Wan L. Lam

Two-dimensional display and whole genome comparison of bacterial pathogen genomes of high G+C DNA content.

An efficient method for the assessment of DNA quality of archival microdissected specimens.

Two-dimensional bacterial genome display: a method for the genomic analysis of mycobacteria.

3p14 and 9p21 loss is a simple tool for predicting second oral malignancy at previously treated oral cancer sites.

Characterization of the recurrent translocation t(1;1)(p36.3;q21.1-2) in non-Hodgkin lymphoma by multicolor banding and fluorescence in situ hybridization analysis.

Novel regions of amplification on 8q distinct from the MYC locus and frequently altered in oral dysplasia and cancer.

Overexpression of LRP12, a gene contained within an 8q22 amplicon identified by high-resolution array CGH analysis of oral squamous cell carcinomas.

Use of complete coverage array comparative genomic hybridization to define copy number alterations on chromosome 3p in oral squamous cell carcinomas.

Methods for high throughput validation of amplified fragment pools of BAC DNA for constructing high resolution CGH arrays.

A tiling resolution DNA microarray with complete coverage of the human genome.

OCGR array: an oral cancer genomic regional array for comparative genomic hybridization analysis.

Delineation of a minimal region of deletion at 6q16.3 in follicular lymphoma and construction of a bacterial artificial chromosome contig spanning a 6-megabase region of 6q16-q21.

Genetic alteration and gene expression modulation during cancer progression.

SeeGH--a software tool for visualization of whole genome array comparative genomic hybridization data.

Serial analysis of gene expression profiles of developmental stages in non-small cell lung carcinoma.

Comprehensive whole genome array CGH profiling of mantle cell lymphoma model genomes.

High-resolution chromosome arm 5p array CGH analysis of small cell lung carcinoma cell lines.

Involvement of multiple developmental genes on chromosome 1p in lung tumorigenesis.

An integrated mBAND and submegabase resolution tiling set (SMRT) CGH array analysis of focal amplification, microdeletions, and ladder structures consistent with breakage-fusion-bridge cycle events in osteosarcoma.

Alteration of AKAP220, an upstream component of the Rb pathway, in oral carcinogenesis.

Array CGH technologies and their applications to cancer genomes.

Chromosome 5p aberrations are early events in lung cancer: implication of glial cell line-derived neurotrophic factor in disease progression.

High-resolution array CGH increases heterogeneity tolerance in the analysis of clinical samples.

Chromosome-wide and promoter-specific analyses identify sites of differential DNA methylation in normal and transformed human cells.

Gain of a region on 7p22.3, containing MAD1L1, is the most frequent event in small-cell lung cancer cell lines.

Multiple microalterations detected at high frequency in oral cancer.

Toluidine blue staining identifies high-risk primary oral premalignant lesions with poor outcome.

High resolution analysis of non-small cell lung cancer cell lines by whole genome tiling path array CGH.

Microarray-based CGH of sporadic and syndrome-related pheochromocytomas using a 0.1-0.2 Mb bacterial artificial chromosome array spanning chromosome arm 1p.

Recent advances in array comparative genomic hybridization technologies and their applications in human genetics.

A stepwise framework for the normalization of array CGH data.

Epigenomics: mapping the methylome.

Comprehensive copy number profiles of breast cancer cell model genomes.

Identification of novel lung genes in bronchial epithelium by serial analysis of gene expression.

Integrating copy number polymorphisms into array CGH analysis using a robust HMM.

Genomic alterations in lobular neoplasia: a microarray comparative genomic hybridization signature for early neoplastic proliferationin the breast.

Cytogenetically balanced translocations are associated with focal copy number alterations.

Whole genome tiling path array CGH analysis of segmental copy number alterations in cervical cancer cell lines.

Large fragment Bst DNA polymerase for whole genome amplification of DNA from formalin-fixed paraffin-embedded tissues.

A comprehensive analysis of common copy-number variations in the human genome.

SIGMA: a system for integrative genomic microarray analysis of cancer genomes.

Resolving the resolution of array CGH.

Heritable skewed X-chromosome inactivation leads to haemophilia A expression in heterozygous females.

Skewed X-chromosome inactivation is associated with primary but not secondary ovarian failure.

Whole-genome analysis and HLA genotyping of enteropathy-type T-cell lymphoma reveals 2 distinct lymphoma subtypes.

Comprehensive serial analysis of gene expression of the cervical transcriptome.

Modeling recurrent DNA copy number alterations in array CGH data.

Genetic changes in the evolution of multidrug resistance for cultured human ovarian cancer cells.

Effect of active smoking on the human bronchial epithelium transcriptome.

Frequent occurrence of deletions in primary mediastinal B-cell lymphoma.

Computational methods for the analysis of array comparative genomic hybridization.

Genomics and premalignant breast lesions: clues to the development and progression of lobular breast cancer.

Sub-megabase resolution tiling (SMRT) array-based comparative genomic hybridization profiling reveals novel gains and losses of chromosomal regions in Hodgkin Lymphoma and Anaplastic Large Cell Lymphoma cell lines.

Up regulation in gene expression of chromatin remodelling factors in cervical intraepithelial neoplasia.

Inverted duplication with terminal deletion of 5p and no cat-like cry.

Epigenetics of cancer progression.

Comment re: a comparison of DNA copy number profiling platforms.

MD-SeeGH: a platform for integrative analysis of multi-dimensional genomic data.

Genomic markers for malignant progression in pulmonary adenocarcinoma with bronchioloalveolar features.

High-resolution whole genome tiling path array CGH analysis of CD34+ cells from patients with low-risk myelodysplastic syndromes reveals cryptic copy number alterations and predicts overall and leukemia-free survival.

Characterization of genes differentially expressed within macrophages by virulent and attenuated Mycobacterium tuberculosis identifies candidate genes involved in intracellular growth.

Evolving strategies for global gene expression analysis of cancer.

Bacterial artificial chromosome fingerprint arrays for the differentiation of transcriptomic differences in mycobacteria.

PIK3CA mutations and copy number gains in human lung cancers.

SIGMA2: a system for the integrative genomic multi-dimensional analysis of cancer genomes, epigenomes, and transcriptomes.

Integrative genomic and gene expression analysis of chromosome 7 identified novel oncogene loci in non-small cell lung cancer.

MET gene amplification or EGFR mutation activate MET in lung cancers untreated with EGFR tyrosine kinase inhibitors.

Multiple aberrations of chromosome 3p detected in oral premalignant lesions.

Array-comparative genomic hybridization in sporadic benign pheochromocytomas.

Defining genomic alteration boundaries for a combined small cell and non-small cell lung carcinoma.

Alterations in genes of the EGFR signaling pathway and their relationship to EGFR tyrosine kinase inhibitor sensitivity in lung cancer cell lines.

Minimum altered regions in early prostate cancer progression identified by high resolution whole genome tiling path BAC array comparative hybridization.

High-resolution array CGH identifies novel regions of genomic alteration in intermediate-risk prostate cancer.

Public databases and software for the pathway analysis of cancer genomes.

Comparative genomic hybridization on BAC arrays.

Methylation analysis by DNA immunoprecipitation (MeDIP).

Multiple pathways in the FGF signaling network are frequently deregulated by gene amplification in oral dysplasias.

Genomic imbalances in precancerous tissues signal oral cancer risk.

Using LongSAGE to Detect Biomarkers of Cervical Cancer Potentially Amenable to Optical Contrast Agent Labelling.

Oncogene mutations, copy number gains and mutant allele specific imbalance (MASI) frequently occur together in tumor cells.

Methylation analysis by DNA immunoprecipitation.

Integrating the multiple dimensions of genomic and epigenomic landscapes of cancer.

Transcriptome profiles of carcinoma-in-situ and invasive non-small cell lung cancer as revealed by SAGE.

Patient-derived first generation xenografts of non-small cell lung cancers: promising tools for predicting drug responses for personalized chemotherapy.

Copy number variations in the human genome and strategies for analysis.

Disruption of the non-canonical WNT pathway in lung squamous cell carcinoma.

An integrative multi-dimensional genetic and epigenetic strategy to identify aberrant genes and pathways in cancer.

Contrasting transcriptional responses of a virulent and an attenuated strain of Mycobacterium tuberculosis infecting macrophages.

FACADE: a fast and sensitive algorithm for the segmentation and calling of high resolution array CGH data.

Array comparative genomic hybridization of peripheral blood granulocytes of patients with myelodysplastic syndrome detects karyotypic abnormalities.

Integrative genomic analyses identify BRF2 as a novel lineage-specific oncogene in lung squamous cell carcinoma.

Lung cancer cell lines as tools for biomedical discovery and research.

A sequence-based approach to identify reference genes for gene expression analysis.

Copy number alterations at polymorphic loci may be acquired somatically in patients with myelodysplastic syndromes.

Genome-wide identification of human microRNAs located in leukemia-associated genomic alterations.

Deciphering squamous cell carcinoma using multidimensional genomic approaches.

Comparison of genome-wide array genomic hybridization platforms for the detection of copy number variants in idiopathic mental retardation.

Cyclin E1 is amplified and overexpressed in osteosarcoma.

The functional role of long non-coding RNA in human carcinomas.

MicroRNA gene dosage alterations and drug response in lung cancer.

Chromosome-wide DNA methylation analysis predicts human tissue-specific X inactivation.

Genetic disruption of KEAP1/CUL3 E3 ubiquitin ligase complex components is a key mechanism of NF-kappaB pathway activation in lung cancer.

Long non-coding RNAs are expressed in oral mucosa and altered in oral premalignant lesions.

miR-101 DNA copy loss is a prominent subtype specific event in lung cancer.

TRAF6 is an amplified oncogene bridging the RAS and NF-κB pathways in human lung cancer.

Human cancer long non-coding RNA transcriptomes.

NKX3.1 haploinsufficiency is prognostic for prostate cancer relapse following surgery or image-guided radiotherapy.

Arsenic biotransformation as a cancer promoting factor by inducing DNA damage and disruption of repair mechanisms.

Arsenic exposure and the induction of human cancers.

Induction of human squamous cell-type carcinomas by arsenic.

Allelic loss of the loci containing the androgen synthesis gene, StAR, is prognostic for relapse in intermediate-risk prostate cancer.

Copy number alterations of c-MYC and PTEN are prognostic factors for relapse after prostate cancer radiotherapy.

Translating cancer 'omics' to improved outcomes.

Integrative Genomics Identified RFC3 as an Amplified Candidate Oncogene in Esophageal Adenocarcinoma.