Department of Immunology,
Division of Hematology,
T Cell Engineering,
Department of Molecular Medicine
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Bone marrow findings of the newly described TEMPI syndrome: when erythrocytosis and plasma cell dyscrasia coexist.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc Mar, 2015 | Pubmed ID: 25216227
The Addition of the BTK Inhibitor Ibrutinib to Anti-CD19 Chimeric Antigen Receptor T Cells (CART19) Improves Responses against Mantle Cell Lymphoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 06, 2016 | Pubmed ID: 26819453
The Microbiome and Immune Regulation After Transplantation.
Transplantation Jan, 2017 | Pubmed ID: 27517729
Dual CD19 and CD123 targeting prevents antigen-loss relapses after CD19-directed immunotherapies.
The Journal of clinical investigation Aug, 2016 | Pubmed ID: 27571406
Chimeric Antigen Receptor T Cells and Hematopoietic Cell Transplantation: How Not to Put the CART Before the Horse.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation Feb, 2017 | Pubmed ID: 27638367
Pharmacovigilance during ibrutinib therapy for chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL) in routine clinical practice.
Leukemia & lymphoma 06, 2017 | Pubmed ID: 27820970
Optimized depletion of chimeric antigen receptor T cells in murine xenograft models of human acute myeloid leukemia.
Blood 04, 2017 | Pubmed ID: 28246194
Overcoming the Immunosuppressive Tumor Microenvironment of Hodgkin Lymphoma Using Chimeric Antigen Receptor T Cells.
Cancer discovery 10, 2017 | Pubmed ID: 28576927
Generating and Expanding Autologous Chimeric Antigen Receptor T Cells from Patients with Acute Myeloid Leukemia.
Methods in molecular biology (Clifton, N.J.) , 2017 | Pubmed ID: 28735493
Liver dysfunction in chronic lymphocytic leukemia: Prevalence, outcomes, and pathological findings.
American journal of hematology Dec, 2017 | Pubmed ID: 28940587
Next-Generation Chimeric Antigen Receptor T-Cell Therapy: Going off the Shelf.
BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy Dec, 2017 | Pubmed ID: 29143249
Outcomes of a large cohort of individuals with clinically ascertained high-count monoclonal B-cell lymphocytosis.
Haematologica 06, 2018 | Pubmed ID: 29419435
Genetic Inactivation of CD33 in Hematopoietic Stem Cells to Enable CAR T Cell Immunotherapy for Acute Myeloid Leukemia.
Cell 05, 2018 | Pubmed ID: 29856956
Autoimmune cytopenias in patients with chronic lymphocytic leukaemia treated with ibrutinib in routine clinical practice at an academic medical centre.
British journal of haematology 11, 2018 | Pubmed ID: 30117139
Chimeric Antigen Receptor T-Cells: Successful Translation of the First Cell and Gene Therapy From Bench to Bedside.
Clinical and translational science 11, 2018 | Pubmed ID: 30242965
GM-CSF inhibition reduces cytokine release syndrome and neuroinflammation but enhances CAR-T cell function in xenografts.
Blood Feb, 2019 | Pubmed ID: 30463995
IGH translocations in chronic lymphocytic leukemia: Clinicopathologic features and clinical outcomes.
American journal of hematology Mar, 2019 | Pubmed ID: 30575108
CAR T Cell Immunotherapy in Human and Veterinary Oncology: Changing the Odds Against Hematological Malignancies.
The AAPS journal Apr, 2019 | Pubmed ID: 30963322
Rapid disease progression following discontinuation of ibrutinib in patients with chronic lymphocytic leukemia treated in routine clinical practice.
Leukemia & lymphoma Apr, 2019 | Pubmed ID: 31014142
Management of cytokine release syndrome: an update on emerging antigen-specific T cell engaging immunotherapies.
Immunotherapy Jul, 2019 | Pubmed ID: 31161844
Clinical characteristics and outcomes of Richter transformation: Experience of 204 patients from a single center.
Haematologica Jun, 2019 | Pubmed ID: 31197071
Myeloid cell and cytokine interactions with chimeric antigen receptor-T-cell therapy: implication for future therapies.
Current opinion in hematology 01, 2020 | Pubmed ID: 31764168
Addition of venetoclax at time of progression in ibrutinib-treated patients with chronic lymphocytic leukemia: Combination therapy to prevent ibrutinib flare.
American journal of hematology 03, 2020 | Pubmed ID: 31788844
Baseline immune dysregulation in autologous stem cell transplant recipients is associated with a 'graft versus host'-like syndrome and poor outcomes.
Bone marrow transplantation 09, 2020 | Pubmed ID: 32161319
The impact of dose modification and temporary interruption of ibrutinib on outcomes of chronic lymphocytic leukemia patients in routine clinical practice.
Cancer medicine 05, 2020 | Pubmed ID: 32187452
A Graduate-Level Interdisciplinary Curriculum in CAR-T Cell Therapy.
Mayo Clinic proceedings. Innovations, quality & outcomes Apr, 2020 | Pubmed ID: 32280931
CAR T-cell therapy for the management of refractory/relapsed high-grade B-cell lymphoma: a practical overview.
Bone marrow transplantation 08, 2020 | Pubmed ID: 32305998
Human chimeric antigen receptor macrophages for cancer immunotherapy.
Nature biotechnology 08, 2020 | Pubmed ID: 32361713
Incidence and risk of tumor lysis syndrome in patients with relapsed chronic lymphocytic leukemia (CLL) treated with venetoclax in routine clinical practice.
Leukemia & lymphoma 10, 2020 | Pubmed ID: 32449401
Atrial fibrillation in patients with chronic lymphocytic leukemia (CLL) treated with ibrutinib: risk prediction, management, and clinical outcomes.
Annals of hematology Jan, 2021 | Pubmed ID: 32488603
Characteristics of late transplant-associated thrombotic microangiopathy in patients who underwent allogeneic hematopoietic stem cell transplantation.
American journal of hematology Jul, 2020 | Pubmed ID: 32618000
CRISPR Taking the Front Seat in Immunotherapy.
Journal of cellular immunology , 2020 | Pubmed ID: 32776020
Disease Flare During Temporary Interruption of Ibrutinib Therapy in Patients with Chronic Lymphocytic Leukemia.
The oncologist 11, 2020 | Pubmed ID: 32886416
Neurotoxicity and Cytokine Release Syndrome After Chimeric Antigen Receptor T Cell Therapy: Insights Into Mechanisms and Novel Therapies.
Frontiers in immunology , 2020 | Pubmed ID: 32983132
A Concise Review of Neurologic Complications Associated with Chimeric Antigen Receptor T-cell Immunotherapy.
Neurologic clinics 11, 2020 | Pubmed ID: 33040871
Anti-CD19 chimeric antigen receptor T-cell therapy in acute lymphocytic leukaemia: a systematic review and meta-analysis.
The Lancet. Haematology Nov, 2020 | Pubmed ID: 33091355
The role of 18F-FDG-PET in detecting Richter's transformation of chronic lymphocytic leukemia in patients receiving therapy with a B-cell receptor inhibitor.
Haematologica 11, 2020 | Pubmed ID: 33131260
GM-CSF Neutralization With Lenzilumab in Severe COVID-19 Pneumonia: A Case-Cohort Study.
Mayo Clinic proceedings 11, 2020 | Pubmed ID: 33153629
Leukemic extracellular vesicles induce chimeric antigen receptor T cell dysfunction in chronic lymphocytic leukemia.
Molecular therapy : the journal of the American Society of Gene Therapy 04, 2021 | Pubmed ID: 33388419
CART Cell Toxicities: New Insight into Mechanisms and Management.
Clinical hematology international Dec, 2020 | Pubmed ID: 33409484
CRISPR Takes the Front Seat in CART-Cell Development.
BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy Mar, 2021 | Pubmed ID: 33638865
Venetoclax treatment of patients with relapsed T-cell prolymphocytic leukemia.
Blood cancer journal 03, 2021 | Pubmed ID: 33654067
In Reply - Clinical Benefit of Lenzilumab in Cases of Coronavirus Disease 2019.
Mayo Clinic proceedings 03, 2021 | Pubmed ID: 33673930
Resistance to CART cell therapy: lessons learned from the treatment of hematological malignancies.
Leukemia & lymphoma 09, 2021 | Pubmed ID: 33682608
The prognostic significance of del6q23 in chronic lymphocytic leukemia.
American journal of hematology 06, 2021 | Pubmed ID: 33749852
CART cell imaging: Paving the way for success in CART cell therapy.
Molecular therapy oncolytics Mar, 2021 | Pubmed ID: 33816781
The CLL International Prognostic Index predicts outcomes in monoclonal B-cell lymphocytosis and Rai 0 CLL.
Blood 07, 2021 | Pubmed ID: 33876228
Distinct immune signatures in chronic lymphocytic leukemia and Richter syndrome.
Blood cancer journal 05, 2021 | Pubmed ID: 33972504
Development of a Clinically Relevant Reporter for Chimeric Antigen Receptor T-cell Expansion, Trafficking, and Toxicity.
Cancer immunology research 09, 2021 | Pubmed ID: 34244299
Cause of death in patients with newly diagnosed chronic lymphocytic leukemia (CLL) stratified by the CLL-International Prognostic Index.
Blood cancer journal 08, 2021 | Pubmed ID: 34354039
Humoral and cellular immune responses to recombinant herpes zoster vaccine in patients with chronic lymphocytic leukemia and monoclonal B cell lymphocytosis.
American journal of hematology 01, 2022 | Pubmed ID: 34699616
Differential transcriptomic profiling in ibrutinib-naïve versus ibrutinib-resistant Richter syndrome.
Hematological oncology Nov, 2021 | Pubmed ID: 34806797
Targeting Cancer-Associated Fibroblasts in the Bone Marrow Prevents Resistance to CART-Cell Therapy in Multiple Myeloma.
Blood Jan, 2022 | Pubmed ID: 35090171
Chronic lymphocytic leukemia (CLL) with Reed-Sternberg-like cells vs Classic Hodgkin lymphoma transformation of CLL: does this distinction matter?
Blood cancer journal 01, 2022 | Pubmed ID: 35091549
Challenges of CAR T-cell Therapy in CLL: Lessons Learned.
Experimental hematology Feb, 2022 | Pubmed ID: 35150777
GM-CSF disruption in CART cells modulates T cell activation and enhances CART cell anti-tumor activity.
Leukemia Jun, 2022 | Pubmed ID: 35440691
CAR-T Cell Therapy: the Efficacy and Toxicity Balance.
Current hematologic malignancy reports Feb, 2023 | Pubmed ID: 36763238
Chimeric antigen receptor T-cell therapy to target hematologic malignancies.
Cancer research Nov, 2014 | Pubmed ID: 25371415
Large B-cell transformation in nodular lymphocyte-predominant Hodgkin lymphoma: 40-year experience from a single institution.
Blood Apr, 2016 | Pubmed ID: 26837698
CAR T cell therapy and the tumor microenvironment: Current challenges and opportunities.
Molecular therapy oncolytics Jun, 2022 | Pubmed ID: 35434273
Serum B-Cell maturation antigen is an independent prognostic marker in previously untreated chronic lymphocytic leukemia.
Experimental hematology Jul, 2022 | Pubmed ID: 35525334
Role of CD19 Chimeric Antigen Receptor T Cells in Second-Line Large B Cell Lymphoma: Lessons from Phase 3 Trials. An Expert Panel Opinion from the American Society for Transplantation and Cellular Therapy.
Transplantation and cellular therapy Sep, 2022 | Pubmed ID: 35768052
Combined ibrutinib and venetoclax for treatment of patients with ibrutinib-resistant or double-refractory chronic lymphocytic leukaemia.
British journal of haematology Oct, 2022 | Pubmed ID: 35841338
Therapy-related myeloid neoplasms following chimeric antigen receptor T-cell therapy for Non-Hodgkin Lymphoma.
Blood cancer journal Jul, 2022 | Pubmed ID: 35882844
Clinical outcomes in patients with chronic lymphocytic leukemia with disease progression on ibrutinib.
Blood cancer journal Sep, 2022 | Pubmed ID: 36050317
Lisocabtagene maraleucel in chronic lymphocytic leukaemia and small lymphocytic lymphoma (TRANSCEND CLL 004): a multicentre, open-label, single-arm, phase 1-2 study.
Lancet (London, England) Aug, 2023 | Pubmed ID: 37295445
AXL Inhibition Improves the Antitumor Activity of Chimeric Antigen Receptor T Cells.
Cancer immunology research Sep, 2023 | Pubmed ID: 37378662
Safety of radiotherapy for second primary malignancies in patients with chronic lymphocytic leukemia receiving concurrent novel agent treatment.
American journal of hematology Nov, 2023 | Pubmed ID: 37614209
Who wins the combat, CAR or TCR?
Leukemia Oct, 2023 | Pubmed ID: 37626090
CD19 occupancy with tafasitamab increases therapeutic index of CART19 cell therapy and diminishes severity of CRS.
Blood Jan, 2024 | Pubmed ID: 37879074
Thyroid-stimulating hormone receptor (TSHR) as a target for imaging differentiated thyroid cancer.
Surgery Jan, 2024 | Pubmed ID: 37919223
Real-world associations of cytokine release syndrome and neurotoxicity with efficacy in patients receiving anti-CD-19 chimeric antigen receptor T-cell therapy for large B-cell lymphoma: the Mayo Clinic experience.
Leukemia & lymphoma Mar, 2024 | Pubmed ID: 38031734
Features and Factors Associated With Myeloid Neoplasms After Chimeric Antigen Receptor T-Cell Therapy.
JAMA oncology Apr, 2024 | Pubmed ID: 38386311
A multicenter study of venetoclax-based treatment for patients with Richter transformation of chronic lymphocytic leukemia.
Blood advances May, 2024 | Pubmed ID: 38537065
Mesenchymal stromal cells with chimaeric antigen receptors for enhanced immunosuppression.
Nature biomedical engineering Apr, 2024 | Pubmed ID: 38561490
Artificial Intelligence Electrocardiography to Predict Atrial Fibrillation in Patients With Chronic Lymphocytic Leukemia.
JACC. CardioOncology Apr, 2024 | Pubmed ID: 38774001
Clonal dynamics of Richter transformation in chronic lymphocytic leukemia.
Hematological oncology Jul, 2024 | Pubmed ID: 38852069
PET Imaging of Differentiated Thyroid Cancer with TSHR-Targeted [Zr]Zr-TR1402.
Molecular pharmaceutics Aug, 2024 | Pubmed ID: 38976794
Chimeric antigen receptor T-cell therapy associated hemophagocytic lymphohistiocytosis syndrome: clinical presentation, outcomes, and management.
Blood cancer journal Aug, 2024 | Pubmed ID: 39134524
IL-4 drives exhaustion of CD8 CART cells.
Nature communications Sep, 2024 | Pubmed ID: 39266501
Bioengineering MSCs for untapped therapeutic potential.
Immunotherapy , 2024 | Pubmed ID: 39268677
Incidence, risk factors, and outcomes of patients with monoclonal B-cell lymphocytosis and chronic lymphocytic leukemia who develop venous thromboembolism.
Journal of thrombosis and haemostasis : JTH Jan, 2025 | Pubmed ID: 39343103
Incidence of Richter transformation of chronic lymphocytic leukemia/small lymphocytic lymphoma in the targeted therapy era.
Leukemia Dec, 2024 | Pubmed ID: 39658628
Chronic Lymphocytic Leukemia Infiltrating in the Brain.
Cureus Nov, 2024 | Pubmed ID: 39712843
Claudia Manriquez Roman1,2,3,4,5,
R. Leo Sakemura1,2,
Brooke L. Kimball1,2,
Fang Jin6,
Roman H. Khadka6,
Mohamad M. Adada1,2,
Elizabeth L. Siegler1,2,
Aaron J. Johnson6,
Saad S. Kenderian1,2,6
1T Cell Engineering Laboratory, Mayo Clinic, Rochester,
2Division of Hematology, Mayo Clinic, Rochester,
3Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic, Rochester,
4Department of Molecular Medicine, Mayo Clinic, Rochester,
5Regenerative Sciences PhD Program, Mayo Clinic, Rochester,
6Department of Immunology, Mayo Clinic, Rochester
1T Cell Engineering, Mayo Clinic,
2Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic,
3Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic,
4Center for Regenerative Biotherapeutics, Mayo Clinic,
5Division of Hematology, Mayo Clinic,
6Department of Immunology, Mayo Clinic
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