Institute of Biological Chemistry
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Glycopeptide biosynthesis: Dbv21/Orf2 from dbv/tcp gene clusters are N-Ac-Glm teicoplanin pseudoaglycone deacetylases and Orf15 from cep gene cluster is a Glc-1-P thymidyltransferase.
Journal of the American Chemical Society Oct, 2006 | Pubmed ID: 17044690
ASFV DNA polymerse X is extremely error-prone under diverse assay conditions and within multiple DNA sequence contexts.
Biochemistry Dec, 2006 | Pubmed ID: 17144676
Identification of histone demethylases in Saccharomyces cerevisiae.
The Journal of biological chemistry May, 2007 | Pubmed ID: 17369256
Dissection of protein-protein interaction and CDK4 inhibition in the oncogenic versus tumor suppressing functions of gankyrin and P16.
Journal of molecular biology Nov, 2007 | Pubmed ID: 17881001
A unique flavin mononucleotide-linked primary alcohol oxidase for glycopeptide A40926 maturation.
Journal of the American Chemical Society Nov, 2007 | Pubmed ID: 17935335
Solution structures of 2 : 1 and 1 : 1 DNA polymerase-DNA complexes probed by ultracentrifugation and small-angle X-ray scattering.
Nucleic acids research Feb, 2008 | Pubmed ID: 18084022
Mismatched dNTP incorporation by DNA polymerase beta does not proceed via globally different conformational pathways.
Nucleic acids research May, 2008 | Pubmed ID: 18385153
Diphosphothreonine-specific interaction between an SQ/TQ cluster and an FHA domain in the Rad53-Dun1 kinase cascade.
Molecular cell Jun, 2008 | Pubmed ID: 18570878
Altered order of substrate binding by DNA polymerase X from African Swine Fever virus.
Biochemistry Jul, 2008 | Pubmed ID: 18598057
Mismatched and matched dNTP incorporation by DNA polymerase beta proceed via analogous kinetic pathways.
Biochemistry Sep, 2008 | Pubmed ID: 18717589
Humoral immunity against capsule polysaccharide protects the host from magA+ Klebsiella pneumoniae-induced lethal disease by evading Toll-like receptor 4 signaling.
Infection and immunity Feb, 2009 | Pubmed ID: 19015249
AMP-activated protein kinase functionally phosphorylates endothelial nitric oxide synthase Ser633.
Circulation research Feb, 2009 | Pubmed ID: 19131647
Trans-cyclization of phosphatidylinositol catalyzed by phospholipase C from Streptomyces antibioticus.
Journal of the American Chemical Society Jun, 2009 | Pubmed ID: 19492832
Unambiguous determination of isobaric histone modifications by reversed-phase retention time and high-mass accuracy.
Analytical biochemistry Jan, 2010 | Pubmed ID: 19699711
JNK-mediated turnover and stabilization of the transcription factor p45/NF-E2 during differentiation of murine erythroleukemia cells.
Proceedings of the National Academy of Sciences of the United States of America Jan, 2010 | Pubmed ID: 19966288
Unique catalytic mechanism of phosphatidylinositol-specific phospholipase C from Streptomyces antibioticus.
Journal of the American Chemical Society Feb, 2010 | Pubmed ID: 20052980
Contributions of conserved TPLH tetrapeptides to the conformational stability of ankyrin repeat proteins.
Journal of molecular biology May, 2010 | Pubmed ID: 20398677
Database search algorithm for identification of intact cross-links in proteins and peptides using tandem mass spectrometry.
Journal of proteome research Jul, 2010 | Pubmed ID: 20469931
High-throughput identification of compounds targeting influenza RNA-dependent RNA polymerase activity.
Proceedings of the National Academy of Sciences of the United States of America Nov, 2010 | Pubmed ID: 20974907
Regioselective deacetylation based on teicoplanin-complexed Orf2* crystal structures.
Molecular bioSystems Apr, 2011 | Pubmed ID: 21267472
The histone H3K36 demethylase Rph1/KDM4 regulates the expression of the photoreactivation gene PHR1.
Nucleic acids research May, 2011 | Pubmed ID: 21296759
Interception of teicoplanin oxidation intermediates yields new antimicrobial scaffolds.
Nature chemical biology May, 2011 | Pubmed ID: 21478878
Regulatory mechanisms of tumor suppressor P16(INK4A) and their relevance to cancer.
Biochemistry Jun, 2011 | Pubmed ID: 21619050
Functions of some capsular polysaccharide biosynthetic genes in Klebsiella pneumoniae NTUH K-2044.
PloS one , 2011 | Pubmed ID: 21765903
Protein kinase A-mediated serine 35 phosphorylation dissociates histone H1.4 from mitotic chromosome.
The Journal of biological chemistry Oct, 2011 | Pubmed ID: 21852232
E339...R416 salt bridge of nucleoprotein as a feasible target for influenza virus inhibitors.
Proceedings of the National Academy of Sciences of the United States of America Oct, 2011 | Pubmed ID: 21930946
Kinetic mechanism of active site assembly and chemical catalysis of DNA polymerase β.
Biochemistry Nov, 2011 | Pubmed ID: 22010960
Structural delineation of MDC1-FHA domain binding with CHK2-pThr68.
Biochemistry Jan, 2012 | Pubmed ID: 22211259
SUMOylation of Blimp-1 is critical for plasma cell differentiation.
EMBO reports Jun, 2012 | Pubmed ID: 22555612
Intermolecular binding between TIFA-FHA and TIFA-pT mediates tumor necrosis factor alpha stimulation and NF-κB activation.
Molecular and cellular biology Jul, 2012 | Pubmed ID: 22566686
Amino acid substitutions of MagA in Klebsiella pneumoniae affect the biosynthesis of the capsular polysaccharide.
PloS one , 2012 | Pubmed ID: 23118860
Loss of the oxidative stress sensor NPGPx compromises GRP78 chaperone activity and induces systemic disease.
Molecular cell Dec, 2012 | Pubmed ID: 23123197
Reversible acetylation regulates salt-inducible kinase (SIK2) and its function in autophagy.
The Journal of biological chemistry Mar, 2013 | Pubmed ID: 23322770
Ubc9 acetylation modulates distinct SUMO target modification and hypoxia response.
The EMBO journal Mar, 2013 | Pubmed ID: 23395904
Phosphorylation of mRNA decapping protein Dcp1a by the ERK signaling pathway during early differentiation of 3T3-L1 preadipocytes.
PloS one , 2013 | Pubmed ID: 23637887
Histone demethylase RBP2 promotes lung tumorigenesis and cancer metastasis.
Cancer research Aug, 2013 | Pubmed ID: 23722541
Evidence that P12, a specific variant of P16(INK4A), plays a suppressive role in human pancreatic carcinogenesis.
Biochemical and biophysical research communications Jun, 2013 | Pubmed ID: 23727582
Molecular basis of the essential s phase function of the rad53 checkpoint kinase.
Molecular and cellular biology Aug, 2013 | Pubmed ID: 23754745
Interaction between salt-inducible kinase 2 (SIK2) and p97/valosin-containing protein (VCP) regulates endoplasmic reticulum (ER)-associated protein degradation in mammalian cells.
The Journal of biological chemistry Nov, 2013 | Pubmed ID: 24129571
Use of quantitative mass spectrometric analysis to elucidate the mechanisms of phospho-priming and auto-activation of the checkpoint kinase Rad53 in vivo.
Molecular & cellular proteomics : MCP Feb, 2014 | Pubmed ID: 24302356
Biosynthesis of streptolidine involved two unexpected intermediates produced by a dihydroxylase and a cyclase through unusual mechanisms.
Angewandte Chemie (International ed. in English) Feb, 2014 | Pubmed ID: 24505011
Tight regulation of a timed nuclear import wave of EKLF by PKCθ and FOE during Pro-E to Baso-E transition.
Developmental cell Feb, 2014 | Pubmed ID: 24576425
How a low-fidelity DNA polymerase chooses non-Watson-Crick from Watson-Crick incorporation.
Journal of the American Chemical Society Apr, 2014 | Pubmed ID: 24617852
Fha interaction with phosphothreonine of TssL activates type VI secretion in Agrobacterium tumefaciens.
PLoS pathogens Mar, 2014 | Pubmed ID: 24626341
How DNA polymerases catalyze DNA replication, repair, and mutation.
Biochemistry May, 2014 | Pubmed ID: 24716436
Structure and mechanism of a nonhaem-iron SAM-dependent C-methyltransferase and its engineering to a hydratase and an O-methyltransferase.
Acta crystallographica. Section D, Biological crystallography Jun, 2014 | Pubmed ID: 24914966
Multiple complexes of long aliphatic N-acyltransferases lead to synthesis of 2,6-diacylated/2-acyl-substituted glycopeptide antibiotics, effectively killing vancomycin-resistant enterococcus.
Journal of the American Chemical Society Aug, 2014 | Pubmed ID: 25095906
Ultrafast water dynamics at the interface of the polymerase-DNA binding complex.
Biochemistry Aug, 2014 | Pubmed ID: 25105470
PP2A and Aurora differentially modify Cdc13 to promote telomerase release from telomeres at G2/M phase.
Nature communications Nov, 2014 | Pubmed ID: 25387524
A ribonuclease coordinates siRNA amplification and mRNA cleavage during RNAi.
Cell Jan, 2015 | Pubmed ID: 25635455
The RNA recognition motif of NIFK is required for rRNA maturation during cell cycle progression.
RNA biology , 2015 | Pubmed ID: 25826659
Uncovering the Mechanism of Forkhead-Associated Domain-Mediated TIFA Oligomerization That Plays a Central Role in Immune Responses.
Biochemistry Oct, 2015 | Pubmed ID: 26389808
Protein Arginine Methyltransferase 8: Tetrameric Structure and Protein Substrate Specificity.
Biochemistry Dec, 2015 | Pubmed ID: 26529540
The nucleolar protein NIFK promotes cancer progression via CK1α/β-catenin in metastasis and Ki-67-dependent cell proliferation.
eLife Mar, 2016 | Pubmed ID: 26984280
TIFA as a crucial mediator for NLRP3 inflammasome.
Proceedings of the National Academy of Sciences of the United States of America 12, 2016 | Pubmed ID: 27965388
Aurora A and NF-κB Survival Pathway Drive Chemoresistance in Acute Myeloid Leukemia via the TRAF-Interacting Protein TIFA.
Cancer research 01, 2017 | Pubmed ID: 28069801
Phospho-Priming Confers Functionally Relevant Specificities for Rad53 Kinase Autophosphorylation.
Biochemistry 09, 2017 | Pubmed ID: 28858528
STRENDA DB: enabling the validation and sharing of enzyme kinetics data.
The FEBS journal 06, 2018 | Pubmed ID: 29498804
TagF-mediated repression of bacterial type VI secretion systems involves a direct interaction with the cytoplasmic protein Fha.
The Journal of biological chemistry 06, 2018 | Pubmed ID: 29599293
Structure of the bifunctional cryptochrome aCRY from Chlamydomonas reinhardtii.
Nucleic acids research 09, 2018 | Pubmed ID: 30032195
Twist and turn: a revised structural view on the unpaired bubble of class II CPD photolyase in complex with damaged DNA.
IUCrJ Sep, 2018 | Pubmed ID: 30224964
Catalytic mechanism of DNA polymerases-Two metal ions or three?
Protein science : a publication of the Protein Society 02, 2019 | Pubmed ID: 30368961
Binding and Enhanced Binding between Key Immunity Proteins TRAF6 and TIFA.
Chembiochem : a European journal of chemical biology 01, 2019 | Pubmed ID: 30378729
Human DNA Polymerase μ Can Use a Noncanonical Mechanism for Multiple Mn-Mediated Functions.
Journal of the American Chemical Society 05, 2019 | Pubmed ID: 31067051
. 9°N DNA polymerase exhibits 3'-esterase activity that can be harnessed for DNA sequencing.
Communications biology , 2019 | Pubmed ID: 31240262
Nonhydrolyzable Heptose Bis- and Monophosphate Analogues Modulate Pro-inflammatory TIFA-NF-κB Signaling.
Chembiochem : a European journal of chemical biology 10, 2020 | Pubmed ID: 32452604
Probing the Active Site of Deubiquitinase USP30 with Noncanonical Tryptophan Analogues.
Biochemistry 06, 2020 | Pubmed ID: 32484330
Vibrio cholerae biofilm scaffolding protein RbmA shows an intrinsic, phosphate-dependent autoproteolysis activity.
IUBMB life Feb, 2021 | Pubmed ID: 33372380
Identification of fidelity-governing factors in human recombinases DMC1 and RAD51 from cryo-EM structures.
Nature communications 01, 2021 | Pubmed ID: 33446654
Use of Quantitative Mass Spectrometric Analysis to Elucidate the Mechanisms of Phospho-priming and Auto-activation of the Checkpoint Kinase Rad53 in Vivo.
Molecular & cellular proteomics : MCP Feb, 2014 | Pubmed ID: 33498138
Synthesis of a biotinylated heptose 1,7-bisphosphate analogue, a probe to study immunity and inflammation.
Organic & biomolecular chemistry Jun, 2021 | Pubmed ID: 33988211
TIFA protein expression is associated with pulmonary arterial hypertension.
Scientific reports Jul, 2021 | Pubmed ID: 34238983
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