Stem Cell Dynamics
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Activated Notch1 alters differentiation of embryonic stem cells into mesodermal cell lineages at multiple stages of development.
Mechanisms of development Jul, 2006 | Pubmed ID: 16822655
Transient expression of PU.1 commits multipotent progenitors to a myeloid fate whereas continued expression favors macrophage over granulocyte differentiation.
Experimental hematology Jan, 2003 | Pubmed ID: 12543105
Recombination signal sequence-binding protein Jkappa alters mesodermal cell fate decisions by suppressing cardiomyogenesis.
Proceedings of the National Academy of Sciences of the United States of America Apr, 2003 | Pubmed ID: 12655061
Dendritic cells under influence of mouse cytomegalovirus have a physiologic dual role: to initiate and to restrict T cell activation.
The Journal of infectious diseases Mar, 2003 | Pubmed ID: 12660946
Notch signaling induces multilineage myeloid differentiation and up-regulates PU.1 expression.
Journal of immunology (Baltimore, Md. : 1950) Jun, 2003 | Pubmed ID: 12759431
Generation of optimized yellow and red fluorescent proteins with distinct subcellular localization.
BioTechniques Mar, 2004 | Pubmed ID: 15038157
Tracking hematopoiesis at the single cell level.
Annals of the New York Academy of Sciences Jun, 2005 | Pubmed ID: 15958713
Cdc42 is not essential for filopodium formation, directed migration, cell polarization, and mitosis in fibroblastoid cells.
Molecular biology of the cell Oct, 2005 | Pubmed ID: 16014609
Common themes and cell type specific variations of higher order chromatin arrangements in the mouse.
BMC cell biology , 2005 | Pubmed ID: 16336643
Adrenomedullin/cyclic AMP pathway induces Notch activation and differentiation of arterial endothelial cells from vascular progenitors.
Arteriosclerosis, thrombosis, and vascular biology Sep, 2006 | Pubmed ID: 16809546
The Rho-GTPase cdc42 regulates neural progenitor fate at the apical surface.
Nature neuroscience Sep, 2006 | Pubmed ID: 16892058
MAPK phosphatase-1 represents a novel anti-inflammatory target of glucocorticoids in the human endothelium.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology Jan, 2007 | Pubmed ID: 17099067
mNotch1 signaling and erythropoietin cooperate in erythroid differentiation of multipotent progenitor cells and upregulate beta-globin.
Experimental hematology Sep, 2007 | Pubmed ID: 17637499
Functional properties of neurons derived from in vitro reprogrammed postnatal astroglia.
The Journal of neuroscience : the official journal of the Society for Neuroscience Aug, 2007 | Pubmed ID: 17687043
Par-complex proteins promote proliferative progenitor divisions in the developing mouse cerebral cortex.
Development (Cambridge, England) Jan, 2008 | Pubmed ID: 18032449
Notch signaling in embryonic and adult myelopoiesis.
Cells, tissues, organs , 2008 | Pubmed ID: 18196925
Exploring hematopoiesis at single cell resolution.
Cells, tissues, organs , 2008 | Pubmed ID: 18230950
Asymmetric Cell Division in Normal and Malignant Hematopoietic Precursor Cells.
Cell stem cell Nov, 2007 | Pubmed ID: 18371383
Imaging stem-cell-driven regeneration in mammals.
Nature May, 2008 | Pubmed ID: 18480816
Asymmetric cell division in normal and malignant hematopoietic precursor cells.
Cell stem cell Nov, 2007 | Pubmed ID: 18938740
Improved prospective identification of megakaryocyte-erythrocyte progenitor cells.
British journal of haematology Feb, 2009 | Pubmed ID: 19036095
Continuous single-cell imaging of blood generation from haemogenic endothelium.
Nature Feb, 2009 | Pubmed ID: 19212410
Late origin of glia-restricted progenitors in the developing mouse cerebral cortex.
Cerebral cortex (New York, N.Y. : 1991) Jul, 2009 | Pubmed ID: 19363148
Hematopoietic cytokines can instruct lineage choice.
Science (New York, N.Y.) Jul, 2009 | Pubmed ID: 19590005
Analyzing cell fate control by cytokines through continuous single cell biochemistry.
Journal of cellular biochemistry Oct, 2009 | Pubmed ID: 19626666
The transcription factors STAT5A/B regulate GM-CSF-mediated granulopoiesis.
Blood Nov, 2009 | Pubmed ID: 19779039
Instruction of lineage choice by hematopoietic cytokines.
Cell cycle (Georgetown, Tex.) Dec, 2009 | Pubmed ID: 19949300
The electronic crystal ball: predicting cell fate from time-lapse data.
Nature methods Mar, 2010 | Pubmed ID: 20195252
Hematopoietic stem cell heterogeneity: subtypes, not unpredictable behavior.
Cell stem cell Mar, 2010 | Pubmed ID: 20207223
Directing astroglia from the cerebral cortex into subtype specific functional neurons.
PLoS biology May, 2010 | Pubmed ID: 20502524
The transcription factor Pax6 regulates survival of dopaminergic olfactory bulb neurons via crystallin αA.
Neuron Nov, 2010 | Pubmed ID: 21092858
Lentiviral vector design and imaging approaches to visualize the early stages of cellular reprogramming.
Molecular therapy : the journal of the American Society of Gene Therapy Apr, 2011 | Pubmed ID: 21285961
Generation of subtype-specific neurons from postnatal astroglia of the mouse cerebral cortex.
Nature protocols Feb, 2011 | Pubmed ID: 21293461
Multi-type branching models to describe cell differentiation programs.
Journal of theoretical biology May, 2011 | Pubmed ID: 21333658
Continuous live imaging of adult neural stem cell division and lineage progression in vitro.
Development (Cambridge, England) Mar, 2011 | Pubmed ID: 21343361
Long-term single-cell imaging of mammalian stem cells.
Nature methods Apr, 2011 | Pubmed ID: 21451514
Wnt to notch relay signaling induces definitive hematopoiesis.
Cell stem cell Jul, 2011 | Pubmed ID: 21726826
Functionally defined substates within the human embryonic stem cell compartment.
Stem cell research Sep, 2011 | Pubmed ID: 21763622
Hierarchical differentiation of myeloid progenitors is encoded in the transcription factor network.
PloS one , 2011 | Pubmed ID: 21853041
The role of Pax6 in regulating the orientation and mode of cell division of progenitors in the mouse cerebral cortex.
Development (Cambridge, England) Dec, 2011 | Pubmed ID: 22031545
Using an adherent cell culture of the mouse subependymal zone to study the behavior of adult neural stem cells on a single-cell level.
Nature protocols Dec, 2011 | Pubmed ID: 22051798
Advances in tracking hematopoiesis at the single-cell level.
Current opinion in hematology Jul, 2012 | Pubmed ID: 22555393
Multi-scale modeling of GMP differentiation based on single-cell genealogies.
The FEBS journal Sep, 2012 | Pubmed ID: 22708849
Stem cell powwow in Squaw Valley.
Development (Cambridge, England) Jul, 2012 | Pubmed ID: 22736242
Molecular live cell bioimaging in stem cell research.
Annals of the New York Academy of Sciences Aug, 2012 | Pubmed ID: 22901252
Hematopoiesis.
Cold Spring Harbor perspectives in biology Dec, 2012 | Pubmed ID: 23209149
Oligodendrogliogenic and neurogenic adult subependymal zone neural stem cells constitute distinct lineages and exhibit differential responsiveness to Wnt signalling.
Nature cell biology Jun, 2013 | Pubmed ID: 23644466
Heterogeneity of sister cell fates.
Nature reviews. Molecular cell biology Jun, 2013 | Pubmed ID: 23698579
Biallelic expression of nanog protein in mouse embryonic stem cells.
Cell stem cell Jul, 2013 | Pubmed ID: 23827706
HSC-explorer: a curated database for hematopoietic stem cells.
PloS one , 2013 | Pubmed ID: 23936191
Probing cellular processes by long-term live imaging--historic problems and current solutions.
Journal of cell science Sep, 2013 | Pubmed ID: 23943879
An automatic method for robust and fast cell detection in bright field images from high-throughput microscopy.
BMC bioinformatics Oct, 2013 | Pubmed ID: 24090363
Prdm6 is essential for cardiovascular development in vivo.
PloS one , 2013 | Pubmed ID: 24278461
Incomplete cytokinesis and re-fusion of small mononucleated Hodgkin cells lead to giant multinucleated Reed-Sternberg cells.
Proceedings of the National Academy of Sciences of the United States of America Dec, 2013 | Pubmed ID: 24302766
Early dynamic fate changes in haemogenic endothelium characterized at the single-cell level.
Nature communications , 2013 | Pubmed ID: 24326267
C/EBPα is required for long-term self-renewal and lineage priming of hematopoietic stem cells and for the maintenance of epigenetic configurations in multipotent progenitors.
PLoS genetics Jan, 2014 | Pubmed ID: 24415956
Leveraging cross-species transcription factor binding site patterns: from diabetes risk loci to disease mechanisms.
Cell Jan, 2014 | Pubmed ID: 24439387
Sonic hedgehog signaling regulates mode of cell division of early cerebral cortex progenitors and increases astrogliogenesis.
Frontiers in cellular neuroscience , 2014 | Pubmed ID: 24653675
Human Pancreatic Cancer-Associated Stellate Cells Remain Activated after in vivo Chemoradiation.
Frontiers in oncology , 2014 | Pubmed ID: 24847445
Circulation-independent differentiation pathway from extraembryonic mesoderm toward hematopoietic stem cells via hemogenic angioblasts.
Cell reports Jul, 2014 | Pubmed ID: 24981862
Instruction of hematopoietic lineage choice by cytokine signaling.
Experimental cell research Dec, 2014 | Pubmed ID: 25046868
Cytokine-regulated GADD45G induces differentiation and lineage selection in hematopoietic stem cells.
Stem cell reports Jul, 2014 | Pubmed ID: 25068120
Single-cell technologies sharpen up mammalian stem cell research.
Nature cell biology Oct, 2014 | Pubmed ID: 25271480
Marker-free detection of progenitor cell differentiation by analysis of Brownian motion in micro-wells.
Integrative biology : quantitative biosciences from nano to macro Feb, 2015 | Pubmed ID: 25514157
Quantitative single-cell approaches to stem cell research.
Cell stem cell Nov, 2014 | Pubmed ID: 25517464
Factor graph analysis of live cell-imaging data reveals mechanisms of cell fate decisions.
Bioinformatics (Oxford, England) Jun, 2015 | Pubmed ID: 25638814
Exit from dormancy provokes DNA-damage-induced attrition in haematopoietic stem cells.
Nature Apr, 2015 | Pubmed ID: 25707806
Single-Stranded DNA-Binding Transcriptional Regulator FUBP1 Is Essential for Fetal and Adult Hematopoietic Stem Cell Self-Renewal.
Cell reports Jun, 2015 | Pubmed ID: 26095368
Inflammation-Induced Emergency Megakaryopoiesis Driven by Hematopoietic Stem Cell-like Megakaryocyte Progenitors.
Cell stem cell Oct, 2015 | Pubmed ID: 26299573
Network plasticity of pluripotency transcription factors in embryonic stem cells.
Nature cell biology Oct, 2015 | Pubmed ID: 26389663
Glutathione peroxidase 4 prevents necroptosis in mouse erythroid precursors.
Blood Jan, 2016 | Pubmed ID: 26463424
Ectopic expression of Msx2 in mammalian myotubes recapitulates aspects of amphibian muscle dedifferentiation.
Stem cell research Nov, 2015 | Pubmed ID: 26468601
STAT5-regulated microRNA-193b controls haematopoietic stem and progenitor cell expansion by modulating cytokine receptor signalling.
Nature communications Nov, 2015 | Pubmed ID: 26603207
Seamless Combination of Fluorescence-Activated Cell Sorting and Hanging-Drop Networks for Individual Handling and Culturing of Stem Cells and Microtissue Spheroids.
Analytical chemistry Jan, 2016 | Pubmed ID: 26694967
DNA-damage response gene GADD45A induces differentiation in hematopoietic stem cells without inhibiting cell cycle or survival.
Stem cells (Dayton, Ohio) Mar, 2016 | Pubmed ID: 26731607
Identification and Successful Negotiation of a Metabolic Checkpoint in Direct Neuronal Reprogramming.
Cell stem cell Mar, 2016 | Pubmed ID: 26748418
Nanog dynamics in single embryonic stem cells.
Cell cycle (Georgetown, Tex.) , 2016 | Pubmed ID: 26760119
Chronic interleukin-1 exposure drives haematopoietic stem cells towards precocious myeloid differentiation at the expense of self-renewal.
Nature cell biology Jun, 2016 | Pubmed ID: 27111842
A Myc-driven self-reinforcing regulatory network maintains mouse embryonic stem cell identity.
Nature communications Jun, 2016 | Pubmed ID: 27301576
Identification of factors promoting ex vivo maintenance of mouse hematopoietic stem cells by long-term single-cell quantification.
Blood Sep, 2016 | Pubmed ID: 27365423
Software tools for single-cell tracking and quantification of cellular and molecular properties.
Nature biotechnology Jul, 2016 | Pubmed ID: 27404877
Early myeloid lineage choice is not initiated by random PU.1 to GATA1 protein ratios.
Nature 07, 2016 | Pubmed ID: 27411635
Challenges in long-term imaging and quantification of single-cell dynamics.
Nature biotechnology Nov, 2016 | Pubmed ID: 27824848
Analysis of Cell Lineage Trees by Exact Bayesian Inference Identifies Negative Autoregulation of Nanog in Mouse Embryonic Stem Cells.
Cell systems Nov, 2016 | Pubmed ID: 27883891
Continuous single cell imaging reveals sequential steps of plasmacytoid dendritic cell development from common dendritic cell progenitors.
Scientific reports Nov, 2016 | Pubmed ID: 27892478
Activity-Independent Effects of CREB on Neuronal Survival and Differentiation during Mouse Cerebral Cortex Development.
Cerebral cortex (New York, N.Y. : 1991) Dec, 2016 | Pubmed ID: 27999124
CSF-1-induced Src signaling can instruct monocytic lineage choice.
Blood Mar, 2017 | Pubmed ID: 28159742
Prospective identification of hematopoietic lineage choice by deep learning.
Nature methods Apr, 2017 | Pubmed ID: 28218899
fastER: a user-friendly tool for ultrafast and robust cell segmentation in large-scale microscopy.
Bioinformatics (Oxford, England) Feb, 2017 | Pubmed ID: 28334115
Hoxa9 and Meis1 Cooperatively Induce Addiction to Syk Signaling by Suppressing miR-146a in Acute Myeloid Leukemia.
Cancer cell Apr, 2017 | Pubmed ID: 28399410
Vitamin A-Retinoic Acid Signaling Regulates Hematopoietic Stem Cell Dormancy.
Cell May, 2017 | Pubmed ID: 28479188
Challenges and emerging directions in single-cell analysis.
Genome biology May, 2017 | Pubmed ID: 28482897
A BaSiC tool for background and shading correction of optical microscopy images.
Nature communications Jun, 2017 | Pubmed ID: 28594001
Lineage Reprogramming of Astroglial Cells from Different Origins into Distinct Neuronal Subtypes.
Stem cell reports Jul, 2017 | Pubmed ID: 28602612
Rebecca E. Nakles1,
Sarah L. Millman1,
M. Carla Cabrera1,
Peter Johnson1,2,
Susette Mueller1,2,
Philipp S. Hoppe3,
Timm Schroeder3,
Priscilla A. Furth1,2,4,5
1Department of Oncology, Georgetown University,
2Lombardi Comprehensive Cancer Center, Georgetown University,
3Stem Cell Dynamics, Helmholtz Zentrum München - German Research Center for Environmental Health,
4Department of Medicine, Georgetown University,
5Department of Nanobiomedical Science and WCU Research Center of Nanobiomedical Science, Dankook University
Rosa Gómez-Villafuertes*,1,2,3,
Lucía Paniagua-Herranz*,1,2,3,
Sergio Gascon*,4,5,
David de Agustín-Durán1,2,3,
María de la O Ferreras1,2,3,
Juan Carlos Gil-Redondo1,2,3,
María José Queipo1,2,3,
Aida Menendez-Mendez1,2,3,
Ráquel Pérez-Sen1,2,3,
Esmerilda G. Delicado1,2,3,
Javier Gualix1,2,3,
Marcos R. Costa6,
Timm Schroeder7,
María Teresa Miras-Portugal1,2,3,
Felipe Ortega1,2,3
1Biochemistry and Molecular Biology Department, Faculty of Veterinary medicine, Complutense University,
2, University Institute for Neurochemistry Research (IUIN),
3, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC),
4Institute of Stem Cell Research, Helmholtz Center Munich, Neuherberg/Munich, Germany Physiological Genomics, Biomedical Center, Ludwig-Maximilians University Munich,
5Toxicology and Pharmacology Department, Faculty of Veterinary medicine, Complutense University,
6Brain Institute, Federal University of Rio Grande do Norte,
7Department of Biosystems Science and Engineering, Eidgenössische Technische Hochschule (ETH) Zurich
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