Marianne E. Bowman

Structure and mechanism of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase. An enzyme in the mevalonate-independent isoprenoid biosynthetic pathway.

Role of hydrogen bonds in the reaction mechanism of chalcone isomerase.

Expanding the biosynthetic repertoire of plant type III polyketide synthases by altering starter molecule specificity.

Conformational flexibility underlies ubiquitin ligation mediated by the WWP1 HECT domain E3 ligase.

A chemical, genetic, and structural analysis of the nuclear bile acid receptor FXR.

Crystal structure of a bacterial type III polyketide synthase and enzymatic control of reactive polyketide intermediates.

Kinetic analysis of Escherichia coli 2-C-methyl-D-erythritol-4-phosphate cytidyltransferase, wild type and mutants, reveals roles of active site amino acids.

An aldol switch discovered in stilbene synthases mediates cyclization specificity of type III polyketide synthases.

Structural elucidation of chalcone reductase and implications for deoxychalcone biosynthesis.

Structure-function-folding relationship in a WW domain.

Biosynthesis of Dictyostelium discoideum differentiation-inducing factor by a hybrid type I fatty acid-type III polyketide synthase.

Structural determinants and modulation of substrate specificity in phenylalanine-tyrosine ammonia-lyases.

Discovery of two cyanobacterial phenylalanine ammonia lyases: kinetic and structural characterization.

Structural basis for high-affinity peptide inhibition of human Pin1.

Structure and reaction mechanism of basil eugenol synthase.

The multiple phenylpropene synthases in both Clarkia breweri and Petunia hybrida represent two distinct protein lineages.

Rapid synthesis of auxin via a new tryptophan-dependent pathway is required for shade avoidance in plants.

Functional analyses of caffeic acid O-Methyltransferase and Cinnamoyl-CoA-reductase genes from perennial ryegrass (Lolium perenne).

Structure-function analyses of a caffeic acid O-methyltransferase from perennial ryegrass reveal the molecular basis for substrate preference.

Evolution of the chalcone-isomerase fold from fatty-acid binding to stereospecific catalysis.

Structural studies of cinnamoyl-CoA reductase and cinnamyl-alcohol dehydrogenase, key enzymes of monolignol biosynthesis.

Structural basis for specific ligation of the peroxisome proliferator-activated receptor δ.

A coupled in vitro/in vivo approach for engineering a heterologous type III PKS to enhance polyketide biosynthesis in Saccharomyces cerevisiae.

Modulation of auxin formation by the cytosolic phenylalanine biosynthetic pathway.