Claes Wahlestedt

Knockdown of BACE1-AS Nonprotein-Coding Transcript Modulates Beta-Amyloid-Related Hippocampal Neurogenesis.

MicroRNA-132 dysregulation in schizophrenia has implications for both neurodevelopment and adult brain function.

Inhibition of natural antisense transcripts in vivo results in gene-specific transcriptional upregulation.

Regulation of chromatin structure by long noncoding RNAs: focus on natural antisense transcripts.

The Emerging Role of Non-Coding RNAs in Drug Addiction.

RNAi joins the "Singles Club".

Personalized medicine in psychiatry: problems and promises.

Targeting long non-coding RNA to therapeutically upregulate gene expression.

Amygdala-Dependent Fear Is Regulated by Oprl1 in Mice and Humans with PTSD.

Regulation of the Apolipoprotein Gene Cluster by a Long Noncoding RNA.

Natural antisense transcripts.

I-BET151 selectively regulates IL-6 production.

Transcriptional repression of ER through hMAPK dependent histone deacetylation by class I HDACs.

Emerging treatment strategies for glioblastoma multiforme.

The BET bromodomain inhibitor I-BET151 acts downstream of smoothened protein to abrogate the growth of hedgehog protein-driven cancers.

HeatmapGenerator: high performance RNAseq and microarray visualization software suite to examine differential gene expression levels using an R and C++ hybrid computational pipeline.

Natural antisense transcripts as therapeutic targets.

The Landscape of long noncoding RNA classification.

Antisense RNA controls LRP1 Sense transcript expression through interaction with a chromatin-associated protein, HMGB2.

Basic biology and therapeutic implications of lncRNA.

Bromodomain inhibitors regulate the C9ORF72 locus in ALS.

The Bromodomain protein BRD4 controls HOTAIR, a long noncoding RNA essential for glioblastoma proliferation.

Screening for Small-Molecule Modulators of Long Noncoding RNA-Protein Interactions Using AlphaScreen.

Epigenetic Readers of Lysine Acetylation Regulate Cocaine-Induced Plasticity.

C9orf72 promoter hypermethylation is reduced while hydroxymethylation is acquired during reprogramming of ALS patient cells.

Orphan diseases: state of the drug discovery art.

Transcriptomic Profiling of Extracellular RNAs Present in Cerebrospinal Fluid Identifies Differentially Expressed Transcripts in Parkinson's Disease.

Altering the course of schizophrenia: progress and perspectives.

The long non-coding RNA FMR4 promotes proliferation of human neural precursor cells and epigenetic regulation of gene expression in trans.

Functional annotation of the vlinc class of non-coding RNAs using systems biology approach.

The BET-Bromodomain Inhibitor JQ1 Reduces Inflammation and Tau Phosphorylation at Ser396 in the Brain of the 3xTg Model of Alzheimer's Disease.

Upregulation of Haploinsufficient Gene Expression in the Brain by Targeting a Long Non-coding RNA Improves Seizure Phenotype in a Model of Dravet Syndrome.

MicroScope: ChIP-seq and RNA-seq software analysis suite for gene expression heatmaps.

Emerging Epigenetic Therapies in Neuroscience: Focus on Bromodomain-Containing Drug Targets.

Ischemic Preconditioning Confers Epigenetic Repression of Mtor and Induction of Autophagy Through G9a-Dependent H3K9 Dimethylation.

How the strengths of Lisp-family languages facilitate building complex and flexible bioinformatics applications.

The FMR1 promoter is selectively hydroxymethylated in primary neurons of fragile X syndrome patients.

Oligonucleotide therapies for disorders of the nervous system.

shinyheatmap: Ultra fast low memory heatmap web interface for big data genomics.

A C9ORF72 BAC mouse model recapitulates key epigenetic perturbations of ALS/FTD.

Oxytocin and social functioning.

Cocaine alters Homer1 natural antisense transcript in the nucleus accumbens.

M344 promotes nonamyloidogenic amyloid precursor protein processing while normalizing Alzheimer's disease genes and improving memory.

Gain of function of ASXL1 truncating protein in the pathogenesis of myeloid malignancies.

Ex-vivo sensitivity profiling to guide clinical decision making in acute myeloid leukemia: A pilot study.

Vitamin C Sensitizes Melanoma to BET Inhibitors.

Cocaine Exposure Increases Blood Pressure and Aortic Stiffness via the miR-30c-5p-Malic Enzyme 1-Reactive Oxygen Species Pathway.

Serum long noncoding RNA HOTAIR as a novel diagnostic and prognostic biomarker in glioblastoma multiforme.

Strategies to Annotate and Characterize Long Noncoding RNAs: Advantages and Pitfalls.

Developments in lncRNA drug discovery: where are we heading?

EZH1 is an antipsychotic-sensitive epigenetic modulator of social and motivational behavior that is dysregulated in schizophrenia.

Inhibition of HDAC3 reverses Alzheimer's disease-related pathologies in vitro and in the 3xTg-AD mouse model.

Enhancement of BDNF Expression and Memory by HDAC Inhibition Requires BET Bromodomain Reader Proteins.

Drug and disease signature integration identifies synergistic combinations in glioblastoma.

HDAC Inhibitors Induce Expression and Promote Neurite Outgrowth in Human Neural Progenitor Cells-Derived Neurons.

Vitamin C supplementation expands the therapeutic window of BETi for triple negative breast cancer.

Longevity-related molecular pathways are subject to midlife "switch" in humans.

Defective HNF4alpha-dependent gene expression as a driver of hepatocellular failure in alcoholic hepatitis.

Ovarian Cancer Treatment Stratification Using Drug Sensitivity Testing.

Dysregulation of the histone demethylase KDM6B in alcohol dependence is associated with epigenetic regulation of inflammatory signaling pathways.

The novel BET-CBP/p300 dual inhibitor NEO2734 is active in SPOP mutant and wild-type prostate cancer.

Novel approach reveals genomic landscapes of single-strand DNA breaks with nucleotide resolution in human cells.

Dipeptide repeat proteins inhibit homology-directed DNA double strand break repair in C9ORF72 ALS/FTD.

Direct Administration and Gene Modulation Using Antisense Oligonucleotides Within the CNS.