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Department of Clinical Medicine (K1)
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Patient-specific neural progenitor cells derived from induced pluripotent stem cells offer a promise of good models for mitochondrial disease.
Cell and tissue research Apr, 2020 | Pubmed ID: 31925525
Disease-specific phenotypes in iPSC-derived neural stem cells with POLG mutations.
EMBO molecular medicine 10, 2020 | Pubmed ID: 32840960
N-acetylcysteine amide ameliorates mitochondrial dysfunction and reduces oxidative stress in hiPSC-derived dopaminergic neurons with POLG mutation.
Experimental neurology 03, 2021 | Pubmed ID: 33264635
Nicotinamide Riboside and Metformin Ameliorate Mitophagy Defect in Induced Pluripotent Stem Cell-Derived Astrocytes With Mutations.
Frontiers in cell and developmental biology , 2021 | Pubmed ID: 34631714
mutations lead to abnormal mitochondrial remodeling during neural differentiation of human pluripotent stem cells via SIRT3/AMPK pathway inhibition.
Cell cycle (Georgetown, Tex.) Jun, 2022 | Pubmed ID: 35298342
Comparing the mitochondrial signatures in ESCs and iPSCs and their neural derivations.
Cell cycle (Georgetown, Tex.) Oct, 2022 | Pubmed ID: 35815665
POLG genotype influences degree of mitochondrial dysfunction in iPSC derived neural progenitors, but not the parent iPSC or derived glia.
Experimental neurology Jul, 2023 | Pubmed ID: 37105450
University of Bergen
Haukeland University Hospital
Kristina Xiao Liang*,1,2,
Anbin Chen*,1,2,3,4,
Cecilie Katrin Kristiansen1,2,
Laurence A. Bindoff1,2
1Department of Clinical Medicine (K1), University of Bergen,
2Neuro-SysMed, Center of Excellence for Clinical Research in Neurological Diseases, Haukeland University Hospital,
3Department of Neurosurgery, Qilu Hospital and Institute of Brain and Brain-Inspired Science, Cheeloo College of Medicine, Shandong University,
4, Shandong Key Laboratory of Brain Function Remodeling
Sharika Marjan1,2,
Tsering Yangzom1,2,
Cecilie Katrin Kristiansen1,3,
Anbin Chen4,
Laurence A. Bindoff1,5,6,
Kristina Xiao Liang1,3
2Centre for International Health, Department of Global Public Health and Primary Care, University of Bergen,
3Neuro-SysMed, Center of Excellence for Clinical Research in Neurological Diseases, Haukeland University Hospital,
4Department of Neurosurgery, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine,
5Department of Neurology, Haukeland University Hospital,
6National Advisory Unit for Congenital Metabolic Diseases, Oslo University Hospital
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