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School of Pharmacy
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GTP binding and intramolecular regulation by the ROC domain of Death Associated Protein Kinase 1.
Scientific reports , 2012 | Pubmed ID: 23019516
Dysfunction of the autophagy/lysosomal degradation pathway is a shared feature of the genetic synucleinopathies.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology Sep, 2013 | Pubmed ID: 23682122
Divergent α-synuclein solubility and aggregation properties in G2019S LRRK2 Parkinson's disease brains with Lewy Body pathology compared to idiopathic cases.
Neurobiology of disease Oct, 2013 | Pubmed ID: 23747310
Inhibition of LRRK2 kinase activity stimulates macroautophagy.
Biochimica et biophysica acta Dec, 2013 | Pubmed ID: 23916833
Pathogenic Parkinson's disease mutations across the functional domains of LRRK2 alter the autophagic/lysosomal response to starvation.
Biochemical and biophysical research communications Nov, 2013 | Pubmed ID: 24211199
Rare variants in LRRK1 and Parkinson's disease.
Neurogenetics Mar, 2014 | Pubmed ID: 24241507
Computational analysis of the LRRK2 interactome.
PeerJ , 2015 | Pubmed ID: 25737818
Cellular processes associated with LRRK2 function and dysfunction.
The FEBS journal Aug, 2015 | Pubmed ID: 25899482
Genetic and phenotypic characterization of complex hereditary spastic paraplegia.
Brain : a journal of neurology 07, 2016 | Pubmed ID: 27217339
mTOR independent regulation of macroautophagy by Leucine Rich Repeat Kinase 2 via Beclin-1.
Scientific reports 10, 2016 | Pubmed ID: 27731364
Genome, transcriptome and proteome: the rise of omics data and their integration in biomedical sciences.
Briefings in bioinformatics Mar, 2018 | Pubmed ID: 27881428
Weighted Protein Interaction Network Analysis of Frontotemporal Dementia.
Journal of proteome research 02, 2017 | Pubmed ID: 28004582
The LRRK2-macroautophagy axis and its relevance to Parkinson's disease.
Biochemical Society transactions 02, 2017 | Pubmed ID: 28202669
LRRK2 and Autophagy.
Advances in neurobiology , 2017 | Pubmed ID: 28353280
The LRRK2 signalling system.
Cell and tissue research Jul, 2018 | Pubmed ID: 29308544
Comparative Protein Interaction Network Analysis Identifies Shared and Distinct Functions for the Human ROCO Proteins.
Proteomics May, 2018 | Pubmed ID: 29513927
mTOR independent alteration in ULK1 Ser758 phosphorylation following chronic LRRK2 kinase inhibition.
Bioscience reports Apr, 2018 | Pubmed ID: 29563162
Tau Mutations Serve as a Novel Risk Factor for Cancer.
Cancer research Jul, 2018 | Pubmed ID: 29794074
Stratification of candidate genes for Parkinson's disease using weighted protein-protein interaction network analysis.
BMC genomics Jun, 2018 | Pubmed ID: 29898659
Analysis of macroautophagy related proteins in G2019S LRRK2 Parkinson's disease brains with Lewy Body pathology.
Brain research Jul, 2018 | Pubmed ID: 30055128
University of Reading
UCL Institute of Neurology
Cattleya S. Leksmono1,
Claudia Manzoni1,2,
James E. Tomkins1,
Walter Lucchesi1,3,
Graeme Cottrell1,
Patrick A. Lewis1
1School of Pharmacy, University of Reading,
2Department of Molecular Neuroscience, UCL Institute of Neurology,
3School of Biological Sciences, Royal Hollway, University of London
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