Jeffrey N. Savas

The Sorting Receptor SorCS1 Regulates Trafficking of Neurexin and AMPA Receptors.

Proteomic Analysis of Protein Turnover by Metabolic Whole Rodent Pulse-Chase Isotopic Labeling and Shotgun Mass Spectrometry Analysis.

Global Analysis of Protein Expression of Inner Ear Hair Cells.

Genomic analysis of 220 CTCLs identifies a novel recurrent gain-of-function alteration in RLTPR (p.Q575E).

Dopamine oxidation mediates mitochondrial and lysosomal dysfunction in Parkinson's disease.

Amyloid Accumulation Drives Proteome-wide Alterations in Mouse Models of Alzheimer's Disease-like Pathology.

Critical period inhibition of NKCC1 rectifies synapse plasticity in the somatosensory cortex and restores adult tactile response maps in fragile X mice.

Resetting the epigenetic balance of Polycomb and COMPASS function at enhancers for cancer therapy.

Uncovering Discrete Synaptic Proteomes to Understand Neurological Disorders.

CATACOMB: An endogenous inducible gene that antagonizes H3K27 methylation activity of Polycomb repressive complex 2 via an H3K27M-like mechanism.

Nucleocytoplasmic Proteomic Analysis Uncovers eRF1 and Nonsense-Mediated Decay as Modifiers of ALS/FTD C9orf72 Toxicity.

The Dichotomous Role of Extracellular Vesicles in the Central Nervous System.

A small UTX stabilization domain of Trr is conserved within mammalian MLL3-4/COMPASS and is sufficient to rescue loss of viability in null animals.

Synapse type-specific proteomic dissection identifies IgSF8 as a hippocampal CA3 microcircuit organizer.

Noise Exposures Causing Hearing Loss Generate Proteotoxic Stress and Activate the Proteostasis Network.

Pulse-Chase Proteomics of the App Knockin Mouse Models of Alzheimer's Disease Reveals that Synaptic Dysfunction Originates in Presynaptic Terminals.

Homer1 promotes dendritic spine growth through ankyrin-G and its loss reshapes the synaptic proteome.

Striatal RGS7 Regulates Depression-Related Behaviors and Stress-Induced Reinstatement of Cocaine Conditioned Place Preference.

Using stable isotope labeling to advance our understanding of Alzheimer's disease etiology and pathology.

NOTCH1-driven UBR7 stimulates nucleotide biosynthesis to promote T cell acute lymphoblastic leukemia.

Levetiracetam Treatment Normalizes Levels of Presynaptic Endocytosis Machinery and Restores Nonamyloidogenic APP Processing in Knock-in Mice.

Long-lived mitochondrial cristae proteins in mouse heart and brain.

Herpesviruses assimilate kinesin to produce motorized viral particles.

Shed CNTNAP2 ectodomain is detectable in CSF and regulates Ca homeostasis and network synchrony via PMCA2/ATP2B2.

Long-lived mitochondrial proteins and why they exist.

HSF2 cooperates with HSF1 to drive a transcriptional program critical for the malignant state.