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Jack H. Skirball Center for Chemical Biology and Proteomics
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Structure and mechanism of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase. An enzyme in the mevalonate-independent isoprenoid biosynthetic pathway.
The Journal of biological chemistry Mar, 2002 | Pubmed ID: 11786530
Role of hydrogen bonds in the reaction mechanism of chalcone isomerase.
Biochemistry Apr, 2002 | Pubmed ID: 11955065
Expanding the biosynthetic repertoire of plant type III polyketide synthases by altering starter molecule specificity.
Proceedings of the National Academy of Sciences of the United States of America Apr, 2002 | Pubmed ID: 11959984
Conformational flexibility underlies ubiquitin ligation mediated by the WWP1 HECT domain E3 ligase.
Molecular cell Jan, 2003 | Pubmed ID: 12535537
A chemical, genetic, and structural analysis of the nuclear bile acid receptor FXR.
Molecular cell Apr, 2003 | Pubmed ID: 12718892
Crystal structure of a bacterial type III polyketide synthase and enzymatic control of reactive polyketide intermediates.
The Journal of biological chemistry Oct, 2004 | Pubmed ID: 15265863
Kinetic analysis of Escherichia coli 2-C-methyl-D-erythritol-4-phosphate cytidyltransferase, wild type and mutants, reveals roles of active site amino acids.
Biochemistry Sep, 2004 | Pubmed ID: 15379557
An aldol switch discovered in stilbene synthases mediates cyclization specificity of type III polyketide synthases.
Chemistry & biology Sep, 2004 | Pubmed ID: 15380179
Structural elucidation of chalcone reductase and implications for deoxychalcone biosynthesis.
The Journal of biological chemistry Aug, 2005 | Pubmed ID: 15970585
Structure-function-folding relationship in a WW domain.
Proceedings of the National Academy of Sciences of the United States of America Jul, 2006 | Pubmed ID: 16807295
Biosynthesis of Dictyostelium discoideum differentiation-inducing factor by a hybrid type I fatty acid-type III polyketide synthase.
Nature chemical biology Sep, 2006 | Pubmed ID: 16906151
Structural determinants and modulation of substrate specificity in phenylalanine-tyrosine ammonia-lyases.
Chemistry & biology Dec, 2006 | Pubmed ID: 17185228
Discovery of two cyanobacterial phenylalanine ammonia lyases: kinetic and structural characterization.
Biochemistry Jan, 2007 | Pubmed ID: 17240984
Structural basis for high-affinity peptide inhibition of human Pin1.
ACS chemical biology May, 2007 | Pubmed ID: 17518432
Structure and reaction mechanism of basil eugenol synthase.
PloS one Oct, 2007 | Pubmed ID: 17912370
The multiple phenylpropene synthases in both Clarkia breweri and Petunia hybrida represent two distinct protein lineages.
The Plant journal : for cell and molecular biology May, 2008 | Pubmed ID: 18208524
Rapid synthesis of auxin via a new tryptophan-dependent pathway is required for shade avoidance in plants.
Cell Apr, 2008 | Pubmed ID: 18394996
Functional analyses of caffeic acid O-Methyltransferase and Cinnamoyl-CoA-reductase genes from perennial ryegrass (Lolium perenne).
The Plant cell Oct, 2010 | Pubmed ID: 20952635
Structure-function analyses of a caffeic acid O-methyltransferase from perennial ryegrass reveal the molecular basis for substrate preference.
The Plant cell Dec, 2010 | Pubmed ID: 21177481
Evolution of the chalcone-isomerase fold from fatty-acid binding to stereospecific catalysis.
Nature May, 2012 | Pubmed ID: 22622584
Structural studies of cinnamoyl-CoA reductase and cinnamyl-alcohol dehydrogenase, key enzymes of monolignol biosynthesis.
The Plant cell Sep, 2014 | Pubmed ID: 25217505
Structural basis for specific ligation of the peroxisome proliferator-activated receptor δ.
Proceedings of the National Academy of Sciences of the United States of America 03, 2017 | Pubmed ID: 28320959
A coupled in vitro/in vivo approach for engineering a heterologous type III PKS to enhance polyketide biosynthesis in Saccharomyces cerevisiae.
Biotechnology and bioengineering 06, 2018 | Pubmed ID: 29457628
Modulation of auxin formation by the cytosolic phenylalanine biosynthetic pathway.
Nature chemical biology 08, 2020 | Pubmed ID: 32284603
The Salk Institute for Biological Studies
Sriram Aiyer1,
Timothy S. Strutzenberg1,
Marianne E. Bowman2,
Joseph P. Noel2,3,
Dmitry Lyumkis1,4,5
1Laboratory of Genetics, The Salk Institute for Biological Studies,
2Jack H. Skirball Center for Chemical Biology and Proteomics, The Salk Institute for Biological Studies,
3Department of Chemistry and Biochemistry, University of California San Diego,
4Graduate School of Biological Sciences, Section of Molecular Biology, University of California San Diego,
5Department of Integrative Structural and Computational Biology, The Scripps Research Institute
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