Paul Brennan

Mechanism of action of a novel latent membrane protein-1 dominant negative.

CD22 is a functional ligand for SH2 domain-containing protein-tyrosine phosphatase-1 in primary T cells.

LY294002 and rapamycin co-operate to inhibit T-cell proliferation.

Reduced tumor necrosis factor signaling in primary human fibroblasts containing a tumor necrosis factor receptor superfamily 1A mutant.

Susceptibility of B lymphocytes to adenovirus type 5 infection is dependent upon both coxsackie-adenovirus receptor and alphavbeta5 integrin expression.

Mutation of the extracellular domain of tumour necrosis factor receptor 1 causes reduced NF-kappaB activation due to decreased surface expression.

Expression of glycosylphosphatidylinositol-anchored CD59 on target cells enhances human NK cell-mediated cytotoxicity.

Epstein-Barr virus represses the FoxO1 transcription factor through latent membrane protein 1 and latent membrane protein 2A.

Epstein-Barr virus induces a distinct form of DNA-bound STAT1 compared with that found in interferon-stimulated B lymphocytes.

The NF-kappaB subunit Rel A is associated with in vitro survival and clinical disease progression in chronic lymphocytic leukemia and represents a promising therapeutic target.

Proliferation and interleukin 5 production by CD8hi CD57+ T cells.

Mcl-1 expression has in vitro and in vivo significance in chronic lymphocytic leukemia and is associated with other poor prognostic markers.

Targeting transcription factors for therapeutic benefit.

The novel nuclear factor-kappaB inhibitor LC-1 is equipotent in poor prognostic subsets of chronic lymphocytic leukemia and shows strong synergy with fludarabine.

Rel a is an independent biomarker of clinical outcome in chronic lymphocytic leukemia.

Cellular uptake, distribution and cytotoxicity of the hydrophobic cell penetrating peptide sequence PFVYLI linked to the proapoptotic domain peptide PAD.

STAT1 contributes to the maintenance of the latency III viral programme observed in Epstein-Barr virus-transformed B cells and their recognition by CD8+ T cells.

Soluble TLR2 reduces inflammation without compromising bacterial clearance by disrupting TLR2 triggering.

NF-kappaB as a prognostic marker and therapeutic target in chronic lymphocytic leukemia.

Interplay between REST and nucleolin transcription factors: a key mechanism in the overexpression of genes upon increased phosphorylation.

Bicarbonate-dependent serine/threonine protein dephosphorylation in capacitating boar spermatozoa.

Genetic modification of primary chronic lymphocytic leukemia cells with a lentivirus expressing CD38.

Proteomics analysis of bladder cancer exosomes.

Co-operative membrane disruption between cell-penetrating peptide and cargo: implications for the therapeutic use of the Bcl-2 converter peptide D-NuBCP-9-r8.

Proteomic profiling of human respiratory epithelia by iTRAQ reveals biomarkers of exposure and harm by tobacco smoke components.

Defining the prognosis of early stage chronic lymphocytic leukaemia patients.

Reactive oxygen species and mitochondrial sensitivity to oxidative stress determine induction of cancer cell death by p21.

Blinatumomab induces autologous T-cell killing of chronic lymphocytic leukemia cells.

A novel Cdk9 inhibitor preferentially targets tumor cells and synergizes with fludarabine.

Development and characterization of a physiologically relevant model of lymphocyte migration in chronic lymphocytic leukemia.

Proteomics-based strategies to identify proteins relevant to chronic lymphocytic leukemia.

External ventricular drainage: Is it time to look at national practice?

Quantitative nuclear proteomics reveals new phenotypes altered in lymphoblastoid cells.

Proteomics analysis of vesicles isolated from plasma and urine of prostate cancer patients using a multiplex, aptamer-based protein array.

Key Molecular Drivers of Chronic Lymphocytic Leukemia.

Genome-wide association analysis implicates dysregulation of immunity genes in chronic lymphocytic leukaemia.

drawProteins: a Bioconductor/R package for reproducible and programmatic generation of protein schematics.

Effective Gene Modification in Mouse Tissue-Resident Peritoneal Macrophages by Intraperitoneal Delivery of Lentiviral Vectors.

Kinomics platform using GBM tissue identifies BTK as being associated with higher patient survival.

100,000 Genomes Pilot on Rare-Disease Diagnosis in Health Care - Preliminary Report.

Essential role of staff development in addressing structural racism.