39 (HC-gp39) stimulates proliferation of human connective-tissue cells and activates both extracellular signal-regulated kinase- and... The Biochemical journal\| PubMed ID: 12071845	2002
[Clinical study of yishen jianpi yangxue tongli therapy in treating polycystic ovary syndrome]. Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine / Zhongguo Zhong xi yi jie he xue hui, Zhongguo Zhong yi yan jiu yuan zhu ban\| PubMed ID: 14666761	2003
The chitinase 3-like protein human cartilage glycoprotein 39 inhibits cellular responses to the inflammatory cytokines interleukin-1 and tumour necrosis factor-alpha. The Biochemical journal\| PubMed ID: 15015934	2004
Radiation therapy for orbital lymphoma. International journal of radiation oncology, biology, physics\| PubMed ID: 15925453	2005
Inflammatory cytokines induce production of CHI3L1 by articular chondrocytes. The Journal of biological chemistry\| PubMed ID: 16234240	2005
Long-term outcome and mortality trends in early-stage, Grade 1-2 follicular lymphoma treated with radiation therapy. International journal of radiation oncology, biology, physics\| PubMed ID: 16243446	2006
Lanosterol biosynthesis in plants. Archives of biochemistry and biophysics\| PubMed ID: 16445886	2006
Stereoselective enzymatic synthesis of chiral alcohols with the use of a carbonyl reductase from Candida magnoliae with anti-Prelog enantioselectivity. The Journal of organic chemistry\| PubMed ID: 16709061	2006
Isolation and expression analysis of a GDSL-like lipase gene from Brassica napus L. Journal of biochemistry and molecular biology\| PubMed ID: 16756759	2006
Overexpression of GbERF confers alteration of ethylene-responsive gene expression and enhanced resistance to Pseudomonas syringae in transgenic tobacco. Journal of biosciences\| PubMed ID: 16809858	2006
Stereoselective ketone reduction by a carbonyl reductase from Sporobolomyces salmonicolor. Substrate specificity, enantioselectivity and enzyme-substrate docking studies. Organic & biomolecular chemistry\| PubMed ID: 16826293	2006
Emergence of a new disease as a result of interspecific virulence gene transfer. Nature genetics\| PubMed ID: 16832356	2006
Comparison of cerebral blood volume and permeability in preoperative grading of intracranial glioma using CT perfusion imaging. Neuroradiology\| PubMed ID: 16937146	2006
Unexpected stereorecognition in nitrilase-catalyzed hydrolysis of beta-hydroxy nitriles. Organic letters\| PubMed ID: 16986917	2006
Oral cancer exams among cigarette smokers in Maryland. Cancer detection and prevention\| PubMed ID: 17113720	2006
Enantioselective enzymatic reductions of sterically bulky aryl alkyl ketones catalyzed by a NADPH-dependent carbonyl reductase. The Journal of organic chemistry\| PubMed ID: 17137377	2006
Scale-up of enzymatic production of lactobionic acid using the rotary jet head system. Biotechnology and bioengineering\| PubMed ID: 17154315	2007
The Tsn1-ToxA interaction in the wheat-Stagonospora nodorum pathosystem parallels that of the wheat-tan spot system. Genome / National Research Council Canada = GÃ©nome / Conseil national de recherches Canada\| PubMed ID: 17213908	2006
Molecular cloning, expression profiling and functional analysis of a DXR gene encoding 1-deoxy-D-xylulose 5-phosphate reductoisomerase from Camptotheca acuminata. Journal of plant physiology\| PubMed ID: 17257708	2008
A molecular modeling study on the enantioselectivity of aryl alkyl ketone reductions by a NADPH-dependent carbonyl reductase. Journal of molecular modeling\| PubMed ID: 17279371	2007
Molecular epidemiology of measles viruses in China, 1995-2003. Virology journal\| PubMed ID: 17280609	2007
Over-expression GbERF2 transcription factor in tobacco enhances brown spots disease resistance by activating expression of downstream genes. Gene\| PubMed ID: 17321073	2007
Isolation and characterization of a class III homeodomain-leucine zipper-like gene from Gossypium barbadense. DNA sequence : the journal of DNA sequencing and mapping\| PubMed ID: 17343206	2006
Discovery of a mandelonitrile hydrolase from Bradyrhizobium japonicum USDA110 by rational genome mining. Journal of biotechnology\| PubMed ID: 17350705	2007
Asymmetric reduction of beta-ketonitriles with a recombinant carbonyl reductase and enzymatic transformation to optically pure beta-hydroxy carboxylic acids. Organic letters\| PubMed ID: 17521195	2007
Genetic and phenotypic architecture of metabolic syndrome-associated components in dyslipidemic and normolipidemic subjects: the GEMS Study. Atherosclerosis\| PubMed ID: 17888929	2008
A new nitrilase from Bradyrhizobium japonicum USDA 110. Gene cloning, biochemical characterization and substrate specificity. Journal of biotechnology\| PubMed ID: 18061298	2008
Inverting the enantioselectivity of a carbonyl reductase via substrate-enzyme docking-guided point mutation. Organic letters\| PubMed ID: 18205368	2008
Isolation of a novel lipase gene from Serratia liquefaciens S33 DB-1, functional expression in Pichia pastoris and its properties. Molecular biotechnology\| PubMed ID: 18219590	2008
[Genetic characterization of Chinese rubella virus isolates from 2003 to 2007]. Bing du xue bao = Chinese journal of virology / [bian ji, Bing du xue bao bian ji wei yuan hui]\| PubMed ID: 18320816	2008
Gambogic acid induced tumor cell apoptosis by T lymphocyte activation in H22 transplanted mice. International immunopharmacology\| PubMed ID: 18573352	2008
Cloning, protein sequence clarification, and substrate specificity of a leucine dehydrogenase from Bacillus sphaericus ATCC4525. Applied biochemistry and biotechnology\| PubMed ID: 18626578	2009
Synthesis of optically pure 2-azido-1-arylethanols with isolated enzymes and conversion to triazole-containing beta-blocker analogues employing click chemistry. The Journal of organic chemistry\| PubMed ID: 18630881	2008
Involvement of matrix metalloproteinase 2 and 9 in gambogic acid induced suppression of MDA-MB-435 human breast carcinoma cell lung metastasis. Journal of molecular medicine (Berlin, Germany)\| PubMed ID: 18777017	2008
Sequence analysis of GDSL lipase gene family in Arabidopsis thaliana. Pakistan journal of biological sciences : PJBS\| PubMed ID: 18819574	2008
Gambogic acid mediates apoptosis as a p53 inducer through down-regulation of mdm2 in wild-type p53-expressing cancer cells. Molecular cancer therapeutics\| PubMed ID: 18852133	2008
Genetic characterization of measles viruses in China, 2004. Virology journal\| PubMed ID: 18928575	2008
Asymmetric synthesis of both antipodes of beta-hydroxy nitriles and beta-hydroxy carboxylic acids via enzymatic reduction or sequential reduction/hydrolysis. The Journal of organic chemistry\| PubMed ID: 19161324	2009
Genome-wide linkage and association analyses to identify genes influencing adiponectin levels: the GEMS Study. Obesity (Silver Spring, Md.)\| PubMed ID: 19165155	2009
Human leukocyte antigen profile in HIV-1 infected individuals and AIDS patients from Chongqing, China. Microbiology and immunology\| PubMed ID: 19703245	2009
Biocatalytic asymmetric amination of carbonyl functional groups - a synthetic biology approach to organic chemistry. Biotechnology journal\| PubMed ID: 19757497	2009
A time-course transcriptome analysis of Escherichia coli with direct electrochemistry behavior in microbial fuel cells. Chemical communications (Cambridge, England)\| PubMed ID: 19826662	2009
Association of HLA-A, B, DRB1 alleles and haplotypes with HIV-1 infection in Chongqing, China. BMC infectious diseases\| PubMed ID: 20003377	2009
Development of a reverse transcription-loop-mediated isothermal amplification (RT-LAMP) system for a highly sensitive detection of enterovirus in the stool samples of acute flaccid paralysis... BMC infectious diseases\| PubMed ID: 20015403	2009
Application of sex-specific single-nucleotide polymorphism filters in genome-wide association data. BMC proceedings\| PubMed ID: 20018050	2009
The Gene, Environment Association Studies consortium (GENEVA): maximizing the knowledge obtained from GWAS by collaboration across studies of multiple conditions. Genetic epidemiology\| PubMed ID: 20091798	2010
[Surveillance on HIV-1 incidence among men who have sex with men in Chongqing, China, 2006 - 2008]. Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi\| PubMed ID: 20193218	2009
Rubella virus genotypes in the People's Republic of China between 1979 and 2007: a shift in endemic viruses during the 2001 Rubella Epidemic. Journal of clinical microbiology\| PubMed ID: 20351211	2010
A genome-wide association study of cleft lip with and without cleft palate identifies risk variants near MAFB and ABCA4. Nature genetics\| PubMed ID: 20436469	2010
A predicted S-type pyocin shows a bactericidal activity against clinical Pseudomonas aeruginosa isolates through membrane damage. FEBS letters\| PubMed ID: 20580355	2010
Novel short antibacterial and antifungal peptides with low cytotoxicity: Efficacy and action mechanisms. Biochemical and biophysical research communications\| PubMed ID: 20603106	2010
Hepatitis B virus-induced liver fibrosis and cirrhosis: the value of liver and spleen volumetry with multi-detector spiral computed tomography. Journal of digestive diseases\| PubMed ID: 20649734	2010
The absence of the luxS gene increases swimming motility and flagella synthesis in Escherichia coli K12. Biochemical and biophysical research communications\| PubMed ID: 20875395	2010
Highly Enantioselective Mutant Carbonyl Reductases Created via Structure-Based Site-Saturation Mutagenesis. The Journal of organic chemistry\| PubMed ID: 20964397	2010
Vaccinia-related kinase 1 is required for the maintenance of undifferentiated spermatogonia in mouse male germ cells. PloS one\| PubMed ID: 21179456	2010
Quality control procedures for genome-wide association studies. Current protocols in human genetics / editorial board, Jonathan L. Haines ... [et al.]\| PubMed ID: 21234875	2011
Genome partitioning of genetic variation for complex traits using common SNPs. Nature genetics\| PubMed ID: 21552263	2011
Evidence for gene-environment interaction in a genome wide study of nonsyndromic cleft palate. Genetic epidemiology\| PubMed ID: 21618603	2011
Accelerating haplotype-based genome-wide association study using perfect phylogeny and phase-known reference data. PloS one\| PubMed ID: 21789217	2011
Engineering microbes to sense and eradicate Pseudomonas aeruginosa, a human pathogen. Molecular systems biology\| PubMed ID: 21847113	2011
Flavivirus RNA cap methyltransferase: structure, function, and inhibition. Frontiers in biology\| PubMed ID: 21927615	2010
Pitfalls of merging GWAS data: lessons learned in the eMERGE network and quality control procedures to maintain high data quality. Genetic epidemiology\| PubMed ID: 22125226	2011
[An outbreak of human orf disease caused by introduced black goats]. Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi\| PubMed ID: 22340880	2011
Genome-wide association analysis of ischemic stroke in young adults. G3 (Bethesda, Md.)\| PubMed ID: 22384361	2011
Detectable clonal mosaicism from birth to old age and its relationship to cancer. Nature genetics\| PubMed ID: 22561516	2012
Prevalence and trend of HIV infection among voluntary blood donors in China since implementation of the Blood Donation Law: a systematic review and meta-analysis. Tropical medicine & international health : TM & IH\| PubMed ID: 22686403	2012
Short communication: emerging transmitted HIV type 1 drug resistance mutations among patients prior to start of first-line antiretroviral therapy in middle and low prevalence sites in China. AIDS research and human retroviruses\| PubMed ID: 22822770	2012
A novel meso-Diaminopimelate dehydrogenase from Symbiobacterium thermophilum: overexpression, characterization, and potential for D-amino acid synthesis. Applied and environmental microbiology\| PubMed ID: 23023754	2012
Systems-level characterization and engineering of oxidative stress tolerance in Escherichia coli under anaerobic conditions. Molecular bioSystems\| PubMed ID: 23224080	2013
Exome array analysis identifies new loci and low-frequency variants influencing insulin processing and secretion. Nature genetics\| PubMed ID: 23263489	2013
Novel strategies for managing dyslipidemia: treatment beyond statins. Postgraduate medicine\| PubMed ID: 23322138	2012
Expansion of the red cell distribution width and evolving iron deficiency as predictors of poor outcome in chronic heart failure. International journal of cardiology\| PubMed ID: 23351789	2013
Transporter engineering for improved tolerance against alkane biofuels in Saccharomyces cerevisiae. Biotechnology for biofuels\| PubMed ID: 23402697	2013
Microbial engineering strategies to improve cell viability for biochemical production. Biotechnology advances\| PubMed ID: 23403071	2013
Complete genome analysis of the C4 subgenotype strains of enterovirus 71: predominant recombination C4 viruses persistently circulating in China for 14 years. PloS one\| PubMed ID: 23441179	2013
Ablative hypofractionated radiotherapy normalizes tumor vasculature in lewis lung carcinoma mice model. Radiation research\| PubMed ID: 23480563	2013
Th17-relevant cytokines vary with sera of different ANA staining patterns. International immunopharmacology\| PubMed ID: 23507192	2013
Genomic analysis of a newly isolated of Japanese encephalitis virus strain, CQ11-66, from a pediatric patient in China. Virology journal\| PubMed ID: 23548058	2013
Reducing the risk of obesity: defining the role of weight loss drugs. Pharmacotherapy\| PubMed ID: 23712541	2013
Polymorphisms in the SOCS7 gene and glucose homeostasis traits. BMC research notes\| PubMed ID: 23767996	2013
Transcriptome response to alkane biofuels in Saccharomyces cerevisiae: identification of efflux pumps involved in alkane tolerance. Biotechnology for biofuels\| PubMed ID: 23826995	2013
Impact of ranolazine on clinical outcomes and healthcare resource utilization in patients with refractory angina pectoris. American journal of cardiovascular drugs : drugs, devices, and other interventions\| PubMed ID: 23873327	2013
Imputation-based genomic coverage assessments of current human genotyping arrays. G3 (Bethesda, Md.)\| PubMed ID: 23979933	2013
Genetic characterization of the hemagglutinin genes of wild-type measles virus circulating in china, 1993-2009. PloS one\| PubMed ID: 24073194	2013
A predicted immunity protein confers resistance to pyocin S5 in a sensitive strain of Pseudomonas aeruginosa. Chembiochem : a European journal of chemical biology\| PubMed ID: 24222552	2013
Study of drug resistance and molecular typing of 59 cholerae01 clinical isolates from 1984 to 2002 in Chongqing, China. International journal of clinical and experimental medicine\| PubMed ID: 24260599	2013
An update on the clinical development of proprotein convertase subtilisin kexin 9 inhibitors, novel therapeutic agents for lowering low-density lipoprotein cholesterol. Cardiovascular therapeutics\| PubMed ID: 24354905	2014
Pfit is a structurally novel Crohn's disease-associated superantigen. PLoS pathogens\| PubMed ID: 24385909	2013
Mutations in PCYT1A, encoding a key regulator of phosphatidylcholine metabolism, cause spondylometaphyseal dysplasia with cone-rod dystrophy. American journal of human genetics\| PubMed ID: 24387990	2014
[Construction and identification of a full-length human secretory antibody library in Pichia pastoris]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology\| PubMed ID: 24405598	2014
Virological outcomes and drug resistance in Chinese patients after 12 months of 3TC-based first-line antiretroviral treatment, 2011-2012. PloS one\| PubMed ID: 24516631	2014
Highly efficient production of peptides: N-glycosidase F for N-glycomics analysis. Protein expression and purification\| PubMed ID: 24582822	2014
Microbial tolerance engineering toward biochemical production: from lignocellulose to products. Current opinion in biotechnology\| PubMed ID: 24743028	2014
[The bio-effects of high single-dose radiation on xenografts of Lewis lung carcinoma]. Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition\| PubMed ID: 24749336	2014
Whole exome sequencing of distant relatives in multiplex families implicates rare variants in candidate genes for oral clefts. Genetics\| PubMed ID: 24793288	2014
Characterization of the genomic architecture and mutational spectrum of a small cell prostate carcinoma. Genes\| PubMed ID: 24823478	2014
Therapeutic microbes for infectious disease. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 24838883	2014
In vitro and in vivo growth suppression of human papillomavirus 16-positive cervical cancer cells by CRISPR/Cas9. Biochemical and biophysical research communications\| PubMed ID: 25044113	2014
Influence of Cofactor Regeneration Strategies on Preparative-Scale, Asymmetric Carbonyl Reductions by Engineered Escherichia coli. Organic process research & development\| PubMed ID: 25067899	2014
Serum albumin changes and multivariate dynamic risk modelling in chronic heart failure. International journal of cardiology\| PubMed ID: 25129278	2014
Expression and biochemical characterization of recombinant human epididymis protein 4. Protein expression and purification\| PubMed ID: 25131860	2014
Genetic Associations with Plasma B12, B6, and Folate Levels in an Ischemic Stroke Population from the Vitamin Intervention for Stroke Prevention (VISP) Trial. Frontiers in public health\| PubMed ID: 25147783	2014
Calculated plasma volume status and prognosis in chronic heart failure. European journal of heart failure\| PubMed ID: 25469484	2015
Novel Deletion of SERPINF1 Causes Autosomal Recessive Osteogenesis Imperfecta Type VI in Two Brazilian Families. Molecular syndromology\| PubMed ID: 25565926	2014
Assessment of incidental findings in 232 whole-exome sequences from the Baylor-Hopkins Center for Mendelian Genomics. Genetics in medicine : official journal of the American College of Medical Genetics\| PubMed ID: 25569433	2015
Lessons learned from whole exome sequencing in multiplex families affected by a complex genetic disorder, intracranial aneurysm. PloS one\| PubMed ID: 25803036	2015
Mechanism of Arctigenin-Induced Specific Cytotoxicity against Human Hepatocellular Carcinoma Cell Lines: Hep G2 and SMMC7721. PloS one\| PubMed ID: 25933104	2015
The Genetic Basis of Mendelian Phenotypes: Discoveries, Challenges, and Opportunities. American journal of human genetics\| PubMed ID: 26166479	2015
Metabolic engineering of Saccharomyces cerevisiae for production of fatty acid short- and branched-chain alkyl esters biodiesel. Biotechnology for biofuels\| PubMed ID: 26543501	2015
Whole-Exome Sequencing in Familial Parkinson Disease. JAMA neurology\| PubMed ID: 26595808	2016
Engineering transcription factors to improve tolerance against alkane biofuels in Saccharomyces cerevisiae. Biotechnology for biofuels\| PubMed ID: 26719765	2015
Clinical efficacy and safety of evolocumab for low-density lipoprotein cholesterol reduction. Vascular health and risk management\| PubMed ID: 27143910	2016
A practical community-based response strategy to interrupt Ebola transmission in sierra Leone, 2014-2015. Infectious diseases of poverty\| PubMed ID: 27491387	2016
Enhanced tumor delivery and antitumor response of doxorubicin-loaded albumin nanoparticles formulated based on a Schiff base. International journal of nanomedicine\| PubMed ID: 27574421	2016
Maternal cardiac function at 35-37 weeks' gestation: prediction for preeclampsia and gestational hypertension. Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology\| PubMed ID: 27619066	2016