Takuro Miyazaki

[Flow-induced Ca2+ transients regulate morphological changes in vascular endothelial cells via calpain-mediated proteolytic cleavage].

Requirement of Ca2+ influx- and phosphatidylinositol 3-kinase-mediated m-calpain activity for shear stress-induced endothelial cell polarity.

Modulation of Ca2+ transients in cultured endothelial cells in response to fluid flow through alphav integrin.

m-Calpain antagonizes RhoA overactivation and endothelial barrier dysfunction under disturbed shear conditions.

Distinct effects of tissue-type plasminogen activator and SMTP-7 on cerebrovascular inflammation following thrombolytic reperfusion.

m-Calpain induction in vascular endothelial cells on human and mouse atheromas and its roles in VE-cadherin disorganization and atherosclerosis.

Hydrogen peroxide-inducible clone 5 (Hic-5) as a potential therapeutic target for vascular and other disorders.

Salusin-β accelerates inflammatory responses in vascular endothelial cells via NF-κB signaling in LDL receptor-deficient mice in vivo and HUVECs in vitro.

Calpain and atherosclerosis.

Identification of Hic-5 as a novel scaffold for the MKK4/p54 JNK pathway in the development of abdominal aortic aneurysms.

NADPH oxidase deficiency exacerbates angiotensin II-induced abdominal aortic aneurysms in mice.

Role of Hic-5 in the formation of microvilli-like structures and the monocyte-endothelial interaction that accelerates atherosclerosis.

Calpastatin counteracts pathological angiogenesis by inhibiting suppressor of cytokine signaling 3 degradation in vascular endothelial cells.

Hic-5 deficiency attenuates the activation of hepatic stellate cells and liver fibrosis through upregulation of Smad7 in mice.

Proteolytic inactivation of anti-angiogenic vasohibin-1 by cancer cells.

Functional Heterogeneity of Nadph Oxidases in Atherosclerotic and Aneurysmal Diseases.

Calpain-6 confers atherogenicity to macrophages by dysregulating pre-mRNA splicing.

Emerging roles of calpain proteolytic systems in macrophage cholesterol handling.

Dysregulation of Calpain Proteolytic Systems Underlies Degenerative Vascular Disorders.

The impact of stromal Hic-5 on the tumorigenesis of colorectal cancer through lysyl oxidase induction and stromal remodeling.

Expression of steroidogenic enzymes and metabolism of steroids in COS-7 cells known as non-steroidogenic cells.

Impact of Dysfunctional Protein Catabolism on Macrophage Cholesterol Handling.

Endothelial calpain systems orchestrate myofibroblast differentiation during wound healing.

L-Leucine increases the daily body temperature and affords thermotolerance in broiler chicks.

Thrombolytic Therapy for Acute Ischemic Stroke: Past and Future.