Matthew D. Neal

Endotoxin inhibits intestinal epithelial restitution through activation of Rho-GTPase and increased focal adhesions.

Preinjury statin use is associated with a higher risk of multiple organ failure after injury: a propensity score adjusted analysis.

The use of pre-operative imaging and intraoperative parathyroid hormone level to guide surgical management of tertiary hyperparathyroidism from X-linked hypophosphatemic rickets: a case report.

Tension pneumopericardium in an infant.

Extracellular high mobility group box-1 (HMGB1) inhibits enterocyte migration via activation of Toll-like receptor-4 and increased cell-matrix adhesiveness.

Nucleotide-binding oligomerization domain-2 inhibits toll-like receptor-4 signaling in the intestinal epithelium.

Intestinal stem cells and their roles during mucosal injury and repair.

DNA attenuates enterocyte Toll-like receptor 4-mediated intestinal mucosal injury after remote trauma.

Over reliance on computed tomography imaging in patients with severe abdominal injury: is the delay worth the risk?

An appraisal of endoscopic retrograde cholangiopancreatography (ERCP) for pancreaticobiliary disease in children: our institutional experience in 231 cases.

Diverting loop ileostomy and colonic lavage: an alternative to total abdominal colectomy for the treatment of severe, complicated Clostridium difficile associated disease.

Intracellular heat shock protein-70 negatively regulates TLR4 signaling in the newborn intestinal epithelium.

Crystalloid to packed red blood cell transfusion ratio in the massively transfused patient: when a little goes a long way.

Amniotic fluid inhibits Toll-like receptor 4 signaling in the fetal and neonatal intestinal epithelium.

Massive transfusion: an evidence-based review of recent developments.

Intestinal epithelial Toll-like receptor 4 regulates goblet cell development and is required for necrotizing enterocolitis in mice.

Endoscopic retrograde cholangiopancreatography is safe and effective for the diagnosis and treatment of pancreaticobiliary disease following abdominal organ transplant in children.

Toll-like receptor 4 is expressed on intestinal stem cells and regulates their proliferation and apoptosis via the p53 up-regulated modulator of apoptosis.

Innate immune activation after transfusion of stored red blood cells.

A critical role for TLR4 induction of autophagy in the regulation of enterocyte migration and the pathogenesis of necrotizing enterocolitis.

Use of a massive transfusion protocol in nontrauma patients: activate away.

Endothelial TLR4 activation impairs intestinal microcirculatory perfusion in necrotizing enterocolitis via eNOS-NO-nitrite signaling.

Discovery and validation of a new class of small molecule Toll-like receptor 4 (TLR4) inhibitors.

Simultaneous extracorporeal membrane oxygenation and therapeutic plasma exchange procedures are tolerable in both pediatric and adult patients.

Prehospital use of nonsteroidal anti-inflammatory drugs (NSAIDs) is associated with a reduced incidence of trauma-induced coagulopathy.

Toll-like receptor 4-mediated endoplasmic reticulum stress in intestinal crypts induces necrotizing enterocolitis.

A novel scoring system to predict the development of necrotizing enterocolitis totalis in premature infants.

Toll-like receptor 4 regulates platelet function and contributes to coagulation abnormality and organ injury in hemorrhagic shock and resuscitation.

Design of the Study of Tranexamic Acid during Air Medical Prehospital Transport (STAAMP) Trial: Addressing the Knowledge Gaps.

X chromosome-linked IRAK-1 polymorphism is a strong predictor of multiple organ failure and mortality postinjury.

Massive transfusion protocol activation does not result in preferential use of older red blood cells.

Taking the Blood Bank to the Field: The Design and Rationale of the Prehospital Air Medical Plasma (PAMPer) Trial.

Synthesis of anti-inflammatory α-and β-linked acetamidopyranosides as inhibitors of toll-like receptor 4 (TLR4).

Platelet-derived HMGB1 is a critical mediator of thrombosis.

Platelet-derived high-mobility group box 1 promotes recruitment and suppresses apoptosis of monocytes.

Dysbiosis Across Multiple Body Sites in Critically Ill Adult Surgical Patients.

Aged Human Stored Red Blood Cell Supernatant Inhibits Macrophage Phagocytosis in an HMGB1 Dependent Manner After Trauma in a Murine Model.

The confusion continues: results from an American Association for the Surgery of Trauma survey on massive transfusion practices among United States trauma centers.

Abnormalities in fibrinolysis at the time of admission are associated with deep vein thrombosis, mortality, and disability in a pediatric trauma population.

Platelet Transfusion in Critical Care and Surgery: Evidence-Based Review of Contemporary Practice and Future Directions.

Surgical rescue: The next pillar of acute care surgery.

In vitro characterization of SynthoPlate™ (synthetic platelet) technology and its in vivo evaluation in severely thrombocytopenic mice.

Management of anticoagulation with rivaroxaban in trauma and acute care surgery: Complications and reversal strategies as compared to warfarin therapy.

Is Coagulopathy an Appropriate Therapeutic Target During Critical Illness Such as Trauma or Sepsis?

Should All Massively Transfused Patients Be Treated Equally? An Analysis of Massive Transfusion Ratios in the Nontrauma Setting.

Trending Fibrinolytic Dysregulation: Fibrinolysis Shutdown in the Days After Injury Is Associated With Poor Outcome in Severely Injured Children.

Precision Correction of Coagulopathy or Prothrombin Complex Concentrates?: Reversal Options for Dabigatran following Trauma.

Extracellular Cyclophilin A Augments Platelet-Dependent Thrombosis and Thromboinflammation.

Principal component analysis of coagulation assays in severely injured children.

Deep vein thrombosis in mice is regulated by platelet HMGB1 through release of neutrophil-extracellular traps and DNA.

Overresuscitation with plasma is associated with sustained fibrinolysis shutdown and death in pediatric traumatic brain injury.

Intravenous synthetic platelet (SynthoPlate) nanoconstructs reduce bleeding and improve 'golden hour' survival in a porcine model of traumatic arterial hemorrhage.

Intravenous administration of synthetic platelets (SynthoPlate) in a mouse liver injury model of uncontrolled hemorrhage improves hemostasis.

Platelet HMGB1 is required for efficient bacterial clearance in intra-abdominal bacterial sepsis in mice.

Heme Oxygenase-2 Localizes to Mitochondria and Regulates Hypoxic Responses in Hepatocytes.

A qualitative study of gender differences in the experiences of general surgery trainees.

Chloroquine reduces hypercoagulability in pancreatic cancer through inhibition of neutrophil extracellular traps.

Blunt cerebrovascular injury in elderly fall patients: are we screening enough?

Design and implementation of the Western Pennsylvania regional Stop the Bleed initiative.

Prehospital Plasma during Air Medical Transport in Trauma Patients at Risk for Hemorrhagic Shock.

ADAMTS13: origins, applications, and prospects.

Tranexamic acid administration is associated with an increased risk of posttraumatic venous thromboembolism.

Reversing anti-factor Xa agents and the unmet needs in trauma patients.

Bacterial contamination of platelets for transfusion: strategies for prevention.

Risk of Venous Thromboembolism for Patients with Pancreatic Ductal Adenocarcinoma Undergoing Preoperative Chemotherapy Followed by Surgical Resection.

A Systematic Review of Gender-Based Differences in Hirsch Index Among Academic Surgeons.

Perceptions Regarding Mentorship Among General Surgery Trainees With Academic Career Intentions.

Implementation of a prehospital air medical thawed plasma program: Is it even feasible?

Early versus late venous thromboembolism: A secondary analysis of data from the PROPPR trial.

Platelet-derived extracellular vesicles released after trauma promote hemostasis and contribute to DVT in mice.

Pass interference: Getting in the way of platelets.

Window of Opportunity to Mitigate Trauma-induced Coagulopathy: Fibrinolysis Shutdown not Prevalent Until 1 Hour Post-injury.

Fibrinolysis Shutdown in Trauma: Historical Review and Clinical Implications.

Platelet Extracellular Vesicles Drive Inflammasome-IL-1β-Dependent Lung Injury in Sickle Cell Disease.

Prehospital plasma in injured patients is associated with survival principally in blunt injury: Results from two randomized prehospital plasma trials.

A comparison between the TEG 6s and TEG 5000 analyzers to assess coagulation in trauma patients.

Correlation of Thromboelastography with Apparent Rivaroxaban Concentration: Has Point-of-Care Testing Improved?

Alterations in platelet behavior after major trauma: adaptive or maladaptive?

Accelerating availability of clinically-relevant parameter estimates from thromboelastogram point-of-care device.

Defining trauma-induced coagulopathy with respect to future implications for patient management: Communication from the SSC of the ISTH.

A systematic review and meta-analysis of traumatic intracranial hemorrhage in patients taking prehospital antiplatelet therapy: Is there a role for platelet transfusions?

Massive transfusion and the response to prehospital plasma: It is all in how you define it.

Prehospital plasma is associated with distinct biomarker expression following injury.

Association Between Preoperative Metformin Exposure and Postoperative Outcomes in Adults With Type 2 Diabetes.

Forgot calcium? Admission ionized-calcium in two civilian randomized controlled trials of prehospital plasma for traumatic hemorrhagic shock.

Venous thromboembolism after tranexamic acid administration: legitimate risk or statistical confounder?

Whole-Blood Resuscitation of Injured Patients: Innovating from the Past.

Effects of Gender Bias and Stereotypes in Surgical Training: A Randomized Clinical Trial.

Traumatic injury results in prolonged circulation of ultralarge von Willebrand factor and a reduction in ADAMTS13 activity.

Characterization of unexpected survivors following a prehospital plasma randomized trial.

High-School Students Can Stop the Bleed: A Randomized, Controlled Educational Trial.

Von Willebrand factor as a thrombotic and inflammatory mediator in critical illness.

The great platelet paradox: evolution of platelet contribution to hemostasis, inflammation, and thrombosis after injury.

Hepatic Surgical Stress Promotes Systemic Immunothrombosis That Results in Distant Organ Injury.

Intravascular hemolysis triggers ADP-mediated generation of platelet-rich thrombi in pre-capillary pulmonary arterioles.

Defining a Research Agenda for Layperson Prehospital Hemorrhage Control: A Consensus Statement.

Platelet-Monocyte Aggregates: Understanding Mechanisms and Functions in Sepsis.

Pharmacologic Prehabilitation-What About "the Polypill"?

The New Zealand white rabbit animal model of acute radiation syndrome: hematopoietic and coagulation-based parameters by radiation dose following supportive care.

Whole Blood is Superior to Component Transfusion for Injured Children: A Propensity Matched Analysis.

Patient and surrogate attitudes via an interviewer-administered survey on exception from informed consent enrollment in the Prehospital Air Medical Plasma (PAMPer) trial.

Tranexamic Acid During Prehospital Transport in Patients at Risk for Hemorrhage After Injury: A Double-blind, Placebo-Controlled, Randomized Clinical Trial.

Whole-Blood Resuscitation of Injured Patients' Plasma.

Association of Prehospital Plasma With Survival in Patients With Traumatic Brain Injury: A Secondary Analysis of the PAMPer Cluster Randomized Clinical Trial.

Evidence-Based and Clinically Relevant Outcomes for Hemorrhage Control Trauma Trials.

Viscoelastic monitoring in trauma resuscitation.

Lipidomic Signatures Align with Inflammatory Patterns and Outcomes in Critical Illness.

Coupled Model of Blood Volume and Activated Clotting Factor Concentration during Childbirth.

Age of thawed plasma does not affect clinical outcomes or biomarker expression in patients receiving prehospital thawed plasma: a PAMPer secondary analysis.

Injured recipients of low-titer group O whole blood have similar clinical outcomes compared to recipients of conventional component therapy: A single-center, retrospective study.

Trauma-induced coagulopathy.

Early Prehospital Tranexamic Acid Following Injury Is Associated With a 30-day Survival Benefit: A Secondary Analysis of a Randomized Clinical Trial.

Does routine postoperative contrast radiography improve outcomes for patients with perforated peptic ulcer? A multicenter retrospective cohort study.

Anti-D alloimmunization in Rh(D) negative adults with severe traumatic injury.

Preventing Thrombohemorrhagic Complications of Heparinized COVID-19 Patients Using Adjunctive Thromboelastography: A Retrospective Study.

Utilizing natural language processing in the diagnosis and treatment of venous thromboembolism.

Therapeutic Anticoagulation with Heparin in Noncritically Ill Patients with Covid-19.

Therapeutic Anticoagulation with Heparin in Critically Ill Patients with Covid-19.

The role of viscoelastic testing in assessing peri-interventional platelet function and coagulation.

Bioinspired artificial platelets: past, present and future.

Platelets amplify endotheliopathy in COVID-19.

Platelet HMGB1 in Platelet-Rich Plasma (PRP) promotes tendon wound healing.

The emerging therapeutic potential of extracellular vesicles in trauma.

Evaluating the Cost-effectiveness of Prehospital Plasma Transfusion in Unstable Trauma Patients: A Secondary Analysis of the PAMPer Trial.

Rapid detection of platelet inhibition and dysfunction in traumatic brain injury: A prospective observational study.

The Epidemiology of Extremity Threat and Amputation after Vasopressor-Dependent Sepsis.

Reduced cleavage of von willebrand factor by ADAMTS13 is associated with microangiopathic acute kidney injury following trauma.

The Pathobiological Basis for Thrombotic Complications in COVID-19: a Review of the Literature.

Multi-omic analysis in injured humans: Patterns align with outcomes and treatment responses.

Effect of P2Y12 Inhibitors on Survival Free of Organ Support Among Non-Critically Ill Hospitalized Patients With COVID-19: A Randomized Clinical Trial.

Hemorrhagic Resuscitation Guided by Viscoelastography in Far-Forward Combat and Austere Civilian Environments: Goal-Directed Whole-Blood and Blood-Component Therapy Far from the Trauma Center.

Platelet-mimicking procoagulant nanoparticles augment hemostasis in animal models of bleeding.

The National Blood Shortage-An Impetus for Change.

Prehospital low titer group O whole blood is feasible and safe: Results of a prospective randomized pilot trial.

Low Titer Group O Whole Blood In Injured Children Requiring Massive Transfusion.

Viscoelastic Hemostatic Assays: A Primer on Legacy and New Generation Devices.

Investigation into the Cost-Effectiveness of Extended Posttraumatic Thromboprophylaxis.

Effect of Antiplatelet Therapy on Survival and Organ Support-Free Days in Critically Ill Patients With COVID-19: A Randomized Clinical Trial.

Neutrophil extracellular traps regulate ischemic stroke brain injury.

Prehospital synergy: Tranexamic acid and blood transfusion in patients at risk for hemorrhage.

Author Correction: Trauma-induced coagulopathy.

Immuno-Thrombotic Complications of COVID-19: Implications for Timing of Surgery and Anticoagulation.

An adaptive platform trial for evaluating treatments in patients with life-threatening hemorrhage from traumatic injuries: Planning and execution.

Platelet dysfunction after trauma: From mechanisms to targeted treatment.

Emerging clinical trial designs may accelerate translation in hematology: lessons from COVID-19.

Toward a more complete understanding of who will benefit from prehospital transfusion.

Illustrated State-of-the-Art Capsules of the ISTH 2022 Congress.

Association Between Time to Source Control in Sepsis and 90-Day Mortality.

Nanomedicine platform for targeting activated neutrophils and neutrophil-platelet complexes using an α-antitrypsin-derived peptide motif.

High Dimensional Multiomics Reveals Unique Characteristics of Early Plasma Administration in Polytrauma Patients With TBI.

Platelet-Inspired Intravenous Nanomedicine for Injury-Targeted Direct Delivery of Thrombin to Augment Hemostasis in Coagulopathies.

Multi-Omic Admission-Based Prognostic Biomarkers Identified by Machine Learning Algorithms Predict Patient Recovery and 30-Day Survival in Trauma Patients.

Relative Hypercoagulopathy of the SARS-CoV-2 Beta and Delta Variants when Compared to the Less Severe Omicron Variants Is Related to TEG Parameters, the Extent of Fibrin Amyloid Microclots, and the Severity of Clinical Illness.

Proteomics of Coagulopathy Following Injury Reveals Limitations of Using Laboratory Assessment to Define Trauma-Induced Coagulopathy to Predict Massive Transfusion.

Lipidomic signatures align with inflammatory patterns and outcomes in critical illness.

EFFECT OF IRRIGATION FLUID COMPOSITION ON HEMOSTASIS IN MOUSE BLEEDING MODELS.

Long-term (180-Day) Outcomes in Critically Ill Patients With COVID-19 in the REMAP-CAP Randomized Clinical Trial.

Plasma proteomics reveals early, broad release of chemokine, cytokine, TNF, and interferon mediators following trauma with delayed increases in a subset of chemokines and cytokines in patients that remain critically ill.

MACROPHAGE SWITCHING: POLARIZATION AND MOBILIZATION AFTER TRAUMA.

Evaluation of critical care burden following traumatic injury from two randomized controlled trials.

Anticoagulation in adult patients supported with extracorporeal membrane oxygenation: guidance from the Scientific and Standardization Committees on Perioperative and Critical Care Haemostasis and Thrombosis of the International Society on Thrombosis and Haemostasis.

High-dimensional proteomics identifies organ injury patterns associated with outcomes in human trauma.

Long-term Outcomes of Parastomal Hernia Repair-The Defect in Knowledge (and Abdominal Wall) Remains.

Heterogeneous Treatment Effects of Therapeutic-Dose Heparin in Patients Hospitalized for COVID-19.

Effects of the circulating environment of COVID-19 on platelet and neutrophil behavior.

Hemostatic In Vitro Properties of Novel Plasma Supernatants Produced from Late-storage Low-titer Type O Whole Blood.

A rapid ABO and RhD test demonstrates high fidelity to blood bank testing for RhD typing.

Prehospital tranexamic acid is associated with a dose-dependent decrease in syndecan-1 after trauma: A secondary analysis of a prospective randomized trial.

Early lyophilized cryoprecipitate enhances the ADAMTS13/VWF ratio to reduce systemic endotheliopathy and lessen lung injury in a mouse multiple-trauma hemorrhage model.

Effect of P2Y12 Inhibitors on Organ Support-Free Survival in Critically Ill Patients Hospitalized for COVID-19: A Randomized Clinical Trial.

Effect of the P-Selectin Inhibitor Crizanlizumab on Survival Free of Organ Support in Patients Hospitalized for COVID-19: A Randomized Controlled Trial.

High Dose of Metformin Decreases Susceptibility to Occlusive Arterial Thrombosis in Diabetic Mice.

Mechanisms and management of the coagulopathy of trauma and sepsis: trauma-induced coagulopathy, sepsis-induced coagulopathy, and disseminated intravascular coagulation.

Effect of therapeutic-dose heparin on severe acute kidney injury and death in noncritically ill patients hospitalized for COVID-19: a prespecified secondary analysis of the ACTIV4a and ATTACC randomized trial.

Evaluating potential disparities in geospatial access to American College of Surgeons/American Association for the Surgery of Trauma-verified emergency general surgery centers.

Precision in Transfusion Medicine.

Effects of inflammation on thrombosis and outcomes in COVID-19: secondary analysis of the ATTACC/ACTIV-4a trial.

Simvastatin in Critically Ill Patients with Covid-19.

High Dose of Metformin Decreases Susceptibility to Occlusive Arterial Thrombosis in Diabetic Mice.

Symptoms and Impaired Quality of Life After COVID-19 Hospitalization: Effect of Therapeutic Heparin in Non-ICU Patients in the Accelerating COVID-19 Therapeutic Interventions and Vaccines 4 Acute Trial: Effect on 3-Month Symptoms and Quality of Life.

Platelet-inspired synthetic nanoparticles improve hemostasis and hemodynamics in a rabbit model of abdominal hemorrhage.

Long wavelength light exposure reduces systemic inflammation coagulopathy and acute organ injury following multiple injuries in mice.

Restoring glucose balance: Conditional HMGB1 knockdown mitigates hyperglycemia in a Streptozotocin induced mouse model.

Contemporary management of major haemorrhage in critical care.

The Hemostatic Resuscitation and Trauma Induced Coagulopathy (HERETIC) meeting: challenging dogma.

Therapeutic plasma exchange is feasible and tolerable in severely injured patients with trauma-induced coagulopathy.

Correction: Contemporary management of major haemorrhage in critical care.

Time to First Whole Blood Associated With Survival-First (Whole) Blood?

Lung Epithelium Releases Growth Differentiation Factor 15 in Response to Pathogen-mediated Injury.

Mechanism matters: mortality and endothelial cell damage marker differences between blunt and penetrating traumatic injuries across three prehospital clinical trials.

Transforming research to improve therapies for trauma in the twenty-first century.

Missingness matters: a secondary analysis of thromboelastography measurements from a recent prehospital randomized tranexamic acid clinical trial.

Advanced and alternative research methods for the acute care surgeon scientist.

Tranexamic acid in trauma: After 3 hours from injury, when is it safe and effective to use again?

Prehospital tranexamic acid is associated with a survival benefit without an increase in complications: Results of two harmonized randomized clinical trials.

Sex dimorphisms in coagulation: Implications in trauma-induced coagulopathy and trauma resuscitation.

Four-factor prothrombin complex concentrate is not inferior to andexanet alfa for the reversal or oral factor Xa inhibitors: An Eastern Association for the Surgery of Trauma multicenter study.

Early Cold Stored Platelet Transfusion Following Severe Injury: A Randomized Clinical Trial.

Whole Blood and Blood Component Resuscitation in Trauma: Interaction and Association with Mortality.

A comparison of computational algorithms for the Bayesian analysis of clinical trials.

Characterization of adverse events in injured patients at risk of hemorrhagic shock: a secondary analysis of three harmonized prehospital randomized clinical trials.

Heparin Dose Intensity and Organ Support-Free Days in Patients Hospitalized for COVID-19.

Trauma patients have reduced ex vivo flow-dependent platelet hemostatic capacity in a microfluidic model of vessel injury.

Association between timing of operative interventions and mortality in emergency general surgery.

Early GFAP and UCH-L1 point-of-care biomarker measurements for the prediction of traumatic brain injury and progression in patients with polytrauma and hemorrhagic shock.

Effect of sodium-glucose co-transporter-2 inhibitors on survival free of organ support in patients hospitalised for COVID-19 (ACTIV-4a): a pragmatic, multicentre, open-label, randomised, controlled, platform trial.

Sodium-glucose co-transporter-2 inhibitors for hospitalised patients with COVID-19: a prospective meta-analysis of randomised trials.

TEMPORARY REMOVAL: Alterations in visible light exposure modulate platelet function and regulate thrombus formation.

A surface-functionalized whole blood-based dielectric microsensor for assessment of clot firmness in a fibrinolytic environment.