Laboratory for Ion Channel Research,
Department of Cellular and Molecular Medicine,
TRP Research Platform Leuven (TRPLe),
Laboratory for Ion Channel Research, Department of Cellular and Molecular Medicine
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Inhibition by mibefradil, a novel calcium channel antagonist, of Ca(2+)- and volume-activated Cl- channels in macrovascular endothelial cells.
British journal of pharmacology Jun, 1997 | Pubmed ID: 9179399
Modulation of voltage-dependent properties of a swelling-activated Cl- current.
The Journal of general physiology Sep, 1997 | Pubmed ID: 9276756
Inhibition of volume-regulated anion channels by expression of the cystic fibrosis transmembrane conductance regulator.
The Journal of physiology Feb, 1999 | Pubmed ID: 9925879
Block by fluoxetine of volume-regulated anion channels.
British journal of pharmacology Jan, 1999 | Pubmed ID: 10077245
Molecular determinants of permeation through the cation channel TRPV4.
The Journal of biological chemistry Sep, 2002 | Pubmed ID: 12093812
Mg2+-dependent gating and strong inward rectification of the cation channel TRPV6.
The Journal of general physiology Mar, 2003 | Pubmed ID: 12601087
Voltage dependence of the Ca2+-activated cation channel TRPM4.
The Journal of biological chemistry Aug, 2003 | Pubmed ID: 12799367
Anandamide and arachidonic acid use epoxyeicosatrienoic acids to activate TRPV4 channels.
Nature Jul, 2003 | Pubmed ID: 12879072
TRPV4 calcium entry channel: a paradigm for gating diversity.
American journal of physiology. Cell physiology Feb, 2004 | Pubmed ID: 14707014
Outer pore architecture of a Ca2+-selective TRP channel.
The Journal of biological chemistry Apr, 2004 | Pubmed ID: 14736889
Intracellular nucleotides and polyamines inhibit the Ca2+-activated cation channel TRPM4b.
Pflugers Archiv : European journal of physiology Apr, 2004 | Pubmed ID: 14758478
Diversity of TRP channel activation.
Novartis Foundation symposium , 2004 | Pubmed ID: 15104180
The principle of temperature-dependent gating in cold- and heat-sensitive TRP channels.
Nature Aug, 2004 | Pubmed ID: 15306801
Decavanadate modulates gating of TRPM4 cation channels.
The Journal of physiology Nov, 2004 | Pubmed ID: 15331675
Invertebrate TRP proteins as functional models for mammalian channels.
Pflugers Archiv : European journal of physiology Dec, 2004 | Pubmed ID: 15480752
Regulation of the Ca2+ sensitivity of the nonselective cation channel TRPM4.
The Journal of biological chemistry Feb, 2005 | Pubmed ID: 15590641
Comparison of functional properties of the Ca2+-activated cation channels TRPM4 and TRPM5 from mice.
Cell calcium Mar, 2005 | Pubmed ID: 15670874
The selectivity filter of the cation channel TRPM4.
The Journal of biological chemistry Jun, 2005 | Pubmed ID: 15845551
Gating of TRP channels: a voltage connection?
The Journal of physiology Aug, 2005 | Pubmed ID: 15878939
TRP channels: a TR(I)P through a world of multifunctional cation channels.
Pflugers Archiv : European journal of physiology Oct, 2005 | Pubmed ID: 16012814
Heat activation of TRPM5 underlies thermal sensitivity of sweet taste.
Nature Dec, 2005 | Pubmed ID: 16355226
Sensing with TRP channels.
Nature chemical biology Jul, 2005 | Pubmed ID: 16408004
The Ca2+-activated cation channel TRPM4 is regulated by phosphatidylinositol 4,5-biphosphate.
The EMBO journal Feb, 2006 | Pubmed ID: 16424899
Calbindin-D28K dynamically controls TRPV5-mediated Ca2+ transport.
The EMBO journal Jul, 2006 | Pubmed ID: 16763551
TRPM8-independent menthol-induced Ca2+ release from endoplasmic reticulum and Golgi.
The Journal of biological chemistry Feb, 2007 | Pubmed ID: 17142461
TRPM8 voltage sensor mutants reveal a mechanism for integrating thermal and chemical stimuli.
Nature chemical biology Mar, 2007 | Pubmed ID: 17293875
Determinants of 4 alpha-phorbol sensitivity in transmembrane domains 3 and 4 of the cation channel TRPV4.
The Journal of biological chemistry Apr, 2007 | Pubmed ID: 17341586
Modulation of TRPs by PIPs.
The Journal of physiology Aug, 2007 | Pubmed ID: 17395625
Deletion of the transient receptor potential cation channel TRPV4 impairs murine bladder voiding.
The Journal of clinical investigation Nov, 2007 | Pubmed ID: 17948126
The taste transduction channel TRPM5 is a locus for bitter-sweet taste interactions.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology May, 2008 | Pubmed ID: 18070821
Transient receptor potential channels in sensory neurons are targets of the antimycotic agent clotrimazole.
The Journal of neuroscience : the official journal of the Society for Neuroscience Jan, 2008 | Pubmed ID: 18199759
Modulation of the transient receptor potential channel TRPA1 by phosphatidylinositol 4,5-biphosphate manipulators.
Pflugers Archiv : European journal of physiology Oct, 2008 | Pubmed ID: 18461353
Neuronal TRP channels: thermometers, pathfinders and life-savers.
Trends in neurosciences Jun, 2008 | Pubmed ID: 18471901
Gain-of-function mutations in TRPV4 cause autosomal dominant brachyolmia.
Nature genetics Aug, 2008 | Pubmed ID: 18587396
Transient receptor potential channels meet phosphoinositides.
The EMBO journal Nov, 2008 | Pubmed ID: 18923420
A TRP channel-steroid marriage.
Nature cell biology Dec, 2008 | Pubmed ID: 19043430
TRPCs, GPCRs and the Bayliss effect.
The EMBO journal Jan, 2009 | Pubmed ID: 19129760
Mutations in the gene encoding the calcium-permeable ion channel TRPV4 produce spondylometaphyseal dysplasia, Kozlowski type and metatropic dysplasia.
American journal of human genetics Mar, 2009 | Pubmed ID: 19232556
Nicotine activates the chemosensory cation channel TRPA1.
Nature neuroscience Oct, 2009 | Pubmed ID: 19749751
Modulation of the cold-activated cation channel TRPM8 by surface charge screening.
The Journal of physiology Jan, 2010 | Pubmed ID: 19948654
Functional characterization of transient receptor potential channels in mouse urothelial cells.
American journal of physiology. Renal physiology Mar, 2010 | Pubmed ID: 20015940
The capsaicin receptor TRPV1 is a crucial mediator of the noxious effects of mustard oil.
Current biology : CB Feb, 2011 | Pubmed ID: 21315593
An introduction to Bernd Nilius's Festschrift.
The Journal of physiology Apr, 2011 | Pubmed ID: 21486837
TRPM3 is a nociceptor channel involved in the detection of noxious heat.
Neuron May, 2011 | Pubmed ID: 21555074
Functional characterization of a chronic cyclophosphamide-induced overactive bladder model in mice.
Neurourology and urodynamics Nov, 2011 | Pubmed ID: 21717507
Ligand stoichiometry of the cold- and menthol-activated channel TRPM8.
The Journal of physiology Oct, 2011 | Pubmed ID: 21878524
Quantifying and modeling the temperature-dependent gating of TRP channels.
Reviews of physiology, biochemistry and pharmacology , 2012 | Pubmed ID: 22298025
Molecular actions of smoking cessation drugs at α4β2 nicotinic receptors defined in crystal structures of a homologous binding protein.
Proceedings of the National Academy of Sciences of the United States of America Jun, 2012 | Pubmed ID: 22619328
Bimodal effects of cinnamaldehyde and camphor on mouse TRPA1.
Pflugers Archiv : European journal of physiology Jun, 2013 | Pubmed ID: 23271453
The puzzle of TRPV4 channelopathies.
EMBO reports Feb, 2013 | Pubmed ID: 23306656
Systematic and quantitative mRNA expression analysis of TRP channel genes at the single trigeminal and dorsal root ganglion level in mouse.
BMC neuroscience Feb, 2013 | Pubmed ID: 23410158
Bladder dysfunction in a transgenic mouse model of multiple system atrophy.
Movement disorders : official journal of the Movement Disorder Society Mar, 2013 | Pubmed ID: 23426727
TRP channels.
Comprehensive Physiology Jan, 2012 | Pubmed ID: 23728980
Mechanisms of transient receptor potential vanilloid 1 activation and sensitization by allyl isothiocyanate.
Molecular pharmacology Sep, 2013 | Pubmed ID: 23757176
Crucial role of TRPC1 and TRPC4 in cystitis-induced neuronal sprouting and bladder overactivity.
PloS one , 2013 | Pubmed ID: 23922735
Allyl isothiocyanate sensitizes TRPV1 to heat stimulation.
Pflugers Archiv : European journal of physiology Mar, 2014 | Pubmed ID: 23955021
Lack of correlation between the amplitudes of TRP channel-mediated responses to weak and strong stimuli in intracellular Ca(2+) imaging experiments.
Cell calcium Nov, 2013 | Pubmed ID: 24079971
Insulin downregulates the expression of the Ca2+-activated nonselective cation channel TRPM5 in pancreatic islets from leptin-deficient mouse models.
Pflugers Archiv : European journal of physiology Mar, 2014 | Pubmed ID: 24221356
Increased β-adrenergic inotropy in ventricular myocardium from Trpm4-/- mice.
Circulation research Jan, 2014 | Pubmed ID: 24226423
Opening of an alternative ion permeation pathway in a nociceptor TRP channel.
Nature chemical biology Mar, 2014 | Pubmed ID: 24390427
Ca(v)3.2 calcium channels: the key protagonist in the supraspinal effect of paracetamol.
Pain Apr, 2014 | Pubmed ID: 24447516
Differential effects of bitter compounds on the taste transduction channels TRPM5 and IP3 receptor type 3.
Chemical senses May, 2014 | Pubmed ID: 24452633
TRP channels and thermosensation.
Handbook of experimental pharmacology , 2014 | Pubmed ID: 24961967
Peripheral thermosensation in mammals.
Nature reviews. Neuroscience Sep, 2014 | Pubmed ID: 25053448
Transient receptor potential channel modulators as pharmacological treatments for lower urinary tract symptoms (LUTS): myth or reality?
BJU international May, 2015 | Pubmed ID: 25060242
Cannabidiol exerts sebostatic and antiinflammatory effects on human sebocytes.
The Journal of clinical investigation Sep, 2014 | Pubmed ID: 25061872
Distinct modes of perimembrane TRP channel turnover revealed by TIR-FRAP.
Scientific reports Nov, 2014 | Pubmed ID: 25407951
Restoration of progranulin expression rescues cortical neuron generation in an induced pluripotent stem cell model of frontotemporal dementia.
Stem cell reports Jan, 2015 | Pubmed ID: 25556567
TRPV4 participates in the establishment of trailing adhesions and directional persistence of migrating cells.
Pflugers Archiv : European journal of physiology Oct, 2015 | Pubmed ID: 25559845
Structure of the SthK carboxy-terminal region reveals a gating mechanism for cyclic nucleotide-modulated ion channels.
PloS one , 2015 | Pubmed ID: 25625648
Functional expression of transient receptor potential channels in human endometrial stromal cells during the luteal phase of the menstrual cycle.
Human reproduction (Oxford, England) Jun, 2015 | Pubmed ID: 25820697
Essential role of transient receptor potential M8 (TRPM8) in a model of acute cold-induced urinary urgency.
European urology Oct, 2015 | Pubmed ID: 25843641
The Ca(2+)-activated cation channel TRPM4 is a negative regulator of angiotensin II-induced cardiac hypertrophy.
Basic research in cardiology , 2015 | Pubmed ID: 26043922
Regulation of the transient receptor potential channel TRPM3 by phosphoinositides.
The Journal of general physiology Jul, 2015 | Pubmed ID: 26123194
(18F)FDG-PET brain imaging during the micturition cycle in rats detects regions involved in bladder afferent signalling.
EJNMMI research Dec, 2015 | Pubmed ID: 26467154
Phosphoinositide regulation of TRPM channels - TRPM3 joins the club!
Channels (Austin, Tex.) , 2016 | Pubmed ID: 26517445
Topographies and isoforms of the progesterone receptor in female human, rat and mouse bladder.
Cell and tissue research 05, 2016 | Pubmed ID: 26650465
Deletion or Inhibition of the Oxygen Sensor PHD1 Protects against Ischemic Stroke via Reprogramming of Neuronal Metabolism.
Cell metabolism Feb, 2016 | Pubmed ID: 26774962
Signature and Pathophysiology of Non-canonical Pores in Voltage-Dependent Cation Channels.
Reviews of physiology, biochemistry and pharmacology , 2016 | Pubmed ID: 26791748
VAMP7 regulates constitutive membrane incorporation of the cold-activated channel TRPM8.
Nature communications Feb, 2016 | Pubmed ID: 26843440
Journey of a cold sensor - VAMP7-dependent transport of TRPM8.
Channels (Austin, Tex.) 09, 2016 | Pubmed ID: 27136369
A TRiP to the plasma membrane.
Temperature (Austin, Tex.) Apr-Jun, 2015 | Pubmed ID: 27227018
TRPM3 in temperature sensing and beyond.
Temperature (Austin, Tex.) Apr-Jun, 2015 | Pubmed ID: 27227024
Gustatory-mediated avoidance of bacterial lipopolysaccharides via TRPA1 activation in Drosophila.
eLife 06, 2016 | Pubmed ID: 27296646
The functional expression of transient receptor potential channels in the mouse endometrium.
Human reproduction (Oxford, England) Jan, 2017 | Pubmed ID: 28077439
A cellular pathway controlling functional plasma membrane incorporation of the cold sensor TRPM8.
Temperature (Austin, Tex.) , 2016 | Pubmed ID: 28090554
Steviol glycosides enhance pancreatic beta-cell function and taste sensation by potentiation of TRPM5 channel activity.
Nature communications 03, 2017 | Pubmed ID: 28361903
TRP channel pores and local calcium signals.
Cell calcium 09, 2017 | Pubmed ID: 28807146
TRPV4 activation triggers protective responses to bacterial lipopolysaccharides in airway epithelial cells.
Nature communications 10, 2017 | Pubmed ID: 29057902
Sensing the heat with TRPM3.
Pflugers Archiv : European journal of physiology 05, 2018 | Pubmed ID: 29305649
Store-independent coupling between the Secretory Pathway Ca transport ATPase SPCA1 and Orai1 in Golgi stress and Hailey-Hailey disease.
Biochimica et biophysica acta. Molecular cell research Jun, 2018 | Pubmed ID: 29555205
Mutations in the voltage-sensing domain affect the alternative ion permeation pathway in the TRPM3 channel.
The Journal of physiology 06, 2018 | Pubmed ID: 29604058
Sensors and regulatory mechanisms of thermal physiology.
Pflugers Archiv : European journal of physiology 05, 2018 | Pubmed ID: 29675676
Differential effects of lipopolysaccharide on mouse sensory TRP channels.
Cell calcium 07, 2018 | Pubmed ID: 29689522
Intravesical Activation of the Cation Channel TRPV4 Improves Bladder Function in a Rat Model for Detrusor Underactivity.
European urology 09, 2018 | Pubmed ID: 29875065
Differential interactions of bacterial lipopolysaccharides with lipid membranes: implications for TRPA1-mediated chemosensation.
Scientific reports 08, 2018 | Pubmed ID: 30104600
Functional Expression of TRP Ion Channels in Endometrial Stromal Cells of Endometriosis Patients.
International journal of molecular sciences Aug, 2018 | Pubmed ID: 30134548
Δ-tetrahydrocannabivarin impairs epithelial calcium transport through inhibition of TRPV5 and TRPV6.
Pharmacological research 10, 2018 | Pubmed ID: 30170189
To flourish or perish: evolutionary TRiPs into the sensory biology of plant-herbivore interactions.
Pflugers Archiv : European journal of physiology 02, 2019 | Pubmed ID: 30229297
Activation of TRPC1 Channel by Metabotropic Glutamate Receptor mGluR5 Modulates Synaptic Plasticity and Spatial Working Memory.
Frontiers in cellular neuroscience , 2018 | Pubmed ID: 30271326
Functional and molecular characterisation of the bilateral pelvic nerve crush injury rat model for neurogenic detrusor underactivity.
BJU international 05, 2019 | Pubmed ID: 30549418
Functional expression of the mechanosensitive PIEZO1 channel in primary endometrial epithelial cells and endometrial organoids.
Scientific reports 02, 2019 | Pubmed ID: 30741991
A Fly's Cool Way to Escape the Heat.
Neuron 02, 2019 | Pubmed ID: 30790534
Mouse TRPA1 function and membrane localization are modulated by direct interactions with cholesterol.
eLife 06, 2019 | Pubmed ID: 31184584
Expression and Functional Role of TRPV4 in Bone Marrow-Derived CD11c Cells.
International journal of molecular sciences Jul, 2019 | Pubmed ID: 31295806
Heat sensing involves a TRiPlet of ion channels.
British journal of pharmacology 10, 2019 | Pubmed ID: 31372975
Targeting TRP Channels - Valuable Alternatives to Combat Pain, Lower Urinary Tract Disorders, and Type 2 Diabetes?
Trends in pharmacological sciences 09, 2019 | Pubmed ID: 31395287
Functional expression and pharmacological modulation of TRPM3 in human sensory neurons.
British journal of pharmacology Jun, 2020 | Pubmed ID: 31985045
Volatile anaesthetics inhibit the thermosensitive nociceptor ion channel transient receptor potential melastatin 3 (TRPM3).
Biochemical pharmacology 04, 2020 | Pubmed ID: 31987857
The Sensory Coding of Warm Perception.
Neuron 06, 2020 | Pubmed ID: 32208171
Mimicking Sampson's Retrograde Menstrual Theory in Rats: A New Rat Model for Ongoing Endometriosis-Associated Pain.
International journal of molecular sciences Mar, 2020 | Pubmed ID: 32230898
Gain of channel function and modified gating properties in TRPM3 mutants causing intellectual disability and epilepsy.
eLife May, 2020 | Pubmed ID: 32427099
TRPV4 Mediates Acute Bladder Responses to Bacterial Lipopolysaccharides.
Frontiers in immunology , 2020 | Pubmed ID: 32435246
The Zinc-Finger Domain Containing Protein ZC4H2 Interacts with TRPV4, Enhancing Channel Activity and Turnover at the Plasma Membrane.
International journal of molecular sciences May, 2020 | Pubmed ID: 32443528
Pharmacological properties of TRPM3 isoforms are determined by the length of the pore loop.
British journal of pharmacology Aug, 2020 | Pubmed ID: 32780479
Why the emperor penguin reigns where elephants shiver.
Cell calcium 11, 2020 | Pubmed ID: 32836018
Upregulation of TRPM3 in nociceptors innervating inflamed tissue.
eLife 09, 2020 | Pubmed ID: 32880575
TRP Channel Cooperation for Nociception: Therapeutic Opportunities.
Annual review of pharmacology and toxicology 01, 2021 | Pubmed ID: 32976736
The TRPM3 ion channel mediates nociception but not itch evoked by endogenous pruritogenic mediators.
Biochemical pharmacology 01, 2021 | Pubmed ID: 33130130
Transient receptor potential channels in sensory mechanisms of the lower urinary tract.
Nature reviews. Urology Mar, 2021 | Pubmed ID: 33536636
The Agonist Action of Alkylphenols on TRPA1 Relates to Their Effects on Membrane Lipid Order: Implications for TRPA1-Mediated Chemosensation.
International journal of molecular sciences Mar, 2021 | Pubmed ID: 33806007
Mapping the expression of transient receptor potential channels across murine placental development.
Cellular and molecular life sciences : CMLS Apr, 2021 | Pubmed ID: 33884443
I scream for ice cream - TRPC5 as cold sensor in teeth.
Cell calcium May, 2021 | Pubmed ID: 33993004
Noémie Luyts1,
Greetje Vande Velde2,
Matthias Vanneste1,
Helene De Bruyn1,
Annelies Janssens1,
Natalie Verstraeten3,
Thomas Voets1,
Wouter Everaerts4
1Laboratory of Ion Channel Research (LICR), VIB-KU Leuven Center for Brain & Disease Research, Leuven, Belgium & Department of Cellular and Molecular Medicine, KU Leuven,
2Biomedical MRI, Department of Imaging & Pathology, KU Leuven,
3Belgium & KU Leuven Centre of Microbial and Plant Genetics, VIB-KU Leuven Center for Microbiology, Leuven,
4Laboratory of Experimental Urology, Department of Development and Regeneration, KU Leuven
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