Department of Neurology
Jeffrey Savas received a Bachelor of Science in Biochemistry and Molecular Biology at the University of California, Santa Cruz. He received his Doctor of Philosophy from the New York University School of Medicine and performed his postdoctoral training at The Scripps Research Institute in La Jolla California. The Savas Lab opened at Northwestern University in the fall of 2015. We investigate how altered protein turnover contributes to neurodegeneration and impaired neuronal communication during the preclinical stage of AD. We are particularly interested in determining how perturbed proteostasis in axon terminals triggers synaptic dysfunction in the early stage of AD. To achieve these goals, we use biochemistry and chemical biology with mass spectrometry-based proteomic analysis.
The Sorting Receptor SorCS1 Regulates Trafficking of Neurexin and AMPA Receptors.
Neuron Aug, 2015 | Pubmed ID: 26291160
Proteomic Analysis of Protein Turnover by Metabolic Whole Rodent Pulse-Chase Isotopic Labeling and Shotgun Mass Spectrometry Analysis.
Methods in molecular biology (Clifton, N.J.) , 2016 | Pubmed ID: 26867752
Global Analysis of Protein Expression of Inner Ear Hair Cells.
The Journal of neuroscience : the official journal of the Society for Neuroscience 02, 2017 | Pubmed ID: 28039372
Genomic analysis of 220 CTCLs identifies a novel recurrent gain-of-function alteration in RLTPR (p.Q575E).
Blood 09, 2017 | Pubmed ID: 28694326
Dopamine oxidation mediates mitochondrial and lysosomal dysfunction in Parkinson's disease.
Science (New York, N.Y.) 09, 2017 | Pubmed ID: 28882997
Amyloid Accumulation Drives Proteome-wide Alterations in Mouse Models of Alzheimer's Disease-like Pathology.
Cell reports Nov, 2017 | Pubmed ID: 29186695
Critical period inhibition of NKCC1 rectifies synapse plasticity in the somatosensory cortex and restores adult tactile response maps in fragile X mice.
Molecular psychiatry 11, 2019 | Pubmed ID: 29703945
Resetting the epigenetic balance of Polycomb and COMPASS function at enhancers for cancer therapy.
Nature medicine 06, 2018 | Pubmed ID: 29785026
Uncovering Discrete Synaptic Proteomes to Understand Neurological Disorders.
Proteomes Jul, 2018 | Pubmed ID: 30029459
CATACOMB: An endogenous inducible gene that antagonizes H3K27 methylation activity of Polycomb repressive complex 2 via an H3K27M-like mechanism.
Science advances 07, 2019 | Pubmed ID: 31281901
Nucleocytoplasmic Proteomic Analysis Uncovers eRF1 and Nonsense-Mediated Decay as Modifiers of ALS/FTD C9orf72 Toxicity.
Neuron 04, 2020 | Pubmed ID: 32059759
The Dichotomous Role of Extracellular Vesicles in the Central Nervous System.
iScience Aug, 2020 | Pubmed ID: 32835924
A small UTX stabilization domain of Trr is conserved within mammalian MLL3-4/COMPASS and is sufficient to rescue loss of viability in null animals.
Genes & development 11, 2020 | Pubmed ID: 33033055
Synapse type-specific proteomic dissection identifies IgSF8 as a hippocampal CA3 microcircuit organizer.
Nature communications 10, 2020 | Pubmed ID: 33057002
Noise Exposures Causing Hearing Loss Generate Proteotoxic Stress and Activate the Proteostasis Network.
Cell reports 11, 2020 | Pubmed ID: 33238128
Pulse-Chase Proteomics of the App Knockin Mouse Models of Alzheimer's Disease Reveals that Synaptic Dysfunction Originates in Presynaptic Terminals.
Cell systems 02, 2021 | Pubmed ID: 33326751
Homer1 promotes dendritic spine growth through ankyrin-G and its loss reshapes the synaptic proteome.
Molecular psychiatry 06, 2021 | Pubmed ID: 33398084
Striatal RGS7 Regulates Depression-Related Behaviors and Stress-Induced Reinstatement of Cocaine Conditioned Place Preference.
eNeuro Mar-Apr, 2021 | Pubmed ID: 33402347
Using stable isotope labeling to advance our understanding of Alzheimer's disease etiology and pathology.
Journal of neurochemistry 10, 2021 | Pubmed ID: 33434345
NOTCH1-driven UBR7 stimulates nucleotide biosynthesis to promote T cell acute lymphoblastic leukemia.
Science advances 01, 2021 | Pubmed ID: 33571115
Levetiracetam Treatment Normalizes Levels of Presynaptic Endocytosis Machinery and Restores Nonamyloidogenic APP Processing in Knock-in Mice.
Journal of proteome research 07, 2021 | Pubmed ID: 34106705
Long-lived mitochondrial cristae proteins in mouse heart and brain.
The Journal of cell biology 09, 2021 | Pubmed ID: 34259807
Herpesviruses assimilate kinesin to produce motorized viral particles.
Nature 11, 2021 | Pubmed ID: 34789877
Shed CNTNAP2 ectodomain is detectable in CSF and regulates Ca homeostasis and network synchrony via PMCA2/ATP2B2.
Neuron 02, 2022 | Pubmed ID: 34921780
Long-lived mitochondrial proteins and why they exist.
Trends in cell biology Feb, 2022 | Pubmed ID: 35221146
HSF2 cooperates with HSF1 to drive a transcriptional program critical for the malignant state.
Science advances Mar, 2022 | Pubmed ID: 35294249
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