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VIB-KU Leuven Center for Microbiology, Leuven

1 ARTICLES PUBLISHED IN JoVE

Immunology and Infection

Longitudinal Follow-Up of Urinary Tract Infections and Their Treatment in Mice using Bioluminescence Imaging

Noémie Luyts¹, Greetje Vande Velde², Matthias Vanneste¹, Helene De Bruyn¹, Annelies Janssens¹, Natalie Verstraeten³, Thomas Voets¹, Wouter Everaerts⁴

¹Laboratory of Ion Channel Research (LICR), VIB-KU Leuven Center for Brain & Disease Research, Leuven, Belgium & Department of Cellular and Molecular Medicine, KU Leuven, ²Biomedical MRI, Department of Imaging & Pathology, KU Leuven, ³Belgium & KU Leuven Centre of Microbial and Plant Genetics, VIB-KU Leuven Center for Microbiology, Leuven, ⁴Laboratory of Experimental Urology, Department of Development and Regeneration, KU Leuven

This manuscript describes the intravesical administration of uropathogenic bacteria with a lux operon to induce a urinary tract infection in mice and subsequent longitudinal in vivo analysis of the bacterial load using bioluminescence imaging.