Geoffrey W. McCaughan

Insights into the pathobiology of hepatitis C virus-associated cirrhosis: analysis of intrahepatic differential gene expression.

Role of primary intrahepatic T-cell activation in the 'liver tolerance effect'.

Expression of growth arrest-specific gene 6 and its receptors in a rat model of chronic renal transplant rejection.

Intrahepatic cytokine profiles associated with posttransplantation hepatitis C virus-related liver injury.

Postoperative administration of donor B cells induces rat kidney allograft acceptance: lack of association with Th2 cytokine expression in long-term accepted grafts.

Withdrawal of immunosuppression in liver transplant recipients: is this as good as it gets?

Cytokine-dependent bystander hepatitis due to intrahepatic murine CD8 T-cell activation by bone marrow-derived cells.

Pathogenesis of hepatitis C virus recurrence in the liver allograft.

Gene array analysis and the liver.

Structural requirements for catalysis, expression, and dimerization in the CD26/DPIV gene family.

SMART amplification maintains representation of relative gene expression: quantitative validation by real time PCR and application to studies of alcoholic liver disease in primates.

Molecular chimeras and mutational analysis in the prolyl oligopeptidase gene family.

Dipeptidyl peptidase IV gene family. The DPIV family.

Intrahepatic expression of collagen and fibroblast activation protein (FAP) in hepatitis C virus infection.

Novel differential gene expression in human cirrhosis detected by suppression subtractive hybridization.

Hepatitis C virus quasispecies: misunderstood and mistreated?

Impact of immunosuppression on immunopathogenesis of liver damage in hepatitis C virus-infected recipients following liver transplantation.

Gene expression profiling of alcoholic liver disease in the baboon (Papio hamadryas) and human liver.

Pharmacotherapy of hepatocellular carcinoma.

Pathogenesis and management of alcoholic hepatitis.

Insulin resistance is associated with chronic hepatitis C virus infection and fibrosis progression [corrected].

A prospective cross-over study comparing the effect of mycophenolate versus azathioprine on allograft function and viral load in liver transplant recipients with recurrent chronic HCV infection.

Increased mononuclear cell activation and apoptosis early after human liver transplantation is associated with a reduced frequency of acute rejection.

Non-oxidative metabolism of ethanol by rat pancreatic acini.

Improved prediction of fibrosis in chronic hepatitis C using measures of insulin resistance in a probability index.

Mechanisms of HCV reinfection and allograft damage after liver transplantation.

Patient and graft survival after liver transplantation for hereditary hemochromatosis: Implications for pathogenesis.

Dipeptidyl peptidase 9 has two forms, a broad tissue distribution, cytoplasmic localization and DPIV-like peptidase activity.

The site of primary T cell activation is a determinant of the balance between intrahepatic tolerance and immunity.

Combined donor leucocyte administration and immunosuppressive drug treatment for survival of rat heart allografts.

Liver transplantation for viral hepatitis.

Development and resolution of experimental colitis in mice with targeted deletion of dipeptidyl peptidase IV.

Posttransplant interleukin-4 treatment converts rat liver allograft tolerance to rejection.

Parenchymal expression of CD86/B7.2 contributes to hepatitis C virus-related liver injury.

Hepascore: an accurate validated predictor of liver fibrosis in chronic hepatitis C infection.

Intrahepatic immunity: a tale of two sites?

Fibroblast activation protein increases apoptosis, cell adhesion, and migration by the LX-2 human stellate cell line.

Immune-mediated hepatitis drives low-level fusion between hepatocytes and adult bone marrow cells.

Early intrahepatic antigen-specific retention of naïve CD8+ T cells is predominantly ICAM-1/LFA-1 dependent in mice.

Molecular characterization of a novel dipeptidyl peptidase like 2-short form (DPL2-s) that is highly expressed in the brain and lacks dipeptidyl peptidase activity.

Predictors of relapse to harmful alcohol after orthotopic liver transplantation.

Zoledronic acid prevents bone loss after liver transplantation: a randomized, double-blind, placebo-controlled trial.

Structure and function in dipeptidyl peptidase IV and related proteins.

DP8 and DP9 have extra-enzymatic roles in cell adhesion, migration and apoptosis.

Extra-enzymatic roles of DPIV and FAP in cell adhesion and migration on collagen and fibronectin.

Extraenzymatic functions of the dipeptidyl peptidase IV-related proteins DP8 and DP9 in cell adhesion, migration and apoptosis.

Intrahepatic gene expression in human alcoholic hepatitis.

Hereditary lysozyme amyloidosis: spontaneous hepatic rupture (15 years apart) in mother and daughter. role of emergency liver transplantation.

Long-term lamivudine monotherapy prevents development of hepatitis B virus infection in hepatitis B surface-antigen negative liver transplant recipients from hepatitis B core-antibody-positive donors.

T lymphocytes interact with hepatocytes through fenestrations in murine liver sinusoidal endothelial cells.

The hepatic transcriptome in human liver disease.

Dietary protein intakes in patients with hepatic encephalopathy and cirrhosis: current practice in NSW and ACT.

Marked changes of the hepatic sinusoid in a transgenic mouse model of acute immune-mediated hepatitis.

Vitamin D replacement for cirrhosis-related bone disease.

Lamivudine plus low-dose hepatitis B immunoglobulin to prevent recurrent hepatitis B following liver transplantation.

Simultaneous vascularized bone marrow transplantation to promote acceptance of hind limb allografts and its effects on central and peripheral chimerism.

The liver: a special case in transplantation tolerance.

Insulin resistance and liver injury in hepatitis C is not associated with virus-specific changes in adipocytokines.

Liver fibrosis: a balance of ACEs?

Combination adefovir-lamivudine prevents emergence of adefovir resistance in lamivudine-resistant hepatitis B.

Up-regulation of proproliferative genes and the ligand/receptor pair placental growth factor and vascular endothelial growth factor receptor 1 in hepatitis C cirrhosis.

Effect of ascites on bone density measurement in cirrhosis.

"I'll never touch it again, doctor!"--harmful drinking after liver transplantation.

Outcome of patients with hepatocellular carcinoma referred to a tertiary centre with availability of multiple treatment options including cadaveric liver transplantation.

Intrahepatic interferon-stimulated gene responses: can they predict treatment responses in chronic hepatitis C infection?

Fibroblast activation protein and chronic liver disease.

Inflammation and repair in viral hepatitis C.

Direct effects of alcohol on hepatic fibrinolytic balance: implications for alcoholic liver disease.

Heart allograft acceptance induced by anti-CD3 antibody in high-responder rats: effect on foxp3 and cytokine expression and graft infiltration.

Adrenal insufficiency and liver disease - Re-search.

Liver tolerance and the manipulation of immune outcomes.

Blocking indoleamine dioxygenase activity early after rat liver transplantation prevents long-term survival but does not cause acute rejection.

Hepatocellular carcinoma development requires hepatic stem cells with altered transforming growth factor and interleukin-6 signaling.

Intrahepatic murine CD8 T-cell activation associates with a distinct phenotype leading to Bim-dependent death.

A randomized study of adefovir dipivoxil in place of HBIG in combination with lamivudine as post-liver transplantation hepatitis B prophylaxis.

Overexpression of indoleamine dioxygenase in rat liver allografts using a high-efficiency adeno-associated virus vector does not prevent acute rejection.

Molecular and cellular aspects of hepatitis C virus reinfection after liver transplantation: how the early phase impacts on outcomes.

Gene therapy in transplantation.

Early high peak hepatitis C viral load levels independently predict hepatitis C-related liver failure post-liver transplantation.

The in vivo expression of dipeptidyl peptidases 8 and 9.

Impact of high-dose peginterferon alfa-2A on virological response rates in patients with hepatitis C genotype 1: a randomized controlled trial.

Bone marrow stem cells and the liver: are they relevant?

Donor and recipient selection leads to good patient and graft outcomes for right lobe split transplantation versus whole graft liver transplantation in adult recipients.

Donor IL-4-treatment induces alternatively activated liver macrophages and IDO-expressing NK cells and promotes rat liver allograft acceptance.

The dipeptidyl peptidase IV family in cancer and cell biology.

Minimal but significant improvement in survival for non-hepatitis C-related adult liver transplant patients beyond the one-year posttransplant mark.

Snipping away at hepatitis C.

Isolated liver transplantation in children with cystic fibrosis--an Australian experience.

Locoregional therapies for hepatocellular carcinoma: which patients are most likely to gain a survival advantage?

Pathogenesis of cholestatic hepatitis C.

Diabetes is a progression factor for hepatic fibrosis in a high fat fed mouse obesity model of non-alcoholic steatohepatitis.

Spontaneous acceptance of mouse kidney allografts is associated with increased Foxp3 expression and differences in the B and T cell compartments.

Discoidin domain receptor 1: isoform expression and potential functions in cirrhotic human liver.

Liver transplantation and hepatitis C: will understanding the interleukin-28B polymorphisms improve outcomes?

Virological response is associated with decline in hemoglobin concentration during pegylated interferon and ribavirin therapy in hepatitis C virus genotype 1.

Approaching the promise of operational tolerance in clinical transplantation.

A novel role of dipeptidyl peptidase 9 in epidermal growth factor signaling.

Feasibility of conducting a randomized control trial for liver cancer screening: is a randomized controlled trial for liver cancer screening feasible or still needed?

Hepatocyte entry leads to degradation of autoreactive CD8 T cells.

Prevention of post liver transplant HBV recurrence.

The long and the short of interferon-gamma-inducible protein 10 in hepatitis C virus infection.

Cancer risk after organ transplantation.

Tolerance in liver transplantation.

Two lymph nodes draining the mouse liver are the preferential site of DC migration and T cell activation.

Naïve CD8 T cell activation by liver bone marrow-derived cells leads to a "neglected" IL-2low Bimhigh phenotype, poor CTL function and cell death.

Is the end of chronic hepatitis C virus infection in sight?

Analysis of human liver disease using a cluster of differentiation (CD) antibody microarray.

Trekking new ground: overcoming medical and social impediments for extended criteria liver transplant recipients.

New therapies against HCV: expected risks and challenges associated with their use in the liver transplant setting.

Expression of common gamma chain signalling cytokines and their receptors distinguishes rejection from tolerance in a rat organ transplant model.

Early hepatocellular carcinoma - is there such a thing as too early?

Vitamin D status does not predict sustained virologic response or fibrosis stage in chronic hepatitis C genotype 1 infection.

Gene therapy for tolerance: high-level expression of donor major histocompatibility complex in the liver overcomes naive and memory alloresponses to skin grafts.

Combination of lamivudine and adefovir without hepatitis B immune globulin is safe and effective prophylaxis against hepatitis B virus recurrence in hepatitis B surface antigen-positive liver transplant candidates.

An international comparison of the effect of policy shifts to organ donation following cardiocirculatory death (DCD) on donation rates after brain death (DBD) and transplantation rates.

Regulation of dipeptidyl peptidase 8 and 9 expression in activated lymphocytes and injured liver.

Operational tolerance in liver transplantation: shall we predict or promote?

Differential migration of passenger leukocytes and rapid deletion of naive alloreactive CD8 T cells after mouse liver transplantation.

De novo malignant disease after liver transplantation? Risk and surveillance strategies.

Pentoxifylline-induced drug rash with eosinophilia and systemic symptoms (DRESS) in a patient with caffeine intolerance.

Nature and outcomes of the increased incidence of colorectal malignancy after liver transplantation in Australasia.

Distribution of interferon lambda-3 gene polymorphisms in Australian patients with previously untreated genotype 1 chronic hepatitis C: Analysis from the PREDICT and CHARIOT studies.

Beyond liver fibrosis: hepatic stellate cell senescence links obesity to liver cancer by way of the microbiome.

Quantitation of fibroblast activation protein (FAP)-specific protease activity in mouse, baboon and human fluids and organs.

ITPA genotype protects against anemia during peginterferon and ribavirin therapy but does not influence virological response.

A rare variant in human fibroblast activation protein associated with ER stress, loss of enzymatic function and loss of cell surface localisation.

Liver transplantation outcomes for Australian Aboriginal and Torres Strait Islanders.

Advances in and the future of treatments for hepatitis C.

Novel aspects of the liver microenvironment in hepatocellular carcinoma pathogenesis and development.

Antigen expression level threshold tunes the fate of CD8 T cells during primary hepatic immune responses.

Intrahepatic activation of naive CD4+ T cells by liver-resident phagocytic cells.

Hepatocyte produced matrix metalloproteinases are regulated by CD147 in liver fibrogenesis.

Is there such a thing as protocol immunosuppression in liver transplantation?

Professor Bruce Hall and the ABC.

Analysis of the intrahepatic ductular reaction and progenitor cell responses in hepatitis C virus recurrence after liver transplantation.

Osteopontin is an important mediator of alcoholic liver disease via hepatic stellate cell activation.

Circulating dipeptidyl peptidase-4 activity correlates with measures of hepatocyte apoptosis and fibrosis in non-alcoholic fatty liver disease in type 2 diabetes mellitus and obesity: A dual cohort cross-sectional study.

Hepatic artery stenosis after liver transplantation: is endovascular treatment always necessary?

Dipeptidyl peptidase 9 subcellular localization and a role in cell adhesion involving focal adhesion kinase and paxillin.

Interleukin-28B rs12979860 C allele: Protective against advanced fibrosis in chronic hepatitis C genotype 1 infection.

Analysis of Post-Liver Transplant Hepatitis C Virus Recurrence Using Serial Cluster of Differentiation Antibody Microarrays.

Could The Morning After liver transplant be immunologically interesting?

Immune outcomes in the liver: Is CD8 T cell fate determined by the environment?

APASL consensus statements and management algorithms for hepatitis C virus infection.

Longitudinal dose and type of immunosuppression in a national cohort of Australian liver, heart, and lung transplant recipients, 1984-2006.

An association of large-fibre peripheral nerve dysfunction with non-invasive measures of liver fibrosis secondary to non-alcoholic fatty liver disease in diabetes.

Circulating CD147 predicts mortality in advanced hepatocellular carcinoma.

Additive impact of pre-liver transplant metabolic factors on survival post-liver transplant.

Deletion of sphingosine kinase 1 ameliorates hepatic steatosis in diet-induced obese mice: Role of PPARγ.

Neuropeptide Y is a physiological substrate of fibroblast activation protein: Enzyme kinetics in blood plasma and expression of Y2R and Y5R in human liver cirrhosis and hepatocellular carcinoma.

High azathioprine dose and lip cancer risk in liver, heart, and lung transplant recipients: A population-based cohort study.

Alcoholic Liver Disease in Asia, Europe, and North America.

Effector T cell function rather than survival determines extent and duration of hepatitis in mice.

Dipeptidyl peptidase 9 enzymatic activity influences the expression of neonatal metabolic genes.

Liver transplantation in Australia and New Zealand.

Iatrogenic immunosuppression and risk of non-Hodgkin lymphoma in solid organ transplantation: A population-based cohort study in Australia.

Divergent Inflammatory, Fibrogenic, and Liver Progenitor Cell Dynamics in Two Common Mouse Models of Chronic Liver Injury.

Midkine Increases Diagnostic Yield in AFP Negative and NASH-Related Hepatocellular Carcinoma.

Accumulation of Deleterious Passenger Mutations Is Associated with the Progression of Hepatocellular Carcinoma.

The CD8 T-cell response during tolerance induction in liver transplantation.

The pro-fibrotic role of dipeptidyl peptidase 4 in carbon tetrachloride-induced experimental liver injury.

Can response to locoregional therapy help predict longterm survival after liver transplantation for hepatocellular carcinoma? A systematic review.

Postreperfusion microcirculatory derangements after liver transplantation: Relationship to hemodynamics, serum mediators, and outcome.

An update on the pathophysiology and management of polycystic liver disease.

Patients with non-viral liver disease have a greater tumor burden and less curative treatment options when diagnosed with hepatocellular carcinoma.

Circulating fibroblast activation protein activity and antigen levels correlate strongly when measured in liver disease and coronary heart disease.

Targeting the vasculature in hepatocellular carcinoma treatment: Starving versus normalizing blood supply.

Interactions between primary sclerosing cholangitis and inflammatory bowel disease: implications in the adult liver transplant setting.

Sclerosing peritonitis post liver transplantation: a rare condition where surgery is an important treatment option.

A Liver Capsular Network of Monocyte-Derived Macrophages Restricts Hepatic Dissemination of Intraperitoneal Bacteria by Neutrophil Recruitment.