Institute for Integrated Cell-Material Sciences (WPI-iCeMS),
Institute for Chemical Research
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[Small molecules that control gene expression].
Seikagaku. The Journal of Japanese Biochemical Society Sep, 2005 | Pubmed ID: 16241004
Synthesis of synthetic small molecule transcription factors (STF).
Nucleic acids symposium series (2004) , 2006 | Pubmed ID: 17150801
Wrenchnolol derivative optimized for gene activation in cells.
Journal of the American Chemical Society Apr, 2009 | Pubmed ID: 19290630
A dumbbell-shaped small molecule that promotes cell adhesion and growth.
Chemistry & biology 07, 2009 | Pubmed ID: 19635414
A small molecule that blocks fat synthesis by inhibiting the activation of SREBP.
Chemistry & biology Aug, 2009 | Pubmed ID: 19716478
Biochemical target isolation for novices: affinity-based strategies.
Chemistry & biology Jun, 2010 | Pubmed ID: 20609411
Deactivation of STAT6 through serine 707 phosphorylation by JNK.
The Journal of biological chemistry Feb, 2011 | Pubmed ID: 21123173
Marine natural product aurilide activates the OPA1-mediated apoptosis by binding to prohibitin.
Chemistry & biology Jan, 2011 | Pubmed ID: 21276946
A novel screen using the Reck tumor suppressor gene promoter detects both conventional and metastasis-suppressing anticancer drugs.
Oncotarget Aug, 2010 | Pubmed ID: 21304177
Chemical library screening identifies a small molecule that downregulates SOD1 transcription for drugs to treat amyotrophic lateral sclerosis.
Journal of biomolecular screening Apr, 2011 | Pubmed ID: 21364087
Small-molecule fluorescent probes for specific RNA targets.
Chemical communications (Cambridge, England) Apr, 2011 | Pubmed ID: 21412566
A mitochondrial surface-specific fluorescent probe activated by bioconversion.
Angewandte Chemie (International ed. in English) Jun, 2011 | Pubmed ID: 21542076
Synthesis and evaluation of diarylthiazole derivatives that inhibit activation of sterol regulatory element-binding proteins.
Journal of medicinal chemistry Jul, 2011 | Pubmed ID: 21561152
Translational repression stabilizes messenger RNA of autophagy-related genes.
Genes to cells : devoted to molecular & cellular mechanisms Aug, 2011 | Pubmed ID: 21790910
[Control and analysis of cells by synthetic small molecules].
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan , 2012 | Pubmed ID: 22687693
Mislocalization and inhibition of acetyl-CoA carboxylase 1 by a synthetic small molecule.
The Biochemical journal Dec, 2012 | Pubmed ID: 23067267
A small molecule that promotes cardiac differentiation of human pluripotent stem cells under defined, cytokine- and xeno-free conditions.
Cell reports Nov, 2012 | Pubmed ID: 23103164
Identification of small molecules that promote human embryonic stem cell self-renewal.
Biochemical and biophysical research communications May, 2013 | Pubmed ID: 23541943
Small-molecule-induced clustering of heparan sulfate promotes cell adhesion.
Journal of the American Chemical Society Jul, 2013 | Pubmed ID: 23822587
VMAT2 identified as a regulator of late-stage β-cell differentiation.
Nature chemical biology Feb, 2014 | Pubmed ID: 24316738
Efficient and rapid induction of human iPSCs/ESCs into nephrogenic intermediate mesoderm using small molecule-based differentiation methods.
PloS one , 2014 | Pubmed ID: 24454758
A chemical probe that labels human pluripotent stem cells.
Cell reports Mar, 2014 | Pubmed ID: 24613351
Selective elimination of human pluripotent stem cells by a marine natural product derivative.
Journal of the American Chemical Society Jul, 2014 | Pubmed ID: 24992689
Synthetic molecules that protect cells from anoikis and their use in cell transplantation.
Angewandte Chemie (International ed. in English) Oct, 2014 | Pubmed ID: 25196666
Live-cell imaging of endogenous mRNAs with a small molecule.
Angewandte Chemie (International ed. in English) Feb, 2015 | Pubmed ID: 25537455
A Potent and Site-Selective Agonist of TRPA1.
Journal of the American Chemical Society Dec, 2015 | Pubmed ID: 26630251
Intracellular Generation of a Diterpene-Peptide Conjugate that Inhibits 14-3-3-Mediated Interactions.
Journal of the American Chemical Society Dec, 2015 | Pubmed ID: 26632868
Dopamine D2 Receptor-Mediated Regulation of Pancreatic β Cell Mass.
Stem cell reports 07, 2016 | Pubmed ID: 27373926
A Synthetic Hybrid Molecule for the Selective Removal of Human Pluripotent Stem Cells from Cell Mixtures.
Angewandte Chemie (International ed. in English) Feb, 2017 | Pubmed ID: 28067441
Vitamin D Metabolite, 25-Hydroxyvitamin D, Regulates Lipid Metabolism by Inducing Degradation of SREBP/SCAP.
Cell chemical biology Feb, 2017 | Pubmed ID: 28132894
Microfluidic-Nanofiber Hybrid Array for Screening of Cellular Microenvironments.
Small (Weinheim an der Bergstrasse, Germany) May, 2017 | Pubmed ID: 28272774
Ivermectin activates GIRK channels in a PIP -dependent, G -independent manner and an amino acid residue at the slide helix governs the activation.
The Journal of physiology Sep, 2017 | Pubmed ID: 28715108
Recent developments for introducing a hexafluoroisopropanol unit into the Vitamin D side chain.
The Journal of steroid biochemistry and molecular biology Mar, 2018 | Pubmed ID: 28716761
Impact of extracellular matrix on engraftment and maturation of pluripotent stem cell-derived cardiomyocytes in a rat myocardial infarct model.
Scientific reports Aug, 2017 | Pubmed ID: 28819182
Method for Imaging Live-Cell RNA Using an RNA Aptamer and a Fluorescent Probe.
Methods in molecular biology (Clifton, N.J.) , 2018 | Pubmed ID: 29130206
Adrenergic receptor agonists induce the differentiation of pluripotent stem cell-derived hepatoblasts into hepatocyte-like cells.
Scientific reports Dec, 2017 | Pubmed ID: 29196668
Chemical decontamination of iPS cell-derived neural cell mixtures.
Chemical communications (Cambridge, England) Feb, 2018 | Pubmed ID: 29350722
Small-molecule screening yields a compound that inhibits the cancer-associated transcription factor Hes1 via the PHB2 chaperone.
The Journal of biological chemistry Mar, 2018 | Pubmed ID: 29523683
Live-cell imaging of multiple endogenous mRNAs permits the direct observation of RNA granule dynamics.
Chemical communications (Cambridge, England) Jun, 2018 | Pubmed ID: 29882951
Yasumasa Mashimo1,2,
Momoko Yoshioka1,
Yumie Tokunaga1,
Christopher Fockenberg1,
Shiho Terada1,
Yoshie Koyama1,
Teiko Shibata-Seki2,
Koki Yoshimoto1,
Risako Sakai1,
Hayase Hakariya1,
Li Liu1,
Toshihiro Akaike3,
Eiry Kobatake2,
Siew-Eng How4,
Motonari Uesugi1,5,
Yong Chen1,6,
Ken-ichiro Kamei1
1Institute for Integrated Cell-Material Sciences (WPI-iCeMS), Kyoto University,
2Department of Life Science and Technology, School of Life Science and Technology, Tokyo Institute of Technology,
3Biomaterials Center for Regenerative Medical Engineering, Foundation for Advancement of International Science,
4Faculty of Science and Natural Resources, Universiti Malaysia Sabah,
5Institute for Chemical Research, Kyoto University,
6, Ecole Normale Supérieure
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