Ming-Daw Tsai

Glycopeptide biosynthesis: Dbv21/Orf2 from dbv/tcp gene clusters are N-Ac-Glm teicoplanin pseudoaglycone deacetylases and Orf15 from cep gene cluster is a Glc-1-P thymidyltransferase.

ASFV DNA polymerse X is extremely error-prone under diverse assay conditions and within multiple DNA sequence contexts.

Identification of histone demethylases in Saccharomyces cerevisiae.

Dissection of protein-protein interaction and CDK4 inhibition in the oncogenic versus tumor suppressing functions of gankyrin and P16.

A unique flavin mononucleotide-linked primary alcohol oxidase for glycopeptide A40926 maturation.

Solution structures of 2 : 1 and 1 : 1 DNA polymerase-DNA complexes probed by ultracentrifugation and small-angle X-ray scattering.

Mismatched dNTP incorporation by DNA polymerase beta does not proceed via globally different conformational pathways.

Diphosphothreonine-specific interaction between an SQ/TQ cluster and an FHA domain in the Rad53-Dun1 kinase cascade.

Altered order of substrate binding by DNA polymerase X from African Swine Fever virus.

Mismatched and matched dNTP incorporation by DNA polymerase beta proceed via analogous kinetic pathways.

Humoral immunity against capsule polysaccharide protects the host from magA+ Klebsiella pneumoniae-induced lethal disease by evading Toll-like receptor 4 signaling.

AMP-activated protein kinase functionally phosphorylates endothelial nitric oxide synthase Ser633.

Trans-cyclization of phosphatidylinositol catalyzed by phospholipase C from Streptomyces antibioticus.

Unambiguous determination of isobaric histone modifications by reversed-phase retention time and high-mass accuracy.

JNK-mediated turnover and stabilization of the transcription factor p45/NF-E2 during differentiation of murine erythroleukemia cells.

Unique catalytic mechanism of phosphatidylinositol-specific phospholipase C from Streptomyces antibioticus.

Contributions of conserved TPLH tetrapeptides to the conformational stability of ankyrin repeat proteins.

Database search algorithm for identification of intact cross-links in proteins and peptides using tandem mass spectrometry.

High-throughput identification of compounds targeting influenza RNA-dependent RNA polymerase activity.

Regioselective deacetylation based on teicoplanin-complexed Orf2* crystal structures.

The histone H3K36 demethylase Rph1/KDM4 regulates the expression of the photoreactivation gene PHR1.

Interception of teicoplanin oxidation intermediates yields new antimicrobial scaffolds.

Regulatory mechanisms of tumor suppressor P16(INK4A) and their relevance to cancer.

Functions of some capsular polysaccharide biosynthetic genes in Klebsiella pneumoniae NTUH K-2044.

Protein kinase A-mediated serine 35 phosphorylation dissociates histone H1.4 from mitotic chromosome.

E339...R416 salt bridge of nucleoprotein as a feasible target for influenza virus inhibitors.

Kinetic mechanism of active site assembly and chemical catalysis of DNA polymerase β.

Structural delineation of MDC1-FHA domain binding with CHK2-pThr68.

SUMOylation of Blimp-1 is critical for plasma cell differentiation.

Intermolecular binding between TIFA-FHA and TIFA-pT mediates tumor necrosis factor alpha stimulation and NF-κB activation.

Amino acid substitutions of MagA in Klebsiella pneumoniae affect the biosynthesis of the capsular polysaccharide.

Loss of the oxidative stress sensor NPGPx compromises GRP78 chaperone activity and induces systemic disease.

Reversible acetylation regulates salt-inducible kinase (SIK2) and its function in autophagy.

Ubc9 acetylation modulates distinct SUMO target modification and hypoxia response.

Phosphorylation of mRNA decapping protein Dcp1a by the ERK signaling pathway during early differentiation of 3T3-L1 preadipocytes.

Histone demethylase RBP2 promotes lung tumorigenesis and cancer metastasis.

Evidence that P12, a specific variant of P16(INK4A), plays a suppressive role in human pancreatic carcinogenesis.

Molecular basis of the essential s phase function of the rad53 checkpoint kinase.

Interaction between salt-inducible kinase 2 (SIK2) and p97/valosin-containing protein (VCP) regulates endoplasmic reticulum (ER)-associated protein degradation in mammalian cells.

Use of quantitative mass spectrometric analysis to elucidate the mechanisms of phospho-priming and auto-activation of the checkpoint kinase Rad53 in vivo.

Biosynthesis of streptolidine involved two unexpected intermediates produced by a dihydroxylase and a cyclase through unusual mechanisms.

Tight regulation of a timed nuclear import wave of EKLF by PKCθ and FOE during Pro-E to Baso-E transition.

How a low-fidelity DNA polymerase chooses non-Watson-Crick from Watson-Crick incorporation.

Fha interaction with phosphothreonine of TssL activates type VI secretion in Agrobacterium tumefaciens.

How DNA polymerases catalyze DNA replication, repair, and mutation.

Structure and mechanism of a nonhaem-iron SAM-dependent C-methyltransferase and its engineering to a hydratase and an O-methyltransferase.

Multiple complexes of long aliphatic N-acyltransferases lead to synthesis of 2,6-diacylated/2-acyl-substituted glycopeptide antibiotics, effectively killing vancomycin-resistant enterococcus.

Ultrafast water dynamics at the interface of the polymerase-DNA binding complex.

PP2A and Aurora differentially modify Cdc13 to promote telomerase release from telomeres at G2/M phase.

A ribonuclease coordinates siRNA amplification and mRNA cleavage during RNAi.

The RNA recognition motif of NIFK is required for rRNA maturation during cell cycle progression.

Uncovering the Mechanism of Forkhead-Associated Domain-Mediated TIFA Oligomerization That Plays a Central Role in Immune Responses.

Protein Arginine Methyltransferase 8: Tetrameric Structure and Protein Substrate Specificity.

The nucleolar protein NIFK promotes cancer progression via CK1α/β-catenin in metastasis and Ki-67-dependent cell proliferation.

TIFA as a crucial mediator for NLRP3 inflammasome.

Aurora A and NF-κB Survival Pathway Drive Chemoresistance in Acute Myeloid Leukemia via the TRAF-Interacting Protein TIFA.

Phospho-Priming Confers Functionally Relevant Specificities for Rad53 Kinase Autophosphorylation.

STRENDA DB: enabling the validation and sharing of enzyme kinetics data.

TagF-mediated repression of bacterial type VI secretion systems involves a direct interaction with the cytoplasmic protein Fha.

Structure of the bifunctional cryptochrome aCRY from Chlamydomonas reinhardtii.

Twist and turn: a revised structural view on the unpaired bubble of class II CPD photolyase in complex with damaged DNA.

Catalytic mechanism of DNA polymerases-Two metal ions or three?

Binding and Enhanced Binding between Key Immunity Proteins TRAF6 and TIFA.

Human DNA Polymerase μ Can Use a Noncanonical Mechanism for Multiple Mn-Mediated Functions.

. 9°N DNA polymerase exhibits 3'-esterase activity that can be harnessed for DNA sequencing.

Nonhydrolyzable Heptose Bis- and Monophosphate Analogues Modulate Pro-inflammatory TIFA-NF-κB Signaling.

Probing the Active Site of Deubiquitinase USP30 with Noncanonical Tryptophan Analogues.

Vibrio cholerae biofilm scaffolding protein RbmA shows an intrinsic, phosphate-dependent autoproteolysis activity.

Identification of fidelity-governing factors in human recombinases DMC1 and RAD51 from cryo-EM structures.

Use of Quantitative Mass Spectrometric Analysis to Elucidate the Mechanisms of Phospho-priming and Auto-activation of the Checkpoint Kinase Rad53 in Vivo.

Synthesis of a biotinylated heptose 1,7-bisphosphate analogue, a probe to study immunity and inflammation.

TIFA protein expression is associated with pulmonary arterial hypertension.