David Depoil

Immunological synapses are versatile structures enabling selective T cell polarization.

Cytotoxic T lymphocytes kill multiple targets simultaneously via spatiotemporal uncoupling of lytic and stimulatory synapses.

CD2 and TCR synergize for the activation of phospholipase Cgamma1/calcium pathway at the immunological synapse.

The role of integrins and coreceptors in refining thresholds for B-cell responses.

CD19 is essential for B cell activation by promoting B cell receptor-antigen microcluster formation in response to membrane-bound ligand.

Phospholipase C-gamma2 and Vav cooperate within signaling microclusters to propagate B cell spreading in response to membrane-bound antigen.

Effects of intracellular calcium and actin cytoskeleton on TCR mobility measured by fluorescence recovery.

Early events of B cell activation by antigen.

The membrane skeleton controls diffusion dynamics and signaling through the B cell receptor.

Dynamic cortical actin remodeling by ERM proteins controls BCR microcluster organization and integrity.

New insights into the T cell synapse from single molecule techniques.