Christopher Aiken

Nef-mediated downregulation of CD4 enhances human immunodeficiency virus type 1 replication in primary T lymphocytes.

Formation of a human immunodeficiency virus type 1 core of optimal stability is crucial for viral replication.

Disassembly of human immunodeficiency virus type 1 cores in vitro reveals association of Nef with the subviral ribonucleoprotein complex.

Nef does not affect the efficiency of human immunodeficiency virus type 1 fusion with target cells.

Small-molecule inhibition of human immunodeficiency virus type 1 replication by specific targeting of the final step of virion maturation.

Bifunctional anti-human immunodeficiency virus type 1 small molecules with two novel mechanisms of action.

Assembly properties of the human immunodeficiency virus type 1 CA protein.

Coupling of human immunodeficiency virus type 1 fusion to virion maturation: a novel role of the gp41 cytoplasmic tail.

Nef stimulates human immunodeficiency virus type 1 replication in primary T cells by enhancing virion-associated gp120 levels: coreceptor-dependent requirement for Nef in viral replication.

The sequence of the CA-SP1 junction accounts for the differential sensitivity of HIV-1 and SIV to the small molecule maturation inhibitor 3-O-{3',3'-dimethylsuccinyl}-betulinic acid.

Structural requirements for recognition of the human immunodeficiency virus type 1 core during host restriction in owl monkey cells.

Betulinic acid derivatives as HIV-1 antivirals.

Antimicrobial peptides from amphibian skin potently inhibit human immunodeficiency virus infection and transfer of virus from dendritic cells to T cells.

Inhibition of HIV-1 maturation via drug association with the viral Gag protein in immature HIV-1 particles.

Maturation of the viral core enhances the fusion of HIV-1 particles with primary human T cells and monocyte-derived macrophages.

A mutation in the human immunodeficiency virus type 1 Gag protein destabilizes the interaction of the envelope protein subunits gp120 and gp41.

Evidence for a functional link between uncoating of the human immunodeficiency virus type 1 core and nuclear import of the viral preintegration complex.

Saturation of TRIM5 alpha-mediated restriction of HIV-1 infection depends on the stability of the incoming viral capsid.

Analysis of HIV-1-X4 fusion with immature dendritic cells identifies a specific restriction that is independent of CXCR4 levels.

Human immunodeficiency virus type 1 resistance to the small molecule maturation inhibitor 3-O-(3',3'-dimethylsuccinyl)-betulinic acid is conferred by a variety of single amino acid substitutions at the CA-SP1 cleavage site in Gag.

Selective restriction of Nef-defective human immunodeficiency virus type 1 by a proteasome-dependent mechanism.

A mutation in alpha helix 3 of CA renders human immunodeficiency virus type 1 cyclosporin A resistant and dependent: rescue by a second-site substitution in a distal region of CA.

Maturation-dependent human immunodeficiency virus type 1 particle fusion requires a carboxyl-terminal region of the gp41 cytoplasmic tail.

Analysis of human cell heterokaryons demonstrates that target cell restriction of cyclosporine-resistant human immunodeficiency virus type 1 mutants is genetically dominant.

Escape from the dominant HLA-B27-restricted cytotoxic T-lymphocyte response in Gag is associated with a dramatic reduction in human immunodeficiency virus type 1 replication.

Nef enhances HIV-1 infectivity via association with the virus assembly complex.

Proteasomal degradation of TRIM5alpha during retrovirus restriction.

Biochemical characterization of a recombinant TRIM5alpha protein that restricts human immunodeficiency virus type 1 replication.

Cyclophilin A-dependent restriction of human immunodeficiency virus type 1 capsid mutants for infection of nondividing cells.

Cell-free assays for HIV-1 uncoating.

Viral and cellular factors that regulate HIV-1 uncoating.

Structural convergence between Cryo-EM and NMR reveals intersubunit interactions critical for HIV-1 capsid function.

Anti-HIV activity of defective cyanovirin-N mutants is restored by dimerization.

TRIM5alpha disrupts the structure of assembled HIV-1 capsid complexes in vitro.

Small-molecule inhibition of human immunodeficiency virus type 1 infection by virus capsid destabilization.

Structure of the HIV-1 full-length capsid protein in a conformationally trapped unassembled state induced by small-molecule binding.

Rhesus TRIM5α disrupts the HIV-1 capsid at the inter-hexamer interfaces.

免疫学： TRIM5 没有双重职责。

Maturation-induced cloaking of neutralization epitopes on HIV-1 particles.

HIV Nuclear Entry: Clearing the Fog.

RING domain mutations uncouple TRIM5α restriction of HIV-1 from inhibition of reverse transcription and acceleration of uncoating.