Department of Health,
Animal Science and Food Safety,
Reproductive and Developmental Biology Laboratory,
Department of Health, Animal Science and Food Safety,
Reproductive and Developmental Biology Laboratory, Department of Health, Animal Science and Food Safety
CURRENT POSITION
Since 2017 Assistant Professor, Animal Anatomy and Physiology, Department of Health Animal Science and Food Safety, Università degli Studi di Milano, Italy
EDUCATION
2009 PhD, Facoltà di Medicina Veterinaria, Università degli Studi di Milano, Italy
2005 DVM, Facoltà di Medicina Veterinaria, Università degli Studi di Milano, Italy, 110/110 with honor
PREVIOUS POSITIONS (last 5 years)
2014 – 2017 Fellow of the Marie Curie - International Outgoing Fellowship program
Outgoing Phase: Center for Reproductive Sciences, University of California San Francisco, USA - Returning Phase: Department of Health, Animal Science and Food Safety, Università degli Studi di Milano, Italy
2013 – 2014 PostDoctoral Researcher, Center for Reproductive Sciences, University of California San Francisco, USA
RESEARCH ACTIVITY
My field of research is Reproductive and Developmental Biology. Within this area, I developed a special interest on oocyte biology and the mechanisms controlling the oocyte to embryo transition. I strongly believe that a deeper knowledge of the mechanisms controlling oocyte nuclear reprogramming into a totipotent cell will improve the current approach to treat female infertility, while also impacting regenerative medicine. Given the difficulties in using human oocytes and embryos for research, and the fact that these cells cannot be propagated in culture, my research is mainly conducted on animal models.
Large-scale chromatin remodeling in germinal vesicle bovine oocytes: interplay with gap junction functionality and developmental competence.
Molecular reproduction and development Jun, 2007 | Pubmed ID: 17075796
Oocyte morphology and transcriptional silencing in relation to chromatin remodeling during the final phases of bovine oocyte growth.
Molecular reproduction and development May, 2008 | Pubmed ID: 17948251
Bovine alpha-1 acid glycoprotein can reduce the chemotaxis of bovine monocytes and modulate CD18 expression.
Veterinary research Sep-Oct, 2008 | Pubmed ID: 18577362
Alpha(1)-acid glycoprotein is contained in bovine neutrophil granules and released after activation.
Veterinary immunology and immunopathology Sep, 2008 | Pubmed ID: 18584879
Developmental competence of gametes reconstructed by germinal vesicle transplantation from fresh and cryopreserved bovine oocytes.
Fertility and sterility Jan, 2010 | Pubmed ID: 18976992
Down-regulatory effect of alpha 1-acid glycoprotein on bovine neutrophil degranulation.
Comparative immunology, microbiology and infectious diseases Jul, 2010 | Pubmed ID: 19167758
Effect of different cryopreservation protocols on cytoskeleton and gap junction mediated communication integrity in feline germinal vesicle stage oocytes.
Cryobiology Aug, 2009 | Pubmed ID: 19460364
Transferability and inter-laboratory variability assessment of the in vitro bovine oocyte maturation (IVM) test within ReProTect.
Reproductive toxicology (Elmsford, N.Y.) Aug, 2010 | Pubmed ID: 20156549
Progesterone receptor membrane component 1 expression and putative function in bovine oocyte maturation, fertilization, and early embryonic development.
Reproduction (Cambridge, England) Nov, 2010 | Pubmed ID: 20739377
Phylogenomic evidence for the presence of a flagellum and cbb(3) oxidase in the free-living mitochondrial ancestor.
Molecular biology and evolution Dec, 2011 | Pubmed ID: 21690562
Gap junction-mediated communications regulate chromatin remodeling during bovine oocyte growth and differentiation through cAMP-dependent mechanism(s).
Biology of reproduction Dec, 2011 | Pubmed ID: 21816847
Changes in histone H4 acetylation during in vivo versus in vitro maturation of equine oocytes.
Molecular human reproduction May, 2012 | Pubmed ID: 22155671
Oocytes isolated from dairy cows with reduced ovarian reserve have a high frequency of aneuploidy and alterations in the localization of progesterone receptor membrane component 1 and aurora kinase B.
Biology of reproduction Mar, 2013 | Pubmed ID: 23325810
Reductions in the number of mid-sized antral follicles are associated with markers of premature ovarian senescence in dairy cows.
Reproduction, fertility, and development Jan, 2014 | Pubmed ID: 23327793
Role of gap junction-mediated communications in regulating large-scale chromatin configuration remodeling and embryonic developmental competence acquisition in fully grown bovine oocyte.
Journal of assisted reproduction and genetics Sep, 2013 | Pubmed ID: 23881161
The effect of cilostamide on gap junction communication dynamics, chromatin remodeling, and competence acquisition in pig oocytes following parthenogenetic activation and nuclear transfer.
Biology of reproduction Sep, 2013 | Pubmed ID: 23926281
Somatic cells regulate maternal mRNA translation and developmental competence of mouse oocytes.
Nature cell biology Dec, 2013 | Pubmed ID: 24270888
Changes in large-scale chromatin structure and function during oogenesis: a journey in company with follicular cells.
Animal reproduction science Sep, 2014 | Pubmed ID: 25028181
Natriuretic peptide precursor C delays meiotic resumption and sustains gap junction-mediated communication in bovine cumulus-enclosed oocytes.
Biology of reproduction Sep, 2014 | Pubmed ID: 25078681
Transferability and inter-laboratory variability assessment of the in vitro bovine oocyte fertilization test.
Reproductive toxicology (Elmsford, N.Y.) Jan, 2015 | Pubmed ID: 25625651
Effect of oral administration of low-dose follicle stimulating hormone on hyperandrogenized mice as a model of polycystic ovary syndrome.
Journal of ovarian research Oct, 2015 | Pubmed ID: 26437930
In vitro maturation affects chromosome segregation, spindle morphology and acetylation of lysine 16 on histone H4 in horse oocytes.
Reproduction, fertility, and development Dec, 2015 | Pubmed ID: 26651296
FSH Regulates mRNA Translation in Mouse Oocytes and Promotes Developmental Competence.
Endocrinology Feb, 2016 | Pubmed ID: 26653334
DAZL and CPEB1 regulate mRNA translation synergistically during oocyte maturation.
Journal of cell science Mar, 2016 | Pubmed ID: 26826184
Dynamic secretion during meiotic reentry integrates the function of the oocyte and cumulus cells.
Proceedings of the National Academy of Sciences of the United States of America Mar, 2016 | Pubmed ID: 26864200
Ultra-low Doses of Follicle Stimulating Hormone and Progesterone Attenuate the Severity of Polycystic Ovary Syndrome Features in a Hyperandrogenized Mouse Model.
Journal of reproduction & infertility Jul-Sep, 2017 | Pubmed ID: 29062793
A prematuration approach to equine IVM: considering cumulus morphology, seasonality, follicle of origin, gap junction coupling and large-scale chromatin configuration in the germinal vesicle.
Reproduction, fertility, and development Jan, 2019 | Pubmed ID: 31630726
Recreating the Follicular Environment: A Customized Approach for In Vitro Culture of Bovine Oocytes Based on the Origin and Differentiation State.
Methods in molecular biology (Clifton, N.J.) , 2021 | Pubmed ID: 33604842
Federica Franciosi1,
Irene Tessaro1,2,
Rozenn Dalbies-Tran3,
Cecile Douet3,
Fabrice Reigner4,
Stefan Deleuze5,
Pascal Papillier3,
Ileana Miclea6,
Valentina Lodde1,
Alberto M. Luciano1,
Ghylene Goudet3
1Department of Health, Animal Science and Food Safety, University of Milan,
2, IRCCS. Istituto Ortopedico Galeazzi,
3PRC, CNRS, IFCE, Université de Tours, INRA,
4PAO, INRA,
5Clinique des Animaux de Compagnie et des Équidés, Université de Liège,
6, University of Agricultural Sciences and Veterinary Medicine, Cluj-Napoca, Romania
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