Department of Immunology,
Division of Hematology,
T Cell Engineering,
Department of Molecular Medicine
Saad S. Kenderian has not added Biography.
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Bone marrow findings of the newly described TEMPI syndrome: when erythrocytosis and plasma cell dyscrasia coexist.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc Mar, 2015 | Pubmed ID: 25216227
The Addition of the BTK Inhibitor Ibrutinib to Anti-CD19 Chimeric Antigen Receptor T Cells (CART19) Improves Responses against Mantle Cell Lymphoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 06, 2016 | Pubmed ID: 26819453
The Microbiome and Immune Regulation After Transplantation.
Transplantation Jan, 2017 | Pubmed ID: 27517729
Dual CD19 and CD123 targeting prevents antigen-loss relapses after CD19-directed immunotherapies.
The Journal of clinical investigation Aug, 2016 | Pubmed ID: 27571406
Chimeric Antigen Receptor T Cells and Hematopoietic Cell Transplantation: How Not to Put the CART Before the Horse.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation Feb, 2017 | Pubmed ID: 27638367
Pharmacovigilance during ibrutinib therapy for chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL) in routine clinical practice.
Leukemia & lymphoma 06, 2017 | Pubmed ID: 27820970
Optimized depletion of chimeric antigen receptor T cells in murine xenograft models of human acute myeloid leukemia.
Blood 04, 2017 | Pubmed ID: 28246194
Overcoming the Immunosuppressive Tumor Microenvironment of Hodgkin Lymphoma Using Chimeric Antigen Receptor T Cells.
Cancer discovery 10, 2017 | Pubmed ID: 28576927
Generating and Expanding Autologous Chimeric Antigen Receptor T Cells from Patients with Acute Myeloid Leukemia.
Methods in molecular biology (Clifton, N.J.) , 2017 | Pubmed ID: 28735493
Liver dysfunction in chronic lymphocytic leukemia: Prevalence, outcomes, and pathological findings.
American journal of hematology Dec, 2017 | Pubmed ID: 28940587
Next-Generation Chimeric Antigen Receptor T-Cell Therapy: Going off the Shelf.
BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy Dec, 2017 | Pubmed ID: 29143249
Outcomes of a large cohort of individuals with clinically ascertained high-count monoclonal B-cell lymphocytosis.
Haematologica 06, 2018 | Pubmed ID: 29419435
Genetic Inactivation of CD33 in Hematopoietic Stem Cells to Enable CAR T Cell Immunotherapy for Acute Myeloid Leukemia.
Cell 05, 2018 | Pubmed ID: 29856956
Autoimmune cytopenias in patients with chronic lymphocytic leukaemia treated with ibrutinib in routine clinical practice at an academic medical centre.
British journal of haematology 11, 2018 | Pubmed ID: 30117139
Chimeric Antigen Receptor T-Cells: Successful Translation of the First Cell and Gene Therapy From Bench to Bedside.
Clinical and translational science 11, 2018 | Pubmed ID: 30242965
GM-CSF inhibition reduces cytokine release syndrome and neuroinflammation but enhances CAR-T cell function in xenografts.
Blood Feb, 2019 | Pubmed ID: 30463995
IGH translocations in chronic lymphocytic leukemia: Clinicopathologic features and clinical outcomes.
American journal of hematology Mar, 2019 | Pubmed ID: 30575108
CAR T Cell Immunotherapy in Human and Veterinary Oncology: Changing the Odds Against Hematological Malignancies.
The AAPS journal Apr, 2019 | Pubmed ID: 30963322
Rapid disease progression following discontinuation of ibrutinib in patients with chronic lymphocytic leukemia treated in routine clinical practice.
Leukemia & lymphoma Apr, 2019 | Pubmed ID: 31014142
Management of cytokine release syndrome: an update on emerging antigen-specific T cell engaging immunotherapies.
Immunotherapy Jul, 2019 | Pubmed ID: 31161844
Clinical characteristics and outcomes of Richter transformation: Experience of 204 patients from a single center.
Haematologica Jun, 2019 | Pubmed ID: 31197071
Myeloid cell and cytokine interactions with chimeric antigen receptor-T-cell therapy: implication for future therapies.
Current opinion in hematology 01, 2020 | Pubmed ID: 31764168
Addition of venetoclax at time of progression in ibrutinib-treated patients with chronic lymphocytic leukemia: Combination therapy to prevent ibrutinib flare.
American journal of hematology 03, 2020 | Pubmed ID: 31788844
Baseline immune dysregulation in autologous stem cell transplant recipients is associated with a 'graft versus host'-like syndrome and poor outcomes.
Bone marrow transplantation 09, 2020 | Pubmed ID: 32161319
The impact of dose modification and temporary interruption of ibrutinib on outcomes of chronic lymphocytic leukemia patients in routine clinical practice.
Cancer medicine 05, 2020 | Pubmed ID: 32187452
A Graduate-Level Interdisciplinary Curriculum in CAR-T Cell Therapy.
Mayo Clinic proceedings. Innovations, quality & outcomes Apr, 2020 | Pubmed ID: 32280931
CAR T-cell therapy for the management of refractory/relapsed high-grade B-cell lymphoma: a practical overview.
Bone marrow transplantation 08, 2020 | Pubmed ID: 32305998
Human chimeric antigen receptor macrophages for cancer immunotherapy.
Nature biotechnology 08, 2020 | Pubmed ID: 32361713
Incidence and risk of tumor lysis syndrome in patients with relapsed chronic lymphocytic leukemia (CLL) treated with venetoclax in routine clinical practice.
Leukemia & lymphoma 10, 2020 | Pubmed ID: 32449401
Atrial fibrillation in patients with chronic lymphocytic leukemia (CLL) treated with ibrutinib: risk prediction, management, and clinical outcomes.
Annals of hematology Jan, 2021 | Pubmed ID: 32488603
Characteristics of late transplant-associated thrombotic microangiopathy in patients who underwent allogeneic hematopoietic stem cell transplantation.
American journal of hematology Jul, 2020 | Pubmed ID: 32618000
CRISPR Taking the Front Seat in Immunotherapy.
Journal of cellular immunology , 2020 | Pubmed ID: 32776020
Disease Flare During Temporary Interruption of Ibrutinib Therapy in Patients with Chronic Lymphocytic Leukemia.
The oncologist 11, 2020 | Pubmed ID: 32886416
Neurotoxicity and Cytokine Release Syndrome After Chimeric Antigen Receptor T Cell Therapy: Insights Into Mechanisms and Novel Therapies.
Frontiers in immunology , 2020 | Pubmed ID: 32983132
A Concise Review of Neurologic Complications Associated with Chimeric Antigen Receptor T-cell Immunotherapy.
Neurologic clinics 11, 2020 | Pubmed ID: 33040871
Anti-CD19 chimeric antigen receptor T-cell therapy in acute lymphocytic leukaemia: a systematic review and meta-analysis.
The Lancet. Haematology Nov, 2020 | Pubmed ID: 33091355
The role of 18F-FDG-PET in detecting Richter's transformation of chronic lymphocytic leukemia in patients receiving therapy with a B-cell receptor inhibitor.
Haematologica 11, 2020 | Pubmed ID: 33131260
GM-CSF Neutralization With Lenzilumab in Severe COVID-19 Pneumonia: A Case-Cohort Study.
Mayo Clinic proceedings 11, 2020 | Pubmed ID: 33153629
Leukemic extracellular vesicles induce chimeric antigen receptor T cell dysfunction in chronic lymphocytic leukemia.
Molecular therapy : the journal of the American Society of Gene Therapy 04, 2021 | Pubmed ID: 33388419
CART Cell Toxicities: New Insight into Mechanisms and Management.
Clinical hematology international Dec, 2020 | Pubmed ID: 33409484
CRISPR Takes the Front Seat in CART-Cell Development.
BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy Mar, 2021 | Pubmed ID: 33638865
Venetoclax treatment of patients with relapsed T-cell prolymphocytic leukemia.
Blood cancer journal 03, 2021 | Pubmed ID: 33654067
In Reply - Clinical Benefit of Lenzilumab in Cases of Coronavirus Disease 2019.
Mayo Clinic proceedings 03, 2021 | Pubmed ID: 33673930
Resistance to CART cell therapy: lessons learned from the treatment of hematological malignancies.
Leukemia & lymphoma 09, 2021 | Pubmed ID: 33682608
The prognostic significance of del6q23 in chronic lymphocytic leukemia.
American journal of hematology 06, 2021 | Pubmed ID: 33749852
CART cell imaging: Paving the way for success in CART cell therapy.
Molecular therapy oncolytics Mar, 2021 | Pubmed ID: 33816781
The CLL International Prognostic Index predicts outcomes in monoclonal B-cell lymphocytosis and Rai 0 CLL.
Blood 07, 2021 | Pubmed ID: 33876228
Distinct immune signatures in chronic lymphocytic leukemia and Richter syndrome.
Blood cancer journal 05, 2021 | Pubmed ID: 33972504
Development of a Clinically Relevant Reporter for Chimeric Antigen Receptor T-cell Expansion, Trafficking, and Toxicity.
Cancer immunology research 09, 2021 | Pubmed ID: 34244299
Cause of death in patients with newly diagnosed chronic lymphocytic leukemia (CLL) stratified by the CLL-International Prognostic Index.
Blood cancer journal 08, 2021 | Pubmed ID: 34354039
Humoral and cellular immune responses to recombinant herpes zoster vaccine in patients with chronic lymphocytic leukemia and monoclonal B cell lymphocytosis.
American journal of hematology 01, 2022 | Pubmed ID: 34699616
Differential transcriptomic profiling in ibrutinib-naïve versus ibrutinib-resistant Richter syndrome.
Hematological oncology Nov, 2021 | Pubmed ID: 34806797
Targeting Cancer-Associated Fibroblasts in the Bone Marrow Prevents Resistance to CART-Cell Therapy in Multiple Myeloma.
Blood Jan, 2022 | Pubmed ID: 35090171
Chronic lymphocytic leukemia (CLL) with Reed-Sternberg-like cells vs Classic Hodgkin lymphoma transformation of CLL: does this distinction matter?
Blood cancer journal 01, 2022 | Pubmed ID: 35091549
Challenges of CAR T-cell Therapy in CLL: Lessons Learned.
Experimental hematology Feb, 2022 | Pubmed ID: 35150777
GM-CSF disruption in CART cells modulates T cell activation and enhances CART cell anti-tumor activity.
Leukemia Jun, 2022 | Pubmed ID: 35440691
CAR-T Cell Therapy: the Efficacy and Toxicity Balance.
Current hematologic malignancy reports Feb, 2023 | Pubmed ID: 36763238
Claudia Manriquez Roman1,2,3,4,5,
R. Leo Sakemura1,2,
Brooke L. Kimball1,2,
Fang Jin6,
Roman H. Khadka6,
Mohamad M. Adada1,2,
Elizabeth L. Siegler1,2,
Aaron J. Johnson6,
Saad S. Kenderian1,2,6
1T Cell Engineering Laboratory, Mayo Clinic, Rochester,
2Division of Hematology, Mayo Clinic, Rochester,
3Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic, Rochester,
4Department of Molecular Medicine, Mayo Clinic, Rochester,
5Regenerative Sciences PhD Program, Mayo Clinic, Rochester,
6Department of Immunology, Mayo Clinic, Rochester
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