Deborah L. French
Center for Cellular and Molecular Therapeutics
Children's Hospital of Philadelphia
Deborah French is a Research Professor in the Department of Pathology and Laboratory Medicine, Perelman School of Medicine University of Pennsylvania. She is Director of the Human Pluripotent Stem Cell Core in the Center for Cellular and Molecular Therapeutics at The Children's Hospital of Philadelphia (CHOP).
Dr. French received her undergraduate degree from Purdue University and her graduate degree from Rush University. She completed her post-doctoral training in the laboratory of Dr. Matthew Scharff at the Albert Einstein College of Medicine.
In 2008, Dr. French established a core infrastructure at CHOP enabling investigators to work with pluripotent stem cells. She is a major collaborator of multi-investigator teams that are utilizing pluripotent stem cells for modeling human disease to study mechanism, development, and establish new therapeutic modalities.
Targeted Application of Human Genetic Variation Can Improve Red Blood Cell Production from Stem Cells.
Cell stem cell Jan, 2016 | Pubmed ID: 26607381
Generation of poikiloderma with neutropenia (PN) induced pluripotent stem cells (iPSCs).
Stem cell research Nov, 2015 | Pubmed ID: 26987923
Monoclonal Antibodies by Somatic Cell Fusion.
ILAR journal / National Research Council, Institute of Laboratory Animal Resources , 1995 | Pubmed ID: 11528032
Two new beta3 integrin mutations in Indian patients with Glanzmann thrombasthenia: localization of mutations affecting cysteine residues in integrin beta3.
Thrombosis and haemostasis Sep, 2002 | Pubmed ID: 12353082
Two novel mutations in the alpha IIb calcium-binding domains identify hydrophobic regions essential for alpha IIbbeta 3 biogenesis.
Blood Mar, 2003 | Pubmed ID: 12424194
Stathmin expression and megakaryocyte differentiation: a potential role in polyploidy.
Experimental hematology May, 2003 | Pubmed ID: 12763137
Integrin beta3 regions controlling binding of murine mAb 7E3: implications for the mechanism of integrin alphaIIbbeta3 activation.
Proceedings of the National Academy of Sciences of the United States of America Sep, 2004 | Pubmed ID: 15277669
Evidence for megakaryocyte engraftment following reduced-intensity conditioning.
Experimental hematology Sep, 2004 | Pubmed ID: 15345290
alphaIIbbeta3 biogenesis is controlled by engagement of alphaIIb in the calnexin cycle via the N15-linked glycan.
Blood Apr, 2006 | Pubmed ID: 16304048
Molecular diversity of Glanzmann thrombasthenia in southern India: new insights into mRNA splicing and structure-function correlations of alphaIIbbeta3 integrin (ITGA2B, ITGB3).
Human mutation Apr, 2006 | Pubmed ID: 16463284
Development and function of myeloid-derived suppressor cells generated from mouse embryonic and hematopoietic stem cells.
Stem cells (Dayton, Ohio) Mar, 2010 | Pubmed ID: 20073041
Generation of transgene-free lung disease-specific human induced pluripotent stem cells using a single excisable lentiviral stem cell cassette.
Stem cells (Dayton, Ohio) Oct, 2010 | Pubmed ID: 20715179
A high-throughput multiplexed screening assay for optimizing serum-free differentiation protocols of human embryonic stem cells.
Stem cell research Mar, 2011 | Pubmed ID: 21169079
High-throughput screening assay for embryoid body differentiation of human embryonic stem cells.
Current protocols in stem cell biology Mar, 2012 | Pubmed ID: 22415836
Self-renewing endodermal progenitor lines generated from human pluripotent stem cells.
Cell stem cell Apr, 2012 | Pubmed ID: 22482503
Trisomy 21-associated defects in human primitive hematopoiesis revealed through induced pluripotent stem cells.
Proceedings of the National Academy of Sciences of the United States of America Oct, 2012 | Pubmed ID: 23045704
Challenges and promises for the development of donor-independent platelet transfusions.
Blood Apr, 2013 | Pubmed ID: 23321255
Megakaryocytes put a foot through the door.
Blood Mar, 2013 | Pubmed ID: 23538231
Patient-derived induced pluripotent stem cells recapitulate hematopoietic abnormalities of juvenile myelomonocytic leukemia.
Blood Apr, 2013 | Pubmed ID: 23620576
AAV-mediated gene therapy for choroideremia: preclinical studies in personalized models.
PloS one , 2013 | Pubmed ID: 23667438
Ribosomal and hematopoietic defects in induced pluripotent stem cells derived from Diamond Blackfan anemia patients.
Blood Aug, 2013 | Pubmed ID: 23744582
Clonal genetic and hematopoietic heterogeneity among human-induced pluripotent stem cell lines.
Blood Sep, 2013 | Pubmed ID: 23940280
High-level transgene expression in induced pluripotent stem cell-derived megakaryocytes: correction of Glanzmann thrombasthenia.
Blood Jan, 2014 | Pubmed ID: 24335497
The negative impact of Wnt signaling on megakaryocyte and primitive erythroid progenitors derived from human embryonic stem cells.
Stem cell research Mar, 2014 | Pubmed ID: 24412757
Utilization of the AAVS1 safe harbor locus for hematopoietic specific transgene expression and gene knockdown in human ES cells.
Stem cell research May, 2014 | Pubmed ID: 24631742
Hematopoietic differentiation of pluripotent stem cells in culture.
Methods in molecular biology (Clifton, N.J.) , 2014 | Pubmed ID: 25062629
Level of RUNX1 activity is critical for leukemic predisposition but not for thrombocytopenia.
Blood Feb, 2015 | Pubmed ID: 25490895
Pluripotent stem cells reveal erythroid-specific activities of the GATA1 N-terminus.
The Journal of clinical investigation Mar, 2015 | Pubmed ID: 25621499
A Doxycycline-Inducible System for Genetic Correction of iPSC Disease Models.
Methods in molecular biology (Clifton, N.J.) , 2016 | Pubmed ID: 25630922
Comparative analysis of human ex vivo-generated platelets vs megakaryocyte-generated platelets in mice: a cautionary tale.
Blood Jun, 2015 | Pubmed ID: 25852052
Inducible Gata1 suppression expands megakaryocyte-erythroid progenitors from embryonic stem cells.
The Journal of clinical investigation Jun, 2015 | Pubmed ID: 25961454
Dysregulation of the Transforming Growth Factor β Pathway in Induced Pluripotent Stem Cells Generated from Patients with Diamond Blackfan Anemia.
PloS one , 2015 | Pubmed ID: 26258650
OCT4 Coordinates with WNT Signaling to Pre-pattern Chromatin at the SOX17 Locus during Human ES Cell Differentiation into Definitive Endoderm.
Stem cell reports Oct, 2015 | Pubmed ID: 26411902
Generation of human control iPS cell line CHOPWT9 from healthy adult peripheral blood mononuclear cells.
Stem cell research Jan, 2016 | Pubmed ID: 27345777
Generation of Hermansky-Pudlak Syndrome Type 1 (HPS1) induced pluripotent stem cells (iPSCs).
Stem cell research Mar, 2016 | Pubmed ID: 27345974
Generation of Hermansky Pudlak syndrome type 2 (HPS2) induced pluripotent stem cells (iPSCs).
Stem cell research Mar, 2016 | Pubmed ID: 27345985
Generation of human control iPS cell line CHOPWT10 from healthy adult peripheral blood mononuclear cells.
Stem cell research Mar, 2016 | Pubmed ID: 27345999
GATA6 Plays an Important Role in the Induction of Human Definitive Endoderm, Development of the Pancreas, and Functionality of Pancreatic β Cells.
Stem cell reports 03, 2017 | Pubmed ID: 28196690
Induced Pluripotent Stem Cell-Derived Megakaryocytes and Platelets for Disease Modeling and Future Clinical Applications.
Arteriosclerosis, thrombosis, and vascular biology 11, 2017 | Pubmed ID: 28982668
Exploring the Interaction Between eIF2α Dysregulation, Acute Endoplasmic Reticulum Stress and DYT1 Dystonia in the Mammalian Brain.
Neuroscience 02, 2018 | Pubmed ID: 29289717
GATA6 suppression enhances lung specification from human pluripotent stem cells.
The Journal of clinical investigation 07, 2018 | Pubmed ID: 29889101
Generation of a human Juvenile myelomonocytic leukemia iPSC line, CHOPi001-A, with a mutation in CBL.
Stem cell research 08, 2018 | Pubmed ID: 30096712
Highly Efficient CRISPR-Cas9-Mediated Genome Editing in Human Pluripotent Stem Cells.
Current protocols in stem cell biology 02, 2019 | Pubmed ID: 30358158
Generation of Spinocerebellar Ataxia Type 2 induced pluripotent stem cell lines, CHOPi002-A and CHOPi003-A, from patients with abnormal CAG repeats in the coding region of the ATXN2 gene.
Stem cell research 01, 2019 | Pubmed ID: 30611021
Modeling Monogenic Diabetes using Human ESCs Reveals Developmental and Metabolic Deficiencies Caused by Mutations in HNF1A.
Cell stem cell Aug, 2019 | Pubmed ID: 31374199
Generation of Human Induced Pluripotent Stem Cells from Peripheral Blood Using the STEMCCA Lentiviral Vector
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