Department of Psychiatry & Behavioral Sciences,
Center for Therapeutic Innovation,
Center for Therapeutic Innovation and Department of Psychiatry & Behavioral Sciences
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Knockdown of BACE1-AS Nonprotein-Coding Transcript Modulates Beta-Amyloid-Related Hippocampal Neurogenesis.
International journal of Alzheimer's disease , 2011 | Pubmed ID: 21785702
MicroRNA-132 dysregulation in schizophrenia has implications for both neurodevelopment and adult brain function.
Proceedings of the National Academy of Sciences of the United States of America Feb, 2012 | Pubmed ID: 22315408
Inhibition of natural antisense transcripts in vivo results in gene-specific transcriptional upregulation.
Nature biotechnology Mar, 2012 | Pubmed ID: 22446693
Regulation of chromatin structure by long noncoding RNAs: focus on natural antisense transcripts.
Trends in genetics : TIG Aug, 2012 | Pubmed ID: 22541732
The Emerging Role of Non-Coding RNAs in Drug Addiction.
Frontiers in genetics , 2012 | Pubmed ID: 22737160
RNAi joins the "Singles Club".
Molecular therapy : the journal of the American Society of Gene Therapy Nov, 2012 | Pubmed ID: 23131851
Personalized medicine in psychiatry: problems and promises.
BMC medicine May, 2013 | Pubmed ID: 23680237
Targeting long non-coding RNA to therapeutically upregulate gene expression.
Nature reviews. Drug discovery Jun, 2013 | Pubmed ID: 23722346
Amygdala-Dependent Fear Is Regulated by Oprl1 in Mice and Humans with PTSD.
Science translational medicine Jun, 2013 | Pubmed ID: 23740899
Regulation of the Apolipoprotein Gene Cluster by a Long Noncoding RNA.
Cell reports Dec, 2013 | Pubmed ID: 24388749
Natural antisense transcripts.
Human molecular genetics Sep, 2014 | Pubmed ID: 24838284
I-BET151 selectively regulates IL-6 production.
Biochimica et biophysica acta Sep, 2014 | Pubmed ID: 24859008
Transcriptional repression of ER through hMAPK dependent histone deacetylation by class I HDACs.
Breast cancer research and treatment Sep, 2014 | Pubmed ID: 25129342
Emerging treatment strategies for glioblastoma multiforme.
EMBO molecular medicine Nov, 2014 | Pubmed ID: 25312641
The BET bromodomain inhibitor I-BET151 acts downstream of smoothened protein to abrogate the growth of hedgehog protein-driven cancers.
The Journal of biological chemistry Dec, 2014 | Pubmed ID: 25355313
HeatmapGenerator: high performance RNAseq and microarray visualization software suite to examine differential gene expression levels using an R and C++ hybrid computational pipeline.
Source code for biology and medicine , 2014 | Pubmed ID: 25550709
Natural antisense transcripts as therapeutic targets.
Drug discovery today. Therapeutic strategies , 2013 | Pubmed ID: 25580147
The Landscape of long noncoding RNA classification.
Trends in genetics : TIG May, 2015 | Pubmed ID: 25869999
Antisense RNA controls LRP1 Sense transcript expression through interaction with a chromatin-associated protein, HMGB2.
Cell reports May, 2015 | Pubmed ID: 25937287
Basic biology and therapeutic implications of lncRNA.
Advanced drug delivery reviews Jun, 2015 | Pubmed ID: 26024979
Bromodomain inhibitors regulate the C9ORF72 locus in ALS.
Experimental neurology Sep, 2015 | Pubmed ID: 26099177
The Bromodomain protein BRD4 controls HOTAIR, a long noncoding RNA essential for glioblastoma proliferation.
Proceedings of the National Academy of Sciences of the United States of America Jul, 2015 | Pubmed ID: 26111795
Screening for Small-Molecule Modulators of Long Noncoding RNA-Protein Interactions Using AlphaScreen.
Journal of biomolecular screening Oct, 2015 | Pubmed ID: 26173710
Epigenetic Readers of Lysine Acetylation Regulate Cocaine-Induced Plasticity.
The Journal of neuroscience : the official journal of the Society for Neuroscience Nov, 2015 | Pubmed ID: 26558777
C9orf72 promoter hypermethylation is reduced while hydroxymethylation is acquired during reprogramming of ALS patient cells.
Experimental neurology Mar, 2016 | Pubmed ID: 26746986
Orphan diseases: state of the drug discovery art.
Wiener medizinische Wochenschrift (1946) Jun, 2017 | Pubmed ID: 26819216
Transcriptomic Profiling of Extracellular RNAs Present in Cerebrospinal Fluid Identifies Differentially Expressed Transcripts in Parkinson's Disease.
Journal of Parkinson's disease , 2016 | Pubmed ID: 26889637
Altering the course of schizophrenia: progress and perspectives.
Nature reviews. Drug discovery 07, 2016 | Pubmed ID: 26939910
The long non-coding RNA FMR4 promotes proliferation of human neural precursor cells and epigenetic regulation of gene expression in trans.
Molecular and cellular neurosciences 07, 2016 | Pubmed ID: 27001315
Functional annotation of the vlinc class of non-coding RNAs using systems biology approach.
Nucleic acids research Apr, 2016 | Pubmed ID: 27001520
The BET-Bromodomain Inhibitor JQ1 Reduces Inflammation and Tau Phosphorylation at Ser396 in the Brain of the 3xTg Model of Alzheimer's Disease.
Current Alzheimer research , 2016 | Pubmed ID: 27117003
Upregulation of Haploinsufficient Gene Expression in the Brain by Targeting a Long Non-coding RNA Improves Seizure Phenotype in a Model of Dravet Syndrome.
EBioMedicine Jul, 2016 | Pubmed ID: 27333023
MicroScope: ChIP-seq and RNA-seq software analysis suite for gene expression heatmaps.
BMC bioinformatics Sep, 2016 | Pubmed ID: 27659774
Emerging Epigenetic Therapies in Neuroscience: Focus on Bromodomain-Containing Drug Targets.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 01, 2017 | Pubmed ID: 27909334
Ischemic Preconditioning Confers Epigenetic Repression of Mtor and Induction of Autophagy Through G9a-Dependent H3K9 Dimethylation.
Journal of the American Heart Association 12, 2016 | Pubmed ID: 28007739
How the strengths of Lisp-family languages facilitate building complex and flexible bioinformatics applications.
Briefings in bioinformatics 05, 2018 | Pubmed ID: 28040748
The FMR1 promoter is selectively hydroxymethylated in primary neurons of fragile X syndrome patients.
Human molecular genetics 11, 2016 | Pubmed ID: 28173181
Oligonucleotide therapies for disorders of the nervous system.
Nature biotechnology 03, 2017 | Pubmed ID: 28244991
shinyheatmap: Ultra fast low memory heatmap web interface for big data genomics.
PloS one , 2017 | Pubmed ID: 28493881
A C9ORF72 BAC mouse model recapitulates key epigenetic perturbations of ALS/FTD.
Molecular neurodegeneration 06, 2017 | Pubmed ID: 28606110
Oxytocin and social functioning.
Dialogues in clinical neuroscience 06, 2017 | Pubmed ID: 28867943
Cocaine alters Homer1 natural antisense transcript in the nucleus accumbens.
Molecular and cellular neurosciences 12, 2017 | Pubmed ID: 29055697
M344 promotes nonamyloidogenic amyloid precursor protein processing while normalizing Alzheimer's disease genes and improving memory.
Proceedings of the National Academy of Sciences of the United States of America 10, 2017 | Pubmed ID: 29073110
Gain of function of ASXL1 truncating protein in the pathogenesis of myeloid malignancies.
Blood Jan, 2018 | Pubmed ID: 29113963
Ex-vivo sensitivity profiling to guide clinical decision making in acute myeloid leukemia: A pilot study.
Leukemia research 01, 2018 | Pubmed ID: 29175379
Vitamin C Sensitizes Melanoma to BET Inhibitors.
Cancer research 01, 2018 | Pubmed ID: 29180474
Cocaine Exposure Increases Blood Pressure and Aortic Stiffness via the miR-30c-5p-Malic Enzyme 1-Reactive Oxygen Species Pathway.
Hypertension (Dallas, Tex. : 1979) Apr, 2018 | Pubmed ID: 29483230
Serum long noncoding RNA HOTAIR as a novel diagnostic and prognostic biomarker in glioblastoma multiforme.
Molecular cancer 03, 2018 | Pubmed ID: 29558959
Strategies to Annotate and Characterize Long Noncoding RNAs: Advantages and Pitfalls.
Trends in genetics : TIG Sep, 2018 | Pubmed ID: 30017313
Developments in lncRNA drug discovery: where are we heading?
Expert opinion on drug discovery Sep, 2018 | Pubmed ID: 30078338
EZH1 is an antipsychotic-sensitive epigenetic modulator of social and motivational behavior that is dysregulated in schizophrenia.
Neurobiology of disease Nov, 2018 | Pubmed ID: 30099093
Inhibition of HDAC3 reverses Alzheimer's disease-related pathologies in vitro and in the 3xTg-AD mouse model.
Proceedings of the National Academy of Sciences of the United States of America Nov, 2018 | Pubmed ID: 30397132
Enhancement of BDNF Expression and Memory by HDAC Inhibition Requires BET Bromodomain Reader Proteins.
The Journal of neuroscience : the official journal of the Society for Neuroscience 01, 2019 | Pubmed ID: 30504275
Drug and disease signature integration identifies synergistic combinations in glioblastoma.
Nature communications 12, 2018 | Pubmed ID: 30552330
HDAC Inhibitors Induce Expression and Promote Neurite Outgrowth in Human Neural Progenitor Cells-Derived Neurons.
International journal of molecular sciences Mar, 2019 | Pubmed ID: 30841499
Vitamin C supplementation expands the therapeutic window of BETi for triple negative breast cancer.
EBioMedicine May, 2019 | Pubmed ID: 30975544
Longevity-related molecular pathways are subject to midlife "switch" in humans.
Aging cell 08, 2019 | Pubmed ID: 31168962
Defective HNF4alpha-dependent gene expression as a driver of hepatocellular failure in alcoholic hepatitis.
Nature communications 07, 2019 | Pubmed ID: 31311938
Ovarian Cancer Treatment Stratification Using Drug Sensitivity Testing.
Anticancer research Aug, 2019 | Pubmed ID: 31366484
Dysregulation of the histone demethylase KDM6B in alcohol dependence is associated with epigenetic regulation of inflammatory signaling pathways.
Addiction biology Aug, 2019 | Pubmed ID: 31373129
The novel BET-CBP/p300 dual inhibitor NEO2734 is active in SPOP mutant and wild-type prostate cancer.
EMBO molecular medicine 11, 2019 | Pubmed ID: 31559706
Novel approach reveals genomic landscapes of single-strand DNA breaks with nucleotide resolution in human cells.
Nature communications 12, 2019 | Pubmed ID: 31862872
Dipeptide repeat proteins inhibit homology-directed DNA double strand break repair in C9ORF72 ALS/FTD.
Molecular neurodegeneration 02, 2020 | Pubmed ID: 32093728
Direct Administration and Gene Modulation Using Antisense Oligonucleotides Within the CNS.
Cellular and molecular neurobiology Jul, 2020 | Pubmed ID: 32656646
Amir Bagheri1,2,
Seyedeh Fatemeh Razavipour3,
Claes Wahlestedt2,
Seyed Javad Mowla1,
Mohammad Ali Faghihi2,4
1Department of Molecular Genetics, Faculty of Biological Sciences, Tarbiat Modares University,
2Center for Therapeutic Innovation and Department of Psychiatry & Behavioral Sciences, University of Miami Miller School of Medicine,
3Department of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine,
4, Persian BayanGene Research and Training Center
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