Motonari Uesugi

[Small molecules that control gene expression].

Synthesis of synthetic small molecule transcription factors (STF).

Wrenchnolol derivative optimized for gene activation in cells.

A dumbbell-shaped small molecule that promotes cell adhesion and growth.

A small molecule that blocks fat synthesis by inhibiting the activation of SREBP.

Biochemical target isolation for novices: affinity-based strategies.

Deactivation of STAT6 through serine 707 phosphorylation by JNK.

Marine natural product aurilide activates the OPA1-mediated apoptosis by binding to prohibitin.

A novel screen using the Reck tumor suppressor gene promoter detects both conventional and metastasis-suppressing anticancer drugs.

Chemical library screening identifies a small molecule that downregulates SOD1 transcription for drugs to treat amyotrophic lateral sclerosis.

Small-molecule fluorescent probes for specific RNA targets.

A mitochondrial surface-specific fluorescent probe activated by bioconversion.

Synthesis and evaluation of diarylthiazole derivatives that inhibit activation of sterol regulatory element-binding proteins.

Translational repression stabilizes messenger RNA of autophagy-related genes.

[Control and analysis of cells by synthetic small molecules].

Mislocalization and inhibition of acetyl-CoA carboxylase 1 by a synthetic small molecule.

A small molecule that promotes cardiac differentiation of human pluripotent stem cells under defined, cytokine- and xeno-free conditions.

Identification of small molecules that promote human embryonic stem cell self-renewal.

Small-molecule-induced clustering of heparan sulfate promotes cell adhesion.

VMAT2 identified as a regulator of late-stage β-cell differentiation.

Efficient and rapid induction of human iPSCs/ESCs into nephrogenic intermediate mesoderm using small molecule-based differentiation methods.

A chemical probe that labels human pluripotent stem cells.

Selective elimination of human pluripotent stem cells by a marine natural product derivative.

Synthetic molecules that protect cells from anoikis and their use in cell transplantation.

Live-cell imaging of endogenous mRNAs with a small molecule.

A Potent and Site-Selective Agonist of TRPA1.

Intracellular Generation of a Diterpene-Peptide Conjugate that Inhibits 14-3-3-Mediated Interactions.

Dopamine D2 Receptor-Mediated Regulation of Pancreatic β Cell Mass.

A Synthetic Hybrid Molecule for the Selective Removal of Human Pluripotent Stem Cells from Cell Mixtures.

Vitamin D Metabolite, 25-Hydroxyvitamin D, Regulates Lipid Metabolism by Inducing Degradation of SREBP/SCAP.

Microfluidic-Nanofiber Hybrid Array for Screening of Cellular Microenvironments.

Ivermectin activates GIRK channels in a PIP -dependent, G -independent manner and an amino acid residue at the slide helix governs the activation.

Recent developments for introducing a hexafluoroisopropanol unit into the Vitamin D side chain.

Impact of extracellular matrix on engraftment and maturation of pluripotent stem cell-derived cardiomyocytes in a rat myocardial infarct model.

Method for Imaging Live-Cell RNA Using an RNA Aptamer and a Fluorescent Probe.

Adrenergic receptor agonists induce the differentiation of pluripotent stem cell-derived hepatoblasts into hepatocyte-like cells.

Chemical decontamination of iPS cell-derived neural cell mixtures.

Small-molecule screening yields a compound that inhibits the cancer-associated transcription factor Hes1 via the PHB2 chaperone.

Live-cell imaging of multiple endogenous mRNAs permits the direct observation of RNA granule dynamics.