Department of Biochemistry
Takuro Miyazaki is an associate professor in the Department of Biochemistry, Showa University School of Medicine in Tokyo, Japan. He received his undergraduate from Showa University School of Pharmacy. He obtained His Ph.D. in 2009 from Showa University School of Pharmacy, with a thesis on calcium homeostasis and mechanotransduction in vascular endothelial cells. In 2011, he was recruited as faculty at Showa University School of Medicine.
His research interests are the field of intracellular protein catabolism, in particular their impact on vascular functions. He discovered that calpain-2, an intracellular calcium-dependent protease, in vascular endothelial cells associates with the pathogenesis of atherosclerosis (Miyazaki T et al. Circulation. 2011;124:2522-2532), and identified that calpain dysregulation is responsible for pathological angiogenesis, such as tumor angiogenesis and retinopathy (Miyazaki T et al. Circ Res. 2015;116:1170-1181). More recent, he identified that calpain-6, an atypical non-proteolytic calpain, participates in cholesterol uptake in macrophages, thereby accelerating atherosclerosis development (Miyazaki T et al. J Clin Invest. 2016;126:3417-3432).
His work has been awarded with several prestigious prizes, among them the Young Investigator’s Award of the Japan Atherosclerosis Society in 2012 and the Young Investigator’s Award of the Japanese Vascular Biology and Medicine Organization in 2013. He is councilor of the Japan Atherosclerosis Society and the Japanese Vascular Biology and Medicine Organization.
[Flow-induced Ca2+ transients regulate morphological changes in vascular endothelial cells via calpain-mediated proteolytic cleavage].
Nihon yakurigaku zasshi. Folia pharmacologica Japonica Oct, 2005 | Pubmed ID: 16327206
Requirement of Ca2+ influx- and phosphatidylinositol 3-kinase-mediated m-calpain activity for shear stress-induced endothelial cell polarity.
American journal of physiology. Cell physiology Oct, 2007 | Pubmed ID: 17596297
Modulation of Ca2+ transients in cultured endothelial cells in response to fluid flow through alphav integrin.
Life sciences Oct, 2007 | Pubmed ID: 17931663
m-Calpain antagonizes RhoA overactivation and endothelial barrier dysfunction under disturbed shear conditions.
Cardiovascular research Feb, 2010 | Pubmed ID: 19752040
Distinct effects of tissue-type plasminogen activator and SMTP-7 on cerebrovascular inflammation following thrombolytic reperfusion.
Stroke Apr, 2011 | Pubmed ID: 21350203
m-Calpain induction in vascular endothelial cells on human and mouse atheromas and its roles in VE-cadherin disorganization and atherosclerosis.
Circulation Dec, 2011 | Pubmed ID: 22064597
Hydrogen peroxide-inducible clone 5 (Hic-5) as a potential therapeutic target for vascular and other disorders.
Journal of atherosclerosis and thrombosis , 2012 | Pubmed ID: 22472216
Salusin-β accelerates inflammatory responses in vascular endothelial cells via NF-κB signaling in LDL receptor-deficient mice in vivo and HUVECs in vitro.
American journal of physiology. Heart and circulatory physiology Jul, 2012 | Pubmed ID: 22561298
Calpain and atherosclerosis.
Journal of atherosclerosis and thrombosis , 2013 | Pubmed ID: 23171729
Identification of Hic-5 as a novel scaffold for the MKK4/p54 JNK pathway in the development of abdominal aortic aneurysms.
Journal of the American Heart Association May, 2014 | Pubmed ID: 24811612
NADPH oxidase deficiency exacerbates angiotensin II-induced abdominal aortic aneurysms in mice.
Arteriosclerosis, thrombosis, and vascular biology Nov, 2014 | Pubmed ID: 25189573
Role of Hic-5 in the formation of microvilli-like structures and the monocyte-endothelial interaction that accelerates atherosclerosis.
Cardiovascular research Mar, 2015 | Pubmed ID: 25587044
Calpastatin counteracts pathological angiogenesis by inhibiting suppressor of cytokine signaling 3 degradation in vascular endothelial cells.
Circulation research Mar, 2015 | Pubmed ID: 25648699
Hic-5 deficiency attenuates the activation of hepatic stellate cells and liver fibrosis through upregulation of Smad7 in mice.
Journal of hepatology Jan, 2016 | Pubmed ID: 26334580
Proteolytic inactivation of anti-angiogenic vasohibin-1 by cancer cells.
Journal of biochemistry Oct, 2016 | Pubmed ID: 27169581
Functional Heterogeneity of Nadph Oxidases in Atherosclerotic and Aneurysmal Diseases.
Journal of atherosclerosis and thrombosis Jan, 2017 | Pubmed ID: 27476665
Calpain-6 confers atherogenicity to macrophages by dysregulating pre-mRNA splicing.
The Journal of clinical investigation 09, 2016 | Pubmed ID: 27525442
Emerging roles of calpain proteolytic systems in macrophage cholesterol handling.
Cellular and molecular life sciences : CMLS 08, 2017 | Pubmed ID: 28432377
Dysregulation of Calpain Proteolytic Systems Underlies Degenerative Vascular Disorders.
Journal of atherosclerosis and thrombosis Jan, 2018 | Pubmed ID: 28819082
The impact of stromal Hic-5 on the tumorigenesis of colorectal cancer through lysyl oxidase induction and stromal remodeling.
Oncogene 03, 2018 | Pubmed ID: 29242607
Expression of steroidogenic enzymes and metabolism of steroids in COS-7 cells known as non-steroidogenic cells.
Scientific reports 02, 2018 | Pubmed ID: 29391479
Impact of Dysfunctional Protein Catabolism on Macrophage Cholesterol Handling.
Current medicinal chemistry , 2019 | Pubmed ID: 29589525
Endothelial calpain systems orchestrate myofibroblast differentiation during wound healing.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology Feb, 2019 | Pubmed ID: 30199285
L-Leucine increases the daily body temperature and affords thermotolerance in broiler chicks.
Asian-Australasian journal of animal sciences Jun, 2019 | Pubmed ID: 30381734
Thrombolytic Therapy for Acute Ischemic Stroke: Past and Future.
Current pharmaceutical design , 2019 | Pubmed ID: 30892155
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