Ken Mackie

Identification of the sites of 2-arachidonoylglycerol synthesis and action imply retrograde endocannabinoid signaling at both GABAergic and glutamatergic synapses in the ventral tegmental area.

CB2-receptor stimulation attenuates TNF-alpha-induced human endothelial cell activation, transendothelial migration of monocytes, and monocyte-endothelial adhesion.

From active ingredients to the discovery of the targets: the cannabinoid receptors.

Understanding cannabinoid psychoactivity with mouse genetic models.

Enzymatic machinery for endocannabinoid biosynthesis associated with calcium stores in glutamatergic axon terminals.

Regulation of CB1 cannabinoid receptor internalization by a promiscuous phosphorylation-dependent mechanism.

Signaling via CNS cannabinoid receptors.

Cannabinoid receptors: where they are and what they do.

Cannabinoid CB2 receptors in the enteric nervous system modulate gastrointestinal contractility in lipopolysaccharide-treated rats.

Endocannabinoid signaling controls pyramidal cell specification and long-range axon patterning.

Wiring and firing neuronal networks: endocannabinoids take center stage.

Building a new conceptual framework for receptor heteromers.

Molecular architecture of endocannabinoid signaling at nociceptive synapses mediating analgesia.

Cannabinoid CB1 receptor-dependent long-term depression in autaptic excitatory neurons.

Cannabinoid signaling in inhibitory autaptic hippocampal neurons.

Repeated homotypic stress elevates 2-arachidonoylglycerol levels and enhances short-term endocannabinoid signaling at inhibitory synapses in basolateral amygdala.

Get stoned in GABAergic synapses.

Monoacylglycerol lipase limits the duration of endocannabinoid-mediated depolarization-induced suppression of excitation in autaptic hippocampal neurons.

The putative cannabinoid receptor GPR55 affects osteoclast function in vitro and bone mass in vivo.

Characterization of cannabinoid-1 receptors in the locus coeruleus: relationship with mu-opioid receptors.

Regulation of MAP kinase-directed mitogenic and protein kinase B-mediated signaling by cannabinoid receptor type 1 in skeletal muscle cells.

CB1 cannabinoid receptors promote oxidative stress and cell death in murine models of doxorubicin-induced cardiomyopathy and in human cardiomyocytes.

Loss of cannabinoid CB1 receptor expression in the 6-hydroxydopamine-induced nigrostriatal terminal lesion model of Parkinson's disease in the rat.

JWH018, a common constituent of 'Spice' herbal blends, is a potent and efficacious cannabinoid CB receptor agonist.

Differential effects of CB(1) neutral antagonists and inverse agonists on gastrointestinal motility in mice.

Transcriptional regulation of cannabinoid receptor-1 expression in the liver by retinoic acid acting via retinoic acid receptor-gamma.

Alterations in the hippocampal endocannabinoid system in diet-induced obese mice.

CB2: a cannabinoid receptor with an identity crisis.

Dynamic changes of CB1-receptor expression in hippocampi of epileptic mice and humans.

Architecture of cannabinoid signaling in mouse retina.

The serine hydrolase ABHD6 controls the accumulation and efficacy of 2-AG at cannabinoid receptors.

Endocannabinoid involvement in endometriosis.

Laserspray ionization, a new method for protein analysis directly from tissue at atmospheric pressure with ultrahigh mass resolution and electron transfer dissociation.

Differential subcellular recruitment of monoacylglycerol lipase generates spatial specificity of 2-arachidonoyl glycerol signaling during axonal pathfinding.

WNT signaling in activated microglia is proinflammatory.

Requirement of cannabinoid CB(1) receptors in cortical pyramidal neurons for appropriate development of corticothalamic and thalamocortical projections.

Presynaptic CB1 receptors regulate synaptic plasticity at cerebellar parallel fiber synapses.

Expression of G protein-coupled receptors and related proteins in HEK293, AtT20, BV2, and N18 cell lines as revealed by microarray analysis.

CP47,497-C8 and JWH073, commonly found in 'Spice' herbal blends, are potent and efficacious CB(1) cannabinoid receptor agonists.

Imaging mass spectrometry in transmission geometry.

Molecular reorganization of endocannabinoid signalling in Alzheimer's disease.

Δ9-Tetrahydrocannabinol (Δ9-THC) attenuates mouse sperm motility and male fecundity.

The atypical cannabinoid O-1602 protects against experimental colitis and inhibits neutrophil recruitment.

Molecular model of cannabis sensitivity in developing neuronal circuits.

Recruitment of prefrontal cortical endocannabinoid signaling by glucocorticoids contributes to termination of the stress response.

Activation of orexin 1 receptors in the periaqueductal gray of male rats leads to antinociception via retrograde endocannabinoid (2-arachidonoylglycerol)-induced disinhibition.

The CB1 cannabinoid receptor C-terminus regulates receptor desensitization in autaptic hippocampal neurones.

Differential signalling in human cannabinoid CB1 receptors and their splice variants in autaptic hippocampal neurones.

Functional selectivity in CB(2) cannabinoid receptor signaling and regulation: implications for the therapeutic potential of CB(2) ligands.

Quinpirole elicits differential in vivo changes in the pre- and postsynaptic distributions of dopamine D₂ receptors in mouse striatum: relation to cannabinoid-1 (CB₁) receptor targeting.

CB₂: therapeutic target-in-waiting.

Plasticity of mouse enteric synapses mediated through endocannabinoid and purinergic signaling.

Cannabinoid 1 receptor promotes cardiac dysfunction, oxidative stress, inflammation, and fibrosis in diabetic cardiomyopathy.

Differential distribution of diacylglycerol lipase-alpha and N-acylphosphatidylethanolamine-specific phospholipase d immunoreactivity in the superficial spinal dorsal horn of rats.

CB₂ cannabinoid receptors inhibit synaptic transmission when expressed in cultured autaptic neurons.

A Primary Cortical Input to Hippocampus Expresses a Pathway-Specific and Endocannabinoid-Dependent Form of Long-Term Potentiation.

Presynaptic CB(1) cannabinoid receptors control frontocortical serotonin and glutamate release--species differences.

Characterisation of cannabinoid 1 receptor expression in the perikarya, and peripheral and spinal processes of primary sensory neurons.

Activation of type 5 metabotropic glutamate receptors and diacylglycerol lipase-α initiates 2-arachidonoylglycerol formation and endocannabinoid-mediated analgesia.

Cannabinoid-1 receptors in the mouse ventral pallidum are targeted to axonal profiles expressing functionally opposed opioid peptides and contacting N-acylphosphatidylethanolamine-hydrolyzing phospholipase D terminals.

Laserspray ionization imaging of multiply charged ions using a commercial vacuum MALDI ion source.

Uncoupling of the endocannabinoid signalling complex in a mouse model of fragile X syndrome.

Brain CB₁ receptor expression following lipopolysaccharide-induced inflammation.

Endocannabinoid-mediated long-term depression of afferent excitatory synapses in hippocampal pyramidal cells and GABAergic interneurons.

Downregulation of cannabinoid receptor 1 from neuropeptide Y interneurons in the basal ganglia of patients with Huntington's disease and mouse models.

CaMKII regulates diacylglycerol lipase-α and striatal endocannabinoid signaling.

Cannabinoid receptors are widely expressed in goldfish: molecular cloning of a CB2-like receptor and evaluation of CB1 and CB2 mRNA expression profiles in different organs.

GPR55, a G-protein coupled receptor for lysophosphatidylinositol, plays a role in motor coordination.

Fmr1 deletion enhances and ultimately desensitizes CB(1) signaling in autaptic hippocampal neurons.

A role for O-1602 and G protein-coupled receptor GPR55 in the control of colonic motility in mice.

Diacylglycerol lipaseα (DAGLα) and DAGLβ cooperatively regulate the production of 2-arachidonoyl glycerol in autaptic hippocampal neurons.

Two novel mutations in ABHD12: expansion of the mutation spectrum in PHARC and assessment of their functional effects.

CB1 cannabinoid receptors couple to focal adhesion kinase to control insulin release.

Mastering tricyclic ring systems for desirable functional cannabinoid activity.

Impaired fear memory specificity associated with deficient endocannabinoid-dependent long-term plasticity.

Gβ₂ mimics activation kinetic slowing of CaV2.2 channels by noradrenaline in rat sympathetic neurons.

The mismatch negativity: a translational probe of auditory processing in cannabis users.

Multiple mechanistically distinct modes of endocannabinoid mobilization at central amygdala glutamatergic synapses.

Mutation of putative GRK phosphorylation sites in the cannabinoid receptor 1 (CB1R) confers resistance to cannabinoid tolerance and hypersensitivity to cannabinoids in mice.

Chronic cannabinoid receptor 2 activation reverses paclitaxel neuropathy without tolerance or cannabinoid receptor 1-dependent withdrawal.

Transmission geometry laserspray ionization vacuum using an atmospheric pressure inlet.

Ligand-specific endocytic dwell times control functional selectivity of the cannabinoid receptor 1.

CB2 Cannabinoid receptors as a therapeutic target-what does the future hold?

Programming of neural cells by (endo)cannabinoids: from physiological rules to emerging therapies.

Cannabinoid receptor 1 promotes hepatocellular carcinoma initiation and progression through multiple mechanisms.

Cannabinoid receptor-interacting protein 1a modulates CB1 receptor signaling and regulation.

CB1 Knockout Mice Unveil Sustained CB2-Mediated Antiallodynic Effects of the Mixed CB1/CB2 Agonist CP55,940 in a Mouse Model of Paclitaxel-Induced Neuropathic Pain.

Molecular-interaction and signaling profiles of AM3677, a novel covalent agonist selective for the cannabinoid 1 receptor.

An animal model of female adolescent cannabinoid exposure elicits a long-lasting deficit in presynaptic long-term plasticity.

Cannabinoid-induced chemotaxis in bovine corneal epithelial cells.

Tolerance to the antinociceptive effects of chronic morphine requires c-Jun N-terminal kinase.

Adolescent cannabis exposure interacts with mutant DISC1 to produce impaired adult emotional memory.

Ultrastructural evidence for synaptic contacts between cortical noradrenergic afferents and endocannabinoid-synthesizing post-synaptic neurons.

Aiming for allosterism: Evaluation of allosteric modulators of CB1 in a neuronal model.

Drug detection and quantification directly from tissue using novel ionization methods for mass spectrometry.

Distribution of the Endocannabinoid System in the Central Nervous System.

An Introduction to the Endogenous Cannabinoid System.

Role of GPR55 during Axon Growth and Target Innervation.

Stress induces analgesia via orexin 1 receptor-initiated endocannabinoid/CB1 signaling in the mouse periaqueductal gray.

Matrix-Assisted Ionization on a Portable Mass Spectrometer: Analysis Directly from Biological and Synthetic Materials.

Lipidomics profile of a NAPE-PLD KO mouse provides evidence of a broader role of this enzyme in lipid metabolism in the brain.

Cannabinoids Occlude the HIV-1 Tat-Induced Decrease in GABAergic Neurotransmission in Prefrontal Cortex Slices.

Mechanisms of Biased β-Arrestin-Mediated Signaling Downstream from the Cannabinoid 1 Receptor.

A broad-based study on hyphenating new ionization technologies with MS/MS for PTMs and tissue characterization.

Broad impact of deleting endogenous cannabinoid hydrolyzing enzymes and the CB1 cannabinoid receptor on the endogenous cannabinoid-related lipidome in eight regions of the mouse brain.

Where's my entourage? The curious case of 2-oleoylglycerol, 2-linolenoylglycerol, and 2-palmitoylglycerol.

A pro-nociceptive phenotype unmasked in mice lacking fatty-acid amide hydrolase.

Functional Selectivity of CB2 Cannabinoid Receptor Ligands at a Canonical and Noncanonical Pathway.

Hierarchical glucocorticoid-endocannabinoid interplay regulates the activation of the nucleus accumbens by insulin.

Western Blotting of the Endocannabinoid System.

Quantitation of Plasma Membrane (G Protein-Coupled) Receptor Trafficking in Cultured Cells.

Orexins contribute to restraint stress-induced cocaine relapse by endocannabinoid-mediated disinhibition of dopaminergic neurons.

Mice Expressing a "Hyper-Sensitive" Form of the Cannabinoid Receptor 1 (CB1) Are Neither Obese Nor Diabetic.

Spatial Distribution of the Cannabinoid Type 1 and Capsaicin Receptors May Contribute to the Complexity of Their Crosstalk.

Novel indole-based compounds that differentiate alkylindole-sensitive receptors from cannabinoid receptors and microtubules: Characterization of their activity on glioma cell migration.

Two Janus Cannabinoids That Are Both CB2 Agonists and CB1 Antagonists.

Inflammation of peripheral tissues and injury to peripheral nerves induce differing effects in the expression of the calcium-sensitive N-arachydonoylethanolamine-synthesizing enzyme and related molecules in rat primary sensory neurons.

Endocannabinoid signalling modulates susceptibility to traumatic stress exposure.

Cannabinoid CB1 receptor overactivity contributes to the pathogenesis of idiopathic pulmonary fibrosis.

Mice expressing a "hyper-sensitive" form of the CB1 cannabinoid receptor (CB1) show modestly enhanced alcohol preference and consumption.

Inflammatory and Neuropathic Nociception is Preserved in GPR55 Knockout Mice.

Endocannabinoid signaling in hypothalamic circuits regulates arousal from general anesthesia in mice.

Modulation of CB1 cannabinoid receptor by allosteric ligands: Pharmacology and therapeutic opportunities.

Cannabinoid CB Agonist GW405833 Suppresses Inflammatory and Neuropathic Pain through a CB Mechanism that is Independent of CB Receptors in Mice.

A GPR119 Signaling System in the Murine Eye Regulates Intraocular Pressure in a Sex-Dependent Manner.

Discovery and characterization of two novel CB1 receptor splice variants with modified N-termini in mouse.

Positive Allosteric Modulation of Cannabinoid Receptor Type 1 Suppresses Pathological Pain Without Producing Tolerance or Dependence.

Chronic Adolescent Δ-Tetrahydrocannabinol Treatment of Male Mice Leads to Long-Term Cognitive and Behavioral Dysfunction, Which Are Prevented by Concurrent Cannabidiol Treatment.

Cannabinoid-1 receptor deletion in podocytes mitigates both glomerular and tubular dysfunction in a mouse model of diabetic nephropathy.

Enantiomer-specific positive allosteric modulation of CB signaling in autaptic hippocampal neurons.

Synthesis of Photoswitchable Δ-Tetrahydrocannabinol Derivatives Enables Optical Control of Cannabinoid Receptor 1 Signaling.

Slowly Signaling G Protein-Biased CB Cannabinoid Receptor Agonist LY2828360 Suppresses Neuropathic Pain with Sustained Efficacy and Attenuates Morphine Tolerance and Dependence.

Endocannabinoid-Specific Impairment in Synaptic Plasticity in Striatum of Huntington's Disease Mouse Model.

GPR55 regulates intraepithelial lymphocyte migration dynamics and susceptibility to intestinal damage.

Δ-Tetrahydrocannabinol changes the brain lipidome and transcriptome differentially in the adolescent and the adult.

Role of Striatal Direct Pathway 2-Arachidonoylglycerol Signaling in Sociability and Repetitive Behavior.

Short-Term Genetic Selection for Adolescent Locomotor Sensitivity to Delta9-Tetrahydrocannabinol (THC).

Cannabidiol Inhibits Endocannabinoid Signaling in Autaptic Hippocampal Neurons.

Controlled-Deactivation CB1 Receptor Ligands as a Novel Strategy to Lower Intraocular Pressure.

Analysis of Endocannabinoid System in Rat Testis During the First Spermatogenetic Wave.

Synthetic peripherally-restricted cannabinoid suppresses chemotherapy-induced peripheral neuropathy pain symptoms by CB1 receptor activation.

Neuroprotective effects of fatty acid amide hydrolase catabolic enzyme inhibition in a HIV-1 Tat model of neuroAIDS.

( R)- N-(1-Methyl-2-hydroxyethyl)-13-( S)-methyl-arachidonamide (AMG315): A Novel Chiral Potent Endocannabinoid Ligand with Stability to Metabolizing Enzymes.

Sex-dependent effects of in utero cannabinoid exposure on cortical function.

Median nerve stimulation induces analgesia via orexin-initiated endocannabinoid disinhibition in the periaqueductal gray.

Cannabinoid CB2 Agonist AM1710 Differentially Suppresses Distinct Pathological Pain States and Attenuates Morphine Tolerance and Withdrawal.

Cannabidiol's Upregulation of -acyl Ethanolamines in the Central Nervous System Requires -acyl Phosphatidyl Ethanolamine-Specific Phospholipase D.

Broad and Region-Specific Impacts of the Synthetic Cannabinoid CP 55,940 in Adolescent and Adult Female Mouse Brains.

GPR55 controls functional differentiation of self-renewing epithelial progenitors for salivation.

Protective Effect of N-Arachidonoyl Glycine-GPR18 Signaling after Excitotoxical Lesion in Murine Organotypic Hippocampal Slice Cultures.

Evidence for a GPR18 Role in Chemotaxis, Proliferation, and the Course of Wound Closure in the Cornea.

Ultrastructural localization of cannabinoid CB1 and mGluR5 receptors in the prefrontal cortex and amygdala.

Self-administration of edible Δ-tetrahydrocannabinol and associated behavioral effects in mice.

Elevated Levels of Arachidonic Acid-Derived Lipids Including Prostaglandins and Endocannabinoids Are Present Throughout ABHD12 Knockout Brains: Novel Insights Into the Neurodegenerative Phenotype.

Cannabinoid receptor-mediated modulation of inhibitory inputs to mitral cells in the main olfactory bulb.

Chronic adolescent exposure to ∆9-tetrahydrocannabinol decreases NMDA current and extrasynaptic plasmalemmal density of NMDA GluN1 subunits in the prelimbic cortex of adult male mice.

Inhibitory Control Deficits Associated with Upregulation of CBR in the HIV-1 Tat Transgenic Mouse Model of Hand.

Cannabinoid Exposure via Lactation in Rats Disrupts Perinatal Programming of the Gamma-Aminobutyric Acid Trajectory and Select Early-Life Behaviors.

Life-long epigenetic programming of cortical architecture by maternal 'Western' diet during pregnancy.

Application of Fluorine- and Nitrogen-Walk Approaches: Defining the Structural and Functional Diversity of 2-Phenylindole Class of Cannabinoid 1 Receptor Positive Allosteric Modulators.

c-Jun N terminal kinase signaling pathways mediate cannabinoid tolerance in an agonist-specific manner.

Interference with the Cannabinoid Receptor CB1R Results in Miswiring of GnRH3 and AgRP1 Axons in Zebrafish Embryos.

Endocannabinoid Signaling Collapse Mediates Stress-Induced Amygdalo-Cortical Strengthening.

One-Stop Microfluidic Assembly of Human Brain Organoids To Model Prenatal Cannabis Exposure.

Endocannabinoid genetic variation enhances vulnerability to THC reward in adolescent female mice.

A Glial-Neuronal Circuit in the Median Eminence Regulates Thyrotropin-Releasing Hormone-Release via the Endocannabinoid System.

Components of Endocannabinoid Signaling System are Expressed in the Perinatal Mouse Cerebellum and Required for its Normal Development.